肖易倍（Yibei Xiao）,博士。中国药科大学教授，博士生导师。主要利用生物化学，微生物学，药物设计学，和生物物理学等多学科结合研究思路与方法，研究细菌的获得性免疫防御系统（CRISPR-Cas）的分子作用机制，RNA病毒的转录复制机制以及抗病毒药物的开发。近三年已在Science,Nature和Cell杂志以第一作者发表论文四篇，共同作者发表两篇。

学习与工作经历
04.2018 -至今(教授):中国药科大学,药学院
02.2014 – 03.2018 (博士后): Department ofMolecular Biology and Genetics, Cornell University,美国
08.2008 - 01.2014 (博士): Institut für Biochemie, Universit?t zu Lübeck,德国
09.2006 - 06.2008 (硕士):武汉大学,生命科学学院
09.2002 - 07.2006 (本科):中国药科大学,生命科学与技术人才培养基地

主要研究方向
1.细菌获得性免疫系统CRISPR-Cas的作用机制。
2.新型CRISPR-Cas系统的开发以及在基因编辑中的应用。
3.新生RNA病毒关键药物靶点的研究以及抑制剂开发。

近五年代表性论文
1. Xiao, Y., Luo, M., AE Dolan., Liao, M., Ke, A. (2018). Structure Basis for RNA-guided DNA degradation by Cascade and Cas3 inType I-E CRISPR-Cas system.Science, (accepted).
2. Xiao, Y., Ng, S.,Nam, KH., & Ke. A. (2017).How Type II CRISPR-Cas establishes immunity through Cas1-Cas2 mediated spacer integration.Nature,550 (7674), 137.
3. Xiao, Y., Luo, M.,Hayes, R. P., Kim, J., Ng, S., Ding, F., Liao, M., Ke, A. (2017). Structure basis for directional R-loop formation and substrate handover mechanisms in Type I CRISPR-Cas system.Cell,170(1), 48-60.
4. MW Brown., KE Dillard.,Y Xiao., AE Dolan., ET Hernandez., S Dahlhauser., …& Finkelstein, I. (2017).Assembly and translocation of a CRISPR-Cas primed acquisition complex.bioRxiv, 208058.
5. Jung, C.,Hawkins, J., Jones Jr, S.,Xiao, Y., … Ke, A., & Finkelstein,I.(2017). Massively parallel biophysical analysis of a CRISPR-Cas protein complex on repurposed next generation sequencing chips.Cell,170(1), 35-47.
6. Xiao, Y. and Ke, A., (2016). PIWI Takes a Giant Step.Cell,167(2), 310-312.
7. Hayes, R. P.,Xiao, Y., Ding, F., Van Erp, P. B., Rajashankar, K., Bailey, S., ... & Ke, A. (2016). Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli.Nature,530(7591), 499-503.
8. Qin, Z.,Xiao, Y., Yang, X., Mesters, J. R., Yang, S., & Jiang, Z. (2015). A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 β-N-acetylglucosaminidase.Scientific reports,5.
9. Huo, Y.,Nam, K. H., Ding, F., Lee, H., Wu, L.,Xiao, Y., ... & Ke, A. (2014). Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.Nature structural & molecular biology,21(9), 771-777.
10. Xiao, Y., Ma, Q., Restle, T., Shang, W., Svergun,D.I., Ponnusamy, R., ... & Hilgenfeld, R. (2012). Nonstructural proteins 7 and 8 of feline coronavirus form a 2: 1 heterotrimer that exhibits primer-independent RNA polymerase activity.Journal of Virology,86(8), 4444-4454.

联系方式：xiao**@gmail.com