职务： 博士生导师
联系电话：
办公地址： 仙林校区化学楼E315
电子邮箱： xujj@nju.edu.cn

课题组主页：





个人简介


1990年毕业于武汉大学化学系
1997、2000年在南京大学分别获得硕士和博士学位
2007年入选教育部“新世纪优秀人才支持计划”
2010年获得国家****科学基金资助
2013年获得中国青年女科学家奖
2014年入选英国皇家化学会会士
2014获批教育部********
现为Scientific Reports、VIEW、《化学学报》、《分析化学》、《分析科学学报》等刊编委
2019年9月起任中国化学会质谱专业委员会副秘书长
2019年1月起任Analytica Chimica Acta的Editor


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工作经历


2000.8-2003.6南京大学化学化工学院 博士、讲师
2003.7-2006.6 南京大学化学化工学院 副教授
2006.7-至今南京大学化学化工学院 教授
2007/2008年度 美国康奈尔大学访问教授


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研究方向


研究方向:生命分析化学（电分析化学、生物传感、单细胞分析、微纳尺度生物分析）




学术成果


1.Hai-Yan Wang, Yi-Fan Ruan, Li-Bang Zhu, Xiao-Mei Shi, Wei-Wei Zhao,* Hong-Yuan Chen and Jing-Juan Xu*, An Integrated Electrochemical Nanodevice for Intracellular RNA Collection and Detection in Single Living Cell, Angew. Chem. Int. Ed.,2021, DOI: 10.1002/anie. and 10.1002/ange.
2.He Gao, Pei Wu , Pei Song, Bin Kang*, Hong-Yuan Chen and Jing-Juan Xu*，Video-rate imaging of sub-10 nm plasmonic nanoparticles in cellular medium free of background scattering, Chem. Sci., 2021, DOI: 10.1039/D0SC04764C
3.Yang Zhao, Hui Wang, Wei Zhao,* Xueli Zhao, Jing-Juan Xu,* and Hong-Yuan Chen, Dark-Field imaging of cation exchange synthesis of Cu_2-xS@Au₂S@Au nanoplates toward plasmonic enhanced hydrogen evolution reaction, ACS Appl. Mater. Interfaces,10.1021/acsami.0c20544
4.Zhi-Hong Xu^?, Hang Gao^?, Nan Zhang, Wei Zhao*, Yixiang Cheng, Jing-Juan Xu*, Hong-Yuan Chen, Ultrasensitive Nucleic Acid Assay Based on Cyclometalated Iridium(III) Complex with High Electrochemiluminescence EfficiencyAnal. Chem., 10.1021/acs.analchem.0c04284
5.Yi-Fan Ruan, Hai-Yan Wang, Xiao-Mei Shi, Yi-Tong Xu, Xiao-Dong Yu, Wei-Wei Zhao*, Hong-Yuan Chen, and Jing-Juan Xu*, Target-Triggered Assembly in Nanopipette for Electrochemical Single Cell Analysis, Anal. Chem., 10.1021/acs.analchem.0c04628
6.Yu-Yang Zhou,*^a,bYang-Ming Ding,^bWei Zhao,^aJian-Hua Dong,^bLiang-Zhi Li,^bHong-Yuan Chen,^aJing-Juan Xu,*^a High Efficiency Near-Infrared Electrogenerated Chemiluminescent Dyes from Bis(4,7-diphenyl-1,10-phenoline) Ruthenium(II) Complexes with Cyclometalated N-heterocyclic Carbene Ligand，Chem. Commun.，2021, DOI: 10.1039/D0CC07595G

2020
7.Jun Hu, Nan Zhang, Pan-Ke Zhang, Yun Chen, Xing-Hua Xia, Hong-Yuan Chen, Jing-Juan Xu*, Coupling Wireless Bipolar Ultramicroelectrode with Nano-electrospray Ionization Mass Spectrometry: Insights into the Ultrafast Initial Step of Electrochemical Reactions, Angew. Chem. Int. Ed., 2020, 59, 18244-18248DOI: 10.1002/anie. and 10.1002/ange.
8.Zhaoshuai Gao, Jian-Hua Wang, Pei Song, Bin Kang,* Jing-Juan Xu, and Hong-Yuan Chen, Spaser Nanoparticles for Ultranarrow Bandwidth STED Super-Resolution Imaging, Adv. Mater., 2020, 32, ** DOI: 10.1002/adma.
9.Ziyu Wang, Jianbin Pan, Qian Li, Yi Zhou, Jing-Juan Xu* and Daoben Hua*，Improved AIE-Active Probe with High Sensitivity for Accurate Uranyl Ion Monitoring in the Wild via Portable Electrochemiluminescence System for Environmental Applications, Adv Funct Mater2020, 30, ** DOI: 10.1002/adfm.
10.Xiao-Mei Shi, Yi-Fan Ruan, Hai-Yan Wang, Wei-Wei Zhao*, Jing-Juan Xu & Hong-Yuan Chen*, A Supersmall Single-Cell Nanosensor for Intracellular K⁺Detection,CCS Chem.2020, 2, 2359–2367 DOI: 10.31635/ccschem.020.
11.Mei-Rong Cui, Xiang-Ling Li*, Hong-Yuan Chen, Jing-Juan Xu*, Smart Engineering of a Self-Powered and Integrated Nanocomposite for Intracellular MicroRNA Imaging，CCS Chem.2020, 2, 2063–2073 DOI: 10.31635/ccschem.020.
12.Hang Gao^?, Nan Zhang^?, Jian-Bin Pan*, Yi-Wu Quan*, Yi-Xiang Cheng, Hong-Yuan Chen and Jing-Juan Xu*, Aggregation-induced enhanced electrochemiluminescence of conjugated Pdots by Trace Ir(III) complex: Insights into structure–property relationships, ACS Appl. Mater. Interfaces, 2020, 48, 54012–54019 10.1021/acsami.0c18197
13.Mei-Rong Cui, Xiang-Ling Li*, Jing-Juan Xu*, Hong-Yuan Chen, Acid-switchable DNAzyme Nanodevice for Imaging Multiple Metal Ions in Living Cells, ACS Appl. Mater. Interfaces, 2020, 12, 13005-13012，DOI：10.1021/acsami.0c00987
14.Xiao-Hong Wang, Zhao-Shuai Gao, Fan Yang, Wen Lei, Jian-Hua Wang, Jian-Bing Pan, Pei Song, Bing Kang*, Jing-Juan Xu*, Hong-Yuan Chen，Quantitative imaging of pN intercellular force and energetic costs during collective cell migration in epithelial wound healing, Anal. Chem., 2020,92, 16180–16187 DOI: 10.1021/acs.analchem.0c03935
15.Jin Wang, Xiang-Ling Li*, Hong-Yuan Chen, Jing-Juan Xu*，Loading-type Plasmonic Nanoparticles for Detection of Peroxynitrite in Living Cells，Anal. Chem., 2020, 92, 15647–15654 DOI: 10.1021/acs.analchem.0c04017
16.Hui Wang,^?Wei Zhao,^?Cong-Hui Xu,* Hong-Yuan Chen, Jing-Juan Xu, Real-Time Tracking the Electrochemical Synthesis of Au@Metal Core-Shell Nanoparticles Toward Photo Enhanced Methanol Oxidation, Anal. Chem., 2020, 92, 14006?14011 DOI: 10.1021/acs.analchem.0c02913
17.Xiang Qin, Zhong-Qiu Li, Yue Zhou, Jian-Bin Pan, Jian Li, Kang Wang, Jing-Juan Xu, Xing-Hua Xia*, Fabrication of High-Density and Superuniform Gold Nanoelectrode Arrays for Electrochemical Fluorescence Imaging, Anal. Chem. 2020, 92, 19, 13493–13499 DOI：10.1021/acs.analchem.0c02918
18.Xiaojian Li,¹Yu Du,¹Huan Wang,¹Hongmin Ma,¹Dan Wu,¹Xiang Ren,¹Qin Wei,^1,* and Jing-Juan Xu,^2,* Self-supply of H₂O₂and O₂by hydrolyzing CaO₂to enhance the electrochemiluminescence of luminol based on closed bipolar electrode,Anal. Chem., 2020, 92, 12693–12699 DOI：10.1021/acs.analchem.0c03170
19.Chun-Qin Zhao, Jing Zhou, Kai-Wen Wu, Shou-Nian Ding*, Jing-Juan Xu, and Hong-Yuan Chen, Plasmonic Enhanced Gold Nanoclusters-Based Photoelectrochemical Biosensor for Sensitive Alkaline Phosphatase Activity Analysis,Anal. Chem.m 2020, 92, 6886–6892 DOI: 10.1021/acs.analchem.9b05432
20.Siqi Zhang, Jiaxi Cheng, Wei Shi, Kai-Bin Li, De-Man Han*, and Jing-Juan Xu, Fabrication of a Biomimetic Nanochannel Logic Platform and Its Applications in the Intelligent Detection of miRNA Related to Liver Cancer, Anal. Chem., 2020, 92,5952–5959 DOI: 10.1021/acs.analchem.0c00147
21.Mei-Rong Cui,¹Li-Xian Chen,¹Xiang-Ling Li,*,^1,2Jing-Juan Xu,*,¹Hong-Yuan Chen¹, NIR Remote-controlled “Lock-Unlock” Nanosystem for Imaging Potassium Ions in Living Cells, Anal. Chem., 2020, 92, 4558-4565, DOI: 10.1021/acs.analchem.9b05820
22.Yu Liu^?, Jin-Wen Shangguan^?, Bi-Yi Xu*, Xiao-Dong Yu, Jing-Juan Xu* and Hong-Yuan Chen*, Abnormal Liquid Chasing Effect in Paper Capillary Enables Versatile Gradient Generation on Microfluidic Paper Analytical Devices, Anal. Chem.,2020, 92, 2722-2730DOI: 10.1021/acs.analchem.9b04934
23.Jian-Hua Wang, Zhaoshuai Gao, Pei Song, Pavel N. Melentiev, Xiao-Hong Wang, He Gao, Fan Yang, Bin Kang*, Jing-Juan Xu, and Hong-Yuan Chen, How Gain Layer Design Determines Performance of Nanoparticle-Based Spaser, J. Phys. Chem. C,2020, 124, 30, 16553–16560 DOI: 10.1021/acs.jpcc.0c03680
24.Juan Song, Jian-Bin Pan, Wei Zhao*, Hong-Yuan Chen, Jing-Juan Xu*, Gold nanorod-assisted near-infrared light-mediated regulation of membrane ion channels activates apoptotic pathways, Chem. Commun., 2020, 56, 6118 - 6121 DOI: 10.1039/D0CC01858A
25.Ming-Ming Chen, Cong-Hui Xu, Wei Zhao*, Hong-Yuan Chen, Jing-Juan Xu, Observing structure-dependent electrocatalytic activity of bimetallic Pd-Au nanorods at single-particle level, Chem. Commum., 2020, 56, 3413-3416，10.1039/D0CC00185F
26.Xue-Jiao Yang, Mei-Rong Cui, Xiang-Ling Li*, Hong-Yuan Chen, Jing-Juan Xu*, Self-powered 3D DNA walker with programmability and signal-amplification for illuminating microRNA in living cells, Chem. Commun., 2020, 56, 2135 - 2138DOI: 10.1039/C9CC09039H
27.Qiu-Mei Feng,^aPo Ma,^aQi-Hang Cao,^aYue-Hua Guo,*^cand Jing-Juan Xu*^b, Aptamer-binding DNA walking machine for sensitive electrochemiluminescence detection of tumor exosomes, Chem. Commun.,2020, 56, 269 - 272, DOI: 10.1039/C9CC08051A
28.Mei-Rong Cui,^?Wei Zhao,^?Xiang-Ling Li, Cong-Hui Xu*, Hong-Yuan Chen, Jing-Juan Xu*, Simultaneous Monitoring of Action Potentials and Neurotransmitter Release from Neuronal Circuit Model, Anal. Chim. Acta, 2020, 1105, 74-81https://doi.org/10.1016/j.aca.2019.11.074
29.Si-Yuan Ji^?, Wei Zhao^?, Hang Gao, Jian-Bin Pan, Cong-Hui Xu*, Yi-Wu Quan*, Jing-Juan Xu*, Hong-Yuan Chen, Highly Efficient Aggregation-Induced Electrochemiluminescence of Polyfluorene Derivative Containing Tetraphenylethylene,iScience,2020, 23, 100774DOI: 10.1016/j.isci.2019.100774
30.Yuan-Cheng Zhu, Zheng Li, Xiang-Nan Liu, Gao-Chao Fan, De-Man Han, Pan-Ke Zhang*, Wei-Wei Zhao*, Jing-Juan Xu, Hong-YuanChen*, Three-dimensional CdS nanosheet-enwrapped carbon fiber framework: Towards split-type CuO-mediated photoelectrochemical immunoassay, Biosens. Bioelectron.,2020, 148, 111836 DOI: 10.1016/j.bios.2019.111836
31.Hai-Jie Lu, Jing-Juan Xu*, Hong Zhou*, Hong-Yuan Chen, Recent Advances in Electrochemiluminescence Resonance Energy Transfer for Bioanalysis: Fundamentals and Applications, TrAC-Trend Anal. Chem., 2020, 122, 115746 DOI: 10.1016/j.trac.2019.115746
32.Hang Gao^?, Nan Zhang^?, Yang Li, Wei Zhao*, Yiwu Quan*, Yixiang Cheng, Hong-Yuan Chen and Jing-Juan Xu*, Trace Ir(III) complex enhanced electrochemiluminescence of AIE-active Pdots in aqueous media, Sci. China Chem.,2020, 63(5), 715-721DOI: 10.1007/s11426-019-9650-8
33.杨雪娇，徐静娟*，陈洪渊, 核酸功能化金纳米探针在活细胞成像方面的应用, 中国科学：化学，2020, 50(5): 583-593DOI：10.1360/SSC-2019-0139
34.Jiang Wang, Li-Juan Huang, Zhen-Jun Xu, Yu Liu, Jing-Juan Xu*, Hong-Yuan Chen, Rapid Analysis of Bacteremia by Membranc Extraction Electrospray Ionization Mass Spectrometry, Chinese J. Anal. Chem., 2020, 48(10): 1315-1324 DOI: 10.1016/S1872-2040(20)60050-0

