刘松琴


东南大学二级教授，博士生导师

[基本情况]

2003年6月在南京大学获分析化学博士学位，2003年8月至2005年8月分别为德国Potsdam大学和加拿大Lakehead University博士后，2005年被聘为东南大学化学化工学院教授。从事生物界面、生物组装和电化学分析方面的教学和科研工作，主持包括国家重大仪器专项（基金委）、国家重点研发计划（科技部）、国家自然科学基金重点/面上、江苏省自然科学基金重点和江苏省工业支撑项目等项目，并开展纳米生物探针、纳米增强高分子材料和纳米钛管氢敏传感器的产业化研究。共发表SCI收录论文260余篇，被SCI刊物他人引用9000余次，获授权发明专利23件，个人H-index为52，分别为五部专著编写5章。获2010年、2015年教育部自然科学奖一等奖，2011年度“全国化工优秀科技工作者”称号。兼任江苏省富碳材料与器件工程实验室主任、中国分析测试协会理事、中国分析测试协会高校分析测试分会常务理事、中国仪器仪表学会分析仪器分会电分析化学专业委员会委员、中国有机电化学与工业行业联合会常务理事、江苏省富碳材料与器件工程专业委员会主任委员、江苏省化学化工学会理事、江苏省分析测试协会常务理事、江苏省分析测试协会高校分会副理事长，并担任World Journal of Biological Chemistry 副主编、Sensors & Transducers Journal编委。
[课题组成员]
老 师：
李颖（女，副教授）、刘安然（男，副教授）、吴亚锋（女）、华鑫（女）
博士生：
周思思（2016秋）、田召燕（2017春）、邵凤英（2017秋）、苏娟（2018春）、李秀秀（2018秋）、顾晓飞（2019秋）、韦巧梅（2019秋）、陈子璇（2018秋硕、2020春博）、王勇（2018秋工博）、陈斌（2019秋工博）
硕士生：
苗娇娜、於明珠、郑骋、万菁（2017硕）；董景娇、陈子璇（2018硕）；李佳佳、刘晰、于素华、韩奕森（2019硕）
毕业生：
[博士]： 吴亚锋、钱静（2008）；操小栋、苏明（2009）；袁亮、徐璇、张林群（2010）；华鑫、卢倩（2011）；俞佳超、卢菊生、李赫楠（2012）；张玉叶、赵岳五、上官莉（2013）；米利、姜玲（2014）；张芬、韦源青、汪侃（2015）
[硕士]：李瑞娜、陈丽媛、陈成良（2007）；袁亮、徐璇、史红艳、宗小敏、张春艳（2008）；潘小虎、李大飞、朱文静、李婷婷、李沛沛、刘晓瑞、郑久松（2009）；张志强、姚莉、黄鸣鹤、张德敏、姚萌（2010）；苏娟、马慧、徐玲玲、杨浩、周志新（2011）；梅园、崔冬梅、钱静、施昊、王建海（2012）；杨晓青、赵芳、陆慧佳、姬静静（2013）；雷泽坤、魏珍珍、印凯飞（2014）；唐敏、梅浩、马梦瑶、刘世玉、马晓兰、李智德（2015）；高雅琼、赵凯歌（2016）
[研究方向]
科学仪器专项：发展单细胞活性分子时空分辨分析系统，实现单细胞生物活性分子如蛋白、核酸、双氧水、多巴胺、抗坏血酸、小RNA等的高时空分辨分析；
外泌体分离、检测与生物应用：构筑微流控芯片，实现外泌体高效捕获与多生物信息获取，探索极端环境外泌体特征及其生物调节的分子基础；
多模态多物理因子干预诊疗一体化纳米生物探针；
多级纳米结构组装与二氧化碳还原：利用多孔材料组装单/多生物分子（酶或菌类）和电子供（受）体，构建多酶、多步骤多功能耦合CO2生物还原体系；
食品安全快检方法学和试剂盒研制。
[代表性论文]
Henan Li, Yawen Mu, Junrong Yan, Dongmei Cui, Weijun Ou, Yakun Wan*, Songqin Liu*, Label-Free Photoelectrochemical Immunosensor for Neutrophil Gelatinase-Associated Lipocalin Based on the Use of Nanobodies. Analytical Chemistry 2015, 86, 8129?8135 (Impact: 5.874)
Fang Zhao, Da Chai, Jusheng Lu, Jiachao Yu, Songqin Liu*, Novel chemiluminescent imaging microtiter plates for high-throughput detection of multiple serum biomarkers related to Down's syndrome via soybean peroxidase as label enzyme. Analytical and Bioanalytical Chemistry 2015, 407, 6117-6126
Yuewu Zhao, Qiuwei Shang, Jiachao Yu, Yuanjian Zhang, Songqin Liu*, Nanostructured 2D Diporphyrin Honeycomb Film: Photoelectrochemistry, Photodegradation, and Antibacterial Activity. ACS Applied Materials & Interfaces 2015, 7(22), 11783-11791 (IF=7.145)
Jusheng Lu, Yanfei Shen* and Songqin Liu*, Enhanced light-driven catalytic performance of cytochrome P450 confined in macroporous silica. Chemical Communications 2016, 52, 7703-7706 (Impact: 6.718)
Zhenzhen Wei, Yafeng Wu, Yuewu Zhao, Li Mi, Jintao Wang, Jimin Wang, Jinjin Zhao, Lixin Wang, Anran Liu, Ying Li, Wei Wei, Yuanjian Zhang, Songqin Liu,* Multifunctional nanoprobe for cancer cell targeting and simultaneous fluorescence/magnetic resonance imaging. Analytica Chimica Acta 938 (2016) 156-164 (Impact: 4.555)
Kan Wang, Li Shangguan, Yuanjian Liu, Ling Jiang, Fen Zhang, Yuanqing Wei, Yuanjian Zhang, Zhengjian Qi, Kang Wang,* and Songqin Liu*, In Situ Detection and Imaging of Telomerase Activity in Cancer Cell Lines via Disassembly of Plasmonic Core-Satellites Nanostructured Probe. Analytical Chemistry 2017, 89, 7262?7268 (IF=6.32)
