自我简介
傅继华，男，1962年出生，博士，副教授，硕士生导师，本科毕业于北京大学生命科学院。学科专业：心血管药理学，从事药理学、毒理学及生理学的研究及教学工作。主要研究方向：胰岛素抵抗相关疾病—2型糖尿病、代谢综合征、高脂血症及动脉粥样硬化等代谢紊乱疾病的共同机制研究、心血管药理研究。
对“饮食与神经因素、内分泌紊乱等多因素同时刺激促进非酒精性脂肪肝发展及血脂紊乱的原理”有独特认识，发现高脂饮食与应激性刺激对代谢综合征的发生有明显的协同作用，不仅可促进脂肪肝向脂肪性肝炎的转化，还可促进胰岛素抵抗、血脂紊乱的发生，并可促进血管、心脏病变。对胰岛素抵抗相关疾病的发病机制有重大发现，国内外首先发现肝脏具有5-HT合成，且发现外周5-HT系统异常是胰岛素抵抗相关性疾病共同的、决定性的原因，已证实高脂饮食、高糖皮质激素血症引起的胰岛素抵抗及肝脏脂代谢紊乱具有共同的基础—外周及肝细胞5-HT合成增加及5-HT 2受体上调，这是本质性原因。已发表研究论文50余篇，其中多篇SCI收载；以第一发明人或合作者形式完成发明专利7项；与企业合作，已主持完成了9个以上新药的临床前药效学或毒理学研究工作；正在主持一项国家自然科学基金(面上项目)项目，一项南京军区医药卫生科研基金(重大专项)项目；参与了10项国家级、省级或市级研究项目，为药理学研究部分负责人。
正在主持的重要科研项目
2014-2016 南京军区医药卫生科研基金，“香卿止痛喷雾剂对军事训练伤快速镇痛消炎作用的临床及机制研究”，项目编号：ZX26；
2016-2019 国家自然科学基金(面上项目)，“外周5-羟色胺系统在糖皮质激素及高脂饮食诱导胰岛素抵抗时的作用研究”，项目编号：**。
发表的典型论文(主要研究领域)
Jihua Fu*, Shaoxin Ma, Xin Li, Shanshan An, Tao Li, Keke Guo, Min Lin, Wei Qu1, Shanshan Wang, Xinyue Dong, Xiaoyu Han, Ting Fu, Xinping Huang, Tianying Wang, Siyu He. Long-term Stress with Hyperglucocorticoidemiainduced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver. International Journal of Biological Sciences. 2016; 12(2): 219-234.
Tao Li, Keke Guo, Wei Qu,YingHan, Shanshan Wang, Min Lin, Shanshan An, XinLi, Shaoxin Ma, Tianying Wang, Shiya Ji, Christian Hanson, JihuaFu*. Important role of 5-hydroxytryptamine in glucocorticoid-induced insulin resistance in liver and intra-abdominal adipose tissue of rats. J Diabetes Investig. 2016; 7: 32–41.
Shaoxin Ma, Tao Li, Keke Guo, Xin Li, Shanshan An, Shanshan Hou, RuChen, BoYang, Siyu Liu, Jihua Fu*. Effective treatment with combination of peripheral 5-hydroxytryptamine synthetic inhibitor and 5-hydroxytryptamine 2 receptor antagonist on glucocorticoid-induced wholebody insulin resistance with hyperglycemia. J Diabetes Investig. 2016, doi: 10.1111/jdