个人信息


个人简介
个人简介
苏州大学医学部基础医学与生物科学学院教授、博士生导师。苏州大学学术委员会委员，农业生物技术与生态研究院长，苏州大学畜牧学一级学科学术带头人、江苏省畜牧学一级重点学科（培育点）学术带头人，中国蚕学会常务理事，中国蚕学会生理与病理学专业委员会主任委员，江苏省蚕学会副理事长。1994年被评为苏州市劳动模范，2001年入选为浙江省“151人才”第二层次培养对象、宁波市十佳科技创新青年，2002年入选江苏省“333高层次人才培养工程”培养对象，2009年获江苏省“六大高峰人才”称号。主要从事家蚕生物化学与分子生物学、家蚕和水生动物病理、生物工厂设计，病毒与宿主互作等研究。2005年来，主持国家自然科学基金5项、主持国家重大研发项目子课题1项，国家“973”计划子课题1项、国家“863”计划子课题1项、省部级课题5项；以通讯作者发表SCI论文85余篇，以第一发明人获国家发明专利13项，主编教材1部，著书1部，获省部级科技进步奖3项；培养博士研究生15人、硕士研究生48人、农业推广硕士研究生12人、教育学硕士研究生7人。



研究领域
1、家蚕生物化学与分子生物学
2、家蚕和水生动物病理
3、生物工厂设计
4、病毒与宿主互作


基本信息






贡成良
职称：教授
院部/部门：医学部基础医学与生物科学学院
学历：博士
学位：博士研究生
毕业学校：浙江大学
毕业专业：特种经济动物饲养

联系方式


通讯地址：苏州工业园区仁爱路199号
邮政编码：215123
电子邮箱：gongcl@suda.edu.cn
联系电话：0086-
传真号码：
办公地点：医学部基础医学与生物科学学院





科学研究


1、国家自然科学基金，BmCPV通过circEgg环状RNA调节组蛋白修饰控制家蚕基因表达和感染进程的机制，**，58万元，2021-2024年，排名1
2、国家重点研发计划项目，人造蛋白细胞工厂的构建与适配调控子课题，2019YFA**，149万元，2020-2025。学术骨干。
3、国家自然科学基金，BmCPV的环RNA vcircRNA_000048抑制病毒感染机制的研究，60万元，2019-2022年，排名1；
4、家蚕种质资源保护,江苏省农林厅，40万元，2019-2021年，排名1
5、家蚕种质资源保护,江苏省农林厅，40万元，2017-2018年，排名1；
6、异育银鲫疱疹病毒病快速检测技术，CX(17)2027，江苏省农业科技自主创新资金，20万元，2017-2019年，排名1；
7、中华绒螯蟹肝胰腺病变综合征病毒性病原的筛查与发病规律研究，D2017-3-1，江苏省水产三新工程项目，80万元，2017-2019年，排名1；
8、异育银鲫苗种生产过程中CyHV-2控制技术研究，BE**，江苏省科技厅现代农业重点项目，100万元，2016-2018，排名1；
9、CyHV-2异育银鲫重大疾病防控技术体系研究与示范-检测技术研究与养殖现场快速检验室建设规范，D2015-12，江苏省水产三新工程项目，35万元，2015-2018，排名1；
10、江苏省主要水产养殖品种重要病害快速检测技术集成创新与应用，D2013-5-3，省水产三新工程项目，100万元，2013-2015年，排名1
11、国家973计划子专题，家蚕遗传操作技术体系研究，80万，2012-2017年，排名1；
12、国家自然科学基金，家蚕细胞质型多角体病毒受体鉴定及入侵细胞的分子机理研究，80万，2012-2016年，排名1；
13、国家自然科学基金，调控BmOVO基因表达干扰家蚕卵巢发育对丝蛋白合成的影响，33万，2011-2013年，排名第1；
14、国家自然科学基金，转基因技术控制家蚕蛹期发育的研究，26万，2006-2009年，排名1；
15、国家自然科学基金，利用RNAi和转基因技术提高家蚕BmNPV抗性的研究，25万，2005-2008年，排名1；
16、江苏省纺织工程优势学科基金，蚕丝生物工程，200万，2010-2013年，排名1；
17、教育部博士点基金优先发展计划，JAK-STAT途径对家蚕病毒感染的免疫应答机制研究，40万，2012-2014年，排名第1；
18、家蚕细胞质型多角体病毒受体基因筛选与鉴定，家蚕基因组生物学国家重点实验室开放基金资助课题，20万，2012-2014年，排名第1；
19、国家863计划子专题，家蚕重要经济性状功能基因的克隆、分子调控与应用研究，25.5万，2006-2010年，排名第1；
20、国家973计划课题，家蚕生物工厂及基因组应用的拓展研究，285万，2005-2010年，排名第3；
21、高等学校博士学科点专项科研基金，转杆状病毒egt基因控制家蚕发育变态的研究，6万，2007-2008年，排名第1；
22、六大高峰人才基金，转基因技术控制家蚕F1代蛹期发育的研究，3万，2011-2013年，排名1；
23、校重大培育项目(应用)，GAL4/UAS双元转基因系统控制家蚕F1代蛹期发育的研究，40万，2010-2012年，排名1；
24、江苏省科技厅自然科学基金，家蚕减数分裂阻滞基因achi的功能及作用机制研究，8万，2010-2012年,排名1；
25、周文林（2005年）、张轶岭（2011年）、郭睿（2012年）、朱敏（2016年）研究生创新计划，江苏省省教育厅，指导老师。