2019
35.Xing Wei^?, Meng-Jiao Zhu^?, Zhe Cheng, Mengjue Lee, Hong Yan*, Changsheng Lu* and Jing-Juan Xu*, Aggregation-Induced Electrochemiluminescence of Carboranyl Carbazoles in Aqueous Media, Angew. Chem. Int. Ed. 2019, 58, 3162 –3166, DOI: 10.1002/anie. andAngew. Chem. 10.1002/ange.
36.Hui Wang,^?Wei Zhao,^?Cong-Hui Xu*, Hong-Yuan Chen, Jing-Juan Xu*, Electrochemical Synthesis of Au@Semiconductor Core-Shell Nanocrystals Guided by Single Particle Plasmonic Imaging, Chem Sci 2019, 10, 9308 – 9314 DOI: 10.1039/C9SC02804H
37.Ming-Ming Chen,^?Wei Zhao,^?Meng-Jiao Zhu, Xiang-Ling Li, Cong-Hui Xu,* Hong-Yuan Chen, Jing-Juan Xu*, Spatiotemporal Imaging of Electrocatalytic Activity on Single 2D Gold Nanoplates, Chem Sci2019, 10, 4141 - 4147 DOI: 10.1039/C9SC00889F
38.Zhaoshuai Gao¹, Lixin Yin¹, Weina Fang², Qingying Kong¹, Chunhai Fan², Bin Kang^1*, Jing-Juan Xu¹, Hong-Yuan Chen¹, Imaging Chladni figure of plasmonic charge density wave in real space, ACS Photonics 2019, 6, 11, 2685-269310.1021/acsphotonics.9b00644
39.Yang Zhao, Xiao-Yu Gao, Hui Wang, Jin Wang, Jie Zhou, Wei Zhao*, Jing-Juan Xu, Hong-Yuan Chen, Ultra-sensitive Detection of MicroRNA via Au@Ag “Nanosnowman”, Anal Chem 2019, 91, 24, 15988-15992 DOI: 10.1021/acs.analchem.9b04715
40.Hai-Jie Lu, Cong-Hui Xu*, Jing-Juan Xu*, Hong-Yuan Chen, Metallic Inverse Opals: An Electrochemiluminescence enhanced Substrate for Sensitive Bioanalysis, Anal Chem 2019, 91, 22, 14.1021/acs.analchem.9b04228
41.Nan Zhang,^?Hang Gao,^?Cong-Hui Xu,* Yixiang Cheng, Hong-Yuan Chen, Jing-Juan Xu,* An efficient electrochemiluminescence enhancement strategy on Bipolar Electrode for bioanalysis, Anal Chem 2019, 91, 12553-1255910.1021/acs.analchem.9b03477
42.Zhi-Hong Xu, Hui Wang, Jing Wang, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen, Bidirectional Electrochemiluminescent Sensing: An Application in Detecting miRNA-141, Anal Chem2019, 91, 12000-12005 DOI: 10.1021/acs.analchem.9b02914
43.Shan-Shan Li, Miao Zhang, Jian-Hua Wang, Fan Yang, Bin Kang,* Jing-Juan Xu, and Hong-Yuan Chen，Monitoring the changes of pH in lysosomes during autophagy and apoptosis by plasmon enhanced Raman imaging, Anal Chem2019, 91, 8398-8405, DOI: 10.1021/acs.analchem.9b01250
44.Jun Hu, Wen Lei, Jiang Wang, Hong-Yuan Chen, Jing-Juan Xu*, Sodium Adduction Mass Spectrometry Reveals the Preservation of Protein Zwitterionic States, Anal Chem2019, 91(12), 7858-7863, DOI: 10.1021/acs.analchem.9b01602
45.Yizhong Shen,^aTingting Wu,^aQian Tian,^b Yu Mao,^aJunjie Hu,^bXiliang Luo,^cYingwang Ye,^a* Hong-Yuan Chen^b and Jing-Juan Xu^b* Engineering of ATP-powered photosensitizer for targeted recycling activatable imaging of microRNA and controllable cascade amplification photodynamic therapy, Anal Chem2019, 91, 7879-7886, 10.1021/acs.analchem.9b01692
46.Shan-Wen Hu, Jin Wang, Ting-Ting Zhang, Xiang-Ling Li*, Hong-Yuan Chen, Jing-Juan Xu*, Targeted Transmembrane Delivery of Ca²⁺via FA-nanogel for Synergistically Enhanced Chemotherapy, ACS Appl. Mater. Interfaces2019, 11(18):16412-16420. Doi: 10.1021/acsami.9b04967
47.Xing Wei, Meng-Jiao Zhu, Hong Yan,* Changsheng Lu* and Jing-Juan Xu*, Recent Advances in Aggregation-Induced Electrochemiluminescence, Chem Eur J 2019, 25, 12671 – 12683 DOI:10.1002/chem.
48.Mei-Rong Cui, Xiang-Ling Li,* Jing-Juan Xu,* Hong-Yuan Chen, Cellular Microenvironment Triggered Self-powered DNAzyme–MnO₂Nanosystem: towards Imaging MicroRNAs in Living Cells, Chem Commun 2019, 55, 13366 – 13369 DOI: 10.1039/C9CC06623C
49.Yun-Lu Zhou,^?Panke Zhang,^?Cong-Hui Xu,* Jing-Juan Xu* and Hong-Yuan Chen, An improvement in scanning electrochemical microscopy based on a plasmon-accelerated electrochemical reaction, Chem Commun 2019, 55, 11275 – 11278, DOI: 10.1039/C9CC04888J
50.Nan Zhang, Wei Zhao, Cong-Hui Xu,* Jing-Juan Xu* and Hong-Yuan Chen, Amperometric monitoring of vesicular dopamine release by gold nanocone electrode, Chem Commun, 2019, 55, 3461 – 3464, DOI: 10.1039/C9CC01280J
51.Jun Hu,^?Wen Lei,^?Jiang Wang, Hong-Yuan Chen, Jing-Juan Xu*, Regioselective 5'-Position Phosphorylation of Ribose and Ribonucleosides: Phosphate Transfer in the Activated Pyrophosphate Complex in Gas Phase, Chem Commun2019, 55, 310 - 313, DOI: 10.1039/C8CC08510B
52.Kai Zhang, Xue-Jiao Yang, Ting-Ting Zhang,Xiang-Ling Li,* Hong-Yuan Chen and Jing-Juan Xu*，In Situ Imaging and Interfering Dicer-mediated Cleavage Process via a Versatile Molecular Beacon Probe, Anal Chim Acta 2019, 1079,146-152DOI: 10.1016/j.aca.2019.06.016
53.Xue-Jiao Yang, Xiang-Ling Li*, Hong-Yuan Chen, Jing-Juan Xu*, A NIR-activated drug and siRNA co-delivery nanocarrier for synergistic therapy of multidrug-resistant cancer, ACS Appl Bio Materials, 2019, 2, 2994-3001, DOI: 10.1021/acsabm.9b00329
54.Xiao-Lei Huo, Hai-Jie Lu, Jing-Juan Xu,* Hong Zhou* and Hong-Yuan Chen, Recent advances of ratiometric electrochemiluminescence biosensors, J Mater Chem B,, 2019, 7, 6469 – 6475, DOI: 10.1039/C9TB01823A
55.Qing-Ying Kong, Fan Yang, Juan Song, Yi-Fan Ruan, Shan-Shan Li, Zhao-Shuai Gao, Bin Kang*, Jing-Juan Xu*, Hong-Yuan Chen, Revealing transient events of molecular recognition via super-localization imaging of single-particle motion, Sci. Reports, 2019, 9(1):4870. DOI: 10.1038/s41598-019-41239-5
56.Kai Zhang, Xue-Jiao Yang, Ting-Ting Zhang, Xiang-Ling Li,* Hong-Yuan Chen and Jing-Juan Xu*, RNA chaperone induced annealing towards: oligouridylated RNA detection in cancer cells, Analyst 2019, 144, 186 – 190; DOI: 10.1039/C8AN01662C
57.Xiao-Lei Huo, Nan Zhang, Jing-Juan Xu*, Hong-Yuan Chen, Ultrasensitive Electrochemiluminescence Immunosensor with Wide Linear Range Based on Multiple Amplification Approach, Electrochem Commun 2019, 98, 33-37DOI: 10.1016/j.elecom.2018.11.014
58.Xiao-Hong Wang, Miao Zhang, Xiao-Lei Huo, Wei Zhao, Bing Kang*, Jing-Juan Xu*, Hong-Yuan Chen, Modulating electronic structure of semiconductor to optimize its electrochemiluminescence performance, Nanoscale Advances, 2019, 1, 1965 – 1969.DOI: 10.1039/C9NA00011A
2018
59.Hong Zhou,¹Jing Liu,¹Jing-Juan Xu,²* Shusheng Zhang¹* and Hong-Yuan Chen², Optical Nano-Biosensing Interface via Nucleic Acid Amplification Strategy: Construction and Application, Chem Soc Rev, 2018, 47, 1996- 2019
60.Pei Song^?, Jian-Hua Wang^?, Miao Zhang, Fan Yang, Hai-Jie Lu, Bin Kang*, Jing-Juan Xu*, Hong-Yuan Chen*, Three-level spaser for next generation luminescent nanoprobe, Sci Adv4, eaat0292 (2018).doi: 10.1126/sciadv.aat0292
61.Juan Song,^?Cong-Hui Xu,^?Shi-Zhen Huang, Wen Lei, Yi-Fan Ruan, Hai-Jie Lu, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen, Ultra-small nanopipette: toward single cell hydrogen peroxide analysis with temporal and spatial resolution, Angew. Chem. Int. Ed. 2018, 57, 13226 –13230 DOI: 10.1002/anie.
62.Meng-Jiao Zhu, Jian-Bin Pan, Zeng-Qiang Wu, Xiao-Yu Gao, Wei Zhao*, Xing-Hua Xia, Jing-Juan Xu* and Hong-Yuan Chen, Electrogenerated Chemiluminescence Imaging of Electrocatalysis at Single Au-Pt Janus Nanoparticle,Angew. Chem. Int. Ed.2018, 57, 4010 –4014（10.1002/anie.）
63.Mei-Xing Li,^?Cong-Hui Xu,^?Nan Zhang, Guang-Sheng Qian, Wei Zhao,* Jing-Juan Xu* and Hong-Yuan Chen, An Exploration of the Kinetics of Toehold Mediated Strand Displacement via Plasmon Rulers, ACS Nano2018, 12, 3341-3350 DOI: 10.1021/acsnano.7b08673
64.Ting-Ting Zhang,^?Cong-Hui Xu,^?Wei Zhao, Yu Gu, Xiang-Ling Li*, Jing-Juan Xu*, Hong-Yuan Chen, Redox-Activated Theranostic Nanoagent: Toward Multi-Mode Imaging Guided Chemo-Photothermal Therapy, Chem Sci 2018, 9, 6749 – 6757, DOI: 10.1039/C8SC02446D
65.Fan Yang, He Gao, Shan-Shan Li, Rui-Bing An, Xiao-Yang Sun, Bin Kang*, Jing-Juan Xu*, Hong-Yuan Chen, Quantitative Imaging of Ultra-trace Endogenous Hydrogen Polysulfide via τ-probe: In Cells and in Vivo, Chem Sci2018, 9, 5556 – 5563
66.Yu Gu, Ting-Ting Zhang, Zhi-Feng Huang, Shan-Wen Hu, Wei Zhao*, Jing-Juan Xu* and Hong-Yuan Chen, An Exploration of Nucleic Acid Liquid Biopsy Using Glucose Meter, Chem Sci2018, 9, 3517 – 3522
67.Mei-Xing Li,^?Wei Zhao,^?Hui Wang, Xiang-Ling Li, Cong-Hui Xu,* Hong-Yuan Chen and Jing-Juan Xu*, Dynamic Single Molecular Rulers: Toward Quantitative Detection of MicroRNA-21 in Living Cells, Anal Chem2018, 90, 14255-14259DOI: 10.1021/acs.analchem.8b03322
68.Xiao-Lei Huo, Nan zhang, Hui Yang, Hong-Yuan Chen, Jing-Juan Xu*, Electrochemiluminescence Resonance Energy Transfer System for Dual-Wavelength Ratiometric miRNA Detection, Anal Chem2018, 90, 13723?13728DOI: 10.1021/acs.analchem.8b04141
69.Hai-Jie Lu¹, Jian-Bin Pan¹, Yin-Zhu Wang¹, Si-Yuan Ji¹, Wei Zhao^1,*, Xi-Liang Luo², Jing-Juan Xu^1,*, Hong-Yuan Chen¹, Electrocheminescence Energy Resonance Transfer System between RuSi Nanoparticles and Hollow Au Nanocages for Nucleic Acid Detection, Anal. Chem., 2018, 90 (17), 10434–10441DOI: 10.1021/acs.analchem.8b02347
70.Xue-Jiao Yang, Kai Zhang, Hong-Yuan Chen, Jing-Juan Xu,¹²* In Situ Visualization of hERG Potassium Channel via Dual Signal Amplification, Anal Chem 2018, 90 (10), 6199–6205
71.Shan-Shan Li, Qing-Ying Kong, Miao Zhang, Fan Yang, Bin Kang,* Jing-Juan Xu,* and Hong-Yuan Chen*, Plasmon-Resonance-Energy-Transfer-Based Spectroscopy on Single Nanoparticles: Biomolecular Recognition and Enzyme Kinetics, Anal Chem2018, 90 (6), 3833–3841
72.Yin-Zhu Wang, Si-Yuan Ji, Heng-Yu Xu, Wei Zhao*, Hong-Yuan Chen and Jing-Juan Xu*, Bidirectional electrochemiluminescence color switch: An application in detecting multi-markers of prostate cancer, Anal Chem 2018, 90 (5), 3570–3575
73.Nan Zhang, Yi-Fan Ruan, Li-Bin Zhang, Wei-Wei Zhao*, Jing-Juan Xu*, and Hong-Yuan Chen*, Nanochannels Photoelectrochemical Biosensor, Anal Chem2018, 90 (3), 2341–2347
74.Mei-Xing Li, Qiu-Mei Feng, Zhen Zhou, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen, Plasmon-Enhanced Electrochemiluminescence for Nucleic Acid Detection Based on Gold Nanodendrites,Anal Chem2018, 90, 1340–1347
