博士研究生导师简介
姓名
吴超
研究方向：
感染病学


联系方式
**，dr.wu@nju.edu.cn

学术兼职：
（1）江苏省医学会感染病学分会，候任主委，2021.12-2024.12
（2）江苏省医师协会感染科医师分会，副会长，2018.11-2021.11
（3）江苏省预防医学会卫生应急专业委员会突发急性传染病防控学组，副组长，2018.11-2021.11
（4）中华医学会肝病学分会第八届委员会委员
（5）中华医学会感染病学分会第十一届委员会委员

个人简介


现任南京大学医学院附属鼓楼医院副院长，感染病科主任医师，南京大学、南京医科大学、南京中医药大学、徐州医科大学教授，硕士及博士研究生导师。江苏省“十二五，十三五”、“科教兴卫生工程”、“领军人才及创新团队”、“江苏省临床医学科技专项”负责人。江苏省医学会感染病学分会候任主任委员，中华医学会肝病学分会委员及感染病分会委员。从事感染病专业临床教学科研工作36年。发表署名论文100余篇，其中SCI收录80余篇，获得国家发明专利3项，软件著作权1项，获得南京市科技进步奖一等奖1项，江苏医学科技奖二等奖1项，江苏省医学科技新技术引进奖一等奖1项，二等奖1项，参编三部专著，以第一负责人承担国家自然科学基金3项、“十三五”传染病重大专项子课题1项，省部级科研项目6项。主要研究方向为病毒性感染后机体免疫调节机制；指导各校感染病专业硕士及博士研究生40 余名；10 余种中文期刊及多个SCI 期刊的编委及特约审稿人。




代表性论文[近5年通讯作者和第一作者]


Huang R, Xia J, Chen Y, Shan C, Wu C*. A family cluster of SARS-CoV-2 infection involving 11 patients in Nanjing, China. Lancet Infect Dis. 2020;20(5):534-535.
Chen Y^#, Tong X^#, Wang J, Huang W, Yin S, Huang R, Yang H, Chen Y, Huang A, Liu Y, Chen Y, Yuan L, Yan X, Shen H*, Wu C*. High SARS-CoV-2 antibody prevalence among healthcare workers exposed to COVID-19 patients. J Infect. 2020; 81:420-426.
Wang J^#, Zhu L^#, Liu L^#, Zhao XA^#, Zhang Z^#, Xue L^#, Yan X, Huang S, Li Y, Cheng J, Zhang B, Xu T, Li C, Ji F, Ming F, Zhao Y, Shao H, Sang D, Zhao H, Guan X, Chen X, Chen Y, Issa R, Wei J, Huang R*, Zhu C*, Wu C*. Overweight and obesity are risks factors of severe illness in patients with COVID-19. Obesity. 2020 Jul 31. Epub ahead of print.
Rui Huang ^#, Li Zhu ^#, Leyang Xue ^#, Longgen Liu ^#, Xuebing Yan ^#, Jian Wang ^#, Biao Zhang, Tianmin Xu, Fang Ji, Yun Zhao, Juan Cheng, Yinling Wang, Huaping Shao, Shuqin Hong , Qi Cao, Chunyang Li, Xiang-an Zhao, Lei Zou, Dawen Sang, Haiyan Zhao, Xinying Guan, Xiaobing Chen, Chun Shan, Juan Xia, Yuxin Chen, Xiaomin Yan, Jie Wei, Chuanwu Zhu*, Chao Wu*.Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center study. PLoS Negl Trop Dis. 2020;14(5):e**.
Li Zhu^#, Jian Wang^#, Rui Huang^#, Longgen Liu, Haiyan Zhao, Chao Wu*, Chuanwu Zhu*. Clinical characteristics of a case series of children with coronavirus disease 2019. Pediatric Pulmonology. 2020;55(6):1430-1432.
Rui Huang #, Haiyan Zhao #, Jian Wang, Xiaomin Yan, Huaping Shao, Chao Wu *. A family cluster of COVID-19 involving an asymptomatic case with persistently positive SARS-CoV-2 in anal swabs. Travel Medicine and Infectious Disease. 2020 May 16. doi: 10.1016/j.tmaid.2020.101745.
Tianmin Xu#, Rui Huang#, Li Zhu#, Jian Wang#, Juan Cheng, Biao Zhang, Haiyan Zhao, Kang Chen, Huaping Shao, Chuanwu Zhu*, Chao Wu*, Longgen Liu*. Epidemiological and clinical features of asymptomatic patients with SARS-CoV-2 infection. Journal of Medical Virology. 2020 Apr 28. doi: 10.1002/jmv.25944.
Yang Li ^#, Chunyang Li ^#, Jian Wang ^#, Chuanwu Zhu, Li Zhu, Fang Ji, Longgen Liu, Tianmin Xu, Biao Zhang, Leyang Xue, Xiaomin Yan, Rui Huang *, Chao Wu *, Xuebing Yan *. A case series of COVID-19 patients with chronic hepatitis B virus infection. J Med Virol. 2020 Jun 19. Epub ahead of print.
Xia J, Huang R, Chen Y, Liu Y, Wang J, Yan X, Zhang Z, Wu C*. Profiles of serum soluble programmed death-1 and programmed death-ligand 1 levels in chronic hepatitis B virus-infected patients with different disease phases and after anti-viral treatment. Aliment Pharmacol Ther. 2020;51(11):1180-1187.
Li Y, Yin S, Chen Y, Zhang Q, Huang R, Jia B, Jie W, Yao K, Wang J, Tong X, Liu Y*, Wu C*. Hepatitis B virus‐induced hyperactivation of B cells in chronic hepatitis B patients via TLR4. J Infect Public Health. J Cell Mol Med. 2020 May 11. doi: 10.1111/jcmm.15202.
Haiyan Chang, Jie Wei, Wanqing Zhou, Xiaomin Yan, Xiaoli Cao, Lingyun Zuo, Shixing Chen, Kefang Yao, Rui Huang, Yuxin Chen*, Chao Wu*.Risk factors and mortality for patients with Bloodstream infections ofKlebsiella pneumoniae during 2014–2018: Clinical impact ofcarbapenem resistance in a large tertiary hospital of China. J Infect Public Health. 2019 Dec 13. In press.
Wang G, Chang H, Jia B, Liu Y, Huang R, Wu W, Hao Y, Yan X, Xia J, Chen Y*, Wu C*. Nucleocapsid protein-specific IgM antibody responses in the disease progression of severe fever with thrombocytopenia syndrome. Ticks Tick Borne Dis 2019;10(3):639-646.
Wang J, Huang R, Yan X, Li M, Chen Y, Xia J, Liu Y, Jia B, Zhu L, Zhang Z, Zhu C*, Wu C*. Red blood cell distribution width: A promising index for evaluating the severity and long-term prognosis of hepatitis B virus-related diseases. Dig Liver Dis. 2020 Apr;52(4):440-446.
Wang J, Xia J, Yan X, Yang Y, Wei J, Xiong Y, Wu W, Liu Y, Chen Y, Jia B, Chen Z, Zhang Z, Ding W, Huang R*, Wu C*. The gamma-glutamyl transpeptidase to platelet ratio predicts liver inflammation in chronic hepatitis B with normal or mildly elevated alanine transaminase. Clin Res Hepatol Gastroenterol. 2020 Mar 5:S2210-7401(20)30034-6.
Wang J, Wu W, Yan X, Wei J, Yao K, Yang Y, Xiong Y, Xia J, Liu Y, Chen Y, Jia B, Zhang Z, Ding W, Huang R*,Wu C*. HBeAg Negativity Is Associated With More Advanced Liver Fibrosis in Patients With Chronic Hepatitis B: A Propensity Score-Matching Analysis. J Clin Gastroenterol. 2019 Nov 27. doi: 10.1097/MCG.1291.
Wang J, Xia J, Yan X, Yang Y, Wei J, Xiong Y, Wu W, Liu Y, Chen Y, Jia B, Chen Z, Zhang Z, Ding W, Huang R*, Wu C*. Plateletcrit as a potential index for predicting liver fibrosis in chronic hepatitis B. J Viral Hepat. 2020 Jan 25. doi: 10.1111/jvh.13264.