科研团队


1、研究团队教师
薛仁宇（副教授）、曹广力（副教授）、胡小龙（副教授）、张星（博士后）、朱敏（师资博士后）、冯永杰（实验师）。
2、在读博士研究生
张云山（畜牧学-特种经济动物饲养科学）、沈泽恩（畜牧学-特种经济动物饲养科学）、潘俊（畜牧学-特种经济动物饲养科学）。
3、在读硕硕士研究生
生物学-生物化学与分子生物学专业：代亚萍、张梓瑶、张亚昕、代坤。
生物学-遗传学专业：曹满满。
畜牧学-特种经济动物饲养科学：童新宇（博士研究生候选人）
4、在读专业硕士
徐劲（在职）、冯侃然（在职）、顾宇超、孙素飞。




论文


一、发表论文（*通讯作者）1.Zhangyan Wang, Yunshan Zhang, Kun Dai, Zi Liang, Min Zha, Mingtian Zhana, Jun Pa, Xiaolong Hua, Xing Zhang, Renyu Xue, Guangli Cao, Chengliang Gong*.circEgg regulates histone H3K9me3 by sponging bmo-miR-3391–5p and encoding circEgg-P122 protein in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology. 2020, 124: 103430
2.Yongjie Feng, Dhiraj Kumar, Xiaolong Hu, Yiling Zhang, Min Zhu, Renyu Xue,Guangli Cao, Chengliang Gong*. Comparative transcriptome analysis of wing discs from Bombyx mori and Bombyx mandarina. Journal of Asia-Pacific Entomology. 2020,23:327-335
3.Tingting Zhang, Rui Yuan, Xing Zhang, Bo Liu, Yang Zhou, Zi Liang, Min Zhu, Mingtian Zhang, Yunshan Zhang, Kun Dai, Ziyao Zhang, Manman Cao Yuchao Gu, Jun Pan, Bingyu Yan, Hanxue Zhu, Yuqun Zhou, Yongjie Feng, Renyu Xue, Guangli Cao, Hui Chen, Xiaolong Hu,Chengliang Gong*. De novo RNA-seq assembly and differential transcriptome analysis of Carassius auratus gibelio after Cyprinid herpesvirus 2 infection. Aquaculture, 2020, 519:734923
4.Yunshan Zhang, Xing Zhang, Zi Liang, Min Zhu, Mingtian Zhang, Tingting Zhang, Ziyao Zhang, Manman Cao, Yuchao Gu, Jun Pan, Bingyu Yan, Hanxue Zhu, Renyu Xue, Guangli Cao, Yuan Gao,, Xiaolong Hu, Chengliang Gong*. Expression pattern and regulatory network of gibel carp (Carassius gibelio) miRNAs and their putative target genes in response to CyHV-2 infection. Aquaculture. 2020, 523: 735178
5.Yunshan Zhang, Xing Zhang, Zi Liang, Kun Dai, Min Zhua, Mingtian Zhang, Jun Pan, Renyu Xue, Guangli Cao, Jian Tang, Xuehong Song, Xiaolong Hu, Chengliang Gong*. Interleukin-17 suppresses grass carp reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling. Aquaculture. 2020, 520: 734969
6.Xing Zhang, Yunshan Zhang, Kun Dai, Zi Liang, Min Zhu, Jun Pan, Mingtian Zhang, Bingyu Yan, Hanxue Zhu, Ziyao Zhang, Yaping Dai, Manman Cao, Yuchao Gu, Renyu Xue，Guangli Cao, Xiaolong Hu, Chengliang Gong*. N6-Methyladenosine Level in Silkworm Midgut/Ovary Cell Line Is Associated With Bombyx mori Nucleopolyhedrovirus Infection. Frontiers in Microbiology. 2020, 10:2988
7.Zi Liang, Yahong Lu, Mengsheng Jiang, Ying Qian, Liyuan Zhu, Sulan Kuang, Fei Chen, Yongjie Feng, Xiaolong Hu, Guangli Cao, Renyu Xue, Chengliang Gong*. Alternative isoforms of BmYki have different transcriptional co-activator activity in the silkworm, Bombyx mori. International Journal of Biochemistry and Cell Biology. 2019, 116:105599
8.Xiaolong Hua, Yaping Dai, Xing Zhang, Kun Dai, Bo Liu, Rui Yuan, Yongjie Feng, Zi Liang, Min Zhu, Mingtian Zhang, Yunshan Zhang, Ziyao Zhang, Manman Cao, Yuchao Gu, Jun Pan, Bingyu Yan, Hanxue Zhu, Renyu Xue, Guangli Cao, Hui Chen, Yujun Wang, Chengliang Gong*. Identification and characterization of novel type of RNAs, circRNAs in crucian carp Carassius auratus gibelio.Fish and Shellfish Immunology. 2019, 94: 50–57
9.Bo Liu, Rui Yuan, Zi Liang, Tingting Zhang, Min Zhu, Xing Zhang, Wei Geng, Ping Fang, Mengsheng Jiang, Zhangyan Wang, Yongjie Feng, Xunmeng Liu, Yang Zhou, Renyu Xue, Guangli Cao, Hui Chen, Xiaolong Hu, Chengliang Gong*. Comprehensive analysis of circRNA expression pattern and circRNA–mRNA–miRNA network in Ctenopharyngodon idellus kidney (CIK) cells after grass carp reovirus (GCRV) infection. Aquaculture. 2019 258 :734349
