个人简介
本科毕业于中国科技大学，博士毕业于华盛顿大学 （圣 路易斯）。
以人细胞和小鼠为模型研究人及哺乳动物microRNA的生成机制，及microRNA对人疾病的调控机理。在Nature、Molecular Cell、PNAS、EMBO、Nucl. Acids Res.等期刊发表多篇文章。
MEMBERSHIP
American Association for the Advancement of Science
RNA Society
Society for Neuroscience
American Society for Biochemistry and Molecular Biology

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教学情况
Fundamental pharmacology （本科生）
生科导论（本科生）
实验动物学大实验（本科生）
RNA research methodologies （硕士、博士研究生）
动物学研究专题（硕士、博士研究生）
生物学研究前沿（博士研究生）

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科研情况
Zeng, Y., Weiss, C., Yao, T. T., Huang, J., Siconolfi-Baez, L., Hsu, P., and Rushbrook, J. I. (1995) Isocitrate dehydrogenase from bovine heart: primary structure of subunit 3/4. Biochem. J. 310: 507-516.
Zeng, Y., Forbes, K. C., Wu, Z., Moreno, S., Piwnica-Worms, H., and Enoch, T. (1998) Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature 395: 507-510.
Zeng, Y. and Piwnica-Worms, H. (1999) DNA damage and replication checkpoints in fission yeast require nuclear exclusion of Cdc25 via 14-3-3 binding. Mol. Cell. Biol. 19: 7410-7419.
Weiss, C., Zeng, Y., Huang, J., Sobocka, M. B., and Rushbrook, J. I. (2000) Bovine NAD+ dependent isocitrate dehydrogenase: alternative splicing and tissue dependent expression of subunit 1. Biochemistry 39: 1807-1816.
Zeng, Y., Russell, R.A., Erlwein, O., Cullen, B.R., and McClure, M.O. (2001) The R region found in the Human Foamy Virus long terminal repeat is critical for both Gag and Pol protein expression. J. Virology 75: 6817-6824.
Wiegand, H. L., Coburn, G. A., Zeng, Y., Kang, Y., Bogerd, H. P., and Cullen, B. R. (2001) Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Mol. Cell. Biol. 22: 245-256.
Zeng, Y., Wagner, E. J., and Cullen, B. R. (2002) Both natural and designed microRNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9: 1327-1333.
Zeng, Y., and Cullen, B. R. (2002) RNA interference in human cells is restricted to the cytoplasm. RNA 8: 855-860.
Zeng, Y., and Cullen, B. R. (2003) Sequence requirements for microRNA processing and function in human cells. RNA 9: 112-123.
Zeng, Y., Yi, R., and Cullen, B. R. (2003) microRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl. Acad. Sci. U.S.A. 100: 9779-9784.
Zeng, Y., and Cullen, B. R. (2004) Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Research 32: 4776-4785.
Zeng, Y., Cai, X., and Cullen, B. R. (2005) Using RNA polymerase II to transcribe artificial microRNAs. Methods in Enzymology 392: 371-380.
Zeng, Y., Yi, R., and Cullen, B. R. (2005) Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO J. 24: 138-148.
Zeng, Y., and Cullen, B. R. (2005) Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences. J. Biol. Chem. 280: 27595-27603.
Zeng, Y., and Cullen, B. R. (2006) Recognition and cleavage of primary microRNA transcripts. Methods Mol. Biol. 342: 49-56.
Zeng, Y., and Cullen, B.R. (2006) The biogenesis and function of microRNAs. In Gene Expression and Regulation, J. Ma ed. (Higher Education Press/Springer), pp. 481-492.
Zeng, Y. (2006) Principles of microRNA production and maturation. Oncogene 25: 6156-6162.
Zeng, Y., Sankala, H., Zhang, X., and Graves, P (2008) Phosphorylation of Argonaute2 at serine 387 facilitates its localization to processing bodies. Biochem. J. 413: 429-436.
Kalscheuer, S., Zhang, X., Upadhyaya, P., and Zeng, Y. (2008) Differential expression of microRNAs in early stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 29: 2394–2399.
Kren, B. T., Wong, P. Y.-P., Sarver, A., Zhang, X., Zeng, Y., and Steer, C. J. (2009) microRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis. RNA Biol. 6: 65-72.
Zhang, X., Xu, W, Tan, J., and Zeng, Y. (2009) Stripping custom microRNA microarrays and the lessons learned about probe:slide interactions. Anal. Biochem. 386: 222-227.
Zhang, X., Graves, P. R., and Zeng, Y. (2009) Stable Argonaute2 overexpression differentially regulates microRNA production. Biochimica Biophysica Acta 1789: 153-159.
Zeng, Y. (2009) Regulation of the mammalian nervous system by microRNAs. Mol. Phar. 75: 259-264.
Zeng, Y. (2009) RNAi in mammalian cells. In RNA Interference: Methods for Plants and Animals, T. Doran and C. Helliwell eds. (CABI International), pp 205-227.
Cunningham, J. M., Oberg, A. L., Borralho, P. M., Kren, B. T., French, A. J., Wang, L., Bot, B. M., Morlan, B. W., Silverstein, K. A. T., Staggs, R., Zeng, Y., Lamblin, A.-F., Hilker, C. A., Fan, J.-B., Steer, C. J., and Thibodeau, S N. (2009) Evaluation of a New High-Dimensional miRNA Profiling Platform. BMC Medical Genomics 2: 57.
Kren, B. T., Wong, P. Y.-P., Shiota, A., Zhang, X., Zeng, Y., and Steer, C. J. (2009) Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol 297: 1181-1192.
Zheng, H., Zeng, Y., Zhang, X., Chu, J., Loh, H. H., and Law, P.-Y. (2010) µ-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD. Mol. Phar. 77: 102-109.
Melkamu, T., Zhang, X., Tan, J., Zeng, Y., and Kassie, F. (2010) Alteration of microRNA expression in vinyl-carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol. Carcinogenesis 31: 252-258.
Zhang, X., and Zeng, Y. (2010) Regulation of mammalian microRNA expression. J. Cardiovascular Translational Res. 3: 197-203.
Park, C. W., Zeng, Y., and Steer, C. J. (2010) Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation. J. Cardiovascular Translational Res. 3: 290-295.
Zheng, H., Zeng, Y., Chu, J., Kam, A. Y. F., Loh, H., and Law, P.-Y. (2010) Modulations of NeuroD Activity Contribute to the Differential Effects of Morphine and Fentanyl on Dendritic Spine Stability. J. Neurosci. 30: 8102-8110.
Chen, Y., Zhou, H., Sarver, A., Zeng, Y., Roy-Chowdhury, J., Steer, C., Sahin, M. B. (2010) Hepatic differentiation of liver derived progenitor cells and microRNA analysis of their in vitro differentiation. Liver Transplantation 16: 1086-1097.
Zeng, H., Chu, J., Zeng, Y., Loh, H. H., and Law, P.-Y. (2010) Yin Yang 1 Phosphorylation Contributes to the Differential Effects of mu-Opioid Receptor Agonists on MicroRNA-190 Expression . J. Biol. Chem 285: 21994-22002.
Zhang, X., and Zeng, Y. (2010) The terminal loop region controls microRNA processing by Drosha and Dicer. Nucl. Acids Res. 38: 7689-7697.
Castro, R. E., Ferreira, D. M. S., Zhang, X., Borralho, P. M., Sarver, A. L., Zeng, Y., Steer, C. J., Kren, B. T., and Rodrigues, C. M. P. (2010) Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid. American Journal of Physiology - Gastrointestinal and Liver Physiology 299: G887-897.
Park, C. W., Zeng, Y., Zhang, X., Subramanian, S., and Steer, C. J. (2010) Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells. RNA Biology 7:606-614. PMID: **.
Ghosh, G., Subramanian, I. V., Adhikari, N., Zhang, X., Joshi, H. P., Basi, D. L., Chandrashekhar, Y. S., Hall, J. L., Roy, S., Zeng, Y., and Ramakrishnan, S. (2010) Hypoxia-induced microRNA-424 expression in endothelial cells regulates HIF-1a isoforms by targeting CUL2 and promotes angiogenesis. J. Clin. Invest. 120: 4141–4154.
Lu, C., Huang, X., Zhang, X., Roensch, K., Cao, Q., Nakayama, K., Blazar, B. R., Zeng, Y., and Zhou, Z. (2011) miR-221 and miR-155 regulate human dendritic cell development, apoptosis and IL-12 production through targeting of p27kip1, KPC1 and SOCS-1. Blood 117: 4293-4303.
Shu, J., Kren, B. T., Xia, Z., Wong, P. Y., Li, L., Hanse, E. A., Min, M. X., Li, B., Albrecht, J. H., Zeng, Y., Subramanian, S., and Steer, C. J. (2011) Genome-wide microRNA downregulation as a negative feedback mechanism in the early phases of liver regeneration. Hepatology 54: 609-619.
Feng, Y., Zhang X., Song, Q., Li, T., and Zeng, Y. (2011) Drosha processing controls the specificity and efficiency of global microRNA expression. Biochimica Biophysica Acta, 1809: 700-707.
Zhang, X., and Zeng, Y. (2011) Performing custom microRNA microarray experiments. Journal of Visualized Experiments 56: e3250.