Li Mi, Jiachao Yu, Fei He, Ling Jiang, Yafeng Wu, Lijun Yang, Xiaofeng Han, Ying Li, Anran Liu, Wei Wei, Yuanjian Zhang, Ye Tian,* Songqin Liu,* Lei Jiang, Boosting Gas Involved Reactions at Nanochannel Reactor with Joint Gas?Solid?Liquid Interfaces and Controlled Wettability. Journal of the American Chemical Society 2017, 139, 10441-10446 (IF=13.858)
Li Shangguan, Yuanqing Wei, Xu Liu, Jiachao Yu and Songqin Liu*, Confining a bi-enzyme inside the nanochannels of a porous aluminum oxide membrane for accelerating the enzymatic reactions. Chemical Communications 2017, 53, 2673--2676 (Impact: 6.718) DOI: 10.1039/c7cc00300e
Yuewu Zhao, Yuanjian Zhang, Anran Liu, Zhenzhen Wei, and Songqin Liu*, Construction of Three-Dimensional Hemin-Functionalized Graphene Hydrogel with High Mechanical Stability and Adsorption Capacity for Enhancing Photodegradation of Methylene Blue. ACS Applied Materials & Interfaces2017, 9, 4006?4014 (IF=7.145)
Kaifei Yin, Anran Liu*, Li Shangguan, Li Mi, Xu Liu, Yuanjian Liu, Yuewu Zhao, Ying Li, Wei Wei, Yuanjian Zhang, Songqin Liu, Construction of iron-polymer-graphene nanocomposites with low nonspecific adsorption and strong quenching ability for competitive immunofluorescent detection of biomarkers in GM crops.Biosensors and Bioelectronics 2017, 90, 321-328 (IF=6.451)
Yuewu Zhao, Ling Jiang, Li Shangguan, Li Mi, Anran Liu, Songqin Liu*, Synthesis of porphyrin-based two-dimensional metalorganic framework nanodisk with small size and less layers. Journal of Materials Chemistry A 2018, 6, 2828-2833; DOI: 10.1039/x0xx00000x (IF =7.443)
Kan Wang, Ling Jiang, Fen Zhang, Yuanqing Wei, Kang Wang,* Huaisheng Wang, Zhengjian Qi, and Songqin Liu*, Strategy for In Situ Imaging of Cellular Alkaline Phosphatase Activity Using Gold Nanoflower Probe and Localized Surface Plasmon Resonance Technique. Analytical Chemistry 2018, 90, 14056?14062 (IF=5.874)DOI: 10.1021/acs.analchem.8b04179
Yuanqing Wei, Zhenzhen Wei, Peicheng Luo, Wei Wei, Songqin Liu*, pH-sensitive metal-phenolic network capsules for targeted photodynamic therapy against cancer cells. Artificial cells, nanomedicine, and biotechnology 2018, 46, 1552-1561. (IF=3.026)
Li Shangguan, Yuanqing Wei, Kan Wang, Yuanjian Zhang*, Songqin Liu**, Highly sensitive fluorescent bioassay of 2,3,7,8-tetrachloro-dibenzo-pdioxin based on abnormal expression of cytochrome P450 1A2 in human cells. Analytica Chimica Acta 2019, 1046, 179-184
Kaige Zhao, Min Tang, Huaisheng Wang, Zhenxian Zhou, Yafeng Wu*, Songqin Liu,*Simultaneous Detection of Three Biomarkers Related to Acute Myocardial Infarction Based on Immunosensing Biochip. Biosensors and Bioelectronics 126 (2019) 767–772
Yaqiong Gao, Yafeng Wu^?, Kaige Zhao, Huaisheng Wang, Songqin Liu, In-Situ imaging detection of cell membrane and intracellular cholesterol via cascade reactions.Biosensors and Bioelectronics 126 (2019) 249–254
Zhaoyan Tian, Li Mi, Yafeng Wu,* Fengying Shao, Mingqiang Zou, Zhenxian Zhou, Songqin Liu*, Visual Electrofluorochromic Detection of Cancer Cell Surface Glycoprotein on a Closed Bipolar Electrode Chip. Analytical Chemistry 2019, 91, 7902?7910 DOI: 10.1021/acs.analchem.9b01760
