职务： 副院长
联系电话： **
办公地址： 仙林校区化学楼E513
电子邮箱： njuzy@nju.edu.cn

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个人简介


张艳，教授，博导，化学化工学院副院长。1997年于吉林大学获学士学位，2002年于南京大学获博士学位，2002-2004年在香港科技大学化学系做博士后，2004-2006年在斯坦福大学医学院做博士后。2006年9月加入南京大学任南京大学化学化工学院教授，2016年起任南京大学化学化工学院副院长。入选南京大学首批登峰B人才支持计划，获首批江苏省****基金，入选中组部第二批青年拔尖人才支持计划。主要研究领域为光化学生物学，以通讯作者在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等期刊发表SCI论文多篇。任江苏省化学化工学会理事会化学生物学专业委员会主任委员、中国化学会青委会委员等。目前主持国家自然科学基金面上项目2项及国家自然科学基金委重大研究计划培育项目1项，参与国家重点研发计划重点专项项目一项。



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工作经历


2006 至今 南京大学化学化工学院 教授
2004-2006 美国斯坦福大学 博士后
2002-2004 香港科技大学 博士后
1997-2002 南京大学 博士
1993-1997 吉林大学 学士


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研究方向


从反应瓶中的光反应到活细胞上的光反应


主要研究方向为光化学生物学，包括光驱动生物正交反应的开发及化学生物学应用。
针对解析生命体系内复杂、动态分子事件对于时空分辨型分子探针的急迫需求，借助光诱导实现对复杂生物环境中生物正交官能团间反应的精准控制，为光诱导成键反应这一传统的有机化学反应找到在构建时空分辨的分子探针这一化学生物学新应用，促进光化学与生命科学研究的交叉和融合。



学术成果



Wang, Y.;Weng,J.;Lin,J.;Ye, D.;Zhang, Y.. NIR Scaffold Bearing Three Handles for Biocompatible Sequential Click Installation of Multiple Functional Arms,J. Am. Chem. Soc.2020, 142, 2787-2794.
Li, J.;Kong, H.; Zhu,C.; Zhang,Y. Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems, Chem. Sci., 2020,11, 3390-3396.
Chen, L.; Sun, Y.;Li, J.;Zhang, Y. Photoactivatable microRNA probe for identification of microRNA targets and light- controlled suppression of microRNA target expression, Chem. Commun., 2020,56, 627- 630.

Wang, Y.; Hu, X.; Weng, J.; Li, J.; Fan, Q.; Zhang, Y.; Ye, D.A Photoacoustic Probe for the Imaging of Tumor Apoptosis by Caspase-Mediated Macrocyclization and Self-Assembly.Angew. Chem. Int. Ed. 2019,58, 4886-4890.
Wang, X.;Xiao, X.;Zhang, B.;Li, J.; Zhang, Y. A self-assembled peptide nucleic acid-microRNA nanocomplex for dual-modulation of cancer-related microRNAs.Chem. Commun. 2019,55, 2106-2109.
Li, J.; Kong, H.; Huang, L.; Cheng, B.; Qin, K.; Zheng M.; Yan, Z.; Zhang, Y.Visible Light-Initiated Bioorthogonal Photoclick Cycloaddition.J. Am. Chem. Soc. 2018,140, 14542-14546.
Xiao, X.; Wang, X.; Wang, Y.; Yu, T.; Huang, L.; Chen, L.; Li, J.; Zhang, C.; Zhang, Y.Multi-functional Peptide-MicroRNA Nanocomplex for Targeted MicroRNA Delivery and Function Imaging.Chem. Eur. J. 2018,24, 2277-2285.
Xiao, X.; Wang, X.; Gao, H.; Chen, X.;Li, J.; Zhang, Y.Cell-Selective Delivery of MicroRNA with a MicroRNA-Peptide Conjugate Nanocomplex.Chem. Asian J.2018,13, 3845-3849.
Zhou, Z.; Xie, X.; Yi, Q.; Yin, W.; Kadi, A. A.; Li, J.; Zhang, Y.Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells.Org. Biomol. Chem. 2017,15, 6892-6895.
Huang, L.; Chen, Y.; Chen, L.; Xiao, X.; Wang, X.; Li, J.; Zhang, Y.Photo-clickable microRNA for in situ fluorescence labeling and imaging of microRNA in living cells.Chem. Commun.2017,53, 6452-6455.
Zhou, Z.; Yi, Q.; Xia, T.; Yin, W.; Kadi, A. A.; Li, J.; Zhang, Y. A photo-degradable supramolecular hydrogel for selective delivery of microRNA into 3D-cultured cells.Org. Biomol. Chem. 2017,15, 2191-2198.
Li, J.; Huang, L.; Xiao, X.; Chen, Y.; Wang, X.; Zhou, Z.; Zhang, C.; Zhang, Y. Photoclickable MicroRNA for the Intracellular Target Identification of MicroRNAs.J. Am. Chem. Soc.2016,138, 15943-15949.
Wang, Y.; Li, J.; Feng, L.; Yu, J.; Zhang, Y.; Ye, D.; Chen, H. Y. Lysosome-Targeting Fluorogenic Probe for Cathepsin B Imaging in Living Cells.Anal. Chem. 2016,88, 12403-12410.
Zheng, M.; Wang, Y.; Shi, H.; Hu, Y.; Feng, L.; Luo, Z.; Zhou, M.; He, J.; Zhou, Z.; Zhang, Y.; Ye, D. Redox-Mediated Disassembly to Build Activatable Trimodal Probe for Molecular Imaging of Biothiols.ACS Nano 2016,10, 10075-10085.
Xiao, X.; Hu, J.; Wang, X.; Huang, L.; Chen, Y.; Wang, W.; Li, J.; Zhang, Y. A dual-functional supramolecular hydrogel based on a spiropyran-galactose conjugate for target-mediated and light-controlled delivery of microRNA into cells.Chem. Commun. 2016,52, 12517-12520.
.Zhou, M.; Hu, J.; Zheng, M.; Song, Q.; Li, J.; Zhang, Y. Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis.Chem. Commun.2016,52, 2342-2345.
Tong, K.; Zheng, T. Y.; Zhang, Y.; Yu, S. Y.Synthesis of ortho-(Fluoro)alkylated Pyridines via Visible Light-Promoted Radical Isocyanide Insertion.Adv. Synth. Catal. 2015,357, 3681-3686.
Wang, W.; Hu, J.; Zheng, M.; Zheng, L.; Wang, H.; Zhang, Y. Multi-responsive supramolecular hydrogels based on merocyanine-peptide conjugates.Org. Biomol. Chem. 2015,13, 11492-11498.
Zheng, M.; Huang, H.; Zhou, M.; Wang, Y.; Zhang, Y.; Ye, D.; Chen, H. Y. Cysteine-Mediated Intracellular Building of Luciferin to Enhance Probe Retention and Fluorescence Turn-On.Chem. Eur. J. 2015,21, 10506-10512.
