个人简介
姓名：莫兴波（1983.5 -），男。


1.学历
2008.07-2013.07，北京协和医学院，中国医学科学院阜外医院，遗传学，博士研究生；
2004.09-2008.07，武汉大学，数学与统计学院，数学，经济学，大学本科；


2.工作经历和任职情况
2013.08-至今，苏州大学，医学部公共卫生学院，遗传流行病与基因组学研究中心。



研究领域
复杂疾病遗传流行病学、基因组学，遗传统计与生物信息学，医学统计学



基本信息
莫兴波
职称： 副教授
院部/部门： 医学部公共卫生学院
学历：
学位：
毕业学校： 北京协和医学院
毕业专业：


联系方式
通讯地址：
邮政编码：
电子邮箱： xbmo@suda.edu.cn
联系电话：
传真号码：
办公地点： 苏州大学独墅湖校区




Copyright ? 2011-2014苏州大学版权所有苏州大学信息化建设与管理中心技术支持




科学研究
承担课题情况


1.苏州大学引进人才科研启动费。
2.中国博士后基金二等资助，课题名称类风湿性关节炎相关lncRNA鉴定及功能机制研究。
3.国家自然科学基金青年基金，课题名称lncRNA在类风湿性关节炎中的调控网络及分子功能机制。
4.医学部学生课外科研项目，课题名称验证差异表达的lncRNA与RA的关系。
5.江苏省高等学校自然科学研究面上项目，课题名称E2F3IT1作为类风湿关节炎新型标志物的评价研究。
6.国家自然科学基金面上项目，课题为新发现的缺血性脑卒中相关基因甲基化及功能蛋白研究。



科研团队



Copyright ? 2011-2014苏州大学版权所有苏州大学信息化建设与管理中心技术支持




论文

发表论文Publications-2020
1.Mo XB^#, Dong CY^#, He P, Wu LF, Lu X, Zhang YH, Deng HW, Deng FY, Lei SF. Alteration of circulating microbiome and its associated regulation role in rheumatoid arthritis: Evidence from integration of multiomics data. Clinical and Translational Medicine;First published: 16 November 2020; https://doi.org/10.1002/ctm2.229
2. Mo XB^#, Zhang H^#, Wang AL, Xu T, Zhang YH. Integrative analysis identifies the association between CASZ1 methylation and ischemic stroke. Neurol Genet; 2020Sep 1;6(5):e509.
3. Mo XB, Sun YH, Zhang YH, Lei SF. Integrative analysis highlighted susceptibility genes for rheumatoid arthritis. Int Immunopharmacol; 2020 Sep;86:106716.
4. Zhang H, Mo X^#, Qian Q, Zhou Z, Zhu Z, HuangFu X, Xu T, Wang A, Guo Z, Lei S, Zhang Y. Associations between potentially functional CORIN SNPs and serum corin levels in the Chinese Han population. BMC Genet; 2019 Dec 19;20(1):99.


