钱鹰
教授，博士生导师 化学化工学院
联系电话： 办公时间：周一至周五
传 真： 主页网址：http://jszy.seu.edu.cn/_s2555/main.psp
办公地点： 办公室 九龙湖校区化学化工楼425室 / 实验室 化工楼443室 电子邮箱：yingqian@seu.edu.cn
通讯地址：东南大学化学化工学院 南京市江宁区东南大学路2号 211189












研究方向




有机光功能材料的分子设计、合成策略及应用研究

有机荧光染料的骨架构筑、荧光传感及近红外荧光成像


靶向光敏剂的精准合成及肿瘤细胞光动力学治疗研究










教育和工作经历


2000 年起任副教授，2007 年迄今任教授，2008 年迄今任博士生导师。东南大学三级教授。2002年3月至2005年3月东南大学分子与生物分子电子学国家重点实验室博士研究生，师从袁春伟教授，获博士学位；1991年9月至1994年3月东南大学分子与生物分子电子学实验室硕士研究生，师从刘举正教授，获硕士学位；1987年9月至1991年7月东南大学化学化工系本科生，获学士学位。长期从事有机光功能材料的设计、制备、性能及应用研究，在二阶非线性光学材料、三阶非线性光学材料、有机存储材料、多光子吸收及上转换荧光材料、光动力学治疗光敏剂及有机荧光探针等方面开展工作，主持完成多项国家自然科学基金项目，其中2012.01-2015.12 主持完成国家自然科学基金面上项目“用于生物标记及荧光成像dendrimer分子的多光子上转换荧光发射及荧光共振能量转移”，2007.01-2009.12 主持完成国家自然科学基金面上项目“杂环多分支双光子荧光材料的制备、双光子吸收及能量传输”。2021.01-2024.12 主持在研1项国家自然科学基金项目。系统研究有机光功能材料的物理内涵和分子设计策略，构建多光子荧光有机材料库，探索有机共轭π体系的构筑与荧光调控，从分子水平上设计、研究对生物体系中的生理病理学标记物具有特异性识别的有机荧光染料，开展高效多光子荧光染料、宽带多光子吸收材料、近红外荧光探针、高分辨荧光成像、肿瘤细胞光动力学治疗等工作，取得系列研究成果，以唯一通讯作者发表SCI收录论文100 余篇，授权22 项发明专利。已培养硕士及博士研究生40 余名，指导的每届研究生均得到严谨规范的科研训练并取得高质量研究成果，连续5 届博士生获得江苏省博士研究生科研创新计划项目。本课题组的博士及硕士研究生均能按学制如期或提前毕业，没有研究生延毕。指导的研究生获得东南大学硕士生国家奖学金和东南大学博士生国家奖学金。指导的连续8 届本科生学位论文被评为东南大学优秀本科毕业论文。东南大学优秀硕士学位论文指导教师。东南大学优秀博士学位论文指导教师。主讲研究生课程现代有机合成以及本科生课程有机合成设计。


钱鹰教授课题组近期发表的部分论文如下:

2020


[1] Chengjun Wang and Ying Qian*. A water soluble carbazolyl-BODIPY photosensitizer with an orthogonal D–A structure for photodynamic therapy in living cells and zebrafish. Biomater. Sci., 2020,8, 830
[2] Ronghua Shen and Ying Qian*. A efficient light-controlled nitric oxide releaser in aqueous solution and its red fluorescence imaging in lysosome. Dyes Pigment., 2020, 176, 108247
[3] Jin Bai and Ying Qian*. Construction of an NIR and lysosome-targeted quinoline-BODIPY photosensitizer and its application in photodynamic therapy for human gastric carcinoma cells. Dyes Pigment., 2020, 181, 108615
[4] Xu Zhi, Baoxing Shen, Ying Qian*. A novel carbazolyl GFP chromophore analogue: synthesis strategy and acidic pH-activatable lysosomal probe for tracing endogenous viscosity changes. New J. Chem., 2020, 44, 8823
[5] Xin Yang,Jin Bai, Ying Qian*. The investigation of unique water-soluble heptamethine cyanine dye for use as NIR photosensitizer in photodynamic therapy of cancer cells. Spectrochim. Acta A, 2020, 228, 117702
[6] Ronghua Shen and Ying Qian*. A turn-on and lysosome-targeted fluorescent NO releaser in water media and its application in living cells and zebrafishes. Spectrochim. Acta A, 2020, 230, 118024
[7] Baoxing Shen, Lingfeng Wang, Xu Zhi, Ying Qian*. Construction of a red emission BODIPY-based probe for tracing lysosomal viscosity changes in culture cells. Sens. Actuators B-Chem., 2020, 304, 127271
[8] Baoxing Shen, Wenyu Zhu, Xu Zhi, Ying Qian*. A lysosome targeting probe based on fluorescent protein chromophore for selectively detecting GSH and Cys in living cells. Talanta, 2020, 208, 120461
[9] Jin Bai, Xin Yang, Ying Qian*. A ratiometric and near-infrared fluorescent probe for discrimination of Cys/Hcy/GSH in aqueous solution and its intracellular imaging in living cells. J.Lumines., 2020, 221, 117055
[10] Lingfeng Wang and Ying Qian*.Near-infrared quinoline-fluoroborodipyrrole dye: Synthesis and lysosomal fluorescence imaging. Chin.J.Org.Chem., 2020, 40, 1246


