课题组负责人
郑慧博士，博导
苏州大学****
郑慧教授，2001年和2006年分别获得中南大学湘雅医学院医学学士学位和博士学位。2008-2013年在美国宾夕法尼亚大学从事干扰素受体的研究工作。2013年1月加入苏州大学生物医学研究院，任职****，同年入选江苏省“高层次海外引进创新创业”人才、江苏省****，2014年入选苏州市紧缺高层次人才，2016年入选江苏省六大人才高峰计划。独立开展工作以来，作为通讯（含共同通讯）作者在国际高水平期刊发表研究论文20余篇，包括Nature Microbiology, Molecular Cell, Nature Communications, PLoS Pathogens (3篇：2016，2018，2020年)，J Immunol，J Biol Chem，Eur J Immunol, Antiviral Res等。相关成果获得了国际病原学、病毒免疫学领域专家的高度关注和好评。

研究方向

我们的研究兴趣是宿主的广谱抗病毒机制。通过揭示宿主多样性的抗病毒信号，发掘宿主的抗病毒潜能，旨在发展出广谱抗病毒策略。目前，我们的研究焦点包括三个方面：1）如何增强先天抗病毒细胞因子Interferon (IFN)的抗病毒活性；2）鉴定具有广谱抗病毒或促病毒活性的宿主蛋白，并揭示其调控病毒感染的机制；3）发展潜在的抗病毒小分子抑制剂和干扰肽。

代表性论文
1. Guo T, Zuo Y, Qian L, Liu J, Yuan Y, Xu K, Miao Y, Feng Q, Chen X, Jin L, Zhang L, Dong C*, Xiong S*, Zheng H*.ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.Nat Microbiol. 2019 Nov;4(11):1872-1884.
(Invited Scientific Blogs by Nature Microbiology Community: “Behind the Paper”: https://naturemicrobiologycommunity.nature.com/posts/48116-exploiting-ifns-antiviral-efficacy-to-fight-a-broad-spectrum-of-viruses)
2. Yuan Y^#, Miao Y^#, Qian L, Zhang Y, Liu C, Liu J, Zuo Y, Feng Q, Guo T, Zhang L, Chen X, Jin L, Huang F, Zhang H, Zhang W, Li W, Xu G, Zheng H*.Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense. Mol Cell. 2020 Feb 20;77(4):734-747.
3. Zuo Y, Feng Q, Jin L, Huang F, Miao Y, Liu J, Xu Y, Chen X, Zhang H, Guo T, Yuan Y, Zhang L, Wang J, Zheng H*. Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling. Nat Commun.2020 Mar 2;11(1):1146.
4. Liu J^#, Jin L^#, Chen X, Yuan Y, Zuo Y, Miao Y, Feng Q, Zhang H, Huang F, Guo T, Zhang L, Zhu L, Qian F, Zhu C,Zheng H*. USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.PLoS Pathog. 2020 Jan 3;16(1):e**.
5. Zhang L, Liu J, Qian L, Feng Q, Wang X, Yuan Y, Zuo Y, Cheng Q, Miao Y, Guo T, Zheng X, Zheng H*. Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome. PLoS Pathog. 2018 May 7;14(5):e**.
6. Feng Q^#, Miao Y^#, Ge J^#, Yuan Y^#, ZuoY, QianL, Liu J, Cheng Q, Guo T, ZhangL, YuZ*,Zheng H*. ATXN3 positively regulates type I-IFN antiviral response by deubiquitinating and stabilizing HDAC3. J Immunol. 2018 Jul 15;201(2):675-687.
（Selected as “Highlight In This Issue”by J Immunol 2018; 201:323-324）
7. Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S, Zheng H*. Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.PLoS Pathog. 2016 Jul 19;12(7):e**.
8. Li L, Qian G, Zuo Y, Yuan Y, Cheng Q, Guo T, Liu J, Liu C, Zhang L,Zheng H*. Ubiquitin-dependent Turnover of ADAR1 is Required for Efficient Antiviral Activity of Type I-interferon.J Biol Chem. 2016 Nov 25;291(48):24974-24985.
9. Zheng H^#, Gupta V^#, Patterson-Fortin J^#, et al. A BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses.Cell Rep. 2013; 5(1): 180-93.
10. Carbone CJ^#,Zheng H^#(Co-first), Bhattacharya S, etal. Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for anti-viral therapies.PNAS. 2012; 109(47): 19226-31.
11. Zheng H, Qian J, Carbone CJ, et al. Vascular endothelial growth factor-induced elimination of type 1 interferon receptor is required for efficient angiogenesis.Blood.2011; 118(14): 4003-6.
12. BhattacharyaS^#,Zheng H^#(Co-first), TzimasC, Carroll M, Baker DP, Fuchs SY. Bcr-abl signals to desensitize chronic myeloid leukemia cells to interferon alpha via accelerating the degradation of its receptor.Blood. 2011;118(15): 4179-87.
13. Zheng H, Qian J, Varghese B, Baker DP, and Fuchs S. Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinaseD2.Mol Cell Biol. 2011;31(4):710-20.
14. Qian J^#,Zheng H^#(Co-first), HuangFu WC, etal. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. PLoS Pathog. 2011 June;7(6):e**.
15. Zheng H, Qian J, Baker DP, and Fuchs SY. Tyrosine phosphorylation of protein kinase D2 mediates the ligand-inducible elimination of the IFNAR1 chain of Type 1 interferon receptor.J Biol Chem. 2011; 286(41):35733-41.

课题组成员

袁玉康博士，讲师
袁玉康于2013年获得临沂大学学士学位，同年考入苏州大学硕博连读。2018年入职苏州大学生物医学研究院师资博后。其研究兴趣主要是干扰素诱导基因调控对干扰素抗病毒功能的影响。



左宜波博士，讲师
左宜波于2015年获得齐鲁工业大学学士学位，同年考入苏州大学硕博连读。2020年入职苏州大学生物医学研究院师资博后。其研究兴趣主要是代谢与IFNs抗病毒活性调控。





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