Wang J, Zhang Z, Yan X, Li M, Xia J, Liu Y, Chen Y, Jia B, Zhu L, Zhu C, Huang R*, Wu C*. Albumin-Bilirubin (ALBI) as an accurate and simple prognostic score for chronic hepatitis B-related liver cirrhosis. Dig Liver Dis. Digestive and Liver Disease 51 (2019) 1172–1178.
Wang J, Chen Z, Yan X, Yang Y, Liu Y, Chen Y, Jia B, Xia J, Xiong Y, Zhang Z, Ding W, Huang R, Wu C. The Easy Liver Fibrosis Test (eLIFT) for predicting advanced liver fibrosis in patients with chronic hepatitis B. Discov Med. 2019;28:149-158.
Rui Huang, Jian Wang, Juan Xia, Zhaoping Zhang, Chao Wu*. Platelet Count and Prediction of Bleeding in Patients With Liver Cirrhosis. Am J Gastroenterol. 2018; 113(9):1396-1397.
Rui Huang, Jian Wang, Juan Xia, Yingying Hao, Chao Wu*. Potential clinical application of strain elastography in chronic liver diseases. J Gastroenterol. 2018; 53(6):795-796.
Huang R, Liu Y, Wang J, Xia J, Yan X, Wu C*. Risk factors of hepatocellular carcinoma after hepatitis B surface antigen seroclearance. J Hepatol 2018; 68: 207-208.
Huang R, Xia J, Wang J, Zhang Z, Wu C*. Red blood cell distribution width: a potential prognostic index for short-term mortality of patients admitted to emergency department for acute decompensation of liver cirrhosis? Eur J Gastroenterol Hepatol 2018;30(3):328.
Jia B, Wu W, Huang R, Wang G, Song P, Li Y, Liu Y, Xiong Y, Yan X, Hao Y, Xia J, Zhang Z, Chen Y, Wu C*. Characterization of clinical features and outcome for human-to-human transmitted severe fever with thrombocytopenia syndrome. Infect Dis (Lond). 2018;50(8):601-608.
Yue Yang, Yanyan Xia, Haiyan Chang, Jian Wang, Chao Wu*, and Zhiyang Li*. A Time-Resolved Fluorescence Immunoassay of Golgi Protein 73 and Its Application in Hepatitis B Virus Related Liver Cirrhosis. Nanosci Nanotechnol Lett. 2018; 10：998-1005.
Yong Liu, Guiyang Wang, Yuxin Chen, Rui Huang, Chen Tian, Yang Li, Xiang-An Zhao, Chao Wu*. HBcAg-induced upregulated 4-1BB ligand on B cells contributes to B-cell hyperactivation during chronic hepatitis B infection. J Med Virol. 2019 May;91(5):781-790
Tian C, Chen Y, Liu Y, Wang S, Li Y, Wang G, Xia J, Zhao XA, Huang R, Lu S*, Wu C*. Use of ELISpot assay to study HBs-specific B cell responses in vaccinated and HBV infected humans. Emerg Microbes Infect 2018;7(1):16.
Huang R, Zhang Z, Wang J, Xiong Y, Wu C*. Letter: more studies are needed to elucidate the impact of HBV/HCV coinfection on cirrhosis and its consequences. Aliment Pharmacol Ther 2018;47(4):542-543.
Huang R, Zhao XA, Wang J, Hao Y, Wu C*.Simple noninvasive tests for the detection of advanced liver fibrosis in patients with chronic hepatitis B. Eur J Gastroenterol Hepatol 2018;30(2):241.
Zhao XA, Chen G, Liu Y, Chen Y, Wu H, Xiong Y, Wang G, Jia B, Li Y, Xia J, Wang J, Yan X, Zhang Z, Huang R*, Wu C*. Curcumin reduces Ly6Chi monocyte infiltration to protect against liver fibrosis by inhibiting Kupffer cells activation to reduce chemokines secretion. Biomed Pharmacother. 2018 Oct;106:868-878.