75.Jin-Wen Shangguan, Yu Liu, Sha Wang, Yun-Xuan Hou, Bi-Yi Xu*, Jing-Juan Xu* and Hong-Yuan Chen, Paper Capillary Empowered Microfluidic Paper Analytical Devices, ACS Sensors 2018, 3 (7), 1416–1423110.1021/acssensors.8b00335
76.Siyuan Ji,^abTongtong Li,^aZhi-Da Gao,^aYan-Yan Song *^aand Jing-Juan Xu*^b, Boosting the oxygen evolution reaction performance of CoS₂microspheres by subtle ionic liquid modification,Chem Commun2018, 54, 8765-8768 DOI: 10.1039/c8cc05352a
77.Xiao-Lei Huo, Hui Yang, Mei-Xing Li, Wei Zhao, Jing-Juan Xu*, Ying Wang*, Xi-Liang Luo, Hong-Yuan Chen, Multi-Segmented CdS-Au Nanorods for Electrochemiluminescence Bioanalysis, Nanoscale, 2018, 10, 19224 - 19230 DOI: 10.1039/C8NR06956E
78.Hai-Jie Lu, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen, Visual electrochemiluminescence ratiometry on bipolar electrode for bioanalysis, Biosens Bioelectron,2018, 102, 624-630
79.Qiu-Mei Feng^a,b, Yue-Hua Guo^b, Jing-Juan Xu^b,*, Hong-Yuan Chen^b, A surface-confined DNA assembly amplification strategy on DNA nanostructural scaffold for electrochemiluminescence biosensing, Biosens Bioelectron,2018, 100, 571 – 576
80.Mei-Xing Li¹, Nan Zhang¹, Wei Zhao^1,*, Xi-Liang Luo², Hong-Yuan Chen¹, Jing-Juan Xu^1,* Ultrasensitive detection of microRNA-21 based on plasmon coupling induced electrochemiluminescence enhancement, Electrochem Commun 2018, 94: 36-40
81.Shan-Wen Hu¹, Shu Qiao¹, Jian-Bin Pan¹, Bin Kang¹*, Maili Liu², Jing-Juan Xu¹*, Hong-Yuan Chen¹，A paper-based SERS chip Test Strip for quantitative detection of Mucin-1 in whole blood，Talanta, 2018, 179, 9-14
82.Tao Yu, Wei Zhao*, Jing-Juan Xu* and Hong-Yuan Chen, A PCR-free colorimetric strategy for visualized assay of telomerase activity, Talanta, 2018, 178, 594 - 599
2017
83.Yizhong Shen,Yidan Sun, Runqi Yan, Erquan Chen, Huan Wang, Deju Ye*, Jing-Juan Xu*, Hong-Yuan Chen*, Rational engineering of semiconductor QDs enabling remarkable 1O2 production for tumor-targeted photodynamic therapy, Biomaterials, 2017, 148, 31-4084.Shan-Shan Li,^⊥Qi-Yuan Guan,^⊥Mengmeng Zheng,^⊥Yu-Qi Wang, Deju Ye, Bin Kang,* Jing-Juan Xu,* and Hong-Yuan Chen*, Simultaneous quantification of multiple endogenous biothiols in single living cells by plasmonic Raman probes, Chem Sci, 2017, 8, 7582 - 758785.Kai Zhang, Xue-Jiao Yang, Wei Zhao,* Ming-Chen Xu, Jing-Juan Xu*, and Hong-Yuan Chen, Regulation and Imaging of Gene Expression via an RNA Interference Antagonistic Biomimetic Probe, Chem Sci, 2017, 8, 4973 – 497786.Bing Kang, Shan-Shan Li, Qi-Yuan Guan, Ai-Ping Chen, Pan-Ke Zhang, Li-Bin Zhang, Ji-Wu Wei, Jing-Juan Xu,*, Hong-Yuan Chen,*Plasmon-enhanced Raman spectroscopic metrics for in situ quantitative and dynamic assays of cell apoptosis and necrosis, Chem Sci,2017, 8, 1243 - 1250 87.Linfeng Sheng, Lesi Cai, Jie Liu, Sichun Zhang, Jing-Juan Xu,* Xinrong Zhang,* Hong-Yuan Chen, Imaging specific newly synthesized proteins within cells by fluorescence resonance energy transfer, Chem Sci,2017, 8, 748 – 75488.Yu Gu¹, Juan Song¹, Mei-Xing Li¹, Ting-Ting Zhang¹, Wei Zhao¹*, Jing-Juan Xu¹*, Maili Liu²and Hong-Yuan Chen¹, Ultrasensitive MicroRNA Assay via Surface Plasmon Resonance Responses of Au@Ag Nanorods Etching, Anal Chem,2017, 89 (19), 10585–**.Fan Yang, Ting-Ting Zhang, Shan-Shan Li, Pei Song, Kai Zhang, Qi-Yuan Quan,Bin Kang*, Jing-Juan Xu*, Hong-Yuan Chen,Endogenous MicroRNA-Triggered and Real-Time Monitored Drug Release via Cascaded Energy Transfer Payloads，Anal Chem,2017, 89 (19),10239–**.Yin-Zhu Wang, Cong-Hui Xu, Wei Zhao*, Qi-Yuan Guan, Hong-Yuan Chen, Jing-Juan Xu*，Bipolar Electrode based Multicolor Electrochemiluminescence Biosensor，Anal Chem，2017, 89 (15), 8050–8056191.Yi-Fan Ruan, Nan Zhang, Yuan-Cheng Zhu, Wei-Wei Zhao*, Jing-Juan Xu* and Hong-Yuan Chen, Photoelectrochemical Bioanalysis Platform of Gold Nanoparticles Equipped Perovskite Bi₄NbO₈Cl, Anal Chem2017, 89 (15), 7869–787592.Xue-Jiao Yang, Kai Zhang, Ting-Ting Zhang, Jing-Juan Xu,* Hong-Yuan Chen, Reliable Fo?rster Resonance Energy Transfer Probe Based on Structure-Switching DNA for Ratiometric Sensing of Telomerase in Living Cells, Anal Chem2017, 89 (7), 4216–4222 93.Shan-Wen Hu, Shu Qiao, Bi-Yi Xu*, Xiang Peng, Jing-Juan Xu*, Hong-Yuan Chen, Dual-functional carbon dots pattern on paper chips for Fe³⁺and ferritin analysis in whole blood, Anal Chem2017, 89, 2131–213794.Jun Hu, Qi-Yuan Guan, Jiang Wang, Xiao-Xiao Jiang, Zeng-Qiang Wu, Xing-Hua Xia, Jing-Juan Xu*, Hong-Yuan Chen, Effect of Nanoemitters on Suppressing the Formation of Metal Adduct Ions in Electrospray Ionization Mass Spectrometry,Anal Chem2017, 89, 1838–1845 95.Ting-Ting Zhang, Fan Yang, Xiang-ling Li, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen, A multifunctional silver nanocomposite for the apoptosis of cancer cell and intracellular imaging, Chem Commun2017, 53, 5614 - 561796.Quang-Sheng Qian, Ting-Ting Zhang, Wei Zhao*, Jing-Juan Xu*, and Hong-Yuan Chen, Single-Molecule Imaging of Telomerase Activity via Linear Plasmon Rulers, Chem Commun,2017,53, 4710 - 471397.Xiao-Lei Huo, Hui Yang, Wei Zhao, Jing-Juan Xu*, Hong-Yuan Chen, Nanopore-Based Electrochemiluminescence for Detection of microRNAs via Duplex-Specific Nuclease-Assisted Target Recycling,ACS Appl. Mater. Interfaces, 2017, 9 (38), 33360–**.Qiu-Mei Feng,¹²Yue-Hua Guo,²Jing-Juan Xu,²* and Hong-Yuan Chen², Self-Assembled DNA Tetrahedral Scaffolds for the Construction of Electrochemiluminescence Biosensor with Programmable DNA Cyclic Amplification, ACS Appl. Mater. Interfaces, 2017, 9 (20), 17637–1764499.Bin Kang, Ming-Bo Zheng, Pei Song, Ai-ping Chen, Ji-Wu Wei, Jing-Juan Xu*, Yi Shi*, Hong-Yuan Chen*, Subcellular-Scale Drug Transport via Ultrasound-Degradable Mesoporous Nanosilicon to Bypass Cancer Drug Resistance, Small2017, .Jin-Wen Shangguan, Yu Liu, Jian-Bin Pan, Bi-Yi Xu*, Jing-Juan Xu*, Hong-Yuan Chen, Microfluidic PDMS on Paper (POP) Devices, Lab Chip, 2017, 17, 120-127101.Yuan-Cheng Zhu, Fei Xu, Nan Zhang, Wei-Wei Zhao,* Jing-Juan Xu* and Hong-Yuan Chen, DNA Sequence Functionalized with Heterogeneous Core?Satellite Nanoassembly for Novel Energy-Transfer-Based Photoelectrochemical Bioanalysis, Biosens Bioelectron,2017,91, 293–298102.Qiu-Mei Feng, Zhen Zhou, Mei-Xing Li, Wei Zhao*, Jing-Juan Xu*, and Hong-Yuan Chen, DNA tetrahedral scaffolds-based platform for the construction of electrochemiluminescence biosensor, Biosens Bioelectron,2017, 90, 251-257
2016
103.Xiang-Ling Li, Zhuo-Lei Zhang, Wei Zhao*, Xing-Hua Xia, Jing-Juan Xu*, Hong-Yuan Chen, Oriented Assembly of Invisible Probes: Towards Single mRNA Imaging in Living Cells,Chem Sci, 2016, 7, 3256 - 3263104.Hai-Wei Shi, Wei Zhao*, Zhen Liu, Xi-Cheng Liu, Jing-Juan Xu*, and Hong-Yuan Chen, A Temporal Sensing Platform Based on Bipolar Electrode for the Ultra-sensitive Detection of Cancer Cell, Anal Chem2016, 88, 8795?8801105.Jun Hu, Xiao-Xiao Jiang, Jiang Wang, Qi-Yuan Guan, Pan-Ke Zhang, Jing-Juan Xu*, Hong-Yuan Chen, Synchronized Polarization Induced Electrospray: Comprehensively Profiling Biomolecules in Single Cells by Combining both Positive-ion and Negative-ion Mass Spectra, Anal Chem,2016, 88, 7245–**.Yuan-Cheng Zhu, Nan Zhang, Yi-Fan Ruan, Wei-Wei Zhao*, Jing-Juan Xu*, and Hong-Yuan Chen, Alkaline Phosphatase Tagged Antibodies on Gold Nanoparticles/TiO2 Nanotubes Electrode: A Plasmonic Strategy for Label-Free and Amplified Photoelectrochemical Immunoassay, Anal Chem,2016, 88, 5626–**.Huai-Rong Zhang^?, Yin-Zhu Wang^?, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen, Visual Color-Switch Electrochemiluminescence Biosensing of Cancer Cell Based on Multichannel Bipolar Electrode Chip, Anal Chem,2016, 88, 2884–**.Qiu-Mei Feng,¹Yi-Zhong Shen,¹Mei-Xing Li¹, Zhuo-Lei Zhang, Wei Zhao*, Jing-Juan Xu* and Hong-Yuan Chen, Dual-wavelength electrochemiluminescence ratiometry based on resonance energy transfer between Au nanoparticles functionalized g-C₃N₄nanosheet and Ru(bpy)₃²⁺for microRNA detection, Anal Chem,2016, 88, 937–944109.Tao Yu, Pan-Pan Dai, Jing-Juan Xu* and Hong-Yuan Chen*, Highly sensitive Colorimetric Cancer Cell Detection Based on dual Signal Amplification, ACS Appl. Mater. Interfaces 2016, 8 (7), 4434–**.Peng Wu, Xiandeng Hou, Jing-Juan Xu,* Hong-Yuan Chen,^*Ratiometric Fluorescent, Electrochemiluminescent, and Photoelectrochemical Chemo/Biosensing based on Semiconductor Quantum Dots, Nanoscale2016, 8, 8427 - **.Mei-Xing Li, Wei Zhao*, Guang-Sheng Qian, Qiu-Mei Feng, Jing-Juan Xu* and Hong-Yuan Chen,Distance Mediated Electrochemiluminescence Enhancement of CdS Thin Film Induced by the Plasmon Coupling of Gold Nanoparticle Dimer, Chem Commun2016, 52, 14230 - **.Guang-Sheng Qian, Bin Kang, Zhuo-Lei Zhang, Xiang-Ling Li, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen，Plasmonic Nanohalo Optical Probes for Highly Sensitive Imaging Survivin mRNA in Living Cells，Chem Commun, 2016, 52, 11052-11055 (Cover paper)113.Fei Xu^?, Yuan-Cheng Zhu^?, Zheng-Yuan Ma, Wei-Wei Zhao*, Jing-Juan Xu* and Hong-Yuan Chen, An Ultrasensitive Energy-transfer Based Photoelectrochemical Protein Biosensor, Chem Commun, 2016, 52, 3034-3037114.Yin-Zhu Wang, Wei Zhao*, Pan-Pan Dai, Hai-Jie Lu, Jing-Juan Xu,* and Hong-yuan Yuan Chen, Spatial-resolved electrochemiluminescence ratiometry based on bipolar electrode for bioanalysis, Biosens Bioelectron,2016, 86, 683-689115.Yingshu Guo, Yujie Wang, Guangxu Yang,Jing-Juan Xu* and Hong-Yuan Chen,MicroRNA-Mediated Signal Amplification Coupled with GNP/dendrimers on a Mass-Sensitive Biosensor and its Application in Intracellular MicroRNA QuantificationBiosens Bioelectron, 2016, 85, 897–902116.Yin-Zhu Wang, Nan Hao, Qiu-Mei Feng, Hai-Wei Shi, Jing-Juan Xu,*and Hong-Yuan Chen, A ratiometric electrochemiluminescence detection for cancer cells using g-C₃N₄nanosheets and Ag-PAMAM-luminol nanocomposites, Biosens Bioelectron, 2016, 77, 76-82
2015

