谭仁祥 教授 博士生导师





办公电话：
邮政编码： 210093

联系地址：
电子邮件： rxtan@nju.edu.cn








个人简介
研究方向
科研成果





个人简介


学术兼职
英国皇家化学会会士（Fellow）; 国家自然科学基金委员会专家咨询委员会委员；《Natural Product Reports》、《Current Medicinal Chemistry》等SCI刊物（顾问）编委。曾任国际天然产物协会主席、《中国抗生素杂志》主编等职。

General Information
Laboratory: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University.
Address: 163 Xianlin Avenue, Nanjing 210023, Jiangsu Province, P. R. China.
Tel: +86 25 8359 2945 (Office)
Fax: +86 25 8330 2728
E-mail: rxtan@nju.edu.cn



研究方向
长期从事天然产物化学研究，涉及植物和微生物来源的新活性分子的发现策略/方法、结构分析、功能鉴定和生物合成途径。已在《Nat. Commun.》、《Proc. Natl. Acad. Sci. USA》、《J. Am. Chem. Soc.》、《Angew. Chem. Int. Ed.》、《Chem. Rev.》等刊物上发表论文260多篇；主编《植物成分分析》、《植物成分功能》、《功能海洋生物分子——发现与应用》、《甾体化学》；取得授权发明专利26件。作为第一完成人，获2009年国家自然科学奖二等奖、2007年“Natural Product Reports Lecture Award”（英国皇家化学会，每年提名授奖一项）、2007年和2005年教育部一等奖等奖项。
Research focuses upon natural products, including the discovery methods, structural analysis, functional identification and biosynthetic pathway in novel molecules from plants and microbes. Published more than 300 papers in a broad range of journals such as Nat. Commun., Proc. Natl. Acad. Sci. USA, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Prod. Rep., Chem. Rev., et. al.



获奖情况
2010年：谈家桢生命科学奖创新奖。
2009年：若干重要药用植物的成分研究. 国家自然科学奖二等奖。
2007年：Natural Product Reports Lecture Award (Royal Society of Chemistry, UK)
2007年：植物内生真菌代谢物研究. 教育部提名国家科学技术奖（自然科学奖）一等奖。
2005年：民间常用草药成分的分析与功能研究. 教育部提名国家科学技术奖（自然科学奖）一等奖。

2010: R. X. Tan. Tan Jia Zhen Innovation Award in Life Sciences, issued by the Committee for Tan Jia Zhen Life Science Award.
2009: R. X. Tan, R. L. Zheng, Z. J. Jia, L. D. Kong, H. Q. Zheng. Phytochemistry of medicinal plants. National Natural Science Award (second class), issued by the State Council of China.
2007: R. X. Tan, C. H. Liu, L. Shen, R. H. Jiao, H. Lv, Y. C. Song, W. X. Zou, J. Y. Liu, G. Ding. Secondary metabolites of endophytic fungi. Natural Science and Technology Award (first class), nominated and issued by the Ministry of Education.
2007: R. X. Tan. Chemical and biological evaluations of endophyte-derived products. Natural Product Reports Lecture Award, issued by the Royal Society of Chemistry, UK.
2005: R. X. Tan, L. D. Kong, L. Luo, C. Xu, J. W. Wang, Y. Q. Hu, L. G. Liu, H. Q. Tang, W. F. Zheng, C. H. Liu, C. X. Zhou. Phytochemical analysis and functional assessment of frequently used herbal medicines. Natural Science and Technology Award (first class), nominated and issued by the Ministry of Education.