Zhao XA, Chen G, Liu Y, Wu H, Chen J, Xiong Y, Tian C, Jia B, Wang G, Xia J, Chen Y, Wang J, Yan X, Zhang Z, Huang R*, Wu C*. Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1hi Monocytes. Evid Based Complement Alternat Med. 2018:**.
Xiong YL, Wu HY, Li Y, Huang R, Liu Y, Chen YX, Zhao XG, Chang HY, Chen J, Wu C*. Characteristics of peripheral and intrahepatic regulatory B cells in HBV-related liver cirrhosis. Int J Clin Exp Pathol. 2018; 11(9):4545-4551.
Jian Wang, Xiaomin Yan, Yuxin Chen, Yong Liu, Li Wang, Bei Jia, Guiyang Wang, Yali Xiong, Peixin Song, Weihua Wu, Juan Xia, Sufang Lu, Zhaoping Zhang, Rui Huang*,Chao Wu*. Characteristics of Hepatitis B Core Antibody Level in the Natural History of Chronic Hepatitis B. Discov Med 2018;26 (143):119-125.
Wang J, Xia J, Zhang R, Yan X, Yang Y, Zhao X, Chang H, Wang G, Chen G, Liu Y, Chen Y, Jia B, Zhang Z, Ding W, Huang R*, Wu C*. A novel index using routine clinical parameters for predicting significant liver inflammation in chronic hepatitis B. J Viral Hepat 2018;25(10):1151-1160.
Huang R, Wang J, Zhao XA, Xia J,Wu C*. The impact of cirrhosis on the efficacy and safety of entecavir for patients with chronic hepatitis B. Eur J Gastroenterol Hepatol 2017;29(11):1314.
Huang R, Wang G, Tian C, Liu Y, Jia B, Wang J, Yang Y, Li Y, Sun Z, Yan X, Xia J, Xiong Y, Song P, Zhang Z, Ding W, Wu C*. Gamma-glutamyl-transpeptidase to platelet ratio is not superior to APRI, FIB-4 and RPR for diagnosing liver fibrosis in CHB patients in China. Sci Rep 2017;7(1):8543.
Jia B^#, Yan X^#, Chen Y, Wang G, Liu Y, Xu B, Song P, Li Y, Xiong Y, Wu W, Hao Y, Xia J, Zhang Z, Huang R *, Wu C*. A scoring model for predicting prognosis of patients with severe fever with thrombocytopenia syndrome. PLoS Negl Trop Dis 2017;11(9):e**.
Wang J, Yan X, Yang Y, Chang H, Jia B, Zhao XA, Chen G, Xia J, Liu Y, Chen Y, Wang G, Wang L, Zhang Z, Ding W, Huang R *, Wu C *.A novel predictive model using routinely clinical parameters to predict liver fibrosis in patients with chronic hepatitis B. Oncotarget 2017;8(35):59257-59267.
Xiaomin Yan^#, Yali Xiong^#, Hongyan Wu, Yong Liu, Yuxin Chen, Guiyang Wang, Zhenhua Sun, Bei Jia, Jun Chen, Jian Wang, Xiangan Zhao, Juan Xia, Zhaoping Zhang, Rui Huang*, Chao Wu*.Accumulation of platelets in the liver may be an important contributory factor to liver injury in chronic hepatitis B virus infection. Int J Clin Exp Pathol 2017;10(6):6924-6929.
Xiang-An Zhao#, Guang-Mei Chen#, Yong Liu, Yu-Xin Chen, Hong-Yan Wu, Jin Chen, Ya-Li Xiong, Chen Tian, Gui-Yang Wang, Bei Jia, Juan Xia, Jian Wang, Xiao-Min Yan, Zhao-Ping Zhang, Rui Huang*, Chao Wu*. Inhibitory effect of silymarin on CCl4-induced liver fibrosis by reducing Ly6Chi monocytes infiltration. Int J Clin Exp Pathol 2017;10(12):11941-11951.
Huang R, Yan X, Liu Y, Zhang Z, Wu C *. Can Transient Elastography Predict Fibrosis Regression in Patients with Chronic Hepatitis B During Long-Term Antiviral Therapy? Am J Gastroenterol 2017;112(9):1477-1478.
