廖志新
博士生导师 化学化工学院
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办公地点：化学化工新楼404室 电子邮箱：zxliao@seu.edu.cn
通讯地址：江苏省南京市江宁区东南大学路2号












研究方向


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?1?.? 天然药物的?活性成分?研究?
2. 中药新药??的?的开发（?新药化学?成分、工艺、药理、?剂型研究）?
3. ?中、西药的?质量标准?研究?
4. 生物?利用度、生物?等效性测量?
5. 药物杂质?含量分析?




荣誉奖励


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?2?004年作为?完成人之一“?中国龙胆科?植物研究”?成果获?省级“科技进步”?一等奖（2004JB?-?1-02-R7)

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学术成果


近五年以通讯作者发表的论文：

1.Zhang, J; Jiang, W; Cao, HJ; Qu, YB; Liao, ZX; Liu, C; Sun, JY. Two new monoterpene lactones from Ligulariarumicifolia (JRDrumm.) SWLiu and their anti-proliferative activities. PHYTOCHEMISTRYLETTERS. 2018. 28. 55-58.
2.Huang, RZ; Jin, L; Wang, CG; Xu, XJ; Du, Y; Liao, N; Ji, M; Liao, ZX; Wang, HS. A pentacyclic triterpene derivative possessingpolyhydroxyl ring A suppresses growth of HeLa cells by reactive oxygenspecies-dependent NF-kappa B pathway. EUROPEAN JOURNAL OF PHARMACOLOGY. 2018.838. 157-169
3.Jiang, W; Huang, RZ; Zhang, J; Guo, T; Zhang, MT; Huang, XC; Zhang, B; Liao, ZX; Sun, J; Wang, HS. Discovery of antitumor ursolic acid long-chaindiamine derivatives as potent inhibitors of NF-kappa B. BIOORGANIC CHEMISTRY.2018. 79. 265-276.
4.Qu, YB; Liao, ZX; Liu, C; Wang, XZ; Zhang, J. EFLDO induces apoptosis in hepatic cancer cells bycaspase activation in vitro and suppresses tumor growth in vivo. BIOMEDICINE& PHARMACOTHERAPY. 2018. 100. 407-416.
5.Zhang, J; Huang, RZ; Cao, HJ; Cheng, AW; Jiang, CS; Liao, ZX; Liu, C; Sun, JY. Chemical composition, in vitro anti-tumor activitiesand related mechanisms of the essential oil from the roots of Potentilladiscolor. INDUSTRIAL CROPS AND PRODUCTS. 2018. 113. 19-27.
6.Huang,RZ; Huang,XC; Zhang,B; Jia,HY;Liao,ZX; Wang,HS.16-O-caffeoyl-16-hydroxylhexadecanoic acid, amedicinal plant-derived phenylpropanoid, induces apoptosis in humanhepatocarcinoma cells through ROS-dependent endoplasmic reticulum stress. PHYTOMEDICINE.2018. 41. 33-44.
7.Zhang, SS; Liao, ZX; Huang, RZ; Gong, CC; Ji, LJ; Sun, HF. A new aromatic glycoside and its anti-proliferativeactivities from the leaves of Bergenia purpurascens. NATURAL PRODUCT RESEARCH.2018. 32. 668-675.
8.Chen, HF; Huang, RZ; Zuo, B; Ji, LJ; Mo, ZJ; Liao, ZX. Anti-proliferativeActivities of Two Flavonols with Unsubstituted B-ring from the Leaves ofPlatanus acerifolia. NATURAL PRODUCT COMMUNICATIONS. 2017. 12. 1701-1704.
9.Liu, HL ; Gong, CC; Liao, ZX; Chen, T; Li, YL, Isolation and Purification of Three Analogues fromClematis akebioides by Molecularly Imprinted Solid-Phase Extraction and HSCCC, CHROMATOGRAPHIA, 2017, 80,1651-1658
10.Huang, RZ; Jin, L; Yao, GY; Dai, WL; Huang, XC; Liao, ZX; Wang, HS, Synthesis and molecular docking study of novel alizarinderivatives containing phosphoryl amino acid moiety as potential antitumoragents, MEDICINAL CHEMISTRY RESEARCH, 2017, 26(10), 2363-2374
11.Huang, RZ; Liang, GB; Huang, XC; Zhang, B; Zhou, MM; Liao, ZX; Wang, HS, Discovery of dehydroabietic acid sulfonamide basedderivatives as selective matrix metalloproteinases inactivators that inhibitcell migration and proliferation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017,138, 979-992
12.Ri-Zhen Huang, Shi-Xian Hua, Zhi-Xin Liao, Xiao-Chao Huang, andHeng-Shan Wang, Side chain functionalized aniline-derived ursolic acid derivatives asmultidrug resistance reversers that block nuclear factor-kappa B (NF-κB)pathway and cell proliferation,[J]. MedChemComm,2017, 8(7), 1421-1434.
13.Ri-Zhen Huang, Bin Zhang, Xiao-Chao Huang,Gui-Bin Liang, Jian-Mei Qin, Ying-Ming Pan, Liao, ZXandHeng-Shan Wang, Synthesis and biological evaluation of terminal functionalizedthiourea-containing dipeptides as antitumor agents，[J]. RSC Adv., 2017, 7, 8866-8878.
14.Gong, CC , Chen, T , Chen, HF, Zhang, SS, Wang, XZ, Sun, J, Li, YL, Liao, ZX, Firstseparation of four aromatic acids and two analogues with similar structures andpolarities from Clematis akebioides by high-speed counter-currentchromatography, [J]. JOURNAL OFSEPARATION SCIENCE, 2016, 39(23), 4660-4666.
15.Gong, CC, Wang, XZ, Ma, DH, Chen, HF, Zhang, SS, Liao, ZX, Microporous carbon from a biologicalwaste-stiff silkworm for capacitive energy storage, [J]. ELECTROCHIMICA ACTA , 2016, 220 ,331-339
16.Yao, GY, Ye, MY, Zhu, YT, Liao, ZX, Wang, HS, Synthesisand Pharmacological Evaluation of Maleopimaric N-arylimides: Identification ofNovel Proapoptotic Agents, [J]. ANTI-CANCERAGENTS IN MEDICINAL CHEMISTRY, 2016, 16(6),755-762 .
17.Wu, L, Liao, ZX, Liu, C, Jia, HY, Sun, JY, EremophilaneSesquiterpenes from the Genus Ligularia, [J]. CHEMISTRY & BIODIVERSITY, 2016, 13(6), 645-671
18.Zuo, B, Liao, ZX, Xu, C, Liu, C, Two novel prenylated kaempferol derivativesfrom fresh bud's fur of Platanus acerifolia and their anti-proliferativeactivities, [J]. NATURAL PRODUCTRESEARCH, 2016, 30(22), 2523-2528.
19.Xu, C, Jia, HY, Zuo, B, Liao, ZX, Ji, LJ, Sun, HF, ;Wang, Q, Chemical Constituents of the Aerial Parts ofEuphorbia nematocypha, [J]. NATURAL PRODUCT COMMUNICATIONS, 2016, 11(2), 177-178
20.Jia H. Y, Liao Z. X., Liu F. Y., et al. A new phenylpropanoid from the rootsof Euphorbia nematocypha [J]. Nat. Prod. Res.2015, 29(7), 650-655.
21.Liu C., Liao Z. X., Liu S. J., et al.A new pregnane glycoside from Rubus phoenicolasius and itsantiproliferative activity [J]. Nat. Prod. Res., 2014, 28(21): 1-4.
22.Liu S. J., Liao Z. X., Liu C., et al.A trehalose ester from Lancea tibetica. [J]. Nat. Prod. Res., 2014, 28(19), 1613-1618.
23.Liu S. J., Liao Z. X., Liu C., et al.Two new sesquiterpenes from Artemisia sieversiana [J]. Fitoterapia,2014, 97: 43-49.
24.Liu S. J., Liao Z. X., Liu C., et al. A new triterpenoid and eremophilanolidefrom Ligularia przewalskii [J].Phytochem. Lett., 2014, 9: 11-16.
25.Liu C., Liao Z. X., Liu S. J., et al.Two New 2,3-Seco-Hopane TriterpeneDerivatives from Megacodon stylophorusand Their Antiproliferative and Antimicrobial Activities [J]. Planta Med.,2014, 80(11), 936-941.
26.Liu C., Liao Z. X., Liu S. J., etal. Two new diterpenederivatives from Euphorbia lunulata Bgeand their anti-proliferative activities [J]. Fitoterapia, 2014, 96: 33-38.
27.Yao G. Y., Ye M. Y., Huang R. Z., Li Y. J.,Pan Y. M., Xu Q., Liao Z. X., WangH. S.. Synthesis and antitumoractivities of novel rhein α-aminophosphonates conjugates [J]. Bioorg.Med. Chem. Lett., 2014, 24(2), 501-507.
28.Yao G. Y., Li Y. J., ZhuY. T., Pan Y. M., Huang F. P., Wang H. S., LiaoZ. X.. Protonation-controlledaxial chirality in maleopimaric imides [J]. New J. Chem., 2014, 38: 693-699.

