个人简介
郭晶晶，教授，博士生导师，南京农业大学“高层次引进人才”。
电子邮箱：guojj@njau.edu.cn；办公地址：逸夫楼5022
研究方向：
以计算生物学为主要研究特色，围绕蛋白质和生物膜的结构与功能开展工作。具体研究方向包括：
1、酶的变构调控机理和功能蛋白质设计
2、基于结构的活性分子设计与筛选
3、分子间相互识别和作用机制
4、生物膜对细菌有机溶剂耐受性的调控机制
研究生招生/博后招聘：
欢迎对计算生物学具有浓厚兴趣的青年学子报考（或免试推荐）硕士及博士研究生，同时欢迎相关领域的博士研究生申请博士后课题合作！

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教学情况
本科生：《生物化学》、《基因工程原理与方法》
研究生：《现代生物化学》、《生物化学》

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科研情况
科研及教育经历：
2019- ：南京农业大学生命科学学院，教授
2017-2018：新加坡南洋理工大学，博士后
2015-2017：河南师范大学，副教授
2013-2015：美国佛罗里达州立大学，联合培养博士生
2009-2015：兰州大学药物化学专业，博士（硕博连续）
2005-2009：河北师范大学化学专业，学士

科研项目：
1、南京农业大学引进人才启动基金，主持
2、国家自然科学基金青年基金，靶向干扰素刺激因子的免疫分子机制、虚拟筛选及生物活性研究，2017/01-2019/12，主持
部分发表论文：
Guo, J.; Zhou, H.-X., Protein Allostery and Conformational Dynamics. Chem. Rev. 2016, 116, 6503-6515.
Guo, J.; Zhou, H.-X., Allosteric activation of SENP1 by SUMO1 beta-grasp domain involves a dock-and-coalesce mechanism. Elife. 2016, 5, e18249.
Guo, J.; Chia, G.; Berezhnoy, N.; Cazenave-Gassiot, A.; Kjelleberg, S.; Hinks, J.; Mu, Y. ; Seviour, T.; Bacterial lipopolysaccharide core structures mediate effects of butanol ingress , BBA-Biomembranes, 2020, 1862(2) : 183150.
Zhong, W.#; Guo, J.#; Cui, L.#; Chionh, Y. H.; Li, K.; El Sahili, A.; Cai, Q.; Yuan, M.; Michels, P. A. M.; Fothergill-Gilmore, L. A.; Walkinshaw, M. D.; Mu, Y.; Lescar, J.; Dedon, P. C., Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis. J. Mol. Biol. 2019, DOI: 10.1016/j.jmb.2019.07.033. (共同一作)
Guo, J.; Wang, J.; Fan, J.; Zhang, Y.; Dong, W.; Chen, C. P., Distinct Dynamic and Conformational Features of Human STING in Response to 2'3'-cGAMP and c-di-GMP. ChemBioChem. 2019, 20, 1838-1847.
Guo, J.; Ho, J. C. S.; Chin, H.; Mark, A. E.; Zhou, C.; Kjelleberg, S.; Liedberg, B.; Parikh, A. N.; Cho, N. J.; Hinks, J.; Mu, Y.; Seviour, T., Response of microbial membranes to butanol: interdigitation vs. disorder. Phys. Chem. Chem. Phys. 2019, 21, 11903-11915.
Guo, J.; Zhou, H.-X., Dynamically driven protein allostery exhibits disparate responses for fast and slow motions. Biophys. J. 2015, 108, 2771-2774.
Guo, J.; Pang, X.; Zhou, H.-X., Two pathways mediate interdomain allosteric regulation in pin1. Structure. 2015, 23, 237-247.
Guo, J.; Zhang, Y.; Ning, L.; Jiao, P.; Liu, H.; Yao, X., Stabilities and structures of islet amyloid polypeptide (IAPP(22-28)) oligomers: From dimer to 16-mer. BBA-Gen. Subjects. 2014, 1840, 357-366.
Guo, J.; Yao, X.; Ning, L.; Wang, Q.; Liu, H., The adsorption mechanism and induced conformational changes of three typical proteins with different secondary structural features on graphene. Rsc Advances. 2014, 4, 9953-9962.
Guo, J.; Li, J.; Zhang, Y.; Jin, X.; Liu, H.; Yao, X., Exploring the Influence of Carbon Nanoparticles on the Formation of beta-Sheet-Rich Oligomers of IAPP(22-28) Peptide by Molecular Dynamics Simulation. Plos One 2013, 8, e65579.
Guo, J.; Wang, X.; Sun, H.; Liu, H.; Yao, X., The molecular basis of IGF-II/IGF2R recognition: a combined molecular dynamics simulation, free-energy calculation and computational alanine scanning study. J. Mol. Model. 2012, 18, 1421-1430.
Guo, J.; Wang, X.; Sun, H.; Liu, H.; Shen, Y.; Yao, X., The evolution of HLA-B*3501 binding affinity to variable immunodominant NP418-426 peptides from 1918 to 2009 pandemic influenza A virus: A molecular dynamics simulation and free energy calculation study. Chem. Biol. Drug. Des. 2012, 79, 1025-1032.
Guo, J.; Ren, H.; Ning, L.; Liu, H.; Yao, X., Exploring structural and thermodynamic stabilities of human prion protein pathogenic mutants D202N, E211Q and Q217R. J. Struct. Biol. 2012, 178, 225-232.
Guo, J.; Ning, L.; Ren, H.; Liu, H.; Yao, X., Influence of the pathogenic mutations T188K/R/A on the structural stability and misfolding of human prion protein: Insight from molecular dynamics simulations. BBA-Gen. Subjects 2012, 1820, 116-123.

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