10.Min Zhu, Kun Li, Yinming Xuan, Zhenli Sun, Bo Liu , Dhiraj Kumar, Ming Jiang, Yunsheng Pan, Yiming Zhang, Yeping Gong, Xiaoping Lu, Deshan Yu, Xiaolong Hu, Guangli Cao, Renyu Xue, Chengliang Gong*. Host Range and Vertical Transmission of Cyprinid herpesvirus 2.Turk. J. Fish.& Aquat. Sci. 2019,19(8): 645-652
11.Bingyu Yan, Xunmeng Liu, Yuqun Zhou, Mingtian Zhang, Ping Fang, Mengsheng Jiang, Rui Yuan, Xiaolong Hu, Guangli Cao, Renyu Xue, Hui Chen, Chengliang Gong*. Transcriptomic analysis reveals that hepatopancreatic necrosis disease in Eriocheir sinensis (Chinese mitten crabs) may be the result of autophagy and apoptosis.Aquaculture. 2020, 515:734579
12.Xiaolong Hu, Fei Chen, Liyuan Zhu, Lei Yu, Min Zhu, ZiLiang, Xing Zhang, Renyu Xue, Guangli Cao, Chengliang Gong*. Bombyx mori cypovirus encoded small peptide inhibits viral multiplication. Developmental& Comparative Immunology.2019，96:51-57
13.Dhiraj Kumara, Zhenli Suna, Guangli Caoa, Renyu Xue, Xiaolong Hua, Chengliang Gong*.Study of gut bacterial diversity of Bombyx mandarina and Bombyx mori through 16S rRNA gene sequencing. Journal of Asia-Pacific Entomology,2019,22: 522–530
14.Li K, Yuan R, Zhang M, Zhang T, Gu Y, Zhou Y, Dai Y, Fang P, Feng Y, Hu X, Cao G, Xue R, Chen H,Gong C*.Recombinant baculovirus BacCarassius-D4ORFs has potential as a live vector vaccine against CyHV-2.Fish Shellfish Immunol. 2019,92:101-110.
15.Zhu M, Hu X, Liang Z, Jiang M, Xue R, Gong Y, Zhang X, Cao G, Gong C*. Functional characterization of BmOVOs in silkworm, Bombyx mori. BMC Genomics. 2019,20(1):342
16.Zhang X, Xia L, Day BA, Harris TI, Oliveira P, Knittel C, Licon AL,Gong C, Dion G, Lewis RV, Jones JA.CRISPR/Cas9 Initiated Transgenic Silkworms as a Natural Spinner of Spider Silk. Biomacromolecules. 2019,20(6):2252-2264
17.Zhang Y, Zhu L, Cao G, Sahib Zar M, Hu X, Wei Y, Xue R, Gong C*. Cell entry of BmCPV can be promoted by tyrosine-protein kinase Src64B-like protein. Enzyme Microb Technol. 2019,121:1-7.
18.Kumar D, Sun Z, Cao G, Xue R, Hu X, Gong C*.Bombyx mori bidensovirus infection alters the intestinal microflora of fifth instar silkworm (Bombyx mori) larvae.J Invertebr Pathol. 2019,163:48-63
19.Liang Z, Lu Y, Qian Y, Zhu L, Kuang S, Chen F, Feng Y, Hu X, Cao G, Xue R, Gong C*. Cultured cells and wing disc size of silkworm can be controlled by the Hippo pathway, Open Biol, 2018, 8(7). pii: 180029
20.Zhu M, Hu X, Cao G, Xue R, Gong C*. Functions and impact of tal-like genes in animals with regard to applied aspects, Appl Microbiol Biotechnol, 2018,
21.Cao G, Gong Y, Hu X, Zhu M, Liang Z, Huang L, Yu L, Xu J, Li K, Zar MS, Xue R, Gong C*. Identification of tarsal-less peptides from the silkworm Bombyx mori, Appl Microbiol Biotechnol, 2018, 102（4）:1809-1822
22.Chen F, Zhu L, Zhang Y, Kumar D, Cao G, Hu X, Liang Z, Kuang S, Xue R, Gong C*. Clathrin-mediated endocytosis is a candidate entry sorting mechanism for Bombyx mori cypovirus, scientific reports, 2018, 8（1）：7268
23.Zhu L, Hu X, Kumar D, Chen F, Feng Y, Zhu M, Liang Z, Huang L, Yu L, Xu J, Xue R, Cao G, Gong C*. Both ganglioside GM2 and cholesterol in the cell membrane are essential for Bombyx mori cypovirus cell entry, DEV COMP IMMUNOL, 2018, 88：161-168
24.Hu X, Zhu M, Liu B, Liang Z, Huang L, Xu J, Yu L, Li K, Jiang M, Xue R, Cao G, Gong C*.Circular RNA alterations in the Bombyx mori midgut following B. mori nucleopolyhedrovirus infection, MOL IMMUNOL, 2018, 101：361-470
25.Liu B, Zhou Y, Li K, Hu X, Wang C, Cao G, Xue R, Gong C*.The complete genome of Cyprinid herpesvirus 2, a new strain isolated from Allogynogenetic crucian carp, Virus, 2018, 256：6-10
26.Rui Guo, Guangli Cao, Renyu Xue, Dhiraj Kumar, Fei Chen, Wei Liu,Yue Jiang,Yahong Lu, Liyuan Zhu, Zi Liang, Sulan Kuang, Xiaolong Hu,Chengliang Gong*.Exogenous gene can be expressed by a recombinant Bombyx mori cypovirus. Appl Microbiol Biotechnol. 2018,102(3):1367-1379