发表论文Publications-2019

1. Mo X, Guo Y, Qian Q, Fu M, Zhang H*. Phosphorylation related SNPs influence lipid levels and rheumatoid arthritis risk by altering gene expression and plasma protein levels. Rheumatology. 2019 Sep 10. DOI: 10.1093/rheumatology/kez466.
2. Mo X, Guo Y, Qian Q, Fu M, Lei S, Zhang Y, Zhang H*. Mendelian randomization analysis revealed potential causal factors for systemic lupus erythematosus. Immunology. 2019 Oct 31. doi: 10.1111/imm.13144.
3. Mo XB, Lei SF, Qian QY, Guo YF, Zhang YH, Zhang H. Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis. J Neurol. 2019 Jul 18. doi: 10.1007/s00415-019-09476-w.
4. Mo X, Lei SF, Zhang Y, Zhang H. Examination of the associations between m6A-associated single nucleotide polymorphisms and blood pressure. Hypertension Research. 2019 Jun 7.DOI : 10.1038/s41440-019-0277-8
5. Zhang H^#, Mo X^#, Zhou Z, Zhu Z, HuangFu X, Xu T, Wang A, Guo Z, Zhang Y. Associations among NPPA gene polymorphisms, serum ANP levels and hypertension in the Chinese Han population. Journal of Human Hypertension. 2019 Jul 24. doi: 10.1038/s41371-019-0219-6.
6. Mo X, Lei SF, Zhang Y, Zhang H. Integrative Analysis Identified IRF6 and NDST1 as Potential Causal Genes for Ischemic Stroke. Frontiers in Neurology. May 2019, 10: 517.
7. Zhang H, Mo X, Zhou Z, Zhu Z, HuangFu X, Guo Z, Zhang Y. Detection of Putative Functional Single Nucleotide Polymorphisms in Blood Pressure Loci and Validation of Association Between Single Nucleotide Polymorphism in WBP1L and Hypertension in the Chinese Han Population. J Cardiovasc Pharmacol. 2019 Jan;73(1):48-55.
8. Mo X, Zhang H, Zhou Z, Zhu Z, HuangFu X, Xu T, Wang A, Guo Z, Zhang Y. SNPs rs** in PRKAG2 may disturb gene expression and consequently affect hypertension. Mol Biol Rep. 2019 Apr;46(2):1617-1624. doi: 10.1007/s11033-019-04610-3.
9. Wang X^#, Mo X^#, Zhang H, Zhang Y, Shen Y. Identification of phosphorylation associated SNPs for blood pressure, coronary artery disease and stroke from genome-wide association studies. Curr Mol Med. 2019 Aug 28. doi: 10.2174/**66**0. [Epub ahead of print]
10. Lu YH, Wang BH, Jiang F, Mo XB, Wu LF, He P, Lu X, Deng FY, Lei SF. Multi-omics integrative analysis identified SNP-methylation-mRNA: Interaction in peripheral blood mononuclear cells. J Cell Mol Med. 2019 May 20. doi: 10.1111/jcmm.14315.
11. Wang BH, Lu YH, Xia W, Wu LF, Mo XB, Lu X, He P, Lei SF. Distribution of single nucleotide polymorphism with a loss of heterozygosity status and its relevance on gene expression in Chinese Han. J Biol Regul Homeost Agents. 2019 Jul-Aug;33(4):1119-1124.



