仲琰
副教授 化学化工学院
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办公地点：化工新大楼314 电子邮箱：@seu.edu.cn
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研究方向


1、抗缺血性脑卒中新药研究；
2、药物新剂型、新制剂研究与应用；
3、药物有机小分子晶体培养与解析。


欢迎对制药工程和化学感兴趣的同学报名！







荣誉奖励


获得“许国平奖教金”




学术成果


以合作单位项目负责人主持完成江苏省自然科学基金面上项目两项、国家自然科学基金面上项目一项；
在Medicinal Chemistry Research, J Molecular Structure, Bioorganic & Medicinal Chemistry Letters, International J Pharmaceutics, European J Pharmaceutical Sciences等期刊发表SCI论文近三十篇。

科技论文：
[1] Zhong Yan, Zhu Yijie, Gao Yarong, Xu Yi, Li Ping, Wu Bin*. Synthesi, crystal structure, Hirshfeld surface analysis and biological activity of 1-(bis(4-methoxyphenyl)methyl)-4-(2-(2-methylphenoxy)ethyl)-piperazine. Chinese J Struct. Chem., 2019, 38: 1093-1098.
[2] Yan Zhong, Xiaofeng Li, Aixia Zhang, Yi Xu, Ping Li, Bin Wu*. Design, synthesis and neuroprotetive activities of novel cinnamide derivatives containing benzylpiperazine moiety. Med. Chem. Res., 2018, 27(5): 1366-1373.
[3] Jiangang Zhong, Jiapei Han, Xiaofeng Li, Yi Xu, Yan Zhong*, Bin Wu*. Synthsis, crystal structure, Hirshfield surfacesanalysis and anti-ischemic activity of cinnamide derivatives. J Mol. Struct., 2018, 1154: 72- 78.
[4] Zhong Yan#, Xu Yi#,Zhang Aixia, Li Xiaofeng, Xu Zhaoying, Li Ping, Wu Bin*. Synthesis and biologicalevaluation of aryloxyacetamide derivatives as neuroprotective agents. Bioorg. Med. Chem. Lett., 2016, 26:
2526-2530.
[5] Zhong Yan, Liu Yalin, Xu Zhaoying, Xu Yi, Li Ping, Wu Bin*. Synthesis, crystal structure and anti-ischemic activity of (E)-1-(4-(bis(4-methoxyphenyl)methyl)piperazin-1-yl)-3-(4-acetoxy-3-methoxyphenyl)prop-2-en-1-one. Chinese J Struct. Chem., 2015, 34: 681-687.
[6] Yan Zhong, Zhaoying Xu, Yao Wang, Yi Xu, Ping Li, Bin Wu*. Synthesis, crystal structure and anti-ischaemic activity of (E)-1-{4-[bis(4-methoxyphenyl)methyl]piperazin-1-yl}-3-(4-chlorophenyl)prop-2-en-1-one. S. Afr. J Chem., 2014, 67: 214-217.
[7] Zhong Yan, Wang Yao,Wang Jing, Xu Yi, Li Ping, Wu Bin*. Synthesis, crystal structureand neuroprotection of methyl 2-((4-(2-methylphenoxy)acetyl)piperazin-1-yl)methyl)benzoate.Chinese J Struct. Chem., 2014, 33:
1096-1101.
[8] Yan Zhong, Jing Wang, Yao Wang, Bin Wu*. Preparation and evaluation of lipsome-encapsulated codrug LMX. Int. J Pharma., 2012, 438: 240-248.
[9] Yan Zhong,Zhaohui Dai, Yi Xu, Yanbo Teng, Bin Wu*. Synthesis, stability and pharmacological evaluationof a novel codrug consisting of lamivudine and ursolic acid. Eur. J Pharm. Sci., 2012, 45: 110-115.
[10] Yan Zhong, Bin Wu*.(E)-3-(2-Ethoxyphenyl)-1-{4-[(2-fluoropheyl)(4-fluorophenyl)methyl]piperazin-1-yl}prop-2-en-1-one. Acta Crystallogr. Sect. E. Struct. Rep. Online, 2012, 68: o1975-o1975.
[11] Yan Zhong, Bin Wu*. 1-[Bis(4-fluorophenyl)methyl]-4-[2-(naphthalen-2-yloxy)ethyl] piperazine. Acta Crystallogr. Sect. E. Struct. Rep. Online, 2012, 68: o1974-o1974.

科研项目：
[1] 国家自然科学基金面上项目(**),具有NMDA受体NR2B选择性拮抗活性的依达拉奉衍生物的发现，已结题；
[2] 江苏省自然科学基金面上项目(BK**)，新型依达拉奉-NMDA受体NR2B选择性拮抗剂孪药的设计、合成及生物活性研究，已结题；
[3] 江苏省自然科学基金面上项目(BK**)，新型多重作用机制抗脑卒中神经保护剂的发现，已结题。

发明专利：
[1] 仲琰，方甜甜，陈俐颐. 1-芳氧乙基哌啶-4-基苯甲酮衍生物及其制备方法和应用. 中国发明专利，申请号：20**；
[2] 仲琰，韩佳沛，方甜甜，陈俐颐.苯并[d]异噻唑-3(2H)-酮衍生物及其制备方法和应用. 中国发明专利，申请号：20**；
[3] 仲琰，周建平，霍美蓉. 一种拉米夫定孪药的制备方法及其应用. 中国发明专利，申请号：85。