个人信息


个人简介
个人简介
B.S., Hunan Agricultural University, 1983
M.S., Sichuan Agricultural University, 1986
Ph.D., University of Edinburgh, United Kingdom, 1996
Postdoctoral Fellow, Medical College of Georgia, 1996 – 1998
Postdoctoral Associate, University of Ottawa, 1998 – 2001
Research Instructor, Vanderbilt University, 2002 – 2005
Assistant Professor, Cornell University, 2006-2014



研究领域
The Long Lab studies:(1) transcriptional control ofcell fate decisions of early pancreatic epithelial cellsduring mammalianembryonic development;(2) cellular and molecular mechanisms of hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC);and(3) genetic factors and signaling pathways mediatingcellularstress-induced neurodegeneration and celldeath in the central nervous system (CNS).Our long-term goalhas beentoidentifynoveltherapeutic intervention targetsand develop new strategies formoreeffectivepreventionand treatment ofchronic human diseases, including diabetesmellitus,neurodegenerativediseases, virallyand nonvirallyinducedliver cancers.

基本信息






龙乔明
职称：教授
院部/部门：剑桥-苏大基因组资源中心
学历：
学位：
毕业学校：
毕业专业：

联系方式


通讯地址：
邮政编码：
电子邮箱：qmlong@suda.edu.cn
联系电话：
传真号码：
办公地点：医学部





科学研究



科研团队





论文


SELECTED PUBLICATIONS:
1.Sha, H.B.,Sun, S.Y., Francisco, A.B.,Ehrhardt,N.,Xue, Z., Liu, L., Lawrence, P., Frits
Mattijssen, F.,Guber, R.,Panhwar, M.S.,Brenna, J.T., Hang Shi, H.,Xue, B.Z., Sander
Kersten, S.,Bensadoun,A.,*Péterfy, M.,*Long, Q.M. and*Qi, L. (2014) The ER-associated
Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism.
Cell Metabolism；Sep 2; 20(3): 458-470. (*Co-senior author).
2.Sun, S. Shi, G., Han, X., Francisco, A.B.,Ji, Y.,Mendonca, N., Liu, X.,Locasale, J.W.,
Simpson, K.W., Duhamel, G.E.,Kersten, S., Yates, J.R. 3rd,*Long, Q.M. and*Qi, L. (2014)
Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation,
endoplasmic reticulum homeostasis, and survival.ProcNatlAcadSciUSA. Jan 22. E582-
591.(*Co-corresponding author).
3.Qin, L.L,Xu, J., Wu, Z.F., Zhang, Z., Li, J.Q.,*Wang, C. and*Long, Q.M. Notch1-mediated
signaling regulates proliferation of porcine satellite cells (PSCs).2013;Cellular Signaling
25: 561–569.(*Co-corresponding author).
4.Francisco, A.B., Singh, R.,Sha, H., Yan, X., Qi, L., Lei, X.G. and *Long, Q.M.Haploid
insufficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) protein predisposes mice to
high fat diet induced hyperglycemia.Journal of Biological Chemistry.2011; 286 (24):
21231-21238.(*Corresponding author).
5.Francisco, A.B., Singh, R., Li, S.,Vani, A., Yang, L., Munroe, R.J.,Diaferia, G.,Cardano, M.,
Biunno, I., Qi, L.,Schimenti, J.C. and *Long, Q.M. Deficiency of SuppressorEnahncerLin
12 1 Like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic
lethality.Journal of Biological Chemistry. 2010; 285 (18):13694-13703. (*Corresponding
author).
6.Li, S., Francisco, A.B., Han, C.,Pattabiraman, S., Foote, M.R., Giesy, S.L., Wang, C.,
Schimenti, J.C., Boisclair, Y.V. and *Long, Q.M.The full-lengthisoformofpleckstrin
homology domain-interacting protein (PHIP) regulates postnatal growth independently of
insulin-like growth factor 1.FEBSlett.2010; 584:4121-4127. (*Corresponding author).
7.Li, S., Francisco, A. B.,Munroe, R. J.,Schimenti, J. C.and*Long, Q.M.SEL1L deficiency
impairs growth and differentiation of pancreatic epithelial cells.BMCDevelopmental Biology.
2010; 10:19.(*Corresponding author).
8.Masui, T.,Long, Q.M.,Beres, T.M., Magnuson, M.A. and MacDonald, R.J.Earlypancreatic
development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1bHLHcomplex.
Genes & Development.2007; 21:2629-2643.
9.Long, Q.M., Huang, H.,Shafizadeh, E. and Lin, S.Stimulation oferythropoiesisby inhibiting
a new hematopoietic death receptor in transgeniczebrafish.Nature Cell Biology. 2000;
2:549-552.
10.Wang, H.,Long, Q.M., Scott, D.M.,Sassa, S. and Lin. S.Azebrafishmodel for
hepatoerythropoieticporphyria.Nature Genetics.1998; 20 (3): 239-43.
11.Long, Q.M.,Meng, A.M., Wang, H.,Jessen, R.J., Farrell, M. and Lin, S.GATA-1 expression
pattern can be recapitulated in living transgeniczebrafishusing GFP reporter
gene.Development. 1997; 124(20): 4105-4111.

荣誉奖励






开授课程


The Science ofBiology、实验动物学
招生信息