27.Hu X, Zhu M, Zhang X, Liu B, Liang Z, Huang L, Xu J, Yu L, Li K, Zar MS, Xue R, Cao G, Gong C* .Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.RNA Biol. 2018 15(2):292-301
28.Sun Z, KumarD, Cao G, Zhu L, Liu B, Zhu M, Liang Z, Kuang S, Chen F, Feng Y, Hu X, Xue R, Gong C*. Effects of transienthigh temperature treatment on the intestinal flora of the silkworm Bombyx mori.Sci Rep. 2017, 7(1):3349
29.Hu X, Zhu M,Liang Z, Kumar D, Chen F, Zhu L, Kuang S, Xue R, Cao G, Gong C*. Proteomic analysis of BmN cell lipid rafts revealsroles in Bombyx mori nucleopolyhedrovirus infection. Mol Genet Genomics, 2017,292(2):465-474
30.Zhang Y, Cao G, Zhu L, Chen F, Zar MS, Wang S, Hu X, Wei Y, Xue R, Gong C*. Integrin beta and receptor for activated proteinkinase C are involved in the cell entry of Bombyx mori cypovirus. Appl Microbiol Biotechnol. 2017, 101(9):3703-3716
31.Song X, Hu X,Sun B, Bo Y, Wu K, Xiao L, Gong C*.A transcriptome analysis focusing on inflammation-related genes of grass carpintestines following infection with Aeromonas hydrophila. Sci Rep. 2017,7:40777
32.He L, Hu X,Zhu M, Liang Z, Chen F, Zhu L, Kuang S, Cao G, Xue R, Gong C*. Identification and characterization of vp7 gene inBombyx mori cytoplasmic polyhedrosis virus. Gene, 2017, 627:343-350
33.Zhonghua Pan,Xuehong Song, Xiaolong Hu, Renyu Xue, Guangli Cao, Mian Sahib Zar, DhirajKumar, Yongjie Feng,Yuhong Wei, Weiye Zhang, Wei Zhang, Chengliang Gong*. Pathological Changes and Risk Factors ofHepatopancreas Necrosis Disease of Mitten Crab, Eriocheir Sinensis. Fisheries and Aquaculture Journal. 2017, 8(3): **
34.Guo R, Cao G,Zhu Y, Kumar D, Xue R, Lu Y, Hu X, GongC*. Novel Infection System of Recombinant BmBDV DNA into BmN Cells ofSilkworm, Bombyx mori. Curr Microbiol. 2016, 73(4):587-94
35.Liu B, GongY, Li Z, Hu X, Cao G, Xue R, Gong C*.Baculovirus-mediated GCRV vp7 and vp6 genes expression in silkworm and grasscarp. Mol Biol Rep. 2016, 43(6):509-15
36.Zheng X, GongY, Kumar D, Chen F, Kuan S, Liang Z, Hu X, Cao G, Xue R, Gong C*. Effect of BBX-B8 overexpression on development,body weight, silk protein synthesis and egg diapauses of Bombyx mori.Transgenic Res. 2016, 25(4):507-16
37.Hao Zhang,Zhenli Sun, Bo Liu, Yinming Xuan, Ming Jiang, Yunsheng Pan, Yiming Zhang,Yeping Gong, Xiaoping Lu, Deshan Yu, Dhiraj Kumar, Xiaolong Hu, Guangli Cao,Renyu Xue, Chengliang Gong*.Dynamic changes of microbial communities in Litopenaeus vannamei cultures andthe effects of environmental factors. Aquaculture. 2016, 455: 97–108
38.Sun Z, Lu Y,Zhang H, Kumar D, Liu B, Gong Y, Zhu M, Zhu L, Liang Z, Kuang S, Chen F, Hu X,Cao G, Xue R, Gong C*.Effects of BmCPV Infection on Silkworm Bombyx mori Intestinal Bacteria. PLoSOne. 2016, 11(1):e**
39.Guo R, CaoG, Lu Y, Xue R, Kumar D, Hu X, GongC*. Exogenous gene can be integrated into Nosema bombycis genome bymediating with a non-transposon vector. Parasitol Res. 2016, 115(8):3093-8
40.Zhang X, GuoR, Kumar D, Ma H, Liu J, Hu X, Cao G, Xue R, Gong C*. Identification, gene expression and immune functionof the novel Bm-STAT gene in virus-infected Bombyx mori. Gene. 2016, 577: 82–88
41.Hu X, JiangY, Gong Y, Zhu M, Zhu L, Chen F, Liang Z, Kuang S, Zar MS, Kumar D, Cao G, XueR, Gong C*. Important rolesplayed by TGF- member of Bmdpp and Bmdaw in BmNPV infection. MolecularImmunology. 2016, 73:122–129
42.Xue R, Hu X,Zhu L, Cao G, Huang M, Xue G, Song Z, Lu J, Chen X, Gong C*. Comparative transcriptomic analysis ofsilkwormBmovo-1 and wild type silkworm ovary. Sci rep. 2015, 5:17867
