姓 名：欧阳艺兰
职称职务：讲师
电子邮箱：y_ouyang@suda.edu.cn


一、学习工作经历

1、学历背景：

2009.9-2013.7 黑龙江大学，本科，制药工程（化学）
2013.9-2016.7 苏州大学，硕士，药物分析学
2016.9-2019.7 苏州大学，博士，药物分析学
2018.10-2019.10 美国伦斯勒理工博士联合培养
二、研究方向
1. 糖胺聚糖等硫酸多糖寡糖的糖组学
2. 肝素及类肝素糖类药物的分析、鉴定
3. 糖类药物的研究与开发

三、主要研究成果

近年来发表SCI论文十余篇。
1、论文
1. Ouyang, Y.^＃; Han, X.^＃; Xia, Q.; Chen, J.; Velagapudi, S.; Xia, K.; Zhang, Z.*; Linhardt, R. J.* Negative-Ion Mode Capillary Isoelectric Focusing Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides. Anal. Chem.2019, 91(1), 846–853.
2.Ouyang, Y.^＃Zeng, Y.; Rong, Y.; Song, Y.; Shi, L.; Chen, B.; Yang, X.; Xu, N.; Linhardt, R. J.; Zhang, Z. * Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two-dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry. Anal. Chem.2015, 87(17): 897-8963.

3. Ouyang, Y.^＃; Yu, Y.; Zhang, F.; Chen, J.; Han, X.; Xia, K.; Yao, Y.; Zhang, Z.*; Linhardt, R. J.* Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications. J. Med. Chem.2019, 62, 1067-1072.
4. Ouyang, Y.^＃; Zeng, Y.; Yi, L.; Tang, H.; Li, D.; Linhardt, R. J.; Zhang, Z.* Qualitative and Quantitative Analysis of Heparin and Low Molecular Weight Heparins Using Size Exclusion Chromatography with Multiple Angle Laser Scattering/Refractive Index and Inductively Coupled Plasma/Mass Spectrometry Detectors. J. Chromatogr. A2017, 1522, 56–61.
5.Ouyang, Y.^＃; Zhu, M.; Wang, X.; Yi, L.; Fareed, J.; Linhardt, R.J.; Zhang, Z.* Systematic Analysis of Enoxaparins from Different Sources with Online One- and Two-dimensional Chromatography. Analyst. 2019, 144, 3746-3755.
6. Ouyang, Y.^＃; Han, X.^＃; Yu, Y.; Chen, J.; Fu, L.; Zhang, F.; Linhardt, R. J.; Fareed, J.; Hoppensteadt, D.; Jeske, W.; Kouta, A.; Zhang, Z.*; Xia, K.* Chemometric Analysis of Porcine, Bovine and Ovine Heparins. J. Pharm. Biomed. Anal.2019, 164, 345-352.
7.Ouyang, Y.^＃;Wu, C^＃.; Sun, X.; Liu, J.; Linhardt, R. J.; Zhang Z.* Development of Hydrophilic-Interaction-Chromatography with Quadruple-Time-of-Flight Mass Spectrometry for Heparin and Low-Molecular-Weight-Heparin Disaccharide Analysis, Rapid Commun. Mass Spectrom., 2016, 30: 277-284.

8. Yi, L.^＃; Ouyang, Y.;Sun, X.; Xu, N.; Linhardt, R. J.; Zhang, Z.* Qualitative and Quantitative Analysis of Branches in Dextran using High-Performance Anion Exchange Chromatography coupled to Quadrupole Time-of-Flight Mass Spectrometry, J. Chromatogr. A2015, 1423, 79-85.

9. Yi, L.^＃; Sun, X.; Du, K.; Ouyang, Y.; Wu, C.; Xu, N.; Linhardt, R. J.; Zhang, Z. * UP-HILIC-MS/MS to Determine the Action Pattern of Penicillium sp. Dextranase, J. Am. Soc. Mass Spectr. 2015, 26, 1174-1185.
10. Yi, L.^＃; Xu, N.; Sun, X.; Li, D.; Tao, L.; Ouyang, Y.; Linhardt, R. J.; Zhang, Z.* N -Glycans Released from Glycoproteins Using a Commercial Kit and Comprehensively Analyzed with a Hypothetical Database. J. Pharm. Anal.2017, 7(2), 87–94.
11. Sarnaika, A.^＃; Abernathy, M. H.; Han, X.; Ouyang, Y.; Xia, K.; Chen, Y.; Cress, B.; Zhang, F.; Lali, A.; Pandit, R.; Linhardt, R. J.; Tang, Y. J.; Koffas, M. A. G.* Metabolic Engineering of Cyanobacteria for Photoautotrophic Production of Heparosan, a Pharmaceutical Precursor of Heparin. Algal Res.2018, 37(June 2018), 57–63.
12. Khan, S.^＃; Liu, J.; Szabo, Z.; Kunnummal, B.; Han, X.; Ouyang, Y.; Linhardt, R. J.; Xia, Q.* On-Line Capillary Electrophoresis/Laser-Induced Fluorescence/Mass Spectrometry Analysis of Glycans Labeled with Teal^TMFluorescent Dye Using an Electrokinetic Sheath Liquid Pump-Based Nanospray Ion Source. Rapid Commun. Mass Spectrom.2018, 32(11), 882–888.
13. Mikael, P. E.^＃; Willard, C.; Koyee, A.; Barlao, C.-G.; Liu, X;Han, X.; Ouyang, Y.; Xia, K.; Linhardt, R. J.; Dordick, J. S.* Remodeling of Glycosaminoglycans During Differentiation of Adult Human Bone Mesenchymal Stromal Cells Toward Hepatocytes. Stem Cells Dev.2018, 28(4), 278–289.
14. Haeger, S. M.^＃; Liu, X.; Han, X.; Brennan McNeil, J.; Oshima, K.; McMurtry, S. A.; Yang, Y.; Ouyang, Y.; Zhang, F.; Nozik-Grayck, E.; Zemans, R. L.; Tuder, R. M.; Bastarache, J. A.; Linhardt, R. J.; Schmidt, E. P.* Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am. J. Respir. Cell Mol. Biol.2018, 59(3), 363–374.

2、课题
1、肝素类药物糖组学研究（**），国家自然科学基金项目（面上），51万，2017.01-2020.12，重要参与者。
2、复杂蛋白聚糖的序列分析（**），国家自然科学基金项目（面上），80万，2015.01-2018.12，重要参与者。