陈佳林
副教授 东南大学医学院
联系电话： 办公时间：8:30-17:00
传 真： 主页网址：
办公地点：东南大学医学院基一楼504 电子邮箱：kiven99999@163.com
通讯地址：南京市鼓楼区丁家桥87号东南大学医学院基一楼504












研究方向



富含胶原组织（角膜、肌腱、软骨等）的修复与再生；
干细胞分化命运的调控；
细胞微环境；
组织工程与再生医学。

组织工程学（Tissue engineering），涉及到生物学、材料学和工程学等多学科，是指利用生物活性物质，通过体外培养或构建的方法，再造或者修复器官及组织的技术。
参考维基百科：https://zh.wikipedia.org/wiki/%E7%BB%84%E7%BB%87%E5%B7%A5%E7%A8%8B%E5%AD%A6

【招生】本课题组与医学院张薇老师课题组联合培养学生，致力于培养干细胞、组织工程和再生医学领域的相关研究人才。欢迎医学、生物学、生物医学工程、生物材料、药学等学生跨专业报考研究生，也欢迎本科生SRTP和毕业设计项目。相关咨询请联系：kiven99999@163.com
张薇老师个人主页：http://jszy.seu.edu.cn/_s2689/main.psp




荣誉奖励


2019.12 东南大学 至善青年****
2017.09 Travel grant from the Wallenberg Foundation, Sweden
2013.12 澳洲政府 2014 Endeavour Australia Cheung Kong Research Fellowship
2011 浙江大学医学部“杏林学术之星”
2010 浙江大学基础医学院POSTER作品竞赛二等奖
2009.11 第四届COA国际学术大会“优秀论文奖”





学术成果



1987年生，本科至博士毕业于浙江大学，2018年10月入职东南大学医学院。共发表学术期刊论文38篇（总影响因子224，被引2000余次，H指数20），其中一作和通讯论文16篇（平均影响因子5.7）。


教育经历：
2009.09 - 2014.06 浙江大学基础医学院，硕博连读，干细胞和再生医学专业
导师：欧阳宏伟 教授
2014.01 - 2014.05 澳大利亚西澳大学，访问****
导师：郑铭豪 教授
2005.09 - 2009.06 浙江大学竺可桢学院，本科，生物科学专业

工作经历：
2018.10 - 至今 东南大学医学院，副教授
2014.09 - 2018.08 瑞典于默奥大学，博士后
导师：Patrik Danielson 教授

学术任职：
中华医学会骨科学分会青年委员。
中国骨科再生医学会（CORMed）成员。
Military Medical Research（入选中国科技期刊卓越行动计划）青年编委。
国际期刊Stem Cells International 客座编辑。
国际期刊Applied Bionics and Biomechanics 客座编辑。
兼任生物材料、干细胞和组织工程领域近10本国际专业SCI期刊的审稿人，期刊包括Acta Biomaterialia, Materials Science & Engineering C, Stem Cell Research & Therapy 等。


科研项目：
南京市留学人员科技创新项目择优资助A类，2020.09-2021.08，负责人
东南大学“至善青年****”支持计划资助，2020.01-2022.12，负责人
国家自然科学基金--青年基金项目，2020.01-2022.12，负责人
江苏省自然科学基金--青年基金项目，2019.07-2022.06，负责人
（省优势）新进教师人才引进启动费，2019.01-2020.12，负责人
东南大学基础科研扶持项目，2019.04-2019.12，负责人
东南大学中央高校建设一流大学（学科）和特色发展引导专项资金经费，2019

