杨华乾****， 博士生导师苏州大学唐仲英医学研究院 血液学研究中心
苏州工业园区仁爱路199号703号楼3634室；邮编：215124
邮箱：hqyang@suda.edu.cn
教育背景：2005~2009 北京理工大学 生物工程专业理学学士
2009~2015 北京大学 生理学专业理学博士，导师王世强教授
2015~2019 美国纽约大学医学院 博士后，合作导师William Coetzee教授
2019~2020 美国纽约大学医学院 研究助理教授、电生理实验中心执行主任
研究领域：心血管电生理课题组以膜片钳等技术研究心血管系统中的离子通道功能及其相关的心血管疾病。主要研究方向包括：
1）ATP敏感钾离子通道（KATP）的转运及在心脏缺血损伤中的保护作用；
2）β肾上腺素受体信号通路对心肌细胞钙稳态的调节及在心肌肥大模型中的作用；
3）新型离子通道的鉴定及其门控性质和通道动力学参数的研究。
代表性成果：1.Yang HQ*, Zhou P*, Wang LP*, Zhao YT, Guo YB, Xu, M, Wang SQ. Compartmentalized β1-adrenergic signaling synchronizes excitation-contraction coupling without modulating individual Ca2+ sparks in healthy and hypertrophied cardiomyocytes. Cardiovasc Res. 2020 Nov 1;116(13):2069-2080. (IF:6.2).
2.Yang HQ, Martinez-Ortiz W, Hwang J, Fan X, Cardozo TJ, Coetzee WA. Palmitoylation of the KATP channel Kir6.2 subunit promotes channel opening by regulating PIP2 sensitivity. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10593-10602. (IF:10.6)
3.Yang HQ, Pérez-Hernández M, Sanchez Alonso JL, Shevchuk A, Gorelik J, Rothenberg E, Delmar M, Coetzee WA. Ankyrin-G Mediates Targeting of both Na+ and KATP Channels to the Cardiac Intercalated Disc. eLife. 2020 Jan 14;9:e52373. (IF:8.5)
4.Yang HQ*, Wang LP*, Gong YY*, Fan XX*, Zhu SY*, Wang XT, Wang YP, Li LL, Xing X, Liu XX, Ji GS, Hou TT, Zhang Y, Xiao RP, Wang SQ. β2-Adrenergic Stimulation Compartmentalizes β1 Signaling into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors. Circ Res. 2019 Apr 26;124(9):1350-1359. (IF: 14.5, 封面文章)
5.Yang HQ, Jana K, Rindler MJ, Coetzee WA. The trafficking protein, EHD2, positively regulates cardiac sarcolemmal KATP channel surface expression: role in cardioprotection. FASEB J. 2018 Mar;32(3):1613-1625. (IF: 5.4)
6.Cerrone M, Montnach J, Lin X, Zhao YT, Zhang M, Agullo-Pascual E, Leo-Macias A, Alvarado FJ, Dolgalev I,Karathanos TV, Malkani K, Van Opbergen CJM, van Bavel JJA, Yang HQ, Vasquez C, Tester D, Fowler S, Liang F, Rothenberg E, Heguy A, Morley GE, Coetzee WA, Trayanova NA, Ackerman MJ, van Veen TAB, Valdivia HH, Delmar M. Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm. Nat Commun. 2017 Jul 24;8(1):106. (IF: 11.9)
7.Yang HQ, Foster MN, Jana K, Ho J, Rindler MJ, Coetzee WA. Plasticity of sarcolemmal KATP channel surface expression: relevance during ischemia and ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1558-66. (IF: 3.9)
8.Xiao E*, Yang HQ*, Gan YH, Duan DH, He LH, Guo Y, Wang SQ, Zhang Y. TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells. Stem Cells. 2015 Feb;33(2):615-21. (IF: 6.0)
9.Rong J*, Han J*, Dong L, Tan Y, Yang H, Feng L, Wang QW, Meng R, Zhao J, Wang SQ, Chen X. Glycan imaging in intact rat hearts and glycoproteomic analysis reveal the upregulation of sialylation during cardiac hypertrophy. J Am Chem Soc. 2014 Dec 17;136(50):17468-76. (IF: 15.0)
10.Wang SQ, Yang HQ. The molecular mechanism of cardiomyocyte excitation-contraction coupling. Science China Life Sciences. 2013;43(10):833~841. (IF: 3.6)
11.Li RC, Tao J, Guo YB, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M, Wang SQ. In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aorticconstricted mice. Circ Res. 2013 Feb 15;112(4):601-5. (IF: 14.5)
*equal contribution
主要学术任职：1. Cell Biochemistry and Biophysics审稿人
2. 中国生理学会会员，美国心脏学会会员，美国生物物理学会会员