近年来申请的国家专利：
1.廖志新, 刘超. 一种化合物及其制备方法与应用.（CNA）
2.廖志新, 胥廉谦, 施天一, 叶润, 贾海洋. 荭草苷在制备抑制血管生成药物中的应用.（CNA）
3.廖志新, 施天一, 胥廉谦, 叶润. 一种塔黄提取物及其应用.（CNA）
4.廖志新,?贾海洋,?刘世军,?刘超,?叶润. 一种高纯芦丁的制备方法.（CNA）
5.廖志新, 叶润, 纪兰菊, 孙洪发, 胥廉谦, 施天一. 一种金雀花碱的提取分离方法.（CNA）
6.廖志新,?刘超,?吴玲,?逯梦娅,?牛宝静. 乳白香青挥发油的制备方法及其应用.（CNA）
7.廖志新,?刘超,?吴玲,?逯梦娅,?马柱坤. 菊叶香藜挥发油的制备及其应用.（CNA）
8.纪兰菊, 廖志新,?孙洪发. 应用高压静电成囊法制备烈香杜鹃挥发油微囊的方法.（CNA）
9.纪兰菊,?张小龙,?孙洪发,?廖志新. 苇叶獐牙菜中新的抗肿瘤成分SwertiridoidA.（CNB）
10.纪兰菊,?廖志新,?张小龙. 一种提高藏药花锚提取物溶出度的固体分散物.（CNB）