姓名：徐海东
职称职务：讲师
电子邮箱：hdxu01@suda.edu.cn
办公地址：云轩楼2413
个人简历:
学习经历：
2008.09-2012.07苏州大学，理学博士
2001.09-2004.07南京中医药大学，医学硕士
1995.09-2000.07河南中医学院，医学本科
工作经历：
2013.10-至今苏州大学医学部药学院，讲师
2016.03-2017.06 美国艾默里大学医学院神经退行性疾病中心，博士后
2006.05-2007.11中国科学院动物研究所生物膜与膜工程国家重点实验室，客座学生
2005.04-2005.09 南京中医药大学温病学教研室，图书管理员
研究方向：
（1）神经元在应激条件下生存与死亡的机制
（2）自噬在神经退行性疾病中的作用
（3）分子伴侣介导的自噬
代表性论文：
1.Xu, H. D.,Wu, D., Gu, J. H., Ge, J. B., Wu, J. C., Han, R., Liang, Z. Q., Qin,Z. H.(2013) The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions.PLoS ONE8 (5): e63232.
2.Wu, F.*,Xu, H. D.*, Wu, J. C., Guan, J. J., Qin,Z. H. (2015) Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease.Neuroscience284:900-911. (*Equal contribution)
3.Li, W., Nie, T.,Xu, H. D., Yang, J., Yang, Q., Mao, Z. (2018) Chaperone-mediated autophagy: advances from bench to bedside.Neurobiology of Diseasepii: S0969-9961(18)30148-7.
4.Li, W., Dou, J., Yang, J.,Xu, H. D., She, H. (2018) Targeting chaperone-mediated autophagy for disease therapy.Current Pharmacology Reports.4 (3), 261-275.
5.Li, W., Zhu, J., Dou, J., She, H., Tao, K.,Xu, H. D., Yang, Q., Mao, Z. (2017)Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy.Nat. Commun.8 (1), 1763.
6.He, Y., She, H., Zhang, T.,Xu, H. D., Cheng, L., Yepes, M., Zhao, Y., Mao, Z. (2017)p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1.J. Cell Biol.217 (1), 315-328.
7.Chen, G., Zhang, B.,Xu, H. D., Sun, Y., Shi, Y., Luo, Y., Jia, H., Wang, F. (2017)Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis.Oncogene36 (50), 6863.
8.Fang, L., Li, B., Guan, J.,Xu, H. D., Shen, G., Gao, Q., Qin, Z. H. (2017)Transcription factor EB is involved in autophagy-mediated chemoresistance to doxorubicin in human cancer cells.Acta Pharmacol Sin.38 (9), 1305
9.Luo, L., Lu, A. M., Dai, J. R., Guo, S. S., Gao, X. F., Gu, Y. R., Zhang, X. F.,Xu, H. D., Zhu, Z., Wood, L., Qin, Z. H. (2017) Lysosomal proteolysis is associated with exercise-induced improvement of mitochondrial quality control in aged hippocampus.J Gerontol.72 (10), 1342-1351.
10.Fan, J., Lin, R. T., Xia, S. Y., Chen, D., Elf, S. E., Liu, S. P., Pan, Y. Z.,Xu, H. D., Shan, C. L., Zhou, L., Lei, Q. Y., Li, Y. C., Mao, H., Lee, B. H., Gaddh, M., Arellano, M. L., Khoury, H. J., Khuri, F. R., Kang, S. M., Doetsch, P. W., Lonial, S., Boggon, T. J., Curran, W. J., Chen, J. (2016) Inhibition of tetrameric acetyl-CoA acetyltransferase 1 attenuates tumor growth.Mol. Cell64 (5), 859-874.
11.Hou, Y. S., Guan, J. J.,Xu, H. D., Wu, F., Sheng, R., Qin, Z. H. (2015) Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-dependent autophagy activation.Mol. Cell Biol.35, 2740-2751.
12.Gu, J. H., Ge, J. B., Li, M.,Xu, H. D., Wu, F., Qin, Z. H. (2013) Poloxamer 188 protects neurons against ischemia/reperfusion injury through preserving integrity of cell membranes and blood brain barrier.PLoS ONE8 (4), e61641.
13.Zhu, Y. S., Zhao, L. X., Liu, L., Gao, P., Tian, W. L., Wang, X. H., Jin, H. J.,Xu, H. D., Chen, Q. (2010) Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis.Protein Cell1 (5), 468-477.
论著：
14.第十章Beclin 1-Bcl-2 复合物在哺乳动物自噬调控中的作用。
徐海东，秦正红. 科学出版社，自噬：生物学与疾病(第二版，2015年)，155-170.
社会任职：
美国神经科学学会 会员
中国神经科学学会 会员
中国药理学会 会员