参编书籍：
《再生医学：基础与临床》 2013，人民卫生出版社
《疫苗工程学》 2020，东南大学出版社


发表论文：
ZhangW*, Ling C, Li XL, Sheng RW, Liu HY, Zhang AN, Jiang YJ, Chen JL*, Yao QQ*.Cell-Free Biomimetic Scaffold with Cartilage Extracellular Matrix-Like Architectures for In Situ Inductive Regeneration of Osteochondral Defects. ACS Biomater Sci Eng2020, 6, 6917-6925. (IF=4.152)
Sheng RW, Jiang YJ, Backman LJ, Zhang W*, Chen JL*. The application of mechanical stimulations in tendon tissue engineering. Stem Cells International 2020, 2020: **. (IF=3.869，一作为大二本科生)
Chen J*, Backman LJ, Zhang W, Ling C, Danielson P*. Regulation of keratocyte phenotype and cell behavior by substrate stiffness. ACS Biomaterials Science & Engineering 2020. 6(9): 5162-5171. (IF=4.152)
Zhang W*, Ling C, Zhang AN, Liu HY, Jiang YJ, Li XL, Sheng RW, Yao QQ*, Chen JL*. An all-silk-derived functional nanosphere matrix for sequential biomolecule delivery and in situ osteochondral regeneration. Bioactive Materials. 2020, 5:832-843. (IF=8.724)
Zhang W*, Ling C, Liu HY, Zhang AN, Mao L, Wang J, Chao J, Backman LJ, Yao QQ*, Chen JL*. Tannic Acid-Mediated Dual Peptide-Functionalized Scaffolds to Direct Stem Cell Behavior and Osteochondral Regeneration. Chem Eng J. 2020, 396:125232. (IF=10.652)
Chen J, Zhang W, Backman LJ, Kelk P, and Danielson P: Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes. Br J Ophthalmol 2018;102; 562-569 (IF=3.611)
Chen J, Zhang W, Kelk P, Backman LJ, and Danielson P: Substance P and Patterned Silk Biomaterial Stimulate Periodontal Ligament Stem Cells to Form Corneal Stroma in a Bioengineered 3D Model. Stem Cell Res Ther 2017;8:260 (IF=5.116)
Chen J, Zhang E, Zhang W, et al. Fos Promotes Early Stage Teno-Lineage Differentiation of Tendon Stem/Progenitor Cells in Tendon. Stem Cells Transl Med. 2017. 6(11): 2009-2019. (IF=6.429)
Chen JL, Lan J, Liu DL, Backman LJ, Zhang W, Zhou QJ,Danielson P. Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/Progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea. Stem Cells Transl Med. 2017;6:1356-1365. (IF=6.429)
Chen J, Chen P, Backman LJ, Zhou Q, Danielson P. Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt. Sci Rep 2016;6:25870. (IF=3.9983.9983)
Chen JL, Zhang W, Liu ZY, Zhu T, Shen WL, Ran JS, Tang QM,Gong XN, Backman LJ, Chen X, Chen XW, Wen FQ, Ouyang HW. Characterization and comparison of post-natal rat Achilles tendon-derived stem cells at different development stages. Sci Rep 2016;6:22946. (IF=3.9983.3??)
Chen JL, Zhang W, Liu ZY, Heng BC, Ouyang HW, Dai XS.Physical regulation of stem cells differentiation into teno-lineage: currentstrategies and future direction. Cell Tissue Res 2015. 360(2):195-207.(IF=4.044)
Shen WL^#, Chen JL^#, Zhu T, Yin Z, Chen X, Chen LK, Fang Z, Heng BC, JiJF, Chen WS, Ouyang HW, Osteoarthritis prevention through meniscal regeneration induced by intra-articular injection of meniscus stem cells. Stem Cells Dev, 2013. 22(14): p. 2071-82. (共一，封面文章??????????, IF=3.082)
Zhang W^#, Chen JL^#, Tao JD, Hu CC,Chen LK, Zhao HS, Xu GW, Heng BC, Ouyang HW. The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold. Biomaterials, 2013. 34(25): p. 6046-57. (共一, IF=10.317, 被引69次)
Shen W^#, Chen J^#, Yin Z, Chen X, LiuH, Heng BC, Chen W, Ouyang HW. Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair. Cell Transplant 2012;21(5):943-958. (共一, IF=3.341, 被引89次)
Chen JL, Yin Z, Shen WL, Chen X, Heng BC, Zou XH, Ouyang HW. Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials 2010. 31(36):9438-9451. (IF=10.317, 被引192次)
Zhang W*, Chen JL, Qu ML, Backman J, Zhang AN, Liu HY, Zhang XP, Zhou QJ*, Danielson P*. Sustained release of TPCA-1 from silk fibroin hydrogels preserves keratocyte phenotype and promotes corneal regeneration by inhibiting interleukin-1β signaling. Adv Healthc Mater. 2020, e**. (IF=7.367)
He SQ, Ruan DF, Chen YW, Ran JS, Chen X, Yin Z, Tang CQ, Huang JY, Heng BC, Chen JL, Chen WS, Shen WL, Ouyang HW. Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages. Stem Cells Transl Med. 2019, 8:1318-1329.(IF=6.429)
El-Habta R, Chen JL, Pingel J, Backman LJ.Tendinosis-like changes in denervated rat Achilles tendon. BMC Musculoskelet Disord. 2018,19:426. (IF=1.879)
Zhang W, Li Y, Jiang DM, XieSJ, Zeng MF, Chen JL, Chen LK,Ouyang HW, Zou XH. Promotion of Hernia Repair with High-Strength, Flexible, and Bioresorbable Silk Fibroin Mesh in a Large Abdominal Hernia Model. ACS Biomaterials Science & Engineering 2018 4 (6), 2067-2080 (IF=4.152)