科研成果
论文
Selected Publications
1. Yuan Tian, Nan Jiang, Ai Hua Zhang, Chao Jun Chen, Xin Zhao Deng, Wen Jing Zhang, Ren Xiang Tan*. Muta-mycosynthesis of naphthalene analogs. Org. Lett. 2015, 17, 1457–1460.
2. Ya Nan Song, Rui Hua Jiao, Wen Jing Zhang, Guo Yan Zhao, Huan Dou, Rong Jiang, Ai Hua Zhang, Ya Yi Hou, Shu Feng Bi, Hui Ming Ge,* Ren Xiang Tan*. New ansamycin derivatives generated by simultaneous mutasynthesis. Org. Lett. 2015, 17, 556–559.
3. W. Yan, H. M. Ge, G. Wang, N. Jiang, Y. N. Mei, R. Jiang, S. J. Li, C. J. Chen, R. H. Jiao, Q. Xu, S. W. Ng, R. X. Tan*. Pictet–Spengler reaction based biosynthetic machinery in fungi. Proc. Natl. Acad. Sci. USA 2014, 111, 18138–18143.
4. X. Lei*, Z. Xu, H. Sun, S. Wang, C. Griesinger, L. Peng, C. Gao*, R. X. Tan*. Graphene oxide liquid crystals as a versatile and tunable alignment medium for the measurement of residual dipolar couplings in organic solvents. J. Am. Chem. Soc. 2014, 136, 11280–11283.
5. W. B. Han, Y. H. Lu, A. H. Zhang, G. F. Zhang, Y. N. Mei, N. Jiang, X. X. Lei, Y. C. Song, S. W, R. X. Tan*. Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species. Org. Lett. 2014, 16, 5366–5369.
6. L. Y. Yao, Y, X. Zhu, R. H. Jiao, Y. H. Lu*, R. X. Tan*. Enhanced production of fumigaclavine C by ultrasound stimulation in a two-stage culture of Aspergillus fumigatus CY018. Bioresource Technol. 2014, 159, 112–117.
7. W. Fang, S. Ji, N. Jiang, W. Wang, G. Y. Zhao, S. Zhang, H. M. Ge, Q. Xu, A. H. Zhang, Y. L. Zhang, Y. C. Song, J. Zhang, R. X. Tan*. Naphthol radical couplings determine structural features and enantiomeric excess of dalesconols in Daldinia eschscholzii. Nat. Commun. 2012, 3, 1039 doi10.1038ncomms2031.
8. L. Lin, R. X. Tan*. Cross-kingdom actions of phytohormones: a functional scaffold exploration. Chem. Rev. 2011, 111, 2734–2760.
9. Y. L. Zhang, J. Zhang, N. Jiang, Y. H. Lu, L. Wang, S. H. Xu, W. Wang, G. F. Zhang, Q. Xu, H. M. Ge, J. Ma, Y. C. Song, R. X. Tan*, Immunosuppressive polyketides from mantis-associated Daldinia eschscholzii. J. Am. Chem. Soc. 2011, 133, 5931–5940.
10. H. M. Ge, W. Yan, Z. K. Guo, Q. Luo, R. Feng, L. Y. Zang, Y. Shen, R. H. Jiao, Q. Xu, R. X. Tan*. Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. Chem. Commun. 2011, 47, 2321–2323.
11. H. M. Ge, W. Y. Zhang, G. Ding, P. Saparpakorn, Y. C. Song, S. Hannongbua, R. X. Tan*. Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture. Chem. Commun. 2008, 5978–5980.
12. Y. L. Zhang, H. M. Ge, W. Zhao, H. Dong, Q. Xu, S. H. Li, J. Li, J. Zhang, Y. C. Song, R. X. Tan*. Unprecedented immunosuppressive polyketides from Daldinia eschscholzii, a mantis-associated fungus. Angew. Chem. Int. Ed. 2008, 47, 5823–5826.

专著
1. 谭仁祥主编，王剑文副主编. 《甾体化学》，化学工业出版社，北京，2008（43.6万字）。
2. 谭仁祥主编，石建功、郭跃伟、徐琛副主编. 《功能海洋生物分子——发现与应用》，科学出版社，北京，2007（110.9万字）。
3. 谭仁祥主编，王剑文、徐琛、崔贵友副主编. 《植物成分功能》，科学出版社，北京，2003（110.3万字）。
4. 谭仁祥主编，孟军才、陈道峰、焦庆才副主编.《植物成分分析》，科学出版社，北京，2002（100.6万字，2004年再版）

Monographs
R. X. Tan, J. W. Wang. Steroid Chemistry. Beijing: Chemical Industry Press, 2008.
R. X. Tan, J. G. Shi, Y. W. Cui, C. Xu. Functional Marine Biomolecules---Discovery & Application. Beijing: Science Press of China, 2007.
R. X. Tan, J. W. Wang, C. Xu, G. Y. Cui. The Function of Phytochemicals. Beijing: Science Press of China, 2003.
R. X. Tan, J. C. Meng, D. F. Chen, Q. C. Jiao. Phytochemical Analyses. Beijing: Science Press of China, 2002.

