钱明成简介


联系方式：
常州大学药学院
江苏省常州市武进区科教城常州大学测试楼A座802
Email:mqian2019@cczu.edu.cn
研究方向：
1、G-蛋白偶联受体(GPCR)变构调节剂的设计、合成及生物活性研究；
2、GPCR二聚化的化学生物学研究；
3、多靶点GPCR配体小分子的设计、合成及生物活性研究；
4、GPCR荧光探针的设计、合成及作用机制研究。
主要教育和工作经历：
2019.04-至今常州大学药学院教师，硕士生导师
2018.01-2018.12根特大学药学院，助理研究员
2013 - 2018比利时根特大学(Ghent University)，药学院，药学博士
江苏省双创博士，常州市龙城英才
代表性科研成果：
1. M. Qian, X. Jiang, M. Zhang, L. Hu, H. Liu, S. Zhao, X. Zhou*, X. Chen*. Synthesis, biological evaluation, and docking study of ring-opening amide analogues of matrine as anti-tumor agents. Chem. Biodiversity.2021. DOI: 10.1002/cbdv..
2. M. Qian, A. Ricarte, E. Wouters, J.A.R. Dalton, M.D.P. Risseeuw, J. Giraldo, S. Van Calenbergh*. Discovery of a true bivalent dopamine D₂receptor agonist. Eur. J. Med. Chem.2021, 212, 113151.
3. V. Fernández-Due?as*^,#, M. Qian^#, J. Argerich, C. Amaral, M.D.P. Risseeuw, S. Van Calenbergh*, F. Ciruela*. Design, synthesis and characterization of a new series of fluorescent metabotropic glutamate receptor type 5 negative allosteric modulators.Molecules2020, 25, 1532. #Co-first author
4. Z. Zhao, G. Liu, Y. Meng, J. Tian, X. Chen, M. Shen, Y. Li, B. Li, Cong Gao, S. Wu, C. Li*, X. He, R. Jiang, M. Qian*, X. Zheng*. Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues.Bioorg. Chem.2019. 93, 103316. * Corresponding author
5. M. Qian,E. Wouters, J. A. R. Dalton, M.D. P.Risseeuw, R.A. J.Crans, C. Stove, J. Giraldo,K. Van Craenenbroeck, S. Van Calenbergh*. Synthesis toward bivalent ligands for the dopamine D₂and metabotropic glutamate 5 receptors.J. Med. Chem.2018,61, 8212?8225.
6. M. Qian, L. Vasudevan, J. Huysentruyt,M.D. P.Risseeuw,C. Stove, P. M. L. Vanderheyden,K. Van Craenenbroeck, S. Van Calenbergh*.Design, synthesis and biological evaluation of novel bivalent ligands targeting dopamine D₂-like receptors and the μ opioid receptor.ChemMedChem2018,13, 944 – 956.