Jiang, H.; An, X.; Tong, K.; Zheng, T.; Zhang, Y.; Yu, S. Visible-light-promoted iminyl-radical formation from acyl oximes: a unified approach to pyridines, quinolines, and phenanthridines.Angew. Chem. Int. Ed. 2015,54, 4055-4059.
Tan, S. B.; Li, J.; Chen, X.; Zhang, W.; Zhang, D.; Zhang, C.; Li, D.; Zhang, Y. Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway.Chem. Biol.2014,21, 1265-1270.
Wang, R.; Jiang, H.; Cheng, Y.; Kadi, A. A.; Fun, H. K.; Zhang, Y.; Yu, S.Somophilic Isocyanide Insertion: Synthesis of 6-Arylated and 6-Trifluoro-methylated Phenanthridines.Synthesis 2014,46, 2711-2726.
Jiang, H.; Cheng, Y.; Wang, R.; Zhang, Y.; Yu, S. Synthesis of isoquinolines via visible light-promoted insertion of vinyl isocyanides with diaryliodonium salts.Chem. Commun. 2014,50, 6164-6167.
Li, J.; Kooger, R.; He, M.; Xiao, X.; Zheng, L.; Zhang, Y. A supramolecular hydrogel as a carrier to deliver microRNA into the encapsulated cells.Chem. Commun. 2014,50, 3722-3724.
Li, J.; Tan, S.; Kooger, R.; Zhang, C.; Zhang, Y. MicroRNAs as novel biological targets for detection and regulation.Chem. Soc. Rev. 2014,43, 506-517.
Jiang, H.; Cheng, Y.; Wang, R.; Zheng, M.; Zhang, Y.; Yu, S. Synthesis of 6-alkylated phenanthridine derivatives using photoredox neutral somophilic isocyanide insertion.Angew. Chem. Int. Ed. 2013,52, 13289-13292.
He, M.; Li, J.; Tan, S.; Wang, R.; Zhang, Y. Photodegradable supramolecular hydrogels with fluorescence turn-on reporter for photomodulation of cellular microenvironments.J. Am. Chem. Soc. 2013,135, 18718-18721.
Li, J.; Zhang, W.; Zhou, M.; Kooger, R.; Zhang, Y. Small molecules modulating biogenesis or processing of microRNAs with therapeutic potentials.Curr. Med. Chem. 2013,20, 3604-3612.
Tan, S. B.; Huang, C.; Chen, X.; Wu, Y.; Zhou, M.; Zhang, C.; Zhang, Y. Small molecular inhibitors of miR-1 identified from photocycloadducts of acetylenes with 2-methoxy-1,4-naphthalenequinone.Bioorg. Med. Chem. 2013,21, 6124-6131.
Jiang, H.; Cheng, Y. Z.; Zhang, Y.; Yu, S. Y.Sulfonation and Trifluoromethylation of Enol Acetates with Sulfonyl Chlorides Using Visible-Light Photoredox Catalysis.Eur. J. Org. Chem. 2013,2013, 5485-5492.
Jiang, H.; Cheng, Y.; Zhang, Y.; Yu, S. De novo synthesis of polysubstituted naphthols and furans using photoredox neutral coupling of alkynes with 2-bromo-1,3-dicarbonyl compounds.Org. Lett. 2013,15, 4884-4887.
Wang, W.; Zhang, W. J.; Wang, L.; Quah, C. K.; Fun, H. K.; Xu, J. H.; Zhang, Y. Photoinduced reactions of para-quinones with bicyclopropylidene leading to diverse polycyclic compounds with spirocyclopropanes.J. Org. Chem. 2013,78, 6211-6222.
Huang, C. M.; Jiang, H.; Wang, R. Z.; Quah, C. K.; Fun, H. K.; Zhang, Y. Photocycloadditions of substituted oxazoles with isoquinoline-1,3,4-trione--chemo-, regio-, diastereoselectivities and transformation of the photocycloadducts.Org. Biomol. Chem. 2013,11, 5023-5033.
Wu, D. D.; Huang, C. M.; Wu, Y. H.; Fun, H. K.; Xua, J. H.; Zhang, Y.Acid-mediated transformation of spirocyclopropyl oxetanes: a facile approach to spirocyclopropyl butenolides and gamma-butyrolactones.Rsc Adv.2013,3, 7529-7536.
Wu, Y.; Zhang, W.; Li, J.; Zhang, Y. Optical imaging of tumor microenvironment.Am. J. Nucl. Med. Mol. Imaging 2013,3, 1-15.
Huang, C.; Zheng, M.; Xu, J.; Zhang, Y. Photo-induced cycloaddition reactions of alpha-diketones and transformations of the photocycloadducts.Molecules 2013,18, 2942-2966.
Jiang, H.; Chen, X. J.; Zhang, Y.; Yu, S. Y.C-H Functionalization of Enamides: Synthesis of beta-Amidovinyl Sulfones via Visible-Light Photoredox Catalysis.Adv. Synth. Catal. 2013,355, 809-813.
Heng Jiang, Chengmei Huang, Jiajia Guo, Chuanqi Zeng, Yan Zhang, and Shouyun Yu,Direct C-H Functionalization of Enamides and Enecarbamates by Using Visible-Light Photoredox Catalysis,Chem. Eur. J.2012, 18, 15158-15166.
Jinbo Li, Kai Chen, Hongguang Liu, Kai Cheng, Meng Yang, Jiping Zhang, Jonathan D. Cheng, Yan Zhang, and Zhen Cheng, Activatable Near-Infrared Fluorescent Probe for In Vivo Imaging of Fibroblast Activation Protein-alpha,Bioconjugate Chem.2012,23,1704?1711.
Xuejiao Chen, Chengmei Huang, Wenjie Zhang, Yihan Wu, Xi Chen, Chen-yu Zhang and Yan Zhang,Universal activator of microRNAs identified from photoreaction products.Chem. Commun., 2012,48, 6432–6434.
Dongdong Wu, Lei Wang, Kai Xu, Jia Song, Hoong-Kun Fun, Jianhua Xu and Yan Zhang,Facile and highly atom-economic approach to biaryl-containing medium-ring bislactones.Chem. Commun., 2012,48,1168– 1170.
Dongdong Wu, Mingtao He, Qidi Liu, Wei Wang, Jie Zhou, Lei Wang, Hoong-Kun Fun, Jianhua Xu and Yan Zhang,Photo-induced Reactions of Bicycloalkylidenes with Isatin and Isoquinolinetrione.Org. Biomol. Chem.,2012,10,3626 – 3635.
Jinbo Li, Subee Tan, Xuejiao Chen, Chen-yu Zhang and Yan Zhang，Peptide aptamers with biological and therapeutic applications.Curr. Med. Chem.,2011,18,4215-4222.
Chengmei Huang, Haitao Yu, Zhengrui Miao, Jie Zhou, Shuai Wang, Hoong-Kun Fun, Jianhua Xu and Yan Zhang,Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles.Org. Biomol. Chem., 2011,9, 3629.
Yucheng Huang, Zhenjun Qiu, Yanmei Xu, Junfeng Shi, Hongkun Lin and Yan Zhang,Supramolecular hydrogels based on short peptides linked with conformational switch.Org. Biomol. Chem., 2011,9,2149-2155.
Lei Wang, Yu-Cheng Huang, Yang Liu, Hoong-Kun Fun, Yan Zhang, Jian-Hua Xu.Photoinduced [4+4], [4+2] and [2+2] cycloadditions of o-quinones with oxazoles — chemo-, regio- and diastereoselectivity.J. Org. Chem.2010,75, 7757.
Haitao Yu, Jinbo Li, Zhuangfei Kou, Xuewen Du, Yi Wei, Hoong-Kun Fun, Jianhua Xu and Yan Zhang，“Photoinduced Tandem Reactions of Isoquinoline-1,3,4-trione with Alkynes To Build Aza-polycycles”，J. Org. Chem.2010,75, 2989.
Haitao Yu, Jinbo Li, Dongdong Wu, Zhenjun Qiu and Yan Zhang, “Chemistry and biological applications of photo-labile organic molecules”Chem. Soc. Rev.,2010,39,464.
Jinbo Li, Dongdong Wu, Zhengrui Miao and Yan Zhang,“Preparation of Quantum Dot Bioconjugates and their Applications in Bio-Imaging”Curr. Pharm. Biotech.,2010,11,662..
Zhenjun Qiu, Haitao Yu, Jinbo Li, Yu Wang and Yan Zhang, “Spiropyran-linked dipeptide forms supramolecular hydrogel with dual responses to light and to ligand–receptor interaction”Chem. Commun.,2009, 3342.




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