学术学位博导
--> 职称：教授
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单位：心脑血管药物重点实验室
qiulunlu@njmu.edu.cn
专业：药理学
个人简介
长期从事心血管疾病的分子遗传和机理研究以及靶标药物开发，主要基于心血管疾病遗传家系和散发病人，开展遗传基因分析，寻找新的心血管疾病致病基因，并对该基因展开深入功能分析，探究其致病机制，寻找潜在药物靶标。近5年通过自主创建10多种转基因小鼠，建立组织特异性敲除，以及荧光蛋白细胞示踪的实验动物模型，以分泌蛋白AGGF1，线粒体蛋白FUNDC1和激酶SNRK为研究对象，多角度多方面地系统深入地揭示心衰发生发展的信号调控网络和分子机理，以及基于该研究成果开发核心调控靶标药物蛋白。自2014年至今发表SCI文章27篇，作为第一作者在Nature Communications,Plos Biology,Circulation,ATVB等杂志发表高水平学术论文。
发表论文:
Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis
Pulsatility index as a novel parameter for perfusion in mouse model of hindlimb ischemia
Type 1 diabetic Akita mouse model is characterized by abnormal cardiac deformation during early stages of diabetic cardiomyopathy with speckle-tracking based strain imaging
Sucrose non-fermenting 1-related kinase promotes angiogenesis in vivo
Binding of fundc1 with inositol 1,4,5-trisphosphate receptor in mitochondria-associated endoplasmic reticulum (ER) membranes maintains mitochondrial dynamics and function in hearts in vivo
Renal resistive index as a novel indicator for renal complications in high-fat diet-fed mice
A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure
Lovastatin alleviates endothelial-to-mesenchymal transition in glomeruli via suppression of oxidative stress and TGF-β1 signaling
Noninvasive regional aortic stiffness for monitoring the early stage of abdominal aortic aneurysm in mice
Angiogenic factor aggf1 activates autophagy with an essential role in therapeutic angiogenesis for heart disease
教材专著:
科研成果:
目前承担的科研项目:
AGGF1在糖尿病下肢血管功能障碍中的作用及机制研究
生长因子AGGF1对糖尿病心肌病的保护作用研究
已经完成的科研项目:
