博士研究生导师简介
姓名
宋勇
研究方向：
胸部肿瘤，急性肺损伤，呼吸危重症
联系方式
M:**O:
E-mail:yong_song6310@yahoo.com
学术兼职：
任中华医学会呼吸分会全国委员（中华医学会呼吸分会肺癌学组委员）、江苏省医学会呼吸病分会副主任委员兼肺癌学组组长、《Translational Lung Cancer Research》杂志（PubMed、SCI收录，IF：5.132 )主编、《中华医学杂志》编委、《医学研究生学报》副主编等国内外学术期刊编委等。
个人简介
南京大学医学院附属金陵医院呼吸与危重症医学科主任、肺癌中心主任、南京大学呼吸病学研究所所长，专业技术3级，文职2级。南京大学、南方医科大学、南京医科大学博士研究生导师 。在呼吸系统疑难病例以及肺癌的综合诊治方面有深厚的造诣。
主持和承担国家自然科学基金、国家新药基金、江苏省重点科研基金等多项研究课题。以第一作者和通讯作者发表研究论著200余篇，SCI论文100余篇，主编主译专著6本。参与多项指南和共识的制定，如《非小细胞肺癌诊疗指南》、《小细胞肺癌诊疗指南》、《肺癌免疫组化专家共识》、《免疫检查点抑制剂相关肺炎诊治专家共识》、《非小细胞肺癌血液EGFR基因突变检测中国专家共识》《肺癌小样本取材相关问题中国专家共识》《免疫治疗共识》等的制定。
以第一完成人获教育部二等奖2项、省部级二等奖3项，第四完成人获国家科技进步二等奖一项。获江苏省医学重点人才、江苏省有突出贡献的中青年专家、
代表性论文[近5年通讯作者和第一作者]
WNT5B exerts oncogenic effects and is negatively regulated by miR-5587-3p in lung adenocarcinoma progression. Oncogene.2020 39(7):1484-1497.通讯作者
LncRNA GMDS-AS1 inhibits lung adenocarcinoma development by regulating miR-96-5p/CYLD signaling.Cancer Med.2020 9(3):1196-1208. 通讯作者
Geranylgeranyl diphosphate synthase 1 knockout ameliorates ventilator- induced lung injury via regulation of TLR2/4-AP-1 signaling.Free Radic Biol Med.2020 147():159-166. 通讯作者
Molecular Characteristics and Clinical Outcomes of EGFR Exon 19 C-Helix Deletion in Non-Small Cell Lung Cancer and Response to EGFR TKIs.Transl Oncol,2020 Sep;13(9):100791. 通讯作者
Neutrophilderived long noncoding RNA IL7R predicts development ofmultiple organ dysfunction syndrome inpatients withtrauma. Received: 8 January 2020 / Accepted: 17 May 2020. 通讯作者
Circulating Tumor DNA Clearance Predicts Prognosis Across Treatment Regimen in a Large Real-World Longitudinally Monitored Advanced Non-Small Cell Lung Cancer Cohort.Transl Lung Cancer Res,2020 Apr;9(2):269-279. 第一作者
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1;316(3):L567-L577. 通讯作者
Eosinophil peroxidase over-expression predicts the clinical outcome of patients with primary lung adenocarcinoma. J Cancer. 2019 Jan 29;10(4):1032-1038. 通讯作者
Topotecan Alleviates Lipopolysaccharide-Mediated Acute Lung Injury Via the NF-κB Signaling Pathway. Journal of Surgical Research. March 2019. 235, 83-92. 通讯作者
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-β1/BMP-4 signaling. Biol Chem.2019 400(12):1617-1627. 通讯作者
Tumor-derived exosomal lncRNA GAS5 as a biomarker for early-stage non-small-cell lung cancer diagnosis. J Cell Physiol.2019 234(11):20721-20727. 通讯作者
Prognostic role of pretreatment neutrophil-to-lymphocyte ratio in non-small cell lung cancer patients treated with systemic therapy: a meta-analysis. Transl Lung Cancer Res.2019 8(3):214-226通讯作者
Treatment of uncommon mutations in non-small cell lung cancer: new evidence and treatment. Transl Lung Cancer Res.2019 8(3):302-316
The association of PD-L1 expression with the efficacy of anti-PD-1/PD-L1 immunotherapy and survival of non-small cell lung cancer patients: a meta-analysis of randomized controlled trials. Transl Lung Cancer Res.2019 8(4):413-428. 通讯作者
The clinicopathological and prognostic significance of PD-L1 expression assessed by immunohistochemistry in lung cancer: a meta-analysis of 50 studies with 11,383 patients. Transl Lung Cancer Res.2019 8(4):429-449
CDCA7 promotes lung adenocarcinoma proliferation via regulating the cell cycle. Pathol Res Pract.2019 215(11):152559. 通讯作者
Clinical significance of PD-L1 expression in serum-derived exosomes in NSCLC patients. J Transl Med.2019 17(1):355. 通讯作者
Irinotecan, topotecan, paclitaxel or docetaxel for second-line treatment of small cell lung cancer: a single-center retrospective study of efficiency comparation and prognosis analysis。Transl Lung Cancer Res 2019 . 通讯作者
Efficacy and Safety of Gefitinib as Third-line Treatment in NSCLC Patients With Activating EGFR Mutations Treated With First-line Gefitinib Followed by Second-line Chemotherapy: A Single-Arm, Prospective, Multicenter Phase II Study (RE-CHALLENGE, CTONG1304).Am J Clin Oncol.2019 42(5):432-439. 第一作者
Long intergenic noncoding RNA 00467 promotes lung adenocarcinoma proliferation, migration and invasion by binding with EZH2 and repressing HTRA3 expression. Molecular Medicine rePorTS 20: 640-654, 2019. 通讯作者
18F-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis of benign pulmonary lesions in sarcoidosis. Transl Lung Cancer Res 2019;8(2):208-213. 通讯作者
Diagnosis status and pathological diagnosis derived treatment of elderly lung cancer patients over 75 years old.Transl Cancer Res 2019;8(1):87-95. 通讯作者
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma. 2018，J Cell Mol Med.通讯作者
The location, histological type and stage of lung cancer are associated with bleeding during endobronchial biopsy.2018, Cancer management and research.通讯作者
Evaluation of pulmonary reexpansion in a porcine model of bronchial foreign body.2018,Pediatric Pulmonology.通讯作者
RNA sequencing enables systematic identification of platelet transcriptomic alterations in NSCLC patients.2018,Biomedicine & Pharmacotherapy.通讯作者
TEAD4 exerts pro-metastatic effects and is negatively regulated by miR6839-3p in lung adenocarcinoma progression.2018, J Cell Mol Med.通讯作者
PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway.2017,Mol Cancer.通讯作者
Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer.2018, J. Cell. Mol.通讯作者
The biology, function and clinical implications of exosomes in lung cancer.Cancer Lett.2017,通讯作者
Downregulation of the long noncoding RNA GAS5-AS1 contributes to tumor metastasis in non-small cell lung cancer.2016,Sci Rep.通讯作者
Efficacy and safety of recombinant human tumor necrosis factor application for the treatment of malignant pleural effusion caused by lung cancer.2016,Thorac Cancer,通讯作者
Association Between the MUC5B Promoter Polymorphism rs** and Idiopathic Pulmonary Fibrosis .2015,Medicine .通讯作者
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.2015,Cancer Lett.通讯作者
Recombinant HMGB1 A box protein inhibits Th17 responses in mice with neutrophilic asthma by suppressing dendritic cell-mediated Th17 polarization.2015,Int Immunopharmacol.通讯作者
承担科研项目[项目负责人]
江苏省重点项目-临床前沿技术课题：基于多组学技术支撑zPDX模型的晚期非小细胞肺癌精准诊疗新平台的简历及推广应用，编号：BE**,400万，2019-2022，第一负责人
国家自然科学基金面上项目：GGPPS1调控肺巨噬细胞NLRP3炎性体启动ARDS炎症瀑布的作用机制，编号：**，50万元 ，2018-2021年，第一负责人
国家自然基金面上项目：Inc-TL7R/DNMT1/Jmjd3通路在线粒体损伤相关分子模式介导的创伤性急性肺损伤的机制研究。编号： ** ，66万元 ， 2016-2019年，第一负责人
国家自然基金：循环mtDNA-NLRP3 炎性体信号通路介导创伤性急性肺损伤发生的分子机制，编号：**，70万元，2014-2017年，第一负责人
获奖情况
教育部科技进步二等奖：非小细胞肺癌精准诊治转化研究及临床应用，2017年，第一完成人
国家科技进步二等奖：肺癌分子靶向精准治疗模式的建立与推广应用，2017年，第四完成人
江苏省科学技术进步奖：急性肺损伤分子发病机制和应用研究，2003年，第一完成人
