张定东 详细介绍
性别 男
职称 教授
最高学历 博士
毕业院校 东南大学
专业领域 水产养殖/水产动物营养与饲料
联系方式 邮箱: zdd_7597@njau.edu.cn；办公室: 逸夫楼3045；手机：**
研究方向 水产动物营养生理学；营养表观遗传学
参加学术团体
及任职情况 （1）江苏省海洋湖沼学会理事；(2) 江苏省水产学会会员；（3）中国营养学会会员；（4）美国糖尿病学会（ADA）会员。
承担项目 （1）江苏省农业科技自主创新项目，CX(20)3109，中华绒螯蟹一龄蟹种性早熟机制及防早熟饲料研究，2020.08-2022.07，30万，主持。（2）南京农业大学泰州研究院项目，水产养殖尾水生态治理科技示范子课题，2020/01-2020/12，10万，主持。（3）国家自然科学基金（面上项目），**，高糖负荷下团头鲂CaSR在GCGR沉默诱导的α-细胞增生中的作用，2020/01-2023/12，58万，主持。（4）国家科技支撑项目(2013BAD20B05)课题子任务，L，长三角现代农业区优质水产养殖技术集成与示范，2013/01-2015/12，51万，主持。（5）江苏省农业科技自主创新项目，CX(16)1004-09，池塘工业化养殖下鱼类营养品质调控技术研发与应用，2016/06-2019/06，40万，主持。（6）江苏省农业科技自主创新项目，CX(15)1011-04，河蟹新品种营养需求与饲料研究关键技术集成，2015/06-2017/12，50万，主持。（7）江苏省水产三新工程项目，Y2014-33，蟹池多品种混养模式下的饲料配套技术研究与集成示范，2014/03-2016/12，45万，主持。（8）农业部淡水渔业与种质资源利用重点实验室开放基金项目，KF201310，miRNA及其靶基因在团头鲂免疫调控中的作用与机制研究，2013/07-2015/06，6万，主持。（9）国家自然科学基金（青年基金），**，尿沉淀细胞DNA甲基化高通量检测方法的研究，2010/01-2012/12，20万，主持。（10）企业横向项目（苏宁现代农业股份有限公司），5万，主持。（11）企业横向项目（江苏海普瑞饲料有限公司），80万，主持。
奖励及荣誉 （1）江苏省“333高层次人才培养工程”第三层次培养对象（2011-2015）；（2）江苏省高校“青蓝工程”优秀青年骨干教师培养对象（2008）；（3）2013年度江苏省海洋与渔业科技创新奖三等奖（5/11）；（4）2016年度江苏省科技进步奖二等奖（5/11）；（5）2016年度江苏省海洋与渔业科技创新奖一等奖（3/11）；（6）2016年度动科院“北正农”奖教金；（7）2018年度中国水产科学研究院科技进步奖一等奖（11/20）；（8）2019年度江苏省高层次创新创业人才引进计划“科技副总”；（9）2019年度中国农业科学院农业信息研究所科技情报分析与评估团队发布: 2019全球“生物学”Top100高产作者（排名90）
论文论著




一、个人简历 (personal profile)

1、教育经历 (education background)
(1) 2003.09-2007.10，东南大学，生物科学与医学工程学院，生物医学工程专业, 博士
(2) 1998.09-2001.07，南京农业大学，渔业学院，水产养殖专业, 硕士
(3) 1994.09-1998.07，南京农业大学，渔业学院，淡水渔业专业, 本科
2、工作经历 (employment record)
(1)2013.02-至今，南京农业大学，动物科技学院，副教授、教授
(2)2017.12-2018.12,Vanderbilt University, School of Medicine, the U.S.A.Visiting Scholar

(3)2010.09-2011.03,University of Munich, Department of Medicine II, Germany. Visiting Scholar
(4)2001.08-2013.02，金陵科技学院，动物科学与技术学院，讲师、副教授

二、发表论文（Publication,*corresponding author; ^# co-first author) 2013 – Present (focus on aquatic animal nutrition)


1.Fan Gao^#, Mingyang Liu^#, Jianqing Tang, Aimin Wang, Hongyan Tian, ChuangWen, Cheng Chi, Guangzhen Jiang, Xiangfei Li, Wenbin Liu, Dingdong Zhang*.Partial replacement of dietary fish oil by beef tallow does not impairantioxidant capacity and innate immunity of red swamp crayfish, Procambarus clarkia. Aquaculture Research. 2021, 00:1–12.
2. Chang He, Xiaoyan Jia, Li Zhang, Fan Gao, Weibo Jiang,Chuang Wen, Cheng Chi, Xiangfei Li, Guangzhen Jiang, Haifeng Mi, Wenbin Liu, Dingdong Zhang*. Dietary berberine can ameliorate glucose metabolism disorderof Megalobrama amblycephala exposed toa high-carbohydrate diet. Fish Physiology and Biochemistry, 2021, Doi: 10.1007/s10695-021-00927-8.
3. Fan Gao, Jie Liu, Aimin Wang, Bo Liu, Hongyan Tian,Xiaochuan Zheng, Xiaoyan Jia, Chang He, Xiangfei Li, Guangzhen Jiang, ChengChi, Wenbin Liu,Dingdong Zhang*. Dietary lipid sources modulatethe intestinal transport of fatty acids in the red swamp crayfishProcambarusclarkii.Aquaculture, 2020, 521:735091.
4. Jie Liu, Erteng Jia, Huajuan Shi, Xiangfei Li,Guangzhen Jiang, Cheng Chi, Wenbin Liu,Dingdong Zhang*. Selectionof reference genes for miRNA quantitative PCR and its application inmiR-34a/Sirtuin-1 mediated energy metabolism inMegalobramaamblycephala.Fish Physiology and Biochemistry, 2019,45:1663-1681.
5. Hongyan Tian,Dingdong Zhang*, XiangfeiLi, Guangzhen Jiang, Wenbin Liu. Photoperiod affects blunt snout bream (Megalobramaamblycephala) growth, diel rhythm of cortisol, activities of antioxidantenzymes and mRNA expression of GH/IGF-I.Comparative Biochemistry andPhysiology, Part B, 2019, 233: 4-10.
6. Jean‐Jacques Yao Adjoumani, Kenneth PrudenceAbasubong, Francis Phiri, Chao Xu, Wenbin Liu,Dingdong Zhang*.Effect of dietary betaine and choline association on lipid metabolism in bluntsnout bream fed a high‐fat diet.Aquaculture Nutrition, 2019,25:1017-1027.
7. Erteng Jia, Xiaochuan Zheng, Huihui Cheng, Jie Liu,Xiangfei Li, Guangzhen Jiang, Wenbin Liu,Dingdong Zhang*. Dietaryfructooligosaccharide can mitigate the negative effects of immunity on Chinesemitten crab fed a high level of plant protein diet.Fish and ShellfishImmunology, 2019, 84:100-107.
8. Erteng Jia^#, Yanan Yan^#, ManZhou, Xiangfei Li, Guangzhen Jiang, Wenbin Liu,Dingdong Zhang*.Combined effects of dietary quercetin and resveratrol on growth performance,antioxidant capability and innate immunity of blunt snout bream (Megalobramaamblycephala).Animal Feed Science and Technology, 2019,256:114268.
9. Si-lei Xia, Xiang-fei Li, Kenneth Prudence Abasubong,Chao Xu, Hua-juan Shi, Wen-bin Liu*,Ding-dong Zhang*. Effects ofdietary glucose and starch levels on the growth, apparent digestibility, andskin-associated mucosal non-specific immune parameters in juvenile blunt snoutbream (Megalobrama amblycephala).Fish and Shellfish Immunology,2018, 79:193-201.
10.Dingdong Zhang*,Yanan Yan, HongyanTian, Guangzhen Jiang, Xiangfei Li, Wenbin Liu. Resveratrol supplementationimproves lipid and glucose metabolism in high-fat diet-fed blunt snoutbream.Fish Physiology and Biochemistry, 2018, 44:163-173.
11. 贾二腾，闫明军，赖起铖，罗文涛，蒋广震，刘文斌，张定东*. 中华绒螯蟹的摄食节律.中国水产科学，2018,25(3):546-554.
12. Jean-Jacques Yao Adjoumani, Kaizhou Wang, Man Zhou,Wenbin Liu,Dingdong Zhang*. Effect of dietary betaine on growthperformance, antioxidant capacity and lipid metabolism in blunt snout bream feda high-fat diet.Fish Physiology and Biochemistry, 2017,43:1733-1745
13. Erteng Jia, Zhuoqin Li, Yunfei Xue, Guangzhen Jiang,Xiangfei Li, Wenbin Liu,Dingdong Zhang*. Effects of dietaryfructooligosaccharide on the growth, antioxidants, immunity and diseaseresistance of Chinese mitten crab.Aquaculture, 2017, 481:154–161.
14. 闫亚楠，夏斯蕾，田红艳，徐超，贾二腾，刘文斌，张定东*. 白藜芦醇对高脂胁迫团头鲂抗氧化能力、非特异免疫机能和抗病力的影响.水生生物学报，2017,41(1):155-164.
15.张定东，李俊怡，王冰柯，李向飞，蒋广震，李鹏飞，蔡万存，刘文斌*. 胆碱对高脂胁迫的团头鲂肝脏抗氧化、组织结构和免疫力的影响.水产学报，2017,41(3):438-447.
16. Kang-Le Lu^#,Ding-Dong Zhang^#,Li-Na Wang, Wei-Na Xu, Wen-Bin Liu*. Molecular characterization of carnitinepalmitoyltransferase IA inMegalobrama amblycephalaandeffects on its expression of feeding status and dietary lipid andberberine.Comparative Biochemistry and Physiology, Part B, 2016,191:20-25.
17.Dingdong Zhang, Kangle Lu, GuangzhenJiang, Wenbin Liu*, Zaijie Dong*, Hongyan Tian, Xiangfei Li. A globaltranscriptional analysis ofMegalobrama amblycephalarevealingthe molecular determinants of diet-induced hepatic steatosis,Gene,2015, 570(2):255-263.
18. Hong-Yan Tian,Ding-Dong Zhang*, Chao Xu,Fei Wang, Wen-Bin Liu*. Effects of light intensity on growth, immune responses,antioxidant capability and disease resistance of juvenile blunt snoutbreamMegalobrama amblycephala.Fish and ShellfishImmunology, 2015, 47(2):674-680.
19. Hongyan Tian,Dingdong Zhang*, XiangfeiLi, Chunnuan Zhang, Yu Qian, Wenbin Liu*. Optimum feeding frequency of juvenileblunt snout breamMegalobrama amblycephala.Aquaculture,2015, 437:60-66.
20.Dingdong Zhang, Kangle Lu, Zaijie Dong*,Guangzhen Jiang, Weina Xu, Wenbin Liu*. The effect of exposure to a high-fatdiet on microRNA expression in the liver of blunt snout bream (MegalobramaAmblycephala).PLoS One, 2014, 9 (5): e96132.

