田大成 教授





办公电话：
邮政编码： 210023

联系地址：
电子邮件： dtian@nju.edu.cn








个人简介
研究方向
科研成果





个人简介


学术兼职



研究方向
从事分子和基因组的进化、植物功能基因组和生物信息学的研究。主要研究方向：
1）植物抗病基因的结构、功能、起源、变异及保存
2）DNA insertion/deletion对遗传变异的影响
3）基因组的非对称性及其非对称DNA的遗传效应
4）肿瘤基因组体细胞突变的分子遗传机制
详细请访问实验室网站：http://gattaca.nju.edu.cn/



获奖情况


科研成果
Selected publications:

Yang S, Wang L, Huang J, Zhang X, Yuan Y, Chen J-Q, Hurst LD*, Tian D* (2015). Parent-progeny sequencing indicates higher mutation rates in heterozygotes. Nature doi:10.1038/nature14649 (IF5y=41.5)

Tian D*, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson R, Bergelson J & Chen JQ. (2008) Single-nucleotide mutation rate increases close to indels in eukaryotes. Nature 455:105-108

Tian D, Shaw B, Chen J, Kreitman M, Bergelson J (2003) Fitness cost of R-gene mediated resistance in Arabidopsis thaliana. Nature 424:74-77

Bergelson J, Kreitman M, Stahl E, Tian D (2001) Evolutionary dynamics of plant R-genes. Science 292:2281-2285

Yang S, Li J, Zhang XH, Zhang QJ, Huang J, Chen JQ, Hartl DL, Tian D*. (2013) Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease. Proc Natl Acad Sci 110: 18572-18577

Yang S, Yuan Y, Wang L, Li J, Wang W, Liu H, Chen JQ, Hurst LD, Tian D*. (2012) Great majority of recombination events in Arabidopsis are gene conversion events. Proc Natl Acad Sci 109 :20992-20997

Araki H, Tian D, Goss EM, Jakob K, Halldorsdottir SS, Kreitman M and Bergelson J. (2006) Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis. Proc Natl Acad Sci 103:5587-5892

Tian D, Akashi H, Stahl E, Bergelson J, Kreitman M (2002) Signature of balancing selection in Arabidopsis. Proc Natl Acad Sci 99:11525-1153

Yue J-X, Meyers BC, Chen J-Q, Tian D*, Yang S. (2012) Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes. New Phytologist 193: 1049–1063 (IF=6.736)

Zhu L, Wang Q, Tang P, Araki H, Tian D*. (2009) Genome-wide association between insertions/deletions and the nucleotide diversity in bacteria. Mol Biol Evol 26:2353-2361 (IF=10.353)

Chen JQ, Wu Y, Yang H, Bergelson J, Kreitman M, Tian D*. (2009) Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria. Mol Biol Evol 26:1523-31 (IF=10.353)

Sun X, Zhang Y, Yang S, Chen JQ, Hohn B, Tian D* (2008) Insertion DNA promotes ectopic recombination during meiosis in Arabidopsis. Mol Biol Evol 25:2079-2083 (IF=10.353)

Gu T, Tan S, Gou X, Araki H, Tian D*. (2010) Avoidance of long mononucleotide repeats in codon pair usage. Genetics 186:1077-1084

Shen J, Araki H, Chen L, Chen JQ, Tian D* (2006) Unique evolutionary mechanism in R-genes under the presence/absence polymorphism in Arabidopsis thaliana. Genetics 172 (2):1243-50