专利
1. 谭仁祥、卫蔚、姜荣、赵国琰. 一种二萜Libertellenone G及其制备方法与用途。申请号： 7.0；申请日2013.1.31.。
2. 谭仁祥、张高飞、宋勇春、崔江涛、汪伟. 一种弯孢霉菌及吲哚里西啶生物碱的制备方法和应用。发明专利号：ZL 2011 1 **.6；证书号：第**号
3. 谭仁祥、毕淑峰、梅亚宁、宋勇春、郭也、李方. 新大环内酯及其制备方法和应用。发明专利号：ZL 2011 1 **.1；证书号：第**号。
4. 谭仁祥、汪伟、宋雅男、沈薇、宋勇春. 一种单一型黑色素及其制备方法和应用。发明专利号：ZL 2011 1 **.5；证书号：第**号。
5. 谭仁祥、张爱华、谷文、宋勇春、王玉蓉、胥苏海. 一类交链孢菌生物碱及其制备方法和用途。发明专利号：ZL 2010 1 **.3。证书号：第**号。
6. 谭仁祥、史大华、吴俊华、宴志强、张丽娜、王玉蓉. 4′,5-二羟基-7-[4-(N,N-二乙氨基)丁氧基]异黄酮及其制备方法和应用。发明专利号：ZL 2010 1 **.7 ；证书号：第**号。
7. 谭仁祥、宋勇春、乔红运、梅亚宁、刘敏、吴琦. 汉城链霉素及其制备方法和应用。发明专利号：ZL 2010 1 **.X；第978509号。
8. 谭仁祥、章华伟、黄午阳、陈菁蓉、谢代前. 一种顶头孢菌素及其制法和用途。发明专利号：ZL 2008 1 **.7。证书号：第753083号。
9. 谭仁祥、徐强、张应烙、赵蔚、黎书华. 一类炭壳菌聚酮及其制法与用途。发明专利号：ZL 2007 1 **.2；证书号：第816924号。
10. 谭仁祥、吴俊华、徐琛、陈运喜、李洪森、李方、周添. 一种鸢尾的医药用途。发明专利号：ZL 2006 1 **.2。证书号：第535870号。

Selected Patents
R. X. Tan, W. Wei, R. Jiang, G. Y. Zhao: Diterpene Libertellenone G and preparation method and use thereof. Appl. No: 7.0.
R. X. Tan, G. F. Zhang, Y. C. Song, J. T. Cui, W. Wang: Method for preparing Curvularin and indolizidine alkaloid and application. Publ. No: ZL 2011 1 **.6. Patent Certificate No: **.
R. X. Tan, S. F. Bi, Y. N. Mei, Y. C. Song,Y. Guo, F. Li: Deminamicin and preparation method and application thereof. Publ. No: ZL 2011 1 **.1. Patent Certificate No: **.
R. X. Tan, W. Wang, Y. N. Song, W. Shen, Y. C. Song: Single-type melanins and their preparation methods and applications. Publ. No: ZL 2011 1 **.5. Patent Certificate No: **.
R. X. Tan, A. H. Zhang, W. Gu, Y. C. Song, Y. R. Wang, S. H. Xu: Alternarlactam and preparation method and application thereof. Publ. No: ZL 2010 1 **.3. Patent Certificate No: **.
R. X. Tan, D. H. Shi, J. H. Wu, Z. Q. Yan, L. N. Zhang, Y.R. Wang: the application of 4’,5- dyhydroxy - 7- [ 4- (N, N- diethylamino) butoxy ] isoflavone in the preparation antineoplastic. Publ. No: ZL 2010 1 **.7. Patent Certificate No: **.
R. X. Tan, Y. C. Song, H. Y. Qiao, Y. N. Mei, M. Liu, Q. Wu: Streptoseomycin and preparation method and application thereof. Publ. No: ZL 2010 1 **.X. Patent Certificate No: 978509.
R. X. Tan, H. W. Zhang, W. Y. Huang, J. R. Chen, D.Q. Xie: Cephalosporium acremonium corda rhzomorph, production method and uses thereof. Publ. No: ZL 2008 1 **.7. Patent Certificate No: 753083.
R. X. Tan, Q. Xu, Y. L. Zhang, W. Zhao, S. H. Li: Carbon shell bacterium polyketone, preparation and uses thereof. Publ. No: ZL 2007 1 **.2. Patent Certificate No: 816924.
R. X. Tan, J. H. Wu, C. Xu, Y. X. Chen, H. S. Li, F. Li, T. Zhou: Medical use of iris. Publ. No: ZL 2006 1 **.2. Patent Certificate No: 535870.