117.Wei-Wei Zhao, Jing-Juan Xu* and Hong-Yuan Chen*, Photoelectrochemical bioanalysis: the state of the art, Chem Soc Rev, 2015, 44, 729-741118.Peng Wu, Chaoying Xu, Xiandeng Hou, Jing-Juan Xu,* Hong-Yuan Chen*, Dual-emitting quantum dots nanohybrid for imaging of latent fingerprints: simultaneous identification of individuals and traffic light-type visualization of TNT, Chem Sci,2015, 6, 4445 - 4450119.Pan-Pan Dai, Tao Yu, Hai-Wei Shi, Jing-Juan Xu*, Hong-Yuan Chen*, General strategy for enhancing electrochemiluminescence of semiconductor nanocrystals by hydrogen peroxide and potassium persulfate as dual coreactants, Anal Chem, 2015, 87 (24), 12372–**.Wei-Wei Zhao, Jing Wang, Yuan-Cheng Zhu, Jing-Juan Xu,* and Hong-Yuan Chen*, Quantum Dots: Electrochemiluminescent and Photoelectrochemical Bioanalysis, Anal Chem (feature article) 2015, 87 (19), 9520–**.Wei-Wei Zhao, Ying-Mei Han, Yuan-Cheng Zhu, Nan Zhang, Jing-Juan Xu* and Hong-Yuan Chen*, DNA Labeling Generates a Unique Amplification Probe for Sensitive Photoelectrochemical Immunoassay of HIV-1 p24 Antigen,Anal Chem, 2015, 87 (11), 5496–**.Mei-Sheng Wu, Zhen Liu, Hai-Wei Shi, Hong-Yuan Chen, Jing-Juan Xu*, Visual Electrochemiluminescence Detection of Cancer Biomarkers on a Closed Bipolar Electrode Array Chip, Anal Chem2015, 87 (1), 530–537123.Peng Wu, Jian-Bing Pan, Xiang-Ling Li, Xiandeng Hou, Jing-Juan Xu,* and Hong-Yuan Chen*, Long-Lived Charge Carriers in Mn-doped CdS Quantum Dots for Photoelectrochemical Cytosensing, Chem Eur J2015, 21, 5129-5135 124.Mei-Sheng Wu, Xiao-Tao Sun, Meng-Jiao Zhu, Hong-Yuan Chen, Jing-Juan Xu*, Mesoporous silica film-assisted amplified electrochemiluminescence for cancer cell detectionChem Commun, 2015, 51, 14072 - **.Nan Hao, Pan-Pan Dai, Tao Yu, Jing-Juan Xu* and Hong-Yuan Chen*, A dual target- recycling amplification stragtegty for sensitive detection of microRNAs based on duplex-specific nuclease and catalytic hairpin assembly, Chem Commun, 2015, 51, 13504 - 13507126.Jing Wang, Xiang-Ling Li, Jia-Dong Zhang, Nan Hao, Jing-Juan Xu* and Hong-Yuan Chen*, Integration of DNA bio-gates and duplex-specific nuclease signal amplification: towards electrochemiluminescence detection of survivin mRNA, Chem Commun2015, 51, 11673 - **.Zheng-Yuan Ma, Yi-Fan Ruan, Nan Zhang, Wei-Wei Zhao, Jing-Juan Xu* and Hong-Yuan Chen*, A new visible-light-driven photoelectrochemical biosensor for probing the DNA-protein interactions, Chem Commun2015, 51, 8381 - **.Yingshu Guo, Jia liu, Guangxu Yang, Xiaofeng Sun, Hong-Yuan Chen, Jing-Juan Xu*, Multiple turnovers of DNAzyme for amplified detection of ATP and reduced thiol in cell homogenates, Chem Commun2015, 51 (5), 862 - 865129.Yan-Yan Zhang¹, Qiu-Mei Feng¹, Jing-Juan Xu* and Hong-Yuan Chen, Silver Nanoclusters for High-Efficiency Quenching of CdS Nanocrystal Electrochemiluminescence and Sensitive Detection of microRNA, ACS Appl. Mater. Interfaces, 2015, 7 (47), 26307–26314130.Shan-Wen Hu, Bi-Yi Xu, Wei-ke Ye, Xing-Hua Xia, Hong-Yuan Chen, Jing-Juan Xu*, Versatile microfludic droplets array for bioanalysis, ACS Appl Mater Inter 2015, 7 (1), 935–940131.Xiao-Rong Li, Ming-Chen Xu, Hong-Yuan Chen, Jing-Juan Xu,* Bimetallic Au@Pt@Au core-Shell nanoparticles on graphene oxide nanosheets for high-performance H₂O₂bi-directional sensing, J Mater Chem B2015, 3, 4355- 4362
2014