2019

[1] Xu Chao and Ying Qian*. A selenamorpholine-based redox-responsive fluorescent probe for targeting lysosome and visualizing exogenous/ endogenous hydrogen peroxide in living cells and zebrafish. J. Mater. Chem. B, 2019, 7, 2714
[2] Chengjun Wang and Ying Qian*. A novel BODIPY-based photosensitizer with pH-active singlet oxygen generation for photodynamic therapy in lysosomes. Org. Biomol. Chem., 2019, 17, 8001
[3] Baoxing Shen and Ying Qian*. Red emission cysteine probe with high selectivity based on fluorescent protein chromophores and turn-on fluorescence in cell cultures. Dyes Pigment., 2019, 166, 350
[4] Xin Yang and Ying Qian*. A near-infrared fluorescent probe for the discrimination of cysteine in pure aqueous solutionand imaging of cysteine in hepatocellular carcinoma cells with facilecell-compatible ability. New J. Chem., 2019, 43, 3725
[5] Ronghua Shen and Ying Qian*. A mitochondria-oriented fluorescent probe for ultrafast and ratiometric detection of HSO₃^- based on naphthalimide-hemicyanine. New J. Chem., 2019, 43, 7606
[6] LuLu Tong and Ying Qian*. A naphthalimide-rhodamine chemodosimeter for hypochlorite based on TBET : High quantum yield and endogeous imaging in living cells. J. Photochem. Photobio. A-Chem., 2019, 368, 62
[7] Lingfeng Wang and Ying Qian*. A novel quinoline-BODIPY fluorescent probe for fast sensing biothiols via hydrogen bonds assisted-deprotonation mechanism and its application in cells and zebrafish imaging. J. Photochem. Photobio. A-Chem., 2019, 372,122
[8] Chunmei Huang and Ying Qian*. A highly sensitive two-photon fluorescent probe for glutathione with near-infrared emission at 719 nm and intracellular glutathione imaging. Spectrochim. Acta A, 2019, 217, 68
[9] Chengjun Wang and Ying Qian*. A TICT-active orthogonal D-A type probe phenothiazine-BODIPY for ratiometric response of hypochlorite and its application in living cells. J. Lumines., 2019, 210, 261
[10] Lingfeng Wang, Jin Bai, Ying Qian*. Synthesis of a triphenylamine BODIPY photosensitizer with D–A configuration and its application in intracellular simulated photodynamic therapy. New J. Chem., 2019, 43, 16829


2018
[1] Xiang Xia, Ying Qian*, Baoxing Shen. Synthesis of a novel BODIPY disulfonate near-infrared fluorescence-enhanced probe with high selectivity to glutathione and two-photon fluorescent turn-on through thiol-induced SNAr substitution. J. Mater. Chem. B, 2018, 6, 3023
[2] LuLu Tong and Ying Qian*. A NIR rhodamine fluorescent chemodosimeter specific for Glutathione: Knoevenagel Condensation,detection of intracellular Glutathione and living cell imaging.J. Mater.Chem. B, 2018, 6, 1791
[3] Xin Yang and Ying Qian*.A NIR cell-compatible fluorescent sensor for glutathione based on Michael addition induced cascade spirolactam opening and its application in hepatocellular carcinoma. J. Mater. Chem. B, 2018, 6, 7486
[4] Baoxing Shen and Ying Qian*.
Building rhodamine-BODIPY fluorescent platform using Click reaction: naked-eye visible and multi-channel chemodosimeter for detection of Hg²⁺and Fe³⁺. Sens. Actuators B- Chem., 2018, 260, 666
[5] Chengjun Wang, Xiang Xia, Jirong Luo, Ying Qian*. A novel near-infrared styryl-BODIPY fluorescent probe for discrimination of GSH and itsapplication in living cells. Dyes Pigment., 2018, 152, 85
[6] Chao Xu and Ying Qian*.The α, β-unsaturated pyrazolone-based fluorescent sensor with red emission and its application for real-time monitoring hypochlorite in cancer cells and zebrafish. Dyes Pigment., 2019, 161, 303
[7] Xiang Xia and Ying Qian*. NIR two-photon fluorescent probe for biothiol detection and imaging of living cells in vivo. Analyst, 2018, 143, 5218
[8] Chao Xu, Ying Qian*, Zhengqing Qi, Changgui Lu,Yiping Cui. A conjugated BODIPY- triphenylamine multi-aldoxime: sonogashira coupling,ratiometric chemodosimeter and rapid detection of hypochlorite with two-photon excited fluorescence. New J. Chem., 2018, 42, 6910
[9] Xiuxiu Xu and Ying Qian*. A novel D-π-A BODIPY-stilbene with aggregation-induced red emission and Its interaction with Bovine Serum Albumin. J. Lumines., 2018, 202, 206



