博士研究生导师简介
姓名
姚兵
研究方向
生殖


联系方式
yaobing@nju.edu.cn

学术兼职：
江苏省医学会生殖医学分会 主任委员
中华医学会生殖医学分会 委员

个人简介

姚兵教授长期从事不孕不育的临床治疗和实验室研究。对男性临床的一些疑难疾病，如少精子症、弱精子症、无精子症、前列腺疾病及勃起功能障碍等的治疗有较为独到之处。荣获江苏省“333工程”第二梯队培养对象”“江苏省科教兴卫工程”“江苏省科教强卫工程”重点培养人才，第一批江苏“卫生拔尖人才”。

代表性论文[近5年通讯作者和第一作者]

Circulating sex hormone levels in relation to male sperm quality. BMC Urol. 2020 Jul 17;20(1):101. IF：1.592
Mitochondria-related miR-574 reduces sperm ATP by targetingND5in aging males. Aging (Albany NY). 2020 May 7;12(9):8321-8338. IF：5.515
Sequential interval micro-droplet loading in closed hemi-straw carrier system: A convenient and efficient method for ultra-rapid cryopreservation in extreme oligozoospermia. Cryobiology. 2020 Feb 10. pii: S0011-2240(19)30234-2. IF: 2.141
Ochratoxin A in human blood plasma samples from apparently healthy volunteers in Nanjing, China.Mycotoxin Res. 2020 Feb 3. IF: 3.741
Impairment of spermatogenesis and motility by the high-fat diet induced dysbiosis of gut microbes. Gut.2020 Jan 2. pii: gutjnl-2019-319127. IF: 17.943
MYPT1 Down-regulation by LPS-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease. Cell Mol Gastroenterol Hepatol.2020;9(2):345-347.e6.IF: 7.076
Profiles of Emerging and Legacy Per-/Polyfluoroalkyl Substances in Matched Serum and Semen Samples: New Implications for Human Semen Quality. Environ Health Perspect. 2019 Dec;127(12):127005. IF: 8.049
The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis. Cell Death Dis. 2019 Jun 6;10(6):450. IF: 5.959
The effect of vitamin D on sperm motility and the underlying mechanism. Asian J Androl. 2019 Jul-Aug;21(4):400-407. IF: 3.259
Sirt1/Nrf2 pathway is involved in oocyte aging by regulating Cyclin B1. Aging (Albany NY). 2018 Oct 27;10(10):2991-3004. IF: 5.179
Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells. Reprod Biol Endocrinol. 2018 Oct 17;16(1):98. IF: 2.849
Spermatogenesis improved by suppressing the high level of endogenous gonadotropins in idiopathic non-obstructive azoospermia: a case control pilot study. Reprod Biol Endocrinol. 2018 Sep 22;16(1):91. IF: 2.849
A single-center performance evaluation of the fully automated iFlash anti-Müllerian hormone immunoassay. Clin Chem Lab Med. 2018 Dec 19;57(2):e19-e22 IF: 3.556
Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer. Oncol Rep. 2018 Sep;40(3):1359-1369. IF: 2.976
Identification and preliminary study of immunogens involved in autoimmune prostatitis in human males. Prostate. 2018 Jun 26. IF: 3.347
Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis. Syst Biol Reprod Med. 2018 Oct;64(5):368-380. IF: 1.176
Analysis of human sperm DNA fragmentation index (DFI) related factors: a report of 1010 subfertile men in China. Reprod Biol Endocrinol. 2018 Mar 14;16(1):23. IF: 2.849
Effects of electroacupuncture on luteal regression and steroidogenesis in ovarian hyperstimulation syndrome model rat.Life Sci. 2018 Mar 15;197:1-9. IF: 2.936
Advanced glycation end product concentrations in follicular fluid of women undergoing IVF/ICSI with a GnRH agonist protocol. Reprod Biomed Online 2018 Jan;36(1):20-25. IF: 3.249
Maternal diabetes impairs the initiation of meiosis in murine female germ cells. Mol Med Rep. 2017 Oct;16(4):5189-5194.IF: 1.714
The toxic effects and possible mechanisms of Brusatol on mouse oocytes.PLoS One. 2017 May 18;12(5):e**.IF: 3.057
TFE3 regulates renal adenocarcinoma cell proliferation via activation of the mTOR pathway. Mol Med Rep. 2017 Sep;16(3):2721-2725. IF: 1.714
Brain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway. Sci Rep.2017 Dec;7(1):180. IF: 5.228
Relationship Between Amyloid Precursor Protein in Seminal Plasma and Abnormal Penile Sympathetic Skin Response in Lifelong Premature Ejaculation. J Sex Med. 2017 Jan;14(1):98-105. IF: 2.844
Relation of size of seminal vesicles on ultrasound to premature ejaculation.Asian J Androl. 2017 Sep-Oct;19(5):554-560.IF: 2.644
Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization. Proc Natl Acad Sci U S A.2016 Oct 18; 113(42): 11907-11912.IF: 9.423
Blastomere removal from cleavage-stage mouse embryos alters placental function, which is associated with placental oxidative stress and inflammation. Sci Rep.2016 Apr 25;6:25023. IF: 5.578
Protective effects of melatonin agonist on radiotherapy-induced ovarian damage in rats. Int J Clin Exp Med,2016,9(2):4023-4028.IF: 1.075
Role of peroxiredoxin2 in H2O2induced oxidative stress of primary Leydig cells. Mol Med Rep.2016 Jun;13(6):4807-13 IF: 1.554
Electroacupuncture decreases the progression of ovarian hyperstimulation syndrome in a rat model. Reprod Biomed Online.2016 May;32(5):538-44. IF: 3.015
Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men.PLoS One. 2016 Jan 4;11(1):e**. IF: 3.234
Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice. Sci Rep.2016 4;6:28917. IF: 5.578
Associations of urinary 5-methyl-2'-deoxycytidine and 5-hydroxymethyl-2'-deoxycytidine with phthalate exposure and semen quality in 562 Chinese adult men.Environ Int.2016 Sep;94:583-90. IF: 5.929
Annexin A5 regulates Leydig cell testosterone production via ERK1/2 pathway. Asian J Androl. 2016 May-Jun;18(3):456-61IF: 2.596


承担科研项目[项目负责人]

国家自然科学基金面上项目，长链非编码RNA TUG1调节睾丸支持细胞功能及作用机制研究，2020.01-2023.12，55万
江苏省医学重点人才,血浆中功能性膜联蛋白5降解片段的发现及生物学功能研究，2016.01-2020.12，50万元
江苏省重点研发计划,无创胚胎染色体筛查技术评估高龄女性胚胎染色体整倍体的多中心临床研究，2016.07-2019.06，200万元，
国家重点基础研究发展计划，脂代谢紊乱与精子发生障碍的分子关联研究，2013.01-2017.12，1900万元
国家自然科学基金面上项目，StarD7及Wnt/β-catenin信号通路对Annexin5刺激大鼠睾丸Leydig细胞合成睾酮的影响，2014.01-2014.12，15万元
国家自然科学基金委员会面上项目，膜联蛋白5对大鼠睾丸Leydig细胞睾酮合成的调控及机制研究，2011.01-2013.12，34万元

获奖情况

精子发生影响因素的集成创新研究, 江苏省医学会, 科技进步, 省部一等奖, 2018