Huang R, Wang J, Xia J, Yan X, Wu C *. Letter: lipid-lowering effect of tenofovir disoproxil fumarate in chronic hepatitis B-more evidence is needed. Aliment Pharmacol Ther 2017;46(8):769-770.
Huang R, Wang J, Hao Y, Yan X, Wu C *.Letter: the potential risk of HBV reactivation in patients with resolved HBV infection during direct-acting antiviral therapy. Aliment Pharmacol Ther 2017;46(7):702-703.
Huang R, Yan X, Xia J, Wang J, Wu C *.Letter: hepatitis B virus reactivation in patients with chronic hepatitis C during direct-acting anti-viral therapy. Aliment Pharmacol Ther 2017;45(12):1558.
Huang R, Yan X, Jia B, Wang G, Liu Y, Wu C *.Letter: need to re-evaluate non-invasive markers for staging fibrosis in chronic delta hepatitis. Aliment Pharmacol Ther 2017;45(4):574-575.
Huang R, Wang G, Liu Y, Jia B, Wu C *.Letter: is body-mass index really associated with fibrosis regression during long-term nucleoside analogue therapy in chronic hepatitis B? Aliment Pharmacol Ther 2017;45(3):482.
Chen Y^#, Jia B^#, Liu Y, Huang R, Chen J*, Wu C.*Risk factors associated with fatality of severe fever with thrombocytopenia syndrome: a meta-analysis. Oncotarget 2017;8(51):89119-89129.
Huang R, Jia B, Wang G, Wu C *.Non-invasive fibrosis markers for chronic hepatitis B in sub-Saharan Africa. Liver Int 2017;37(11):1738.
Huang R, Xia J, Yan X, Liu Y, Wu C *. Serum cartilage oligomeric matrix protein levels as a novel non-invasive biomarker for liver fibrosis in patients with chronic viral hepatitis? It is too early. Eur J Intern Med 2017;42:e24.
Chen Y, Jia B, Huang R, Yan X, Xiong Y, Liu Y, Wu C *. Occupational Severe Fever With Thrombocytopenia Syndrome Following Needle-Stick Injury. Infect Control Hosp Epidemiol 2017;38(6):760-762.
Wang G, Liu Y, Huang R, Jia B, Su R, Sun Z, Tian C, Xiong Y, Xia J, Yan X, Zhang Z, Wu C *.Characteristics of regulatory B cells in patients with chronichepatitis B virus infection in different immune phases. Discov Med 2017;23(128):295-304.
Huang R, Xia J, Liu Y, Zhang Z, Wu C*.Acoustic radiation force impulse in the diagnosis of liver fibrosis in patients with chronic hepatitis B. Eur J Gastroenterol Hepatol. 2017;29(8):980-981.
Wu K^#, Huang R^#, Wu H, Liu Y, Yang C, Cao S, Hou X, Chen B, Dai J*, Wu C*.Collagen-binding vascular endothelial growth factor attenuates CCl4-induced liver fibrosis in mice. Mol Med Rep 2016;14(5):4680-4686.
Rui Huang, Yong Liu, Yali Xiong, Hongyan Wu, Guiyang Wang, Zhenhua Sun, Jin Chen, Xiaomin Yan, Zhiyun Pan, Juan Xia, Zhaoping Zhang, Jinke Wang, Chao Wu*. Curcumin protects against liver fibrosis by attenuating infiltration of Gr1^himonocytes through inhibition of monocyte chemoattractant protein-1. Discov Med 2016;21(118):447-457.
Rui Huang, Hongyan Wu, Yong Liu, Chenchen Yang, Kangkang Wu, Zhiyun Pan, Juan Xia, Ran Su, Yali Xiong, Guiyang Wang, Zhenhua Sun, Xiaomin Yan, Chao Wu*. Increase of infiltrating monocytes in the livers of patients with chronic liver diseases. Discov Med, 2016; 21(113): 25-33.
Wu P, Huang R, Xiong YL, Wu C*. Protective effects of curcumin against liver fibrosis through modulating DNA methylation. Chin J Nat Med 2016;14(4):255-64.