43.Hu X, ShenY, Zheng Q, Wang G, Wu X, Gong C*.Bm59 is an early gene, but is unessential for the propagation and assembly ofBombyx mori nucleopolyhedrovirus. Mol Genet Genomics. 2016, 291(1):145-54
44.Hu X, ZhangX, Wang J, Huang M, Xue R, Cao G, GongC*. Transcriptome analysis of BmN cells following over-expression ofBmSTAT. Mol Genet Genomics. 2015, 290(6):2137-46
45.Hu X, Zhu M,Wang S, Zhu L, Xue R, Cao G, Gong C*.Proteomics analysis of digestive juice from silkworm during Bombyx morinucleopolyhedrovirus infection. Proteomics. 2015, (15):2691-700
46.Guo R, WangS, Xue R, Cao G, Hu X, Huang M, Zhang Y, Lu Y, Zhu L, Chen F, Liang Z, Kuang S, Gong C*. The gene expressionprofile of resistant and susceptible Bombyx mori strains revealscypovirus-associated variations in host gene transcript levels. Appl MicrobiolBiotechnol. 2015, 99(12):5175-87
47.Liu W, LiuJ, Lu Y, Gong Y, Zhu M, Chen F, Liang Z, Zhu L, Kuang S, Hu X, Cao G, Xue R, Gong C*. Immune signalingpathways activated in response to different pathogenic micro-organisms inBombyx mori. Molecular Immunology. 2015, 65(2):391-7
48.Zhu M, LiuB, Cao G, Hu X, Wei Y, Yi J, Zhou Y, Pan G, Wang J, Xue R, Gong C*. Identification and rapid diagnosis of the pathogenresponsible for haemorrhagic disease of the gill of Allogynogenetic cruciancarp. Journal of Virological Methods. 2015, 219:67-74
49.Li Z, JiangY, Cao G, Li J, Xue R, Gong C*.Construction of Transgenic Silkworm Spinning Antibacterial Silk withFluorescence. Molecular Biology Reports. 2015, 42(1):19-25.
50.Zhang P,Zhong J, Cao G, Xue R, Gong C*.BmAly Is an Important Factor in Meiotic Progression and SpermatidDifferentiation in Bombyx mori (Lepidoptera: Bombycidae). Journal of InsectScience. 2014, 14:188
51.Zhang YL,Xue RY, Cao GL, Meng XK, Zhu YX, Pan ZH, GongCL*. Nonvirus encoded proteins could be embedded into Bombyx moricypovirus polyhedral. Mol Biol Rep. 2014:2657-2666
52.He L, Cao G,Huang M, Xue R, Hu X, Gong C*.Expression pattern of immunoglobulin superfamily members in the silkworm. Gene.2014,548(2):189-209
53.XuehongSong, Jie Zhao, Yunxuan Bo, Zhaojun Liu, Kang Wu, Chengliang Gong*. Aeromonas hydrophila induces intestinalinflammation in grass carp (Ctenopharyngodon idella): An experimental model.Aquaculture.2014, 434:171-178
54.Zhen Li,Guangli Cao, Renyu Xue, ChengliangGong*. Methods for transferring gene into silkworm and expression ofhGM-CSF in silk glands of transgenic silkworm. Journal of Chemical andPharmaceutical Research.2014,6(5): 118-129
55.Xue R, HuX1, Cao G1, Huang M, Xue G, Qian Y, Song Z, Gong C*. Bmovo-1 Regulates Ovary Size in the Silkworm,Bombyx mori. PLOS ONE.2014,9(8): e104928
56.Song Z,Zhang M, Xue R, Cao G, Gong C*.Reducing blood glucose levels in TIDM mice with an orally administered extractof sericin from hIGF-I-transgenic silkworm cocoons. Food and ChemicalToxicology.2014,67:249-254
57.Yin Y, CaoG, Xue R, Gong C*.Construction of transformed, cultured silkworm cells and transgenic silkwormusing the site-specific integrase system from phage ?C31. Molecular BiologyReports. 2014, 41(10):6449-6456.
58.Zhang P,Wang J, Lu Y, Hu Y, Xue R, Cao G, GongC*. Resistance of transgenic silkworm to BmNPV could be improved bysilencing ie-1 and lef-1 genes. Gene Ther. 2014, 21(1):81-88
59.Zhang YL,Xue RY, Cao GL, Zhu YX, Pan ZH, GongCL*. Shotgun proteomic analysis of wing discs from the domesticatedsilkworm (Bombyx mori) during metamorphosis. Amino Acids. 2013,45(5):1231-1241
60.Xue R, LiuL, Cao G, Xu S, Li J, Zou Y, Chen H, GongC*. Oral vaccination of BacFish-vp6 against grass carp reovirus evokingantibody response in grass carp. Fish & Shellfish Immunology. 2013, 34:348-355
