学术学位博导
--> 职称：教授
单位：病理学系
zzy@njmu.edu.cn
专业：病理学与病理生理学（病理学）
个人简介
张志远教授长期专注于神经系统疾病，特别是从免疫病理学的角度出发，构建和完善了一系列动物模型和实验平台，深入研究和探讨了神经系统的退行性病变（阿尔茨海默病为代表），脑和脊柱外伤后继发损伤和炎性反应，多发性硬化为代表地自身免疫病、缺血性脑损伤等。目前主要关注糖脂代谢紊乱与神经炎症和阿尔茨海默病相关的病理变化及其发病机制。目前，有多项专利正在申请之中。回国后已获得了2项国家自然科学基金面上项目、江苏省双创团队、南京医科大学引进人才基金等项目；发表SCI论文40余篇，其中第一/通讯作者25篇，包括Acta Neuropathol，J Neurosci，J Immunol，Brain Pathol等病理、免疫学界广受认可的期刊；并担任J Cell Mol Med，J Neuropathol Exp Neurol， Neuroscience，Plos One等SCI杂志的审稿人。
发表论文:
Resolvin D1 programs inflammation resolution by increasing TGF- β expression induced by dying cell clearance in experimental autoimmune neuritis
Icariin ameliorates neuropathological changes,TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis
Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice
Computer-aided identification of protein targets of four polyphenols in Alzheimer’s disease and their protective effects in its mouse model
Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model
Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis
Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria
Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling
The deficiency of macrophage erythropoietin signaling contributes to delayed acute inflammation resolution in diet-induced obese mice
Natural Diterpenoid Oridonin Ameliorates Experimental Autoimmune Neuritis by Promoting Anti-inflammatory Macrophages through Blocking Notch Pathway
教材专著:
科研成果:
目前承担的科研项目:
2017年江苏省双创团队，核心成员
Resolvin D1介导的炎症主动消散在术后认知功能障碍中的作用及机制研究81771171
髓系细胞作为阿尔茨海默病外周Aβ储存槽的调控机制81571240
已经完成的科研项目:
