宋一之研究员
研究方向：
电子邮件：songyz@sibet.ac.cn
电话：
通讯地址：苏州市高新区科技城科灵路88号







简历： 宋一之，研究员，2001年进入清华大学环境工程系学习，先后获得工学学士、博士学位。2011-2018年期间先后在清华大学、英国谢菲尔德大学和英国牛津大学任博士后研究员。2018年参与创办以开发临床微生物诊断工具为目标的医疗器械企业。2020年加入中国科学院苏州生物医学工程技术研究所。
长期以来主要从事病原微生物和单细胞分析等领域的研究，在微生物单细胞表型的拉曼光谱学、单细胞基因组扩增、临床耐药菌耐药特征和合成生物学工具开发等领域取得了一系列重要的原创性成果。
发表SCI收录论文和英文专著章节26篇，授权发明专利4项，实用新型专利授权3项。作为项目负责人或子课题项目负责人承担中科院装备研制、国家重点研发计划、863计划课题、科技部基础工作专项课题和博士后基金课题。多项研究成果已被转化，受到市场一致认可。一项成果形成国家行业标准，成绩较为突出。

获奖及荣誉： 苏州市高新区领军人才（2020）
上海市青年“****”（2019）

社会任职：
研究方向： （1） 病原菌感染精准诊断技术
（2） 细菌耐药机制研究
（3） 新型拉曼光谱技术、设备开发与生物医学应用
（4） 合成生物学

承担项目情况：
代表论著： 1. Yi X, Song Y*, et al , Analytical Chemistry, 2021 doi:10.1021/acs.analchem.0c04709
2. Chen, J. X.; Lim, B.; Steel, H.; Song, Y.; Ji, M.; Huang, W. E., Redesign of ultrasensitive and robust RecA gene circuit to sense DNA damage. Microbial Biotechnology, 2021
3. Jiang B, Song Y, Liu Z, Huang WE, Li G, Deng S, Xing Y, Zhang D. Whole-cell bioreporters for evaluating petroleum hydrocarbon contamination. Critical Reviews in Environmental Science and Technology 2020: 1-51.
4. Song Y., et al. Overproduction of proteorhodopsin enhances long-term viability of Escherichia coli. Applied and environmental microbiology. 2020. 86(1) 02087-19
5. Song, Y., Rampley, C. P. N., Chen, X., Du, F., Thompson, I. P., & Huang, W. E. (2019). Application of Bacterial Whole-Cell Biosensors in Health. In G. Thouand (Ed.), Handbook of Cell Biosensors (pp. 1-17). Cham: Springer International Publishing.
6. Zhang, Q. Song, Y, et al. Monitoring Cr toxicity and remediation process – combining a whole-cell bioreporter and Cr isotope techniques, Water Research, 2019. 153:295-303
7. Liang, B., Gao, Y., Xu, J., Song, Y., Xuan, L., Shi, T., Chen, Z. J. Raman profiling of embryo culture medium to identify aneuploid and euploid embryos. Fertility and Sterility, 2019. 111(4), 753-762.e751.
8. Jing, X., H. Gou, Y. Gong, X. Su, Xu, Y. Ji, Y. Song, I. P. Thompson, J. Xu and W. E. Huang, Raman-activated cell sorting and metagenomic sequencing revealing carbon-fixing bacteria in the ocean. Environ Microbiol. 2018( doi: 10.1111/1462-2920.14268.)
9. Cui, Z., X. Luan, H. Jiang, Q. Li, G. Xu, C. Sun, L. Zheng, Y. Song, P. A. Davison and W. E. Huang, Application of a bacterial whole cell biosensor for the rapid detection of cytotoxicity in heavy metal contaminated seawater. Chemosphere 2018. 200: 322-329.
10. Yuan, X., Song Y., Song Y., et al., Effect of laser irradiation on cell function and its implications in Raman spectroscopy. Applied and Environmental Microbiology, 2018.(doi:10.1128/AEM.02508-17)
11. Song, Y, Kaster AK, Vollmers J, Song Y, Davison PA, Frentrup M, et al. Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea. Microb Biotechnol. 2017;10(1):125-37
12. Song, Y., et al., Raman-Deuterium Isotope Probing for in-situ identification of antimicrobial resistant bacteria in Thames River. Scientific Reports, 2017. 7(1): p. 16648
13. Xu J., Zhu D., Ibrahim D., Allen R., Gibson M., Fowler W., Song Y., et al. Raman Deuterium Isotope Probing Reveals Microbial Metabolism at the Single-Cell Level. Analytical Chemistry, 2017. 89(24): p. 13305-13312
14. Wang Y, Song Y, Tao Y, Muhamadali H, Goodacre R, Zhou N-Y, Preston GM, Xu J, Huang WE. 2016. Reverse and Multiple Stable Isotope Probing to Study Bacterial Metabolism and Interactions at the Single Cell Level. Analytical Chemistry 88:9443-9450
15. Song, Y., H. Yin, and W.E. Huang, Raman activated cell sorting. Current Opinion in Chemical Biology, 2016. 33: 1-8
16. Song, Y., et al., A whole-cell bioreporter approach for the genotoxicity assessment of bioavailability of toxic compounds in contaminated soil in China. Environ Pollut, 2014. 195: 178-84
17. Song Y., Zhang D., Karen P., et al. Bacterial Whole-Cell Biosensors in Environmental Health // Victor R. Preedy. Biosensors and Environmental Health. CRC Press: Boca Raton, 2012
18. Song, Y., G. Li, etc., Optimization of Bacterial Whole Cell Bioreporters for Toxicity Assay of Environmental Samples, Environmental Science & Technology, 2009. 43(20):7931-7938
19. Song, Y. Z. Hahn, T. etc., Ultrasound-mediated DNA transfer for bacteria, Nucleic Acids Research, 2007. 35(19):e129