132.Peng Wu, Xiandeng Hou, Jing-Juan Xu,* and Hong-Yuan Chen*, Electrochemically-generated versus Photo-excited Luminescence from Semiconductor Nanomaterials: Bridging the Valley between Two Worlds, Chem Rev2014, 114 (21), 11027–11059133.Wei-Wei Zhao, Jing-Juan Xu* and Hong-Yuan Chen*, Photoelectrochemical DNA biosensors, Chem Rev, 2014, 114, 7421?7441134.Jing-Juan Xu, Wei-Wei Zhao, Shi-Ping Song, Chun-Hai Fan* and Hong-Yuan Chen*, Functional nanoprobes for ultrasensitive detection of biomolecules: an update, Chem Soc Rev, 2014, 43, 1.Wei-Wei Zhao, Ru Chen, Pan-Pan Dai, Xiang-Ling Li, Jing-Juan Xu* and Hong-Yuan Chen*, A General Strategy for Photoelectrochemical Immunoassay Using an Enzyme Label Combined with a CdS Quantum Dot/TiO₂Nanoparticle Composite Electrode,Anal Chem2014, 86 (23), 11513–**.Xiang-Ling Li, Nan Hao, Hong-Yuan Chen, Jing-Juan Xu,* Tumor Marker Mediated “on-demand” Drug Release and Real-Time Monitoring System Based on Multifunctional Mesoporous Silica Nanoparticles, Anal Chem2014, 86 (20), 10239–**.Yan-Yan Zhang, Hong Zhou, Peng Wu, Huai-Rong Zhang, Jing-Juan Xu,* and Hong-Yuan Chen, In Situ Activation of CdS Electrochemiluminescence Film and Its Application in H₂S Detection, Anal Chem2014, 86 (17), 8657–**.Mei-Sheng Wu, Li-Jing He, Jing-Juan Xu*, Hong-Yuan Chen, RuSi@Ru(bpy)₃²⁺/ Au@Ag₂S nanoparticles Electrochemiluminescence Resonance Energy Transfer System for Sensitive DNA detection, Anal Chem2014, 86 (9), 4559–**.Huai-Rong Zhang, Mei-Sheng Wu, Jing-Juan Xu,* and Hong-Yuan Chen, Signal-on dual-potential electrochemiluminescence based on luminol-Au bifunctional nanoparticles for telomerase detection, Anal Chem2014, 86 (8), 3.Nan Hao, Xiang-Ling Li, Huai-Rong Zhang, Jing-Juan Xu* and Hong-Yuan Chen*, Highly sensitive ratiometric electrochemiluminescence biosensor for microRNAs detection based on cyclic enzyme amplification and resonance energy transfer, Chem Commun2014, 50 (94), 14828 - **.Huai-Rong Zhang, Yin-Zhu Wang, Mei-Sheng Wu, Qiu-Mei Feng, Hai-Wei Shi, Hong-Yuan Chen, Jing-Juan Xu*, Visual Electrochemiluminescence Detection of Telomerase Activity Based on Multifunctional Au Nanoparticles modified with G-quadruplexes Deoxyribozymes and Luminol, Chem Commun2014, 50 (83), 12575 - **.Zheng-Yuan Ma, Jian-Bin Pan, Cai-Yu Lu, Wei-Wei Zhao,Jing-Juan Xu* and Hong-Yuan Chen*, Folding-based Photoelectrochemical Biosensor: Binding-induced Conformation Change of QDs-tagged DNA probe for Mercury(Ⅱ) Detection, Chem Commun2014, 50 (81), 12088 - **.Qiu-Mei Feng, Jian-Bin Pan, Huai-Rong Zhang, Jing-Juan Xu*, Hong-Yuan Chen, Disposable paper-based electrochemiluminescence on bipolar electrodes for sensitive detection of cancer biomarker, Chem Commun2014, 50 (75), 10949 - 10951(highlighted as cover)144.Meng Xiong, Nan Hao, Tao Yu, Jing-Juan Xu*, Hong-Yuan Chen*, Photopatterning poly(N-isopropylacrylamide) membrane in microfluidic chip for high-level enrichment and efficient release of DNA molecules, Chem Commun2014, 50 (71), 10303 - **.Zong-Hua Wang, Cai-Yu Lu, Jing Liu, Jing-Juan Xu*, Hong-Yuan Chen, Improved G-quadruplex DNAzyme for dual-functional electrochemical biosensing of ATP and hydrogen peroxide from cancer cells, Chem Commun2014, 50, 1178-1180 (highlighted as back cover)146.Li Deng, Ying Du, Jing-Juan Xu*, Hong-Yuan Chen, An off-on-off electrochemiluminescence approach for ultrasensitive detection of thrombin, Biosens Bioelectron2014, 59, 58–63147.Hai-Wei Shi, Mei-Sheng Wu, Ying Du, Jing-Juan Xu*, Hong-Yuan Chen, Electrochemiluminescence Aptasensor Based on Bipolar Electrode for Detection of Adenosine in Cancer Cells, Biosens Bioelectron2014, 55, 459-463148.Xiao-Rong Li, Xiang-Ling Li, Ming-Chen, Xu, Jing-Juan Xu* Hong-Yuan Chen, Gold nanodendrities on graphene oxide nanosheets for oxygen reduction reaction, J. Mater. Chem. A, 2014, 2 (6), 1697- 1703(highlighted as back cover)149.Jing Liu, Cai-Yu Lu, Hong Zhou, Jing-Juan Xu*, Hong-Yuan Chen, Flexible Microchip Electrode Array for Multiplexed Immunoelectrochemical Measurement of three Protein Biomarkers for Prostate Cancer ACS Applied Mater Interfaces2014, 6 (22), 20137–**.Nan Hao, Jin-Yi Li, Meng Xiong, Xing-Hua Xia, Jing-Juan Xu* and Hong-Yuan Chen*, A graphene oxide/poly(dimethylsiloxane) composite for remote control of localized wettability, ACS Appl Mater Interfaces2014, 6 (15): 11869–11873
2013
151.Mei-Sheng Wu, Da-Jing Yuan, Jing-Juan Xu*, Hong-Yuan Chen, Electrochemiluminescence on Bipolar Electrodes for Visual Bioanalysis, Chem Sci2013, 4 (3), 1182 - **.Xiang-Ling Li, Shu Shan, Meng Xiong, Jing-Juan Xu*, Hong-Yuan Chen, On-chip Selective Capture of Cancer Cells and Ultrasensitive Fluorescence Detection of Survivin mRNA in single Living Cells, Lab Chip2013, 13 (19), 3868 - **.Bi-Yi Xu, Shan-Wen Hu, Guang-Sheng Qian, Jing-Juan Xu*, Hong-Yuan Chen*, A novel microfluidic platform with stable concentration gradient for on chip cell culture and screening assays, Lab Chip2013, 13 (18), 3714 - **.Wei-Wei Zhao, Shu Shan, Zheng-Yuan Ma, Lin-Na Wan, Jing-Juan Xu* and Hong-Yuan Chen*, Acetylcholine Esterase Antibodies on BiOI Nanoflakes/TiO₂Nanoparticles Electrode: A Case of Application for General Photoelectrochemical Enzymatic Analysis, Anal Chem2013, 85 (24), 11686–**.Nan Hao, Meng Xiong, Jia-dong Zhang, Jing-Juan Xu* and Hong-Yuan Chen*, A portable thermo-powered high-throughput visual electrochemiluminescence sensor, Anal Chem2013, 85 (24), pp 11715–11719 (highlighted as cover)156.Mei-Sheng Wu, Da-Jing Yuan, Jing-Juan Xu*, Hong-Yuan Chen, Sensitive Electrochemiluminescence Biosensor Based on Au-ITO Hybrid Bipolar Electrode Amplification System for Cell Surface Protein Detection, Anal Chem2013, 85 (24), 11960–**.Wei-Wei Zhao, Zheng-Yuan Ma, Jing-Juan Xu* and Hong-Yuan Chen*, In Situ Modification of Semiconductor Surface by an Enzymatic Process: A General Strategy for Photoelectrochemical Bioanalysis, Anal Chem2013, 85 (18), 8503–8506 158.Huai-Rong Zhang, Jing-Juan Xu*, Hong-Yuan Chen, Electrochemiluminescence Ratiometry: A New Approach to DNA Biosensing, Anal Chem2013, 85, 5321–**.Jing Liu, Cai-Yu Lu, Hong Zhou, Jing-Juan Xu*, Zong-Hua Wang, Hong-Yuan Chen*, Dual-functional electrochemical biosensor for the detection of prostate specific antigen and telomerase activity, Chem Commun 2013, 49, 6602 - **.Hong Zhou, Yan-Yan Zhang, Jing Liu, Jing-Juan Xu* and Hong-Yuan Chen, Efficient quenching of Electrochemiluminescence from K-doped graphene-CdS:Eu NCs by G-quadruplexes/hemin and target recycling-assisted amplification for ultrasensitive DNA biosensing, Chem Commun 2013, 49, 2.Li-Jing He, Mei-Sheng Wu, Jing-Juan Xu*, Hong-Yuan Chen*, Reusable Potassium Ion Biosensor based on Electrochemiluminescence Resonance Energy Transfer, Chem Commun 2013, 49, 1.Fen-Ying Kong, Bi-Yi Xu, Ying Du, Jing-Juan Xu* and Hong-Yuan Chen, A branched electrode based electrochemical platform: towards new label-free and reagentlessly simultaneous detection of two biomarkers, Chem Commun2013, 49, 1052-1054 (cover feature)163.Jing Wang, Wei-Wei Zhao, Hong Zhou, Jing-Juan Xu* and Hong-Yuan Chen, Amplified Electrochemiluminescence Detection of DNA-binding Protein Interactions Based on the Synergy Effect of Electron and Energy Transfer Between CdS Nanocrystals and Gold Nanoparticles, Biosens Bioelectron2013, 41, 615–620164.Fen-Ying Kong, Bi-Yi Xu, Jing-Juan Xu*, Hong-Yuan Chen, Simultaneous electrochemical immunoassay using quantum dots/DNA nanochains as labels, Biosens Bioelectron2013, 39, 177–182
2012
165.Xiao-Rong Li , Fen-Ying Kong , Jing Liu , Tong-Ming Liang , Jing-Juan Xu*, Hong-Yuan Chen，Synthesis of Potassium-Doped Graphene and Its Application in Nitrite Selective Sensing, Adv Funct Mater 2012, 22: 1.Bi-Yi Xu, Shan-Wen Hu, Xiao-Na Yan, Xing-Hua Xia, Jing-Juan Xu*, Hong-Yuan Chen, On chip steady liquid-gas phase separation for flexible generation of dissolved gas concentration gradient,Lab Chip, 2012, 12 (7), 1281 - 1288
167.Bi-Yi Xu, Xiao-Na Yan, Jia-Dong Zhang, Jing-Juan Xu*, Hong-Yuan Chen, Glass over-etching to bridge micro- and nanofluidics,Lab Chip, 2012, 12, 381–386168.Wei-Wei Zhao, Zheng-Yuan Ma, Dong-Yang Yan, Jing-Juan Xu* and Hong-Yuan Chen, In situ Enzymatic Ascorbic Acid Production as Electron Donor for CdS Quantum Dots Equipped TiO₂Nanotubes: A General and Efficient Approach for New Photoelectrochemical Immunoassay,Anal Chem,2012, 84 (24), 10518–**.Wei-Wei Zhao, Pei-Pei Yu, Yun Shan, Jing Wang, Jing-Juan Xu* and Hong-Yuan Chen, Exciton-Plasmon interactions between CdS Quantum Dots and Ag Nanoparticles in Photoelectrochemical system and its biosensing application, Anal Chem2012, 84(14), 5892-5897 170.Mei-Sheng Wu, Guang-sheng Qian, Jing-Juan Xu*, Hong-Yuan Chen,Sensitive Electrochemiluminescence Detection of c-Myc mRNA in Breast Cancer Cells on a Wireless Bipolar Electrode, Anal Chem 2012, 84, 5407–5414171.Mei-Sheng Wu, Hai-Wei Shi, Li-Jing He, Jing-Juan Xu*, Hong-Yuan Chen, Microchip Device with 64-site Electrode Array for Multiplexed Immunoassay of Cell Surface Antigens based on Electrochemiluminescence Resonance Energy Transfer, Anal Chem2012, 84 (9), 4207–**.Xian-Bo Zhang, Zeng-Qiang Wu, Kang Wang, Jie Zhu, Jing-Juan Xu,* Xing-Hua Xia*, Hong-Yuan Chen, Gravitational Sedimentation Induced Blood Delamination for Continuous Plasma Separation on a Microfluidics Chip,Anal Chem,2012, 84 (8), 3780–3786 173.Wei-Wei Zhao, Zheng-Yuan Ma, Pei-Pei Yu, Xiao-Ya Dong, Jing-Juan Xu* and Hong-Yuan Chen, Highly Sensitive Photoelectronchemical Immunoassay with Enhanced Amplification Using Horseradish Peroxidase Induced Biocatalytic Precipitation on a CdS Quantum Dots Multilayer Electrode, Anal Chem, 2012, 84, 917–923174.Bi-Yi Xu, Zhe-Qin Yang, Jing-Juan Xu*, Xing-Hua Xia, Hong-Yuan Chen*, Liquid-gas dual phase microfluidic system for continuous CaCO₃nanosphere particles generation and simultaneous fluorophore doping, Chem. Commun.,2012, 48, 11635–11637(cover feature)175.Wei-Wei Zhao, Long Zhang, Jing-Juan Xu*, Hong-Yuan Chen, Cell Surface Carbohydrates Evaluation via Photoelectrochemical Approach, Chem Commun 2012, 48 (76), 9456 - 9458 (cover featur5.856e)176.Chun-Yuan Tian, Jing-Juan Xu* and Hong-Yuan Chen, A novel aptasensor for the detection of adenosine in cancer cells by electrochemiluminescence of nitrogen doped TiO2 nanotubes, Chem Commun,2012, 48, 8234–**.Jing Wang, Wei-Wei Zhao, Xiao-Rong Li, Jing-Juan Xu* and Hong-Yuan Chen, Potassium-doped graphene enhanced electrochemiluminescence of SiO₂/CdS nanocomposites for highly sensitive detection of TATA-binding protein, Chem Commun,2012, 48 (51), 6429 - **.Wei-Wei Zhao,Xiao-Ya Dong, Jing Wang, Fen-Ying Kong, Jing-Juan Xu* and Hong-Yuan Chen*, Immunogold Labeling-Induced Synergy Effect for Amplified Photoelectrochemical Immunoassay of Prostate-Specific Antigen，Chem Commun2012, 48 (43), 5253 - 5255 (back cover feature)179.Wei-Wei Zhao, Chun-Yuan Tian, Jing-Juan Xu* and Hong-Yuan Chen, The Coupling of Localized Surface Plasmon Resonance-Based Photoelectrochemistry and Nanoparticle Size Effect: Towards Novel Plasmonic Photoelectrochemical Biosensing, Chem Commun2012, 48 (6), 895 - 897 180.Xiao-Ya Dong, Xiao-Na Mi, Long Zhang, Tong-Ming Liang, Jing-Juan Xu*, Hong-Yuan Chen, DNAzyme-functionalized Pt nanoparticles/carbon nanotubes for amplified sandwich electrochemical DNA analysis, Biosens Bioelectron2012, 38, 337–341181.Ping Tong, Wei-Wei Zhao, Lan Zhang*, Jing-Juan Xu*, Hong-Yuan Chen, Double-probe Signal enhancing Strategy for Toxin Aptasensing Based on Rolling Circle Amplification, Biosens Bioelectron2012, 33, 146– 151182.Li Deng, Yun Shan, Jing-Juan Xu*, Hong-Yuan Chen, Electrochemiluminescence Behaviors of Eu³⁺-Doped CdS Nanocrystals Film in Aqueous Solution, Nanscale2012,4, 831-836183.Hong Zhou, Yan-Yan Zhang, Jing Liu, Jing-Juan Xu*, Hong-Yuan Chen, Sensitive and selective DNA detection based on electrochemiluminescence resonance energy transfer between CdS:Eu nancrystals and Au nanorods, J Phys Chem C2012, 116 (33), pp 17773–17780
2011
184.Mei-Sheng Wu, Bi-Yi Xu, Hai-Wei Shi, Jing-Juan Xu*, Hong-Yuan Chen, Electrochemiluminescence analysis of folate receoptors on cell membrane with on-chip bipolar electrode, Lab Chip,2011, 11 (16), 2720 - 2724
185.Hong Zhou, Jing Liu, Jing-Juan Xu*, Hong-Yuan Chen, Highly Sensitive Electrochemiluminescence Detection of Single-Nucleotide Polymorphisms based on Isothermal Cycle-assisted Triple-stem Probe with Dual-nanoparticle Label, Anal. Chem., 2011, 83 (21), 8320–8328186.Jing Wang, Yun Shan, Wei-Wei Zhao, Jing-Juan Xu*, Hong-Yuan Chen, Gold Nanoparticle Enhanced Electrochemiluminescence of CdS Thin Films for Ultrasensitive Thrombin Detection, Anal. Chem.,2011, 83, 4004-4011 187.Wei-Wei Zhao, Jing Wang, Jing-Juan Xu* and Hong-Yuan Chen, Energy transfer between CdS quantum dots and Au nanoparticles in photoelectrochemical detection, Chem. Commun., 2011, 47 (39), 10990 - 10992188.Hong Zhou, Jing Liu, Jing-Juan Xu*, Hong-Yuan Chen, Ultrasensitive DNA detection based on Au nanoparticles and isothermal circular double-assisted electrochemiluminescence signal amplification,Chem. Commun., 2011, 47 (29), 8358 - 8360189.Mei-Sheng Wu, Hai-Wei Shi, Jing-Juan Xu* and Hong-Yuan Chen, CdS Quantum dots/ Ru(bpy)₃²⁺electrochemiluminescence resonance energy transfer system for sensitive cytosensing, Chem. Commun.2011, 47 (27), 7752 - 7754.190.Jing Liu, Hong Zhou, Jing-Juan Xu*, Hong-Yuan Chen,An Effective DNA-based Electrochemical Switch for Reagentless Detection of Living Cells,Chem. Commun., 2011, 47 (15), 4388 - **.Xiao-Ya Dong, Xiao-Na Mi, Wei-Wei Zhao, Jing-Juan Xu*, Hong-Yuan Chen, CdS Nanoparticles Functionalized Colloidal Carbon Nanoparticles: Preparation, Characterization and Application for Electrochemical Detection of Thrombin, Biosens. Bioelectron. 26 (2011) 3654–**.Ping Tong, Lan Zhang,* Jing-Juan Xu,* Hong-Yuan Chen, Simply Amplified Electrochemical Aptasensor of Ochratoxin A Based on Exonuclease-Catalyzed Target Recycle,Biosens. Bioelectron.,2011, 29, 97-101193.Shao-Peng Chen, Xiao-Dong Yu, Jing-Juan Xu* and Hong-Yuan Chen, Gold nanoparticles-coated magnetic microspheres as affinity matrix for detection of hemoglobin A1c in blood by microfluidic immunoassay, Biosens. Bioelectron.26 (2011) 4779– 4784
194.Yun Shan, Jing-Juan Xu* and Hong-Yuan Chen,Enhanced Electrochemiluminescence Quenching of CdS:Mn nanocrystals by CdTe QDs-doped Silica Nanoparticles for Ultrasensitive Detection of Thrombin, Nanoscale, 2011, 3, 2916-2923
195.Xiao-Rong Li, Bo Wang, Jing-Juan Xu*, Hong-Yuan Chen, In vitro detection of superoxide anion released from cancer cells based on potassium-doped carbon nanotubes-ionic liquid composite gels, Nanoscale, 2011, 3, 5026



课程名称、上课时间地点


研究生课程：电化学研究方法
授课对象：化院研一新生
授课时间：秋季学期

教学大纲、考试要求


授课形式和成绩考核授课形式：多媒体+专题讨论
成绩考核：平时成绩+ 专题演讲+ 期末论文


教学资源（上课讲义、参考资料等）


推荐使用的主要参考书1．A.J.Bard and L.R.Faulkner, Electrochemical methods, fundamentals and applications (2nd Edition), John Wiley & Sons, 2001
2. 阿伦.J.巴德，拉里.R.福克纳著，邵元华，朱果逸等译，电化学方法－原理和应用（第二版），化学工业出版社，2005
3. 吴浩青，李永舫，电化学动力学，高等教育出版社，1998
4. 查全性，电极过程动力学导论（第三版），科学出版社，2002



课题组风采


招聘信息：课题组常年招聘专职科研人员、博士后


专职科研人员：
赵微 研究员
徐琮辉 研究员
宋娟 副研究员
胡 军 博士后（南京医科大学）
沈益忠 博士后（在职-合肥工业大学）
周宇扬 博士后（在职-苏州科技大学）
王忠霞 博士后（在职-盐城工学院）
王成双 博士后（在职-盐城工学院）
吕松伟 博士后（在职-常州大学）
史笑梅 博士后

博士生：
阮一帆、雷雯、王海燕、周洁、王惠、陈明明、王璐璇、赵子媛、余巧、李庆悦、李晓琼、吕品田、徐一童、王冰、王靖薷、高杭（合带）

硕士生：
刘映雪、罗丹、浩海丽、张仙、张钰雯