2017

[1] Shankun Yao and Ying Qian*. A naphthalimide–rhodamine two-photon fluorescent turn-on probe for hypochlorous acid by desulfurization-cyclization and fluorescence resonance energy transfer. Sens. Actuators B- Chem., 2017, 252, 877
[2] Baoxing Shen and Ying Qian*. Click synthesis, Hg²⁺ sensor and intramolecular fluorescence resonance energy transfer in novel BODIPY dendrons. Sens. Actuators B- Chem., 2017, 239, 226
[3] Baoxing Shen, Ying Qian*,Zheng-qing Qi, Changgui Lu, Qi Sun, Xiang Xia, Yiping Cui. Near-infrared BODIPY two-photon ClO^- probe based on thiosemicarbazide desulfurization reaction: naked-eye detection and mitochondrial imaging. J. Mater.Chem. B, 2017,5, 5854
[4] Jianfeng Liu and Ying Qian*. A novel naphthalimide-rhodaminedye: intramolecular fluorescence resonance energy transfer and ratiometric chemodosimeter for Hg²⁺ and Fe³⁺. Dyes Pigment., 2017, 136, 782
[5] Xiuxiu Xu and Ying Qian*. A novel (3, 6-di-tert-butylcarbazol-9-yl) Triphenylamine-BODIPY-Tricyanofuran conjugated dye: synthesis and rapid naked-eye detection of hypochlorite. New J. Chem., 2017, 41, 9607
[6] Shankun Yao and Ying Qian*. A smart two-photon fluorescent platform based on desulfurization-cyclization: naphthalimide-rhodamine chemodocimeter for Hg²⁺,NIR emission at 746 nm and through-bond energy transfer. New J. Chem., 2017, 41, 13495
[7] Jianfeng Liu and Ying Qian*. A novel pyridylvinyl naphthalimide-rhodamine dye:synthesis, naked-eye visible and ratiometric chemodosimeter for Hg²⁺/Fe³⁺. J. Lumines., 2017, 187, 33
[8] Qian Li and Ying Qian*. A red-emissive oxadiazol-triphenylamine BODIPY dye: Synthesis, Aggregation-induced fluorescence enhancement and cell imaging. J.Photochem. Photobio. A-Chem., 2017,336, 183
[9] Xiuxiu Xu and Ying Qian*. A novel pyridyltriphenylamine–BODIPY aldoxime: naked-eye visible and fluorometric chemodosimeter for hypochlorite. Spectrochim.Acta A, 2017, 183, 356
[10] Qian Li, Chengjun Wang and Ying Qian*. BODIPY-Triphenylamine with conjugated pyridines and a quaternary pyridium salt: synthesis,aggregation-induced red emission and interaction with Bovine Serum Albumin. J.Photochem. Photobio. A-Chem., 2017, 346, 311




钱鹰教授课题组已授权发明专利:

[1]一种具有三光子荧光特性的噁二唑-三苯胺-蒽共轭分子(ZL 2.0)
钱鹰，王彬彬，崔一平，吕昌贵，周志强
[2]一种2,5-二芳基-1,3,4-噁二唑类荧光分子及其制备方法(ZL 2013 1 **.5)
钱鹰，王彬彬，王轶丽, 管成飞， 陶在琴
[3]一种多臂萘酰亚胺荧光分子及其制备方法(ZL 2013 1 **.5)
钱鹰，罗晓燕
[4]一种具有聚集诱导发光性质的吡啶-三苯胺-蒽共轭分子(ZL 2013 1 **.7)
钱鹰，管成飞
[5]一种9,10-二芳基乙烯基蒽聚集诱导发光分子及其制备方法(ZL 3.1)
钱鹰，夏超，管成飞
[6]一种红光发射三苯胺吡啶盐荧光分子及其制备方法(ZL 2.3)
钱鹰，陶在琴
[7]二苯基噁二唑-萘二甲酰亚胺荧光探针及其应用(ZL 3.6)
钱鹰，牛艳芳，孙京府
[8]一种苝二酰亚胺-罗丹明荧光探针及其制备方法和应用(ZL 8.3)
钱鹰，严小璇，成焕仁
[9]一种2-吡啶乙烯基萘酰亚胺荧光树形分子及其制备方法和应用(ZL 8.1)
钱鹰，胡秀东, 孙京府
[10]一种罗丹明-萘二甲酰亚胺荧光分子及其制备方法和应用(ZL 6.9)
钱鹰，孙京府，牛艳芳
[11]一种咔唑基三苯胺-噁二唑荧光分子及其制备方法和应用(ZL 8.4)
钱鹰，曹多军，靳永昌
[12]一种吡啶乙烯基三苯胺-罗丹明荧光分子PTRh及其制备方法和应用
(ZL 2.4)
钱鹰，曹多军
[13]一种罗丹明-(4-二甲基氨乙基氨基-1,8-萘二甲酰亚胺)荧光探针、制备方法和应用
(ZL7.5)
钱鹰，牛艳芳，孙京府
[14]一种苝二酰亚胺-氟硼二吡咯荧光树形分子及其制备方法和应用
(ZL2.0)
钱鹰，成焕仁
[15]一种咔唑基三苯胺-氟硼二吡咯荧光分子BCPA-BODIPY及其制备方法和应用
(ZL6.4)
钱鹰，李倩，沈宝星
[16]一种萘酰亚胺-氟硼二吡咯荧光分子NP-BODIPY及其制备方法和应用
(ZL1.X)
钱鹰，沈宝星
[17]一种罗丹明-双吡啶甲基氨基萘酰亚胺荧光探针REPN及其制备方法和应用
（ZL5.8）
钱鹰，刘剑峰
[18]一种噁二唑三苯胺-氟硼二吡咯红光化合物OPA-BODIPY及其制备方法和应用
（ZL3.0）
钱鹰，李倩, 李金钊
[19]一种多吡啶萘酰亚胺荧光树形分子及其制备方法和应用
（ZL3.0）
钱鹰，刘剑峰
[20]一种近红外反应型双光子荧光探针及其制备方法和应用
（ZL2.5）
钱鹰，姚善昆
[21]一种近红外波段反应型生物硫醇双光子荧光探针及其制备方法和应用
（ZL0.3）
钱鹰，夏祥
[22]一种溶酶体定位荧光探针硒代吗啉-氟硼二吡咯及其制备方法和应用
（ZL9.4）
钱鹰，许超，李金钊

2020年课题组秋游登山




2019年教师节课题组合影




2018年春季郊游课题组合影


欢迎报考钱鹰教授课题组博士及硕士研究生！









荣誉奖励



2008 年江苏省优秀本科毕业论文一等奖 指导教师
2010 年江苏省优秀硕士学位论文 指导教师
指导的连续8届本科生学位论文被评为东南大学优秀本科毕业论文
2010 年东南大学优秀硕士学位论文 指导教师
2020 年东南大学优秀博士学位论文 指导教师
主持“有机化学课程建设”获1999 年东南大学优秀教学成果奖
主持“化工及制药专业有机化学课程改革”获2004年东南大学优秀教学成果奖
2004 年获“吴健雄/袁家骝”奖
《有机化学》2017-2018 年度优秀论文奖
国家自然科学奖评审专家














学术成果


长期从事有机光功能材料的设计、制备、性能及应用研究，在二阶非线性光学材料、三阶非线性光学材料、有机存储材料、多光子吸收及上转换荧光材料、光动力学治疗光敏剂及有机荧光探针等方面开展工作，主持多项国家自然科学基金项目，系统研究有机光功能材料的物理内涵和分子设计策略，构建多光子荧光有机材料库，探索有机共轭π体系的构筑与荧光调控，从分子水平上设计、研究对生物体系中的生理病理学标记物具有特异性识别的有机荧光染料，开展高效多光子荧光染料、宽带多光子吸收材料、近红外荧光探针、高分辨荧光成像、肿瘤细胞光动力学治疗等工作，取得系列研究成果，以唯一通讯作者发表SCI收录论文100 余篇，已授权22 项发明专利。