发表论文Publications-2018
1. ZhuH, Wu LF,Mo XB, Lu X, Tang H, ZhuXW, Xia W, Guo YF, Wang MJ, Zeng KQ, Wu J, Qiu YH, Lin X, Zhang YH, Liu YZ, YiNJ, Deng FY, Lei SF. Rheumatoid arthritis-associated DNA methylation sites inperipheral blood mononuclear cells. Ann Rheum Dis. 2019 Jan;78(1):36-42. Epub 2018Oct 8.
2.Mo XB, Wu LF, Lu X, Zhu XW, Xia W, WangL, He P, Bing PF, Zhang YH, Deng FY, Lei SF*. Detection of lncRNA-mRNAinteraction modules by integrating eQTL with weighted gene co-expressionnetwork analysis. Funct Integr Genomics. 2018 Oct 2. 2019 Mar;19(2):217-225.doi:10.1007/s10142-018-0638-4.
3.Mo X,Lei S, Zhang Y, Zhang H*. Genome-wideenrichment of m6A-associated single-nucleotide polymorphisms in the lipid loci.Pharmacogenomics J. 2018 Sep 27. 2019 Aug;19(4):347-357.doi: 10.1038/s41397-018-0055-z.
4.Mo XB, Wu LF, Cai XM, Tang ZX, Lu X,Zhang YH, Deng FY, Lei SF. Integrative analysis identified mediation effects oflncRNAs on the correlations between methylation and mRNA. Int J Biochem CellBiol. 2018 Nov;104:66-72. doi: 10.1016/j.biocel.2018.09.005.
5.Mo XB, Lei SF, Zhang YH, Zhang H. Detectionof m6A-associated SNPs as potential functional variants for coronary arterydisease. Epigenomics. 2018 Oct;10(10):1279-1287. doi: 10.2217/epi-2018-0007.
6.Mo XB, Zhang YH, Lei SF. Genome-WideIdentification of N6-Methyladenosine (m6A) SNPs Associated With RheumatoidArthritis. Front Genet. 2018 Aug 3;9:299.
7.Mo XB, Zhang YH, Lei SF. Genome-wideidentification of m6A-associated SNPs as potential functionalvariants for bone mineral density. Osteoporos Int. 2018 Sep;29(9):2029-2039. doi:10.1007/s00198-018-4573-y.
8.Mo X, Zhang H, Lei S, Xu T, Wang A, GuoZ, Zhang Y. Putative functional SNPs in SLC22A3 and H3F3B might influence thedevelopment of CAD by regulating the lipid levels. Thromb Res. 2018 Jun2;168:37-39.
9.WangWY, Ge B, Shi J, Zhou X, Wu LF, Tang CH, Zhu DC, Zhu H,Mo XB, Zhang YH, Deng FY, Lei SF. Plasma gelsolin is associatedwith hip BMD in Chinese postmenopausal women. PLoS One. 2018 May22;13(5):e**
10. WuLF, Zhu DC, Tang CH, Ge B, Shi J, Wang BH, Lu YH, He P, Wang WY, Lu SQ, ZhongJ, Zhou X, Zhu K, Ji W, Gao HQ, Gu HB,MoXB, Lu X, Zhang L, Zhang YH, Deng FY, Lei SF. Association of Plasma Irisinwith Bone Mineral Density in a Large Chinese Population Using an ExtremeSampling Design. Calcif Tissue Int. 2018 Sep;103(3):246-251.
11.WuLF, Zhu DC, Wang BH, Lu YH, He P, Zhang YH, Gao HQ, Zhu XW, Xia W, Zhu H,Mo XB, Lu X, Zhang L, Zhang YH, DengFY, Lei SF.Relative abundance of mature myostatin rather thantotal myostatin is negatively associated with bone mineral density in Chinese.JCell Mol Med. 2018 Feb;22(2):1329-1336.
12.LuYH, Wang BH, Xia W,Mo XB, Wu LF,Zhu XW, He P, Xie FF, Lu X, Deng FY, Lei SF.The distribution and functional relevance analysis ofruns of homozygosity (ROHs) in Chinese Han female population.Mol Genet Genomics. 2018 Feb;293(1):197-206.
13.WangL, Zhu J, Deng FY, Wu LF,Mo XB, ZhuXW, Xia W, Xie FF, He P, Bing PF, Qiu YH, Lin X, Lu X, Zhang L, Yi NJ, ZhangYH, Lei SF.Correlation analyses revealed global microRNA-mRNAexpression associations in human peripheral blood mononuclear cells.Mol Genet Genomics. 2018 Feb;293(1):95-105.
14. XieFF, Deng FY, Wu LF,Mo XB, Zhu H, WuJ, Guo YF, Zeng KQ, Wang MJ, Zhu XW, Xia W, Wang L, He P, Bing PF, Lu X, ZhangYH, Lei SF.Multiple correlation analyses revealed complexrelationship between DNA methylation and mRNA expression in human peripheralblood mononuclear cells.Funct Integr Genomics. 2018Jan;18(1):1-10.
15. ZhangH,Mo X, Zhou Z, Zhu Z, Huangfu X,Xu T, Wang A, Guo Z, Zhang Y. Smoking modifies the effect of two independentSNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Hanpopulation. J Genet. 2018 Sep;97(4):987-994.
16.莫兴波,张永红*，基于多组学的心血管疾病危险因素研究.中华疾病控制杂志，2018,22(9):873-879.


