尹骏，男，中共党员，博士，中国药科大学生物制药教研室副研究员，硕士研究生导师。
?教育经历：
2011.9-2016.6，中国药科大学，微生物与生化药学，硕博连读；
2009.9-2011.6，中国药科大学，生化制药，本科；
2007.9-2009.6，南京大学，生化制药，本科。
?工作经历：
2019.7-至今，中国药科大学生命科学及技术学院副研究员、硕士研究生导师；
2016.8-2019.6，中国药科大学生命科学及技术学院师资博士后。
?研究方向：
1. 生物大分子药物成药性研究；
2. 聚多肽平台的开发及应用。
?科研项目（主持在研的国家级项目3项，参与“重大新药创制”重大专项、国家自然科学基金等课题7项）：
主持项目：
1.超电荷聚多肽介导的Cas9蛋白选择性递释及其在治疗非小细胞肺癌中的应用（国家自然科学基金青年项目，**）
2.聚多肽与Cas9融合蛋白的构建及在肿瘤基因编辑中的应用（中国博士后基金面上资助，2017M611957）
3.新型长效靶向抗耐药肿瘤蛋白DNA药物偶联物的开发（中国博士后特别资助项目，2019T120486）
?近三年发表论文（IF >10 的1篇，IF >5的5篇）：
1.Jun Yin#, Dingkang Liu#, Lichen Bao, Qun Wang, Ye Chen, Shan Hou, Yali Yue, Wenbing Yao*, Xiangdong Gao*. Tumor targeting and microenvironment-responsive multifunctional fusion protein for pro-apoptotic peptide delivery. Cancer letter, 2019, 452: 38-50. [IF:6.508]
2.Jun Yin#, Shan Hou#, Qun Wang, Lichen Bao, Dingkang Liu, Yali Yue, Wenbing Yao*, Xiangdong Gao*. Microenvironment-Responsive Delivery of the Cas9 RNA-Guided Endonuclease for Efficient Genome Editing. Bioconjugate Chemistry, 2019, 30(3):898-906. [IF: 4.485]
3.Jun Yin#, Qun Wang#, Shan Hou, Lichen Bao, Wenbing Yao*, Xiangdong Gao*. Potent Protein Delivery into Mammalian Cells via a Supercharged Polypeptide. Journal of the American Chemical Society, 2018, 140, 17234-17240. [IF: 14.695]
4.Lichen Bao#, Jun Yin#, Wen Gao, Qun Wang, Wenbing Yao*, Xiangdong Gao*. A long-acting FGF21 alleviates hepatic steatosis and inflammation in NASH mice partly through an FGF21- adiponectin- IL17A axis. British Journal of Pharmacology, 2018, 175, 3379-3393. [IF: 6.583]
5.Jun Yin, Lichen Bao, Rong Chen, Wen Gao, Xiangdong Gao*, Wenbing Yao*. Enhanced expression and distinctive characterization of a long-acting FGF21 and its potential to alleviate nonalcoholic steatohepatitis. Biochimie, 2018,151, 166-175. [IF: 3.362]
6.Wen Gao#, Jun Yin#, Lichen Bao, Qun Wang, Shan Hou, Yali Yue, Wenbing Yao* and Xiangdong Gao*. Engineering Extracellular Expression Systems in Escherichia coli Based on Transcriptome Analysis and Cell Growth State. Acs Synthetic Biology, 2018, 7(5):1291. [IF: 5.571]
7.Jun Yin, Lichen Bao, Hong Tian, Qun Wang, Xiangdong Gao*, Wenbing Yao*. Genetic fusion of human fgf21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity. British Journal of Pharmacology, 2016, 173(14), 2208-2223. [IF: 5.491]
8.Jun Yin, Lichen Bao, Hong Tian, Xiangdong Gao*, Wenbing Yao*. Quantitative relationship between the mrna secondary structure of translational initiation region and the expression level of heterologous protein in escherichia coli. Journal of Industrial Microbiology & Biotechnology, 2016, 43(1), 97-102. [IF: 2.81]
?联系方式：
Email：junyin@cpu.edu.cn