应 征
Zheng Ying, Ph.D.
zheng.ying@suda.edu.cn


RESEARCH INTERESTS
Increasing evidence indicates that further exploration of protein quality controlsystemis critical for understandingthe basicmechanismunderlyingneurodegenerative disorders including amyotrophic lateral sclerosis,Parkinson’sdiseaseandAlzheimer’sdisease.The goal of our studies is todescribehowprotein quality control systems,includingautophagy-lysosomepathwayand ubiquitin-proteasome system,fail toprotectneuronsat disease stages.To this end, we will use cell biology, molecular biology, biochemical approaches and genetic manipulation of animal modelsto investigate the relationship between protein quality controlsystemandneurodegeneration.


EDUCATION
1. 2004-2009University of Science and Technology of China
Ph.DinNeurobiology, November 2009
2. 2000-2004University of Science and Technology of China
B.S. in Bioscience, July 2004


RESEARCH EXPERIENCE
1. 2016-presentProfessor
Department of Pharmacology, Soochow University College of Pharmaceutical
Sciences
2. 2012-2016AssociateProfessor
Department of Pharmacology, Soochow University College of Pharmaceutical
Sciences
3. 2010-2012Postdoctoral Research Associatewith Dr. Arthur Horwich
Yale University School of Medicine/Howard Hughes Medical Institute(HHMI)
4. 2004-2009Ph.DStudent with Dr. Guanghui Wang
Laboratory of Molecular Neuropathology, Department of Neurobiology, School ofLife Sciences, University of Science and Technology of China


SCIENTIFIC TITLE ANDAWARD
2015-presentAssociate Editor of the Journal of Alzheimer's Disease(JAD)
2010Qiu Shi Graduate Student ScholarshipbyHong Kong Qiu Shi Science & Technologies Foundation


SELECTED PUBLICATIONS
(¹Co-first author)(*Correspondingauthor)
1.Wang M¹, Wang H¹, Tao Z, Xia Q, Hao Z, PrehnJHM, Zhen X, Wang G*,Ying Z*(2020).C9orf72associates with inactive RRAG GTPases and regulatesMTORC1-mediatedautophagosomal and lysosomal biogenesis.Aging Cell.19(4):e13126.


2.Zhang Z¹, Wang N¹, Ma Q, Chen Y, Yao L, Zhang L, Li Q, Shi M, Wang H*,Ying Z* (2020). Somatic and germline mutations of the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells.Acta Pharmacol Sin.41(1):93-100.


3.Wang N¹, Ma Q¹, Peng P¹, Yu Y, Xu S, Wang G,Ying Z*, Wang H* (2020).Autophagy andubiquitin-proteasomesystemcoordinate to regulatetheprotein quality controlof neurodegenerative disease-associated DCTN1.Neurotox Res.37(1):48-57.


4.Chen Y,WangH,Ying Z*, Gao Q* (2020).Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy.Biochem Biophys Res Commun.526(1):231-238.


5.Wang H¹, Wang N¹,XuD¹, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, PrehnJHM,Wang G,Ying Z*. Oxidation of multiple MiT/TFE transcription factors linksoxidative stress to transcriptionalcontrol ofautophagy and lysosomebiogenesis.Autophagy.2019 Dec 18:1-14. doi: 10.1080/**.2019.**. [Epub ahead of print]


6.Chen Y¹, Xu S¹, Wang N, Ma Q,PengP, Yu Y,Ying Z*, Wang H* (2019).Dynasore suppresses mTORC1 activity and induces autophagy to regulate the clearance of protein aggregates in neurodegenerative diseases.Neurotox Res.36(1):108-116.


7.ZhangZ¹, WangH¹, DingQ¹, XingY¹,Xu D¹,XuZ, ZhouT, QianB, JiC,PanX, ZhongA,YingZ*, ZhouC*, ShiM* (2017).Thetumorsuppressorp53regulatesautophagosomalandlysosomalbiogenesisin lung cancer cells by targeting transcription factorEB.Biomed Pharmacother. 89:1055-1060.


8.Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J,Ying Z* and Wang G* (2016).TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.EMBO J.35(2):121-42.Notes:Cover storyandhighlightedinNews & Views inthis issue.


9.Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H* and Wang G* (2016).TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners.Autophagy12(4):707–8.


10.Xia Q,WangG*,WangH, Hu Q,YingZ* (2016).Folliculin, a tumor suppressor associated with Birt-Hogg-Dube′ (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.Hum Mol Genet.25(1):83-96.


11.Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, Chen D, Fu C, Zheng L,YingZ*, Wang G* (2015).Induction of COX-2-PGE2 synthesisby activation oftheMAPK/ERK pathway contributesto neuronaldeath triggered by TDP-43-depletedmicroglia.Cell Death Dis.6:e1702.


12.Xia Q,WangH, Zhang Y,YingZ* andWangG* (2015).Loss of TDP-43 Inhibits ALS-linked Mutant SOD1 Aggresome Formation in an HDAC6-dependent Manner.J Alzheimers Dis.45(2):373-86.


13.Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*,Ying Z* (2015). Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.Hum Mol Genet.24(9):2426-41.


14.Zhou L¹, Wang H¹, Ren H, Hu Q,Ying Z* andWangG* (2015).Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease.Mol Neurobiol.52(3):1180-9.(¹Co-first author)


15.Zhou L, Wang H, Chen D, Gao F,Ying Z* andWangG* (2014).p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine.Int J Mol Sci.15(9):14997-15010.


16.Zhou L, Wang H, Wang P, Ren H, Chen D,Ying Z* andWangG* (2013).Ataxin-3 protects cells againstH2O2-induced oxidative stress by enhancing the interactionbetween bcl-xl and bax.Neuroscience.243:14-21.


17.Zhou L, Wang H, Ren H, Chen D, Gao F, Hu Q, Fu C, Xu R,Ying Z* andWangG* (2013).Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro.Acta Pharmacol Sin.34(5):651-6.


18.Ying Z¹, Wang H¹, Wang G*(2013).The ubiquitin proteasome system as a potential target for the treatment of neurodegenerative diseases.Curr Pharm Des.19(18):3305-14.(¹Co-first author)


19.Wang H¹,Ying Z¹, Wang G* (2012).Ataxin-3 regulates aggresome formation ofcopper-zinc superoxide dismutase (SOD1)by editing K63-linked polyubiquitin chains.J Biol Chem.287(34):28576-85.(¹Co-first author)


20.Ying Z, Wang H, Fan H, Wang G* (2011).The ER-associated degradation systemregulatesaggregation and degradation of mutant neuroserpin.J Biol Chem. 286(23):20835-44.


21.Ying Z,Wang H, Fan H, Zhu X, Zhou J,Fei E, Wang G* (2009).Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.Hum Mol Genet.18(22):4268-81.