61.Ying Qian,Jiabin Liu, Guangli Cao, Renyu Xue, ChengliangGong*, Cloning and Sequence Analysis of Hippo Pathway Related MajorGenes of Silkworm (Bombyx mori), Advanced Materials Research,2013 ,796 : 48-56
62.Jiabin Liu,Ying Qian, Renyu Xue, Guangli Cao, ChengliangGong*, Prediction of genes regulated by JAK-STAT signal pathway,Advanced Materials Research,2013 ,796 : 25-35
63.Zhang P, CaoG, Sheng J, Xue R, Gong C*.BmTGIF, a Bombyx mori Homolog of Drosophila DmTGIF, Regulates Progression ofSpermatogenesis. Plos one. 2012,7(11):e47861
64.Xue R, ChenH, Cui L, Cao G, Zhou W, Zheng X, GongC*.Expression of hGM-CSF in silk glands of transgenic silkworms usinggene targeting vector. Transgenic Res. 2012,21(1):101-111
65.Cao,Guangli; Meng, Xiangkun; Xue, Renyu; Zhu, Yuexiong; Zhang, Xiaorong; Pan,Zhonghua; Zheng, Xiaojian; Gong,Chengliang*. Characterization of the complete genome segments fromBmCPV-SZ, a novel isolate Bombyx mori cypovirus 1 isolate, Canadian Journal ofMicrobiology. 2012 58(7):872-883
66.Xue R, WangY, Cao G, Pan Z, Zheng X, Zhou W, GongC*. Lowering Blood Glucose of Diabetes Mellitus Mice by OralAdministration with Transgenic hIGF-I Silkworms，Journal of Agricultural and Food Chemistry,2012,60(12):6559-6564
67.Hao-KunZhang, Guang-Li Cao, Xiao-Rong Zhang, Xiao-Juan Wang, Ren-Yu Xue, Cheng-Liang Gong*. Effects ofBmKIT3R Gene Transfer on Pupal Development of Bombyx mori Linnaeus Using aGal4/UAS Binary Transgenic System, Journal of Agricultural and Food Chemistry,2012，60(12):3173-3179
68.XiaolinZhang, Shitang Ma, Meisong Qin, Guoliang Zhou, Lili Zhou, Yanxi Fang, Hao Yu, Chengliang Gong*. Oralimmunisation with silkworm pupae powder containing recombinant UreB of H.pylori affords prophylactic and therapeutic effects against H. pylori infectionin mice，AfricanJournal of Microbiology Research，2012，6(16)：3761-3767
69.Zhang X, XueR, Cao G, Hu X, Wang X, Pan Z, Xie M, Yu X, Gong C*. Effects of egt Gene Transfer on Development ofBombyx mori. Gene. 2012,491(2):272-277
70.Hu Xiaolong,Xue Renyu, Cao Guangli, Zhang Xing, Zhang Yilin, Yu Xiaohua, Zhang Yuqing, Gong Chengliang*. Elementary researchof the formation mechanism of sex-related fluorescent cocoon of silkworm,Bombyx mori. Mol Biol Rep. 2012,39(2):1395-1409
71.Zheng XiaoJian, Lu Ye, Zhang Pen Jie, Zhang Xiao Li, Cao Guang Li, Xue Ren Yu, Gong Cheng Liang*. Effect ofinhibiting the expression of insulin-like peptide gene BBX-B8 on developmentand reproduction of silkworm, Bombyx mori. Afr. J. Biotechnol. 2012,11(10):2548-2554
72.XiaoliZhang, Renyu Xue, Guangli Cao, Zhonghua Pan, Xiaojian Zheng, Chengliang Gong*. Silkworms canbe used as an animal model to screen and evaluate gouty therapeutic drugs.Journal of Insect Science.12:4
73.HaokunZhang, Guangli Cao, Yanmei Li, Renyu Xue, ChengliangGong*. Expression of human Glanulocyte Marcophage colony stimulatingfactor in stably-transformed BmN cells and Sf-21 cells and silkworm by anon-transposon vector，JOURNALOF ANIMAL AND VETERINARY ADVANCES，2012(11)16:2890-2897
74.Renyu Xue,Qin Zhang, Yuhong Wei, Yuexiong Zhu, Xiaoyan Zhou, Guangli Cao, Chengliang Gong*. Sequentialmethod for rapid early diagnosis of white spot syndrome virus in crayfish.African Journal of Biotechnology. 2012,11(58):12232-12239
75.Cong L, CaoG, Renyu X, Zhonghua P, Xiaojian Z, Zhou W, Gong C*. Reducing blood glucose level in diabetes mellitusmice by orally administering the silk glands of transgenic hIGF-I silkworms.Biochem Biophys Res Commun. 2011, 410(4):721-725
76.Li Y, Cao G,Wang Y, Xue R, Zhou W, Gong C*.Expressionof the hIGF-I gene driven by the Fhx/P25 promoter in the silk glands of germlinesilkworm and transformed BmN cells. Biotechnol Lett. 2011, 33(3):489-494
77.Wang, X.;Cao, G.; Xue, R.; Xie, M.; Zhang, X.; Yu, X.; Gong, C*. Effects of BmKIT3R gene transfer on thedevelopment and survival of silkworm Bombyx mori. J Biosci Bioeng.. 2011,112(6)：523-528
78.Lu Ye, ZhengXiao Jian, Xue Ren Yu, Cao Guang Li, Shen Wei De, Gong Cheng Liang*. Antiproliferative activity of recombinanthuman interferon-λ2 expressed in stably transformed BmN cells. Afr. J.Biotechnol. 2011,10(37): 7260-7266
79.Zhang X,Shen W, Lu Y, Zheng X, Xue R, Cao G, Pan Z, Gong C*. Expression of UreB and HspA of Helicobacter pyloriin silkworm pupae and identification of its immunogenicity. Mol Biol Rep. 2011,38(5):3173-3180
80.Cao G, ZhangY, Xue R, Zhu Y, Wei Y, Zheng X, GongC*. Alternative splicing, expression patterns and promoter charactersof vasa-like gene from the silkworm, Bombyx mori. Mol Biol Rep. 2012, 39(5):5967-5976
81.Guangli Cao,Renyu Xue, Yuexiong Zhu, Yuhong Wei, ChengliangGong*. Nuclear mitochondrial DNA pseudogenes in the genome of thesilkworm, Bombyx mori. J Comp Biol Bioi Res. 2011, 3(7): 103-119
82.CUI Lin-Lin,XUE Ren-Yu, LUYe, CAOGuang-Li, GONGCheng-Liang*. Expression of hIL-28A in Transgenic Silkworm Mediated byNon-transposon Vector. Progress in Biochemistry and Biophysics. 2011,38(8):724-729
83.Hu XL, CaoGL, Xue RY, Zheng XJ, Zhang X, Duan HR, GongCL*. The complete mitogenome and phylogenetic analysis of Bombyxmandarina strain Qingzhou. Mol Biol Rep. Mol Biol Rep. 2010, 37(6):2599-2608
84.Li Y, Cao G,Chen H, Jia H, Xue R, Gong C*.Expression of the hGM-CSF in the silk glands of germline of gene-targetedsilkworm. Biochem Biophys Res Commun. 2010,391(3):1427-1431
85.MENGXiang-kun, GONG Cheng-liang, XUE Ren-yu, CAO Guang-li, ZHU Yueyong, GONG Chengliang*. Cloning andsequence analysis of lef-3 gene from Pieris rapae granulovirus. AgriculturalSciences In China. 2010,9(5)：681-689
86.RY Xue, X.Li, Y. Zhao, XL Pan, XX Zhu, GL Cao, CLGong*. Elementary research into the transformation BmN cells mediatedby the piggyBac transposon vector. J Biotechnol. 2009,144(4):272-278
87.Zhao Y, LiX, Cao G, Xue R, Gong C*.Expression of hIGF-I in the silk glands of transgenic silkworms and intransformed silkworm cells. Sci China C Life Sci. 2009, 52(12):1131-1139
88.LU Yin-Song,XUE Ren-Yu, CAO Guang-Li, ZHANG Peng -Jie, LIU Bo, GONG Cheng-Liang*. Resistance to BmNPV of TransformationCells Expressing Short lef-1 dsRNA. Progress in Biochemistry and Biophysics.2009, 36(10): 1356-1363
89.Wenlin Zhou, Chengliang Gong, Renyu Xue,Guangli Cao, Jinru Cao, Aihong Ye, Hongbiao, Weng,Yongqiang Wang. GermlineTransformation of the Silkworm Bombyx mori L. by Sperm-MediatedGeneTransfer. BIOLOGY OF REPRODUCTION,2012, 87(6):144, 1–5
二、专利（第一发明人）
(1)人表皮生长因子核酸序列及其应用，ZL 8.x
(2)一种发育可控的家蚕的构建方法及发育控制方法，ZL1.0
(3)一种提高原蚕产卵量的方法，ZL9.8
(4)一种载有人胰岛素样生长因子-I基因的重组转基因载体及其应用，ZL7.8
(5)一种草鱼出血病口服疫苗的制备方法，ZL1.5
(6)一种家蚕生物反应器制备人白介素28A的方法及其制药用途，ZL6.1
(7)一种构建转基因家蚕微孢子虫的方法，ZL8.8
(8)改造重组家蚕核型多角体病毒的基因工程载体的构建方法，ZL3.2
(9)制备转基因家蚕的方法及其制药用途，ZL9.8
(10)一种控制家蚕蛹期发育的方法，ZL4.4
(11)一种家蚕质型多角体的体外构建方法,ZL3.2
(12)一种表达红色荧光蛋白的重组家蚕质型多角体病毒的构建方法,ZL4.7
(13) 基于杆状病毒表达系统制备包裹鲤疱疹病毒II型抗原的多角体方法，ZL1.4
三、著书
(1)Trends in Insect Molecular Biology and Biotechnology, Kumar, Dhiraj; Gong, Chengliang(Eds.), Springer Nature, 2017, SBN 978-3-319-61342-0
(2)家蚕病理学（全国高等农业院校教材，全国高等农业院校教学指导委员会审定）。北京：中国农业出版社，2001，主编：金伟；副主编：鲁兴萌：编者：万永继、贡成良、廖富萍。
(3)蚕病的发生与防治,南京，江苏科技出版社,1994年,编者：钱元骏、吴友良、郭锡杰、贡成良。
(4)蚕桑高新技术研究与进展，中国农业大学出版社，2012年，主编：鲁兴萌，编委：楼程富，谈建中，贡成良，缪云根，吴小锋，朱祥瑞，曹广力，薛仁宇
(5)生物化学与分子生物实验指导，苏州，苏州大学出版社，2010年，主编：贡成良，曲春香.
(6)家蚕饲养与良种繁育学（新世纪蚕学特色专业系列教材），北京，高等教育出版社，2015，主编：朱勇，编者:刘劲、许雅香、贡成良、李春峰、吴大洋、张高军、林英、林健荣、赵天福、潘中华
(7)蚕病的识别与防治, CCTV-7,1999,剧本主编:贡成良





荣誉奖励


1、浙江省151人才,2001
2、江苏省“333工程”第三层次培养对象,1997年，2002年，2007年
3、宁波十佳科技创新青年（宁波市第二届十大科技创新奖）,2001年
4、浙江省宁波市“4321”人才,2000年
5、苏州市劳动模范,1994年
6、江苏省普通高校优秀青年骨干教师,1992,1994年
7、江苏省六大高峰人才,2009年
8、新型蚕用烟熏消毒剂研究，苏州市科技进步3等奖,1997年,排名1
9、家蚕微粒子病研究，苏州市科技进步3等奖,2001,排名1
10、用BmNPV表达丙型肝炎抗原蛋白，苏州市进步2等奖,2002,排名4
11、天康宁胶囊，宁波市科技进步2等奖,2001,排名6
12、杆状病毒基因及表达系统产业化开发研究，苏州大学科技进步2等奖,2004年,排名1
13、中华绒螯蟹颤抖病防治技术研究，上海市科学技术优胜奖,2003
14、全国大学生的创业杯比赛获优胜奖,1999
15、全国大学生挑战杯获二等奖；指导教师,2001
16、SARS-CoVS蛋白、M蛋白在E.coli和家蚕中的表达，江苏省普通高等学校本专科毕业设计(论文)一等奖，指导教师,2006
17、大学生科研能力培养的探讨，苏州大学教学成果1等奖,2007,排名1
18、江苏省水生动物重要病害测报及防控技术集成与应用，江苏省农业技术推广3等奖,2015,排名2
19、草鱼出血病核酸疫苗的研制，江苏省海洋与渔业局科技创新2等奖,2014,排名2
20、江苏省主要水生动物疾病防控关键技术集成与示范，江苏省农业技术推广3等奖,2018,排名3
21、江苏省主要经济鱼类重要病害防控技术集成与应用，第四届中国水产学会范蠡科技奖，一等奖，,2019,排名2
22、第二届“东方紫杯”全国大学生蚕桑生物技术创新大赛硕士生组特等奖,2019,指导教师
23、第二届“东方紫杯”全国大学生蚕桑生物技术创新大赛博士生组一等奖,2019,指导教师




开授课程


1、转基因及转基因食品安全性
2、食品生物化学
3、食品生物化学实验
4、食品生物技术
5、生物化学与分子生物学
6、高级生物化学

招生信息


1、博士研究生招生学科、专业
090504特种经济动物饲养科学
100706药理学，生物制药
2、硕士研究生招生学科、专业
0710生物学，生物化学与分子生物学
090504特种经济动物饲养科学
3、专业硕士学位
420100教育硕士（生物）
470105农业推广（养殖）





研究项目（旧版）

荣誉奖励（旧版）

科研成果（旧版）