Mechanism of hyperalgesia in primary afferent
Yi Zhu
Associate Professor
Ph.D. University of Maryland 2011
M.S. Soochow University 2004
B.S. China Pharmaceutical University 1999
yzhu@suda.edu.cn



Research Interest
GABAA receptor function in the regulation of neuronal excitability, mechanism of inflammatory pain
Representative Publications
1.Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain. Stéphanie Ratté,Yi Zhu, Kwan Yeop Lee, Steven A Prescott. Elife,Elife20141;3:e02370. Epub 2014 Apr 1
2.Activity-dependent hyperpolarization of EGABA is absent in cutaneous DRG neurons from inflamed rats.Zhu Y, Zhang XL, Gold MS.Neuroscience.2013Oct 14;256C:1-9.
3.Inflammation-induced shift in spinal GABAA signaling is associated with a tyrosine kinase-dependent increase in GABAA current density in nociceptive afferents.Zhu Y, Dua S, Gold MS.J Neurophysiol.2012Nov;108(9):2581-93
4.Persistent inflammation increases GABA-induced excitation of rat cutaneous dorsal root ganglion neurons in vitro.Zhu Y, Lu SG, Gold MS.Neuroscience.2012Sep 18;220:330-40.
5.Prostaglandin A1 inhibits increases in intracellular calcium concentration, TXA2 production and platelet.Zhu Y, Gu ZL, Liang ZQ, Zhang HL, Qin ZH.Acta Pharmacologica Sinica.2006May;27(5): 549-554.