发表论文Publications-2017
1.MoXB, Wu LF, Zhu XW, Xia W, Wang L, He P, Bing PF, Lu X, Zhang YH, Deng FY, LeiSF. Identification and evaluation of lncRNA and mRNA integrative modules inhuman peripheral blood mononuclear cells. Epigenomics. 2017 Jul;9(7):943-954.(IF =4.541,二区)


2.Xia W, Zhu XW,Mo XB, Wu LF, Wu J, Guo YF, Zeng KQ, Wang MJ, Lin X, Qiu YH,Wang L, He P, Xie FF, Bing PF, Lu X, Liu YZ, Yi NJ, Deng FY, Lei SF. Integrativemulti-omics analysis revealed SNP-lncRNA-mRNA (SLM) networks in humanperipheral blood mononuclear cells. Hum Genet. 2017 Apr;136(4):451-462. doi:10.1007/s00439-017-1771-1. Epub 2017 Feb 28. (IF =4.637,二区)

发表论文Publications-2016
1.Zhang H,Mo X*, Xu T, Bu X, Lei S, Zhang Y. Detecting novel genes for low-densitylipoprotein cholesterol in European population using bioinformatics analysis.Personalized Medicine.May 2016 ,Vol. 13, No. 3, 225-231,http://www.futuremedicine.com/doi/abs/10.2217/pme.16.1?journalCode=pme.(doi:10.2217/pme.16.1.)(IF =1.336,四区)
2.Mo X, Zhang H, Xu T, Bu X, Lei S, Zhang Y*. Identification of important genes associatedwith total cholesterol using bioinformatics analysis.Pharmacogenomics.2016 Feb;17(3):219-230.DOI 10.2217/PGS.15.164(IF =3.218,二区).


3. ZhuH, Xia W, Mo XB, Lin X, Qiu YH, Yi NJ, Zhang YH, Deng FY, Lei SF. Gene-BasedGenome-Wide Association Analysis in European and Asian Populations IdentifiedNovel Genes for Rheumatoid Arthritis.PLoS One. 2016 Nov 29;11(11):e**.doi: 10.1371/journal.pone.**.




发表论文Publications-2015

1.Zhang H#,Mo X#, Xu T, Bu X, Lei S, ZhangY*. Novel Genes Affecting Blood Pressure Detected via Gene-Based AssociationAnalysis.G3: Genes, Genomes, Genetics;2015Mar26;5(6):1035-42.doi:10.1534/g3.115.016915.(IF =3.198,四区)
2.Mo X, Lu X, Zhang Y, Zhang Z,Deng F, Lei S*.Gene-Based Association AnalysisIdentifiedNovel Genes Associated with Bone Mineral Density.PLoS One.2015 Mar 26;10(3):e**.Doi: 10.1371/journal.pone.**.(IF=3.534,三区)
3.Wang L, Wu LF, Lu X,Mo XB, Tang ZX, Lei SF, Deng FY. IntegratedAnalyses of Gene Expression Profiles Digs out Common Markers for RheumaticDiseases.PLoS One. 2015 Sep 9;10(9):e**.(IF=3.534,三区)
4.Lin X, Deng FY,Mo XB, Wu LF,Lei SF*.Functionalrelevance for multiple sclerosis-associated genetic variants.Immunogenetics. 2015 Jan;67(1):7-14.doi: 10.1007/s00251-014-0803-4.(被SCI收录)(IF =2.448,三区)
5. Lu X, Wang L, Lin X, Huang J, Gu CC, He M, Shen H, He J, Zhu J, Li H,Hixson JE, Wu T, Dai J, Lu L, Shen C, Chen S, He L, Mo Z, Hao Y,Mo X, Yang X, Li J, Cao J, Chen J, FanZ, Li Y, Zhao L, Li H, Lu F, Yao C, Yu L, Xu L, Mu J, Wu X, Deng Y, Hu D, ZhangW, Ji X, Guo D, Guo Z, Zhou Z, Yang Z, Wang R, Yang J, Zhou X, Yan W, Sun N,Gao P, Gu D*.Genome WideAssociation Study in Chinese Identifies Novel Loci for Blood Pressure andHypertension.HumMol Genet. 2015 Feb 1;24(3):865-74. doi: 10.1093/hmg/ddu478.(被SCI收录)(IF=6.677,二区)
6. Liu F, Yang X,Mo X, Huang J,Chen J, Kelly TN, Hixson JE, Rao DC, Gu CC, Shimmin LC, Chen J, Rice TK, Li J,Schwander K, He J, Liu DP, Gu D*.Associations ofepithelial sodium channel genes with blood pressure: the GenSalt study.J Hum Hypertens.2015 Apr;29(4):224-8.doi: 10.1038/jhh.2014.78.(被SCI收录)(IF =2.692,三区)


发表论文Publications-2014
1.Zhu H,Deng F,Mo X,Qiu Y,Lei S*. Pharmacogenetics and pharmacogenomics forrheumatoid arthritis responsiveness to methotrexate treatment: the 2013 update.Pharmacogenomics.2014;15(4):551-566.(被SCI收录)(IF =3.425,二区)
2. Liu X, Hao Y, Wang L, Li H, Lu X, Cao J, Hu Y,Mo X, Peng X, Gu D*.Functional Analysisof SNPs in the Regulation of CARM1 Expression and Plasma Homocysteine Levels.Circ Cardiovasc Genet. 2014 Oct;7(5):642-9.doi: 10.1161/CIRCGENETICS.113.000408.(被SCI收录)(IF =5.337,二区)

会议(conference)-2014：
1.Mo XB, Zhang H, Lei SF, Zhang YH. Integrating genetic and gene expression evidence into genome-wideassociation analysis identified novel genes for lipid traits. Cardiology. 2014,129(suppl 1): 54.(被SCI收录)
2.Mo XB, Deng FY, Lei SF. Gene-BasedGenome-wide Association Analysis Identified Novel Susceptibility GenesAssociated with Bone Mineral Density. 7thInternational Conferenceon Osteoporosis and Bone Research. Oral Presentation (English). October 17,2014. Xiamen, China.



发表论文Publications- Before 2014
1.Mo X#,Liu X#, Wang L, Li H, Lu X, Huang J, Chen J, Cao J, Li J, Chen S, Tang Y, Peng X, Gu D*. Lipoproteinlipase gene polymorphism rs** functionally influences serum lipidconcentrations.Atherosclerosis.2013;229(2):511-516.(被SCI收录)(IF =3.971,二区)
2.Mo X#, Liu X#, Wang L, Lu X, Chen S, Li H, Huang J, Chen J, Cao J, Li J, Tang Y, Gu D*. Association of lipoproteinlipase polymorphism rs** with serum lipid concentrations and LPL geneexpression.J Hum Genet.2013;58(3):160-164.(被SCI收录)(IF =2.526,三区)
3.Mo X,Hao Y, Yang X, Chen S, Lu X, GuD*. Association between polymorphisms in the coagulation factor VII gene andcoronary heart disease risk in different ethnicities: a meta-analysis.BMC Medical Genetics.2011; 12:107.(被SCI收录)(IF =2.45,三区)
4.莫兴波，顾东风*.基因型填补的原理与方法及其在遗传流行病学研究中的应用.中华流行病学杂志. 2010; 31(6):702-706.
5. Zhang H,Mo X,Hao Y, Huang J, Lu X, Cao J, Gu D*. Association between adiponectin and incident risk of coronary heartdisease: a meta-analysis.AM J MED SCI.2013; 345(6):455-461.(被SCI收录)(IF =1.515,四区)
6. Zhang H,Mo X,Hao Y, Gu D*. Associationbetween polymorphisms in the adiponectin gene and cardiovascular disease: ameta-analysis.BMC Med Genet. 2012;13:40.(被SCI收录)(IF =2.45,三区)
7. Yang Y,Mo X,Chen S, Lu X, Gu D*.Association of peroxisome proliferator-activated receptor gamma coactivator 1alpha gene polymorphisms and type 2 diabetes mellitus: a meta-analysis.Diabetes Metab Res Rev. 2011;27(2):177-184.(被SCI收录)(IF =3.593,三区)
8.张欢，莫兴波，郝永臣，陈恕凤，鲁向锋*.脂联素基因单核苷酸多态性与脑卒中和高血压相关性的荟萃分析.中国分子心脏病学杂志. 2012; 12(3):136-139.
9. Wang Q, Hao Y,Mo X,Wang L, Lu X, Huang J, Cao J, Li H, Gu D*.PLA2G7gene polymorphisms and coronary heart disease risk: A meta-analysis.ThrombRes. 2010;126(6):498-503.(被SCI收录)(IF =2.427,三区)
10. Yang Y, Li JX, Chen JC, Cao J, Lu XF, Chen SF, Wu XG, Duan XF,Mo XB, Gu DF*. Effect of elevated total cholesterol level andhypertension on the risk of fatal cardiovascular disease: a cohort study ofChinese steelworkers.Chin Med J(Engl). 2011 Nov;124(22):3702-6.(被SCI收录)(IF =1.016,四区)
11. Liang X, Wang Q, Yang X, Cao J, Chen J,Mo X, Huang J, Wang L,Gu D*. Effect of mobile phoneintervention for diabetes on glycaemic control: a meta-analysis.DiabetMed. 2011 Apr;28(4):455-63.(被SCI收录)(IF =3.064,三区)
12. Lu X, Wang L, Chen S, He L, Yang X, Shi Y, Cheng J, Zhang L, Gu CC,Huang J, Wu T, Ma Y, Li J, Cao J, Chen J, Ge D, Fan Z, Li Y, Zhao L, Li H, ZhouX, Chen L, Liu D, Chen J, Duan X, Hao Y, Wang L, Lu F, Liu Z, Yao C, Shen C, PuX, Yu L, Fang X, Xu L, Mu J, Wu X, Zheng R, Wu N, Zhao Q, Li Y, Liu X, Wang M,Yu D, Hu D, Ji X, Guo D, Sun D, Wang Q, Yang Y, Liu F, Mao Q, Liang X, Ji J,Chen P,Mo X, Li D, Chai G, Tang Y,Li X, Du Z, Liu X, Dou C, Yang Z, Meng Q, Wang D, Wang R, Yang J, Schunkert H,Samani NJ, Kathiresan S, Reilly MP, Erdmann J; Coronary ARtery DIseaseGenome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium, Peng X, WuX, Liu D, Yang Y, Chen R, Qiang B, Gu D*.Genome-wideassociation study in Han Chinese identifies four new susceptibility loci forcoronary artery disease.Nat Genet. 2012 Jul 1;44(8):890-4.(被SCI收录)(IF =29.648,一区)
会议（conference）- Before 2014:
1.莫兴波，刘雪会，王来元，李宏帆，陈恕凤，顾东风.脂蛋白脂酶基因(LPL)3′非翻译区microRNA结合位点多态性与血脂水平及冠心病风险的关联分析。中国循环杂志。2012年8月第27券增刊，第103页。
2.莫兴波，刘雪会，王来元，陈恕凤，鲁向锋，李宏帆，顾东风.脂蛋白脂酶基因(LPL)单核苷酸多态性与血脂水平关联分析。中国循环杂志。2012年8月第27券增刊，第105页。
3.莫兴波，郝永臣，陈京萍，顾东风.凝血因子Ⅶ基因多态性与冠心病风险的meta分析。中国循环杂志。2010年8月第25券增刊，第6页。
4.Mo XB,Hao YC, Chen JP, GuDF. Polymorphisms in the Coagulation Factor VII Gene and the Risk of CoronaryHeart Disease: A Meta-Analysis of 32 Case-Control Studies.Cardiology.2010, 117(suppl 1): 6.(被SCI收录)

#并列第一作者；*通讯作者。



荣誉奖励
1、苏州大学第十六届青年教师课堂教学竞赛三等奖,苏州大学,2017年11月
2、苏州大学2017届毕业实习优秀实习指导教师,苏州大学教务部,2017年6月27日
3、优秀社会服务工作奖,苏州大学医学部公共卫生学院,2017年1月8日





Copyright ? 2011-2014苏州大学版权所有苏州大学信息化建设与管理中心技术支持




开授课程
承担《医学统计学》，《SAS统计软件包》，《趣味统计》、《流行病学》、《生物文献检索》、《医学科研方法》、《卫生经济学》等课程的教学工作。


招生信息



Copyright ? 2011-2014苏州大学版权所有苏州大学信息化建设与管理中心技术支持






研究项目（旧版）

荣誉奖励（旧版）

科研成果（旧版）