Rui Huang, Hongyan Wu, Yong Liu, Yali Xiong, Juan Xia, Zhiyun Pan, Guiyang Wang, Zhenhua Sun, Xiaomin Yan, Jun Chen, Zhaoping Zhang, Chao Wu*.B cells may play a pathological role inhepatic inflammation in chronic liver diseases. Int J Clin Exp Pathol, 2016; 9(3):3630-3635.
Rui Huang, Chenchen Yang, Yong Liu, Juan Xia, Ran Su, Yali Xiong, Guiyang Wang, Zhenhua Sun, Xiaomin Yan, Shan Lu, Chao Wu*.Serum gamma-glutamyltransferase for monitoring natural course and predicting treatment outcome of chronic hepatitis B virus infection, World J Gastroenterol, 2015; 21(34): 9957-9965.



承担科研项目[项目负责人]

“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项，2018ZX**，乙肝相关肝癌精准诊疗标志物的研发与转化，2018/01-2020/12，子课题负责人，135万，主持，在研；
HCV CHIME program by Gilead Sciences: Conquering Hepatitis vIa Micro-Elimination, IN-CN-987-5343, Hepatitis C Surveillance with linkage to care of patients from non-infectious departments in tertiary hospitals from Jiangsu, China, 2019/01-2020/12, Principal Investigator, 33万美元，主持，在研；
美国斯坦福大学医学中心合作项目，来自亚洲肝病联盟的丙型肝炎真实世界证据：REAL-C，2018/08-2019/07，12万，主持，在研；
国家自然科学基金面上项目，**，B细胞分泌CCL7趋化Gr1hi单核细胞肝脏浸润促进肝纤维化发生的机制研究，2017/01-2020/12，57万，主持，在研；
江苏省科技计划，BE**，慢性乙型肝炎综合免疫评估体系的建立及精准诊疗新策略，2017/07-2020/06，200万，主持，在研；
江苏省医学创新团队项目，CXTDA**，基于综合免疫评估体系的慢性乙型肝炎精准诊疗新策，2016/01-2020/12，450万，主持，在研；
南京市医学科技发展重大项目，ZDX16004，慢性乙型肝炎个体化治疗新策略，2016/06-2019/12，100万，主持，在研；
南京市科技发展计划，，基于临床诊疗的慢性HBV感染者队列研究，2015/01-2017/12，10万，主持，在研；
国家自然科学基金面上项目，**，调节性B细胞在慢性HBV感染中的免疫负性调控作用及机制研究，2015/01-2016/12，30万，主持，已结题；
江苏省临床医学科技专项，BL**，以活化B细胞技术为基础的慢性乙型病毒性肝炎治疗新策略，2012/01-2015/12，50万，主持，已结题；
江苏省医学领军人才与创新团队资助项目，LJ20115，以活化B细胞技术为基础的病毒性肝炎个体化综合抗病毒治疗新策略，2011/01-2016/12，80万，已结题；
南京市医学科技发展重点项目，ZKX09032，慢性 HBV感染者的长期队列随访的建立及临床转归的研究，2010/01-2012/12，8 万，主持，已结题；
国家自然科学基金面上项目，**，抗原负载的活化B细胞对HBV抗原特异性CT L的诱导作用，2009/01-2011/12，33万，主持，已结题。




获奖情况

吴超，黄睿，刘勇，严晓敏，陈雨欣，张昭萍, 王健，熊亚莉，夏娟，慢性乙型肝炎的免疫发病机制及临床相关研究，江苏省医学会，医学科技奖二等奖，2019；
吴超，陈军浩，刘勇，黄睿，严晓敏，夏娟，郝迎迎，慢性乙型肝炎患者免疫调节机制研究及其在治疗中的应用，南京市人民政府，科技进步一等奖，2016；
吴超，刘勇，陈军浩. 外周血B细胞活化及抗HBV的临床应用，江苏省卫生厅，医学新技术 引进奖，一等奖，2013；
吴超，夏娟，程健. 流式检测外周血T细胞表面PD-1的表达对临床慢乙肝患者免疫状态的判断及抗病毒疗效的评估，江苏省卫生厅，医学新技术引进奖，二等奖，2012.