个人信息


个人简介
2006.9-2010.6 南京大学 物理学院 凝聚态物理 本科
2010.9-2015.6 南京大学 物理学院 软物质物理硕博连读
2015.8-2020.9苏州大学 软凝聚态物理及交叉研究中心 副教授
2020.10-至今苏州大学 软凝聚态物理及交叉研究中心****

主要从事计算软物质物理、纳米-生物界面相互作用及自组装等方面的理论模拟研究，包括通过结合理论与分子模拟研究纳米粒子与细胞的相互作用（例如纳米粒子与细胞膜、细胞内外蛋白等相互作用的内在分子机理及纳米粒子对生物体潜在毒性的研究等），利用全原子模拟和粗粒化模拟研究生物分子(蛋白质、DNA等)的组装机理。目前已在SCI杂志发表论文40余篇。其中以第一作者和通讯作者身份（含共同）在Nature Communications（2篇）, J. Am. Chem. Soc.（4篇）, ACS Central Science, Angew. Chem. Int. Ed.（2篇）, ACS Nano（2篇）, Biomaterials（3篇）, Small 等一流SCI杂志发表论文30余篇，包括9篇封面/封底论文；累计引用超1000次（H-index 18），单篇最高他引180余次，3篇论文他引超100次，3篇论文曾入选ESI高被引论文。目前承担国家自然科学青年基金1项和国家自然科学面上项目1项。2016年入选苏州市高等院校、科研院所紧缺高层次人才，2017年入选苏州大学首批优秀青年****，2019年获江苏省科学技术二等奖（排名第2）。

近期代表性工作(详细论文发表清单见成果奖励):
1.Angew. Chem. Int. Ed., 59, 9617-9623 (2020)
2.J. Am. Chem. Soc., 142, 4800-4806 (2020) [Back Cover]
3. J. Am. Chem. Soc., 141, 18910-18915 (2019)
4ACS Nano, 13, 13474-13485 (2019)
5. J. Am. Chem. Soc., 141, 16014-16023 (2019)
6. Nature Communications, 10, 4520 (2019)
7.J. Am. Chem. Soc., 141, 583-591(2019) [Front Cover]
8.ACS Central Science, 4, 1344-1351(2018) [Highlighted by First Reactions]
9.Nature Communications, 8, 2131 (2017)
10.Angew. Chem. Int. Ed., 56, 10691-10695 (2017) [Back Cover, Hot Paper]
11.Small, 11, 1055-1071 (2015) [Inside Cover, ESI Highly Cited Paper]
12. Biomaterials,35, 8703-8710 (2014)
13.Biomaterials,34, 8401-8407 (2013)
14.ACS Nano, 6, 1230-1238 (2012)
15.Biomaterials,33, 5798-5802 (2012)






研究领域
1.纳米粒子与细胞膜界面作用的物理机理；
2.蛋白冠对纳米粒子生物学行为的影响；
3.新冠病毒与受体、抗体相互作用的分子机制；
4.纳米粒子、大分子自组装机理研究。


基本信息






丁泓铭
职称：教授
院部/部门：物理科学与技术学院
学历：
学位：
毕业学校：
毕业专业：

联系方式


通讯地址：
邮政编码：
电子邮箱：dinghm@suda.edu.cn
联系电话：
传真号码：
办公地点：物理科技楼247室





科学研究


近些年来，纳米材料已经在很多科学技术领域得到了广泛的应用。作为其中发展最为迅猛的崭新领域之一，纳米医学目前得到了大家越来越多的重视。与传统材料相比，纳米材料由于其独特的物理化学性质，使其在生物传感，细胞成像，药物输运等方面有着显著的优势。理解纳米材料与生物体，尤其是与细胞和生物大分子(蛋白、DNA/RNA等)间的相互作用对在生物医药领域更好地利用纳米材料（例如提高输运效率同时减少毒副作用）有着非常重要的科学意义。


本课题组力图从理论模拟角度来研究上述问题，期望能够从微观介观角度揭示它们间的相互作用机理，并进一步地与国内相关实验课题组合作设计出新型的纳米生物材料。
科研项目：目前承担国家自然科学青年基金一项（“复杂环境中纳米材料与细胞相互作用的理论模拟研究” 2017-2019）和国家自然科学基金面上项目一项（“纳米材料与血浆蛋白相互作用的物理机理及调控策略研究”2019-2022）。

科研团队


与马余强教授（****、****）联合团队：
博士研究生： 倪崧荻（博士二年级），徐耀（南京大学联合培养，博士二年级），尹跃文（博士一年级）
硕士研究生： 陈远强（硕士二年级），盛艳静（硕士二年级），朱雨欣（硕士一年级）
本科生： 王敏 （大四）

已毕业研究生：
1. 夏强胜 （2015级在职博士，安庆师范大学副教授） 以第一作者身份在Nanoscale发表两篇论文（其中一篇选为封底），J. Phys. D发表一篇论文；
2. 余幼胜（2015级博士，南京大学联合培养） 以第一作者身份在Phys. Chem. Chem. Phys.（封面论文）,RSC Adv.发表论文各一篇，以第二作者身份在Nanoscale、Inorganic Chemistry发表论文各一篇，目前在东华理工大学工作；
3. 沈琳（2015级硕士）以第一作者身份在Langmuir发表论文一篇，目前在苏州工业园区从事IT行业；
4.黄路易 （2016级硕士，南京大学联合培养）以第一作者身份在Nanoscale（封面论文）发表论文一篇，获得国家奖学金，目前在网易工作;
5.卢翔（2017级博士，南京大学联合培养）以第一作者身份在Nature Communications发表论文一篇，获得国家奖学金，目前在无锡医药企业工作;




论文


Cover Gallery:

已发表论文（*通讯作者，#并列一作，红色为代表作）：
43.Ya-Tong Zhao, Shuai Yan, Bin Huang, Liuyan Yang, Hong-ming Ding*, Ping Wang, and Ai-Jun Miao*, Unbound Natural Organic Matter Competes with Nanoparticles for Internalization Receptors During Cell Uptake, Environ. Sci. Technol., 54, 15215–15224 (2020);
42.Yu-sheng Yu, Rong-ri Tan*, and Hong-ming Ding*, Controlling ion transport in a C2N-based nanochannel with tunable interlayer spacing, Phys. Chem. Chem. Phys., 22, 16855-16861 (2020);
41.Rongying Liu, Zdravko Kochovski, Long Li, Yue-wen Yin, Jing Yang, Guang Yang, Guoqing Tao, Anqiu Xu, Ensong Zhang, Hong-ming Ding*, Yan Lu*, Guosong Chen*, Ming Jiang, Fabrication of Pascal-triangle Lattice of Proteins by InducingLigand Strategy, Angew. Chem. Int. Ed., 59, 9617-9623 (2020);
40.Qiang-Sheng Xia#, Tao Zhu#, Zhongying Jiang, Hong-ming Ding*and Yu-qiang Ma*, Enhancing the targeting ability of nanoparticles via protected copolymers, Nanoscale, 12, 7804-7813 (2020);
39.Lingling Wu#, Hongming Ding#, Xin Qu, Xianai Shi, Jianmin Yang, Mengjiao Huang, Jialu Zhang, Huimin Zhang, Jia Song, Lin Zhu, Yanling Song,* Yuqiang Ma,* Chaoyong Yang*, Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability, J. Am. Chem. Soc., 142, 4800-4806 (2020);
38.Guoqing Tao, Tan Ji, Ning Wang, Guang Yang, Xiaolai Lei, Wei Zheng, Rongying Liu, Xuyang Xu, Ling Yang, Guang-Qiang Yin, Xiaojuan Liao, Xiaopeng Li, Hong-ming Ding, Xiaoming Ding, Jinfu Xu*, Hai-Bo Yang*, Guosong Chen*, Self-Assembled Saccharide-Functionalized Amphiphilic Metallacycles as Biofilms Inhibitor via “Sweet Talking”, ACS Macro Lett.9, 61-69 (2020);
37. Min Li#, Hong-ming Ding#, Meihua Lin#, Fangfei Yin, Lu Song, Xiuhai Mao, Fan Li, Zhilei Ge, Lihua Wang, Xiaolei Zuo*, Yuqiang Ma*, Chunhai Fan, DNA framework-programmed cell capture via topology-engineered receptor-ligand interactions, J. Am. Chem. Soc., 141, 18910-18915 (2019);
36. Guang Yang, Wei Zheng, Guoqing Tao, Libin Wu, Qi-Feng Zhou, Zdravko Kochovski, Tan Ji, Huaijun Chen, XiaopengLi, Yan Lu, Hong-ming Ding*, Hai-Bo Yang*, Guosong Chen*, Ming Jiang, Diversiform and Transformable Glyco-Nanostructures Constructed from Amphiphilic Supramolecular Metallocarbohydrates through Hierarchical Self-Assembly: The Balance between Metallacycles and Saccharides, ACS Nano,13, 13474-13485(2019);
35.Xiang Lu, Peipei Xu, Hong-Ming Ding*, You-Sheng Yu, Da Huo*, Yu-Qiang Ma*,Tailoring the component of protein corona via simple chemistry, Nat. Commun.10, 4520 (2019);
34.Gui-Fei Huo, Xueliang Shi*, Qian Tu, Yi-Xiong Hu, Gui-Yuan Wu, Guang-Qiang Yin, Xiaopeng Li, Lin Xu,Hong-Ming Ding*, Hai-Bo Yang*, Radical-Induced Hierarchical Self-Assembly Involving Supramolecular Coordination Complexes in Both Solution and Solid States, J. Am. Chem. Soc.141, 16014-16023 (2019);
33. Song-di Ni, Yue-wen Yin, Xiao-lei Li, Hong-ming Ding*, Yu-qiang Ma, Controlling the Interaction of Nanoparticles with Cell Membranes by the Polymeric Tether, Langmuir35, 12851-12857 (2019);[Inside Cover]
32.Zhen Li, Yufei Zhang, Libin Wu, Wei Yu, Thomas R. Wilks, Andrew P. Dove, Hong-ming Ding*, Rachel K. O’Reilly*, Guosong Chen*, and Ming Jiang, Glyco-Platelets with Controlled Morphologies via Crystallization-Driven Self-Assembly and Their Shape-Dependent Interplay with Macrophages, ACS Macro Lett., 8, 596-602 (2019);
31.Wei Zheng, Wei Wang, Shu-ting Jiang, Guang Yang, Zhen Li, Xu-qing Wang, Guang-qiang Yin, Ying Zhang, Hongwei Tang, Xiaopeng Li,Hong-ming Ding*, Guosong Chen*, Hai-Bo Yang*,Supramolecular Transformation of Metallacycle-Linked Star Polymers Driven by Simple Phosphine Ligand-Exchange Reaction,J. Am. Chem. Soc.,141, 583-591 (2019);[Front Cover]