Spang C, Backman LJ, Le RS, Chen J, Danielson P. Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells. BMC Musculoskelet Disord.2017.18(1): 218. (IF=1.879)
Zhang W, Chen L, Chen J, Wang L, Gui X, Ran J, Xu G,Zhao H, Zeng M, Ji J, Qian L, Zhou J, Ouyang H, Zou X. Silk Fibroin BiomaterialShows Safe and Effective Wound Healing in Animal Models and a Randomized Controlled Clinical Trial. Adv HealthcMater 2017. 6. (封面文章, IF=7.367)
Zhang W, Chen J, Backman LJ, Malm AD, Danielson P. Surface Topography andMechanical Strain Promote Keratocyte Phenotype and Extracellular MatrixFormation in a Biomimetic 3D Corneal Model. Adv Healthc Mater. 2017. 6(5). (封面文章, IF=7.367)
Spang C, Chen J, Backman LJ. The tenocyte phenotype of human primary tendoncells in vitro is reduced by glucocorticoids. BMC Musculoskelet Disord. 2016;17:467.(IF=1.879)
Yin Z, Hu JJ, Yang L, ZhengZF, An CR, Wu BB, Zhang C, Shen WL, Liu HH, Chen JL, Heng BC, Guo GJ, Chen X, Ouyang HW. Single-cell analysis reveals a nestin+ tendon stem/progenitor cell population with strong tenogenic potentiality. Science Advances, 2016. 2(11):e**-e**.(IF=13.116)
Yin Z, Chen X, Song HX, Hu JJ, Tang QM, Zhu T, Shen WL, Chen JL, Liu H, Heng BC, Ouyang HW. Electrospun scaffolds for multiple tissues regeneration in vivo through topography dependent induction of lineage specific differentiation. Biomaterials 2015;44:173-185. (IF=10.317)
Tang QM, Chen JL, Shen WL, Yin Z, Liu HH, Fang Z, Heng BC, Ouyang HW, Chen X. Fetal and adult fibroblasts display intrinsic differences in tendon tissue engineering and regeneration. Sci Rep2014;4:5515. (IF=3.998)
Shen WL, Chen JL, Zhu T, Chen LK, Zhang W, Fang Z, Heng BC, Yin Z, Chen X,Ji JF, Chen WS, Ouyang HW. Intra-Articular Injection of Human MeniscusStem/Progenitor Cells Promotes Meniscus Regeneration and Ameliorates Osteoarthritis Through Stromal Cell-Derived Factor-1/CXCR4-Mediated Homing. Stem Cells Transl Med, 2014. 3(3): p. 387-94. (IF=6.429)
Chen X, Yin Z, Chen JL, Liu HH, Shen WL, Fang Z, ZhuT, Ji JF, Ouyang HW, Zou XH. Scleraxis-overexpressed human embryonic stemcell-derived mesenchymal stem cells for tendon tissue engineering with knittedsilk-collagen scaffold. Tissue Eng Part A,2014. 20(11-12): p. 1583-92. (IF=3.496)
Fang Z, Zhu T, Shen WL, Tang QM, Chen JL, Yin Z, Ji JF, Heng BC, Ouyang HW, Chen X. Transplantationof fetal instead of adult fibroblasts reduces the probability of ectopicossification during tendon repair. TissueEng Part A, 2014. 20(13-14): p.1815-26. (IF=3.496)
Shen W, Chen X, Hu Y, Yin Z, Zhu T, Hu J, Chen J, Zheng Z, Zhang W, Ran J, HengBC, Ji J, Chen W, Ouyang HW. Long-term effects of knitted silk-collagen spongescaffold on anterior cruciate ligament reconstruction and osteoarthritisprevention. Biomaterials 2014;35(28):8154-8163. (IF=10.317)
Zhang W, Chen J, Tao J, Jiang Y, Hu C, Huang L, Ji JF, Ouyang HW. The use oftype 1 collagen scaffold containing stromal cell-derived factor-1 to create amatrix environment conducive to partial-thickness cartilage defects repair. Biomaterials2013;34(3):713-723. (IF=10.317)
Chen X, Yin Z, Chen JL, Shen WL, Liu HH, Tang QM, FangZ, Lu LR, Ji JF, Ouyang HW. Force and scleraxis synergistically promote thecommitment of human ES cells derived MSCs to tenocytes. Sci Rep, 2012. 2: p.977. (IF=3.998)
Zou XH, Jinag YZ, Chen JL, Chen X, Ouyang HW. Tissueengineering for soft tissue regeneration. Science.2012 April:(Suppl: regenerative medicine in China): 33-34. (Science专刊)
Zhang W, Chen J, Zhang S, Ouyang HW. Inhibitory function of parathyroidhormone-related protein on chondrocyte hypertrophy: the implication forarticular cartilage repair. Arthritis ResTher 2012;14(4):221. (IF=4.103)
Yin Z, Chen X, Chen JL, Shen WL, Hieu NT, Gao L, andOuyang HW. The regulation of tendon stem cell differentiation by the alignmentof nanofibers. Biomaterials 2010;31(8):2163-2175. (IF=10.317)
Shen W,Chen X, Chen J, Yin Z, Heng BC, ChenW, Ouyang HW. The effect of incorporation ofexogenous stromal cell-derived factor-1 alpha within a knitted silk-collagensponge scaffold on tendon regeneration. Biomaterials2010;31(28):7239-7249. (IF=10.317)
Yin Z, Chen X, Chen JL, Ouyang HW. Stem cells fortendon tissue engineering and regeneration. Expert Opin Biol Ther 2010;10(5):689-700. (IF=3.224)
注：上述标注均为2019年度影响因子：2019 Journal Citation Reports (Clarivate Analytics 2020)。