Zeng, Y. (2011) The functional consequences and implications of relative substrate specificity in complex biochemical systems. Front. Genetics 2: 65.
Feng, Y., Zhang, X., Graves, P., and Zeng, Y. (2012) A comprehensive analysis of precursor microRNA cleavage by human Dicer. RNA 18: 2083-2092.
Graves, P., and Zeng, Y. (2012) Biogenesis of mammalian microRNAs: a global view. Genomics Proteomics & Bioinformatics 10: 239-245.
Zhang, X., Graves, P., and Zeng, Y. (2013) Overexpression of human Argonaute2 inhibits cell and tumor growth. Biochimica Biophysica Acta-General Subjects 1830: 2553–2561.
Banerjee, S., Meng, J., Das, S., Krishnan, A., Haworth, J., Charboneau, R., Zeng, Y., Ramakrishnan, S., and Roy, S. (2013) Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a. Scientific Reports 3: 1977.
Zheng, Y., Tan, D., Chen, Z., Hu, C., Mao, Z. J., Singleton, T. P., Zeng, Y., Shao, X., and Yin, B. (2014) A Non-genetic approach to labelling acute myeloid leukemia and bone marrow cells with quantum dots. J. Nanosci. Nanotechnol. 14: 4014-4021.
Zeng, Y. (2014) Relative Specificity: all substrates are not created equal. Genomics Proteomics & Bioinformatics 12: 1-7.
Joshi, H. P., Subramanian, I. V., Ghosh, G., Rupaimoole, R., ,Evans, C., Saluja, M., Jing, Y., Cristina, I., Zeng, Y., Shah, V. H., Sood, A. K., and Ramakrishnan, S. (2014) Dynamin 2 along with its intron-associated miR-199a reciprocally regulate HIF-1 and metastasis. Proc. Natl. Acad. Sci. U.S.A. 111 :5331–5336.
Hu, C., Chen, Z, Zhao, W., Wei, L, Zheng, Y., He, C., Zeng, Y., and Yin, B. (2014) Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir. Biomol Ther. 22: 114-121.
Li, L., Feng, H., Da, Q., Jiang, H., Chen, L., Xie, L., Huang, Q., Xiong, H., Luo, F., Kang, L., Zeng, Y., Hu, H., Hou, W., and Feng, Y. (2016) Expression of HIV-encoded microRNA-TAR and its inhibitory effect on viral replication in human primary macrophages. Arch Virol. 161(5): 1115-1123
Lin, J., Xia, J. Chen, Y.T., Zhang, K.Y., Zeng, Y., and Yang, Q. (2017) H9N2 avian influenza virus enhances the immune responses of BMDCs by down-regulating miR29c. Vaccine 35: 729-737.
Zhang, X., Li, P., Lin, J., Huang, H., Yin, B., and Zeng, Y. (2017) The insertion in the double-stranded RNA binding domain of human Drosha is important for its function. Biochim Biophys Acta. 1860: 1179-1188.
Lin, J., Xia, J., Tu, C. Z., Zhang, K. Y., Zeng, Y., and Yang, Q. (2017) H9N2 avian influenza virus protein PB1 enhances the immune responses of bone marrow-derived dendritic cells by down-regulating miR375. Front Microbiol. 8: 287.
Zhang, X., Hu, S., Su, J., Xie, Z., Li W., and Zeng, Y. (2018) Correlation analyses reveal a limited role of transcription in genome-wide differential microRNA expression in mammals. Front. Genet. 9: 154.
Huang, Q., Chen, L., Luo, M., Lv, H., Luo, D., Li, T., Huang, S., Xie, L., Teng, Y., Liu, Z., Luo, F., Xiong, H., Zeng, Y., Hou, W., and Feng, Y. (2018) HIV-1-Induced miR-146a Attenuates Monocyte Migration by Targeting CCL5 in Human Primary Macrophages. AIDS Res Hum Retroviruses 34: 580-589.
Teng, Y., Luo, M., Yu, T., Chen, L., Huang, Q., Chen, S., Xie, L., Zeng, Y., Luo, F., Xiong, H., Liu, Y., Hou, W., and Feng, Y. (2019) CRISPR/Cas9-mediated deletion of miR-146a enhances antiviral response in HIV-1 infected cells. Genes Immun. 20: 327-337.
Li, P., Tian, Q., Hu, M., Li, W., Zhang, X., and Zeng, Y. (2019) Cloning, expression, and characterization of the zebrafish Dicer and Drosha enzymes. Biochem Biophys Res Commun. 514: 200-204.
Li, P., Chen, Y., Juma, C. A., Yang, C., Huang, J., Zhang, X., and Zeng, Y. (2019) Differential inhibition of target gene expression by human microRNAs. Cells 8: 791.

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