30. Lu-yi Huang, You-sheng Yu, Xiang Lu,Hong-ming Ding*and Yu-qiang Ma*,Designing nanoparticle-containing polymeric substrate for detecting cancer cells by computer simulations, Nanoscale,11, 2170-2178 (2019);[Back Cover]
29. You-sheng Yu, Lu-yi Huang, Xiang Lu, andHong-ming Ding*,Ion transport through a nanoporous C2N membrane: Effectof electric field and layer number, RSC Advances, 8, 36705-36711 (2018);
28.Hong-ming Ding#,Jiang Li#, Nan Chen, Xingjie Hu, Xiafeng Yang, Linjie Guo, Qian Li, Xiaolei Zuo, Lihua Wang, Yu-qiang Ma*,Chunhai Fan*,DNA Nanostructure-Programmed Like-Charge Attraction at the Cell-Membrane Interface.ACS Central Science,4, 1344-1351(2018);(Highlighted by First Reactions,Doi:10.1021/acscentsci.8b00600)
27. Yan Xu, You-sheng Yu, Xin-da Huang, Song-song Bao,Hong-ming Ding*, Yu-qiang Ma and Li-min Zheng*,Counteranion Modulated Crystal Growth and Function of One-Dimensional Homochiral Coordination Polymers: Morphology, Structures, and Magnetic Properties.Inorganic Chemistry, 57, 12143-12154 (2018).
26. Lin Sheng,Hong-ming Ding*, Yu-qiang Ma*,Computational Design of a Functionalized Substrate for Capturing Nanoparticles with Specific Size and Shape,Langmuir, 34, 9829-9835(2018);
25. Guang Yang, Rongting Hu,Hong-ming Ding*, Z. Kochovski, Shilin Mei, Yan Lu, Yu-qiang Ma, Guosong Chen* and Ming Jiang, CO2-switchable response of protein microtubule: behaviour and mechanism,Mater. Chem. Front., 2, 1642-1646 (2018) ;
24. Da Huo#,Hong-ming Ding#, Shan Zhou, Jun Li, Jing Tao, Yu-qiang Ma* and Younan Xia*, Facile synthesis of gold trisoctahedral nanocrystals with controllable sizes and dihedral angles,Nanoscale, 10, 11034-11042 (2018); (collaborate with experiments)
23. You-sheng Yu, Xiang Lu,Hong-ming Ding*and Yu-qiang Ma*, Computational investigation on DNA sequencing using functionalized graphene nanopores,Phys. Chem. Chem. Phys., 20, 9063-9069 (2018)[Back Cover];
22. Rong-ting Hu, Guang Yang,Hong-ming Ding*, Jinbiao Ma, Yu-qiang Ma, Jianhua Gan* and Guosong Chen*, Competition between Supramolecular Interaction and Protein–Protein Interaction in Protein Crystallization: Effects of Crystallization Method and Small Molecular Bridge,Ind. Chem. Eng. Res.57, 6726-6733 (2018);
21. Qiang-sheng Xia,Hong-ming Ding*and Yu-qiang Ma*, Design strategy of pH-sensitive triblock copolymer micelles for efficient cellular uptake by computer simulations,Journal of Physics D: Applied Physics,51, 124002 (2018);
20.Hong-ming Dingand Yu-qiang Ma*, Computational approaches to cell–nanomaterial interactions: keeping balance betweentherapeutic efficiency and cytotoxicity,Nanoscale Horiz., 3, 6-27 (2018);[Back cover] (ESI Highly Cited Paper)
19. Jian Huang#,Hong-ming Ding#, Yan Xu#,Dai Zeng, Hui Zhu, Dong-Mian Zang, Song-Song Bao*, Yu-qiang Ma* and Li-Min Zheng*, Chiral Expression from Molecular to Macroscopic Level via pH Modulation in Terbium Coordination Polymers,Nat. Commun., 8, 2131 (2017);(collaborate with experiments)
18. Qiang-sheng Xia,Hong-ming Ding*and Yu-qiang Ma*, Can dual-ligand targeting enhance cellular uptake of nanoparticles,Nanoscale,9, 8982-8989 (2017);[Back cover]