2003-2012(Design microarrays to identify DNA methylation markers forclinicaldiagnosis)
1. Min Pan, Qinyu Ge, Hailing Li, Qi Yang, JiafengLu,Dingdong Zhang, Zuhong Lu*. Sequencing the miRNAs in maternalplasma from women before and after parturition.Journal of Nanoscienceand Nanotechnology, 12: 1–9, 2012.
2. Yunfei Bai, Dai Lin, Qin Han, Yaojuan Jia, JingTu, Junfeng Luo, Qinyu Ge,Dingdong Zhang, Zuhong Lu*.Discrimination of single nucleotide mutation by using a new class ofimmobilized shared-stem double-stranded DNA probes.Journal ofBiomedical Nanotechnology, 7:1–8, 2011.
3. Yao Yang, Wei Wang, Yanqiang Li, Jing Tu, YunfeiBai, Pengfeng Xiao,Dingdong Zhang, Zuhong Lu*. Identification ofmethylated regions with peak search based on Poisson model from massivelyparallel methylated DNA immunoprecipitation sequencing data.Electrophoresis,31: 3537–3544, 2010.
4.Dingdong Zhang^#, Yan Wang^#,Yunfei Bai, Qinyu Ge, Yingjuan Qiao, Junfeng Luo, Chao Jia, Zuhong Lu*. A novelmethod to quantify local CpG methylation density by regional methylationelongation assay on microarray.BMC Genomics, 2008, 9:59.
5. Yan Wang^#,Dingdong Zhang^#,Wenli Zheng, Junfeng Luo, Yunfei Bai, Zuhong Lu*. Multiple gene methylation ofnonsmall cell lung cancers evaluated with 3-dimensional microarray.Cancer,2008, 112:1325-1336.
6.Dingdong Zhang^#, YunfeiBai^#, Yan Wang, Junfeng Luo, Qinyu Ge, Yingjuan Qiao, Chao Jia,Zuhong Lu*. Detailed methylation patterns and protein expression profiles ofMGMT in colorectal carcinoma surgical margins.Clinical Biochemistry,2008, 41(1-2):19-25.
7. Qinyu Ge, Yunfei Bai,Dingdong Zhang,Zuhong Lu*. Microarray Detection of Fetal DNA Levels in Maternal Plasma.AnalyticalLetters, 2007, 40: 1540-1548.
8. Qinyu Ge, Zhaobin Liu, Yunfei Bai,DingdongZhang, Pinfei Yu, Zuhong Lu*. Emulsion PCR-based method to detect Ychromosome microdeletions.Analytical Biochemistry, 2007, 367(2):173-178.
9. Zhixiang Wu, Junfeng Luo, Qinyu Ge,DingdongZhang, Yan Wang, Chao Jia, Zuhong Lu*. Allele-specific extension onmicroarray for DNA methylation analysis.Analytica Chimica Acta,2007, 603(2):199-204.
10.Dingdong Zhang, Yunfei Bai, Qinyu Ge, YingjuanQiao, Yan Wang, Zaozao Chen, Zuhong Lu*. Microarray-based molecular marginmethylation pattern analysis in colorectal carcinoma.AnalyticalBiochemistry, 2006, 355(1):117-124.
11.Yan Wang, Wenli Zheng, Junfeng Luo,DingdongZhang, Zuhong Lu*. In situ bisulfite modification of membrane-immobilizedDNA for multiple methylation analysis.Analytical Biochemistry,2006, 359(2): 183-188.
12.Wenli Zheng, Yan Wang,Dingdong Zhang,Junfeng Luo, Zuhong Lu, A microarray to analyze methylation patterns of E-cadgene 5’CpG islands,4’th International Forum of Post-GenomeTechnologies(IFPT’4), 286~290, September 25-26, 2006, Hangzhou,China.