Yuanqing Wei, Hongping Xia, Fen Zhang, Kan Wang, Peicheng Luo, Yafeng Wu,* and Songqin Liu. Theranostic Nanoprobe Mediated Simultaneous Monitoring and Inhibition of PGlycoprotein Potentiating Multidrug-Resistant Cancer Therapy. Analytical Chemistry 2019, 91, 11200?11208
Yafeng Wu, Guang Yang, Mingchang Lin, Xiangyu Kong, Li Mi, Songqin Liu, Guosong Chen, Ye Tian, Lei Jiang. Continuously Tunable Ion Rectification and Conductance in Submicrochannels Stemming from Thermoresponsive Polymer Self-Assembly. Angewandte Chemie-International Edition 2019, 58, 12481-12485. https://doi.org/10.1002/anie.
Yafeng Wu, Fen Zhang, Kan Wang, Peicheng Luo, Yuanqing Wei,* and Songqin Liu*, Activatable Fluorescence Imaging and Targeted Drug Delivery via Extracellular Vesicle-Like Porous Coordination Polymer Nanoparticles. Analytical Chemistry 2019, 91, 14036?14042
Li Mi, Jing Sui, Yafeng Wu,* Geyu Liang, Yuanjian Zhang, Yuepu Pu, Ye Tian,* Songqin Liu,* and Lei Jiang, Bioinspired in Vitro Lung Airway Model for Inflammatory Analysis via Hydrophobic Nanochannel Membrane with Joint Three-Phase Interface. Analytical Chemistry2019, 91, 15804?15810, DOI: 10.1021/acs.analchem.9b04114
Fengying Shao, Li Mi,* Zhaoyan Tian, Cheng Zheng, Yuanjian Zhang, Quan Li, and Songqin Liu*, Promoting Photodegradation Efficiency via a Heterojunction Photocatalyst Combining with Oxygen Direct and Fast Diffusion from the Gas Phase to Active Catalytic Sites. ACS Applied Materials and Interfaces 2019, 11, 44922?44930
Cheng Zheng, Xueying Qiu, Jianyu Han,* Yafeng Wu,* and Songqin Liu, Zero-Dimensional-g-CNQD-Coordinated Two-Dimensional Porphyrin MOF Hybrids for Boosting Photocatalytic CO₂Reduction. ACS Appl. Mater. Interfaces 2019, 11, 42243?42249
Jiaona Miao, Anran Liu*, Lina Wu, Mingzhu Yu, Wei Wei, Songqin Liu, Magnetic ferroferric oxide and polydopamine molecularly imprinted polymer nanocomposites based electrochemical impedance sensor for the selective separation and sensitive determination of dichlorodiphenyltrichloroethane (DDT). Analytica Chimica Acta 2020, 1095, 82-92
Juan Su, Fubing Wu, Hongping Xia,* Yafeng Wu * and Songqin Liu *, Accurate cancer cell identification and microRNA silencing induced therapy using tailored DNA tetrahedron nanostructures. Chemical Science 2020, 11, 80
Sisi Zhou, Tao Hu, Fen Zhang, Dezhi Tang, Dake Li,* Jian Cao, Wei Wei, Yafeng Wu,* and Songqin Liu*, Integrated Microfluidic Device for Accurate Extracellular Vesicle Quantification and Protein Markers Analysis Directly from Human Whole Blood.Analytical Chemistry 2020, 92, 1, 1574-1581
Fen Zhang, Wenming Liu,* Sisi Zhou, Ling Jiang, Kan Wang, Yuanqing Wei, Anran Liu, Wei Wei, and Songqin Liu*,Investigation of Environmental Pollutant-Induced Lung Inflammation and Injury in a 3D Coculture-Based Microfluidic Pulmonary Alveolus System. Analytical Chemistry 2020, https://dx.doi.org/10.1021/acs.analchem.0c00759
Jing Wan, Li Mi,* Zhaoyan Tian, Quan Li and Songqin Liu*, A single-liquid miniature biofuel cell with boosting power density via gas di?usion bioelectrodes. Journal of Materials Chemistry B, 2020, 8, 3550