17. Guang Yang#,Hong-ming Ding#, Zdravko Kochovski#, Rongting Hu, Yan Lu, Yu-qiang Ma*, Guosong Chen* and Ming Jiang, Highly Ordered Self-Assembly of Native Proteins into 1D, 2D, and 3D Structures Modulated by the Tether Length of Assembly-Inducing Ligands,Angew. Chem. Int. Ed., 56, 10691 –10695 (2017);[Back Cover, Hot Paper](collaborate with experiments)
16. Jia-wei Feng,Hong-ming Ding*and Yu-qiang Ma*, Water desalination by electrical resonance inside carbon nanotube,Phys. Chem. Chem. Phys., 18,28290-28296 (2016);
15.Hong-ming Dingand Yu-qiang Ma*, Design strategy ofsurface decoration for efficient delivery of nanoparticles by computer simulation,Scientific Reports, 6, 26783 (2016);
14. Zhen-lu Li,Hong-ming Ding*and Yu-qiang Ma*, Interaction of peptides with cell membranes: insights from molecular modeling, Journal of Physics: Condensed Matter, 28, 083001 (2016). (Topical Review)
13.Hong-ming Dingand Yu-qiang Ma*, Theoretical and computational investigations of nanoparticle-biomembrane interactions in cellular delivery,Small, 11, 1055-1071 (2015);(ESI Highly Cited Paper)
12. Qun-li Lei, Jia-wei Feng,Hong-ming Ding, Chun-lai Ren* and Yu-qiang Ma*, Modeling stretching-induced immiscibility in nonmonodisperse polymer systems,ACS Macro Lett., 4, 1033-1038 (2015);
11. Jia-wei Feng,Hong-ming Dingand Yu-qiang Ma*, Self-assembly of fullerenes and graphene flake: A molecular dynamics study,Carbon, 90, 34-43 (2015);
10.Hong-ming Dingand Yu-qiang Ma*, Computer simulation of the role of protein corona in cellular delivery of nanoparticles,Biomaterials, 35, 8703-8710 (2014);
9. Jia-wei Feng,Hong-ming Ding, Chun-lai Ren and Yu-qiang Ma*, Pumping of water by rotating chiral carbon nanotube,Nanoscale, 6, 13606-13612 (2014) ;
8. Jia-wei Feng,Hong-ming Dingand Yu-qiang Ma*, Controlling water flow inside carbon nanotube withlipid membranes,J. Chem. Phys., 141, 094901 (2014); (Cover Featured Article)
7. Zhen-lu Li, Jing-jing Wang,Hong-ming Dingand Yu-qiang Ma*, Influence of different membrane environments on the behavior ofcholesterol,RSC Adv., 4, 53090-53096 (2014);
6.Hong-ming Dingand Yu-qiang Ma*, Design maps for cellular uptake of gene nanovectors by computersimulation,Biomaterials, 34, 8401-8407 (2013);
5.Hong-ming Dingand Yu-qiang Ma*, Controlling cellular uptake of nanoparticles with pH-sensitive polymers,Scientific Reports, 3, 2804 (2013);
4. Zhen-lu Li,Hong-ming Dingand Yu-qiang Ma*, Translocation of polyarginines and conjugatednanoparticles across asymmetric membranes,Soft Matter, 9,1281-1286 (2013);
3.Hong-ming Ding, Wen-de Tian and Yu-qiang Ma*, Designing nanoparticle translocationthrough membranes by computer simulations,ACS Nano, 6, 1230-1238(2012);(2013-2016 ESI Highly Cited Paper)
2.Hong-ming Dingand Yu-qiang Ma*, Role of physicochemical properties of coating ligands inreceptor-mediated endocytosis of nanoparticles,Biomaterials, 33,5798-5802 (2012);
1.Hong-ming Dingand Yu-qiang Ma*, Interactions between Janus particles and membranes,Nanoscale,4, 1116-1122 (2012).


荣誉奖励


1、2017年度苏州大学首批优秀青年****
2、2016年度苏州市高等院校、科研院所紧缺高层次人才




开授课程


1.计算物理 （大三）
2. 普通物理实验 （大一、大二）
招生信息


一级学科为物理学、化学、计算机科学、材料科学等学科方向的本科生，可与南京大学联合培养。
联系方式：
苏州大学本部物理科技楼247室
联系电话：
dinghm@suda.edu.cn





研究项目（旧版）

荣誉奖励（旧版）

科研成果（旧版）