三、专利 (Patents)
1.张定东，刘文斌，徐维娜，蒋广震，李向飞，孙存鑫，蔡万存. 一种鱼粉替代物及其制备方法与应用. 专利号：ZL0.5 (2019年11月05日)
2.孙存鑫，张定东，刘文斌，徐维娜，蒋广震，李向飞.一种渔用复合型诱食剂及其制备方法与应用. 专利号：ZL5.0 (2020年08月25日)
3.徐维娜，刘文斌，张定东，蒋广震，鲁康乐，秦钦.一种改善黄颡鱼鱼苗食性转换期肠道功能的微生态饲料.专利号：ZL0.3 (2014年5月07日)
4.李向飞，刘文斌，徐超，蒋广震，张定东. 一种改善鱼体糖耐受性的调控组合物及其制备方法与应用. 专利号：ZL8.6 (2019年02月26日)
5.蒋广震, 刘文斌, 周嫚, 李向飞,张定东. 一种以甘草提取物为主的调控剂、及其制备方法与应用. 专利号：ZL7.7 (2018年11月23日)
6.李向飞，刘文斌，王冰柯，蒋广震，张定东. 一种渔用糖代谢调控物及其制备方法与应用. 专利号：ZL0.2（2018年9月18日）
7. 蒋广震；刘文斌；李向飞；张定东；米海峰；吴业阳. 一种维生素强化的团头鲂抗逆饲料的维生素添加剂.专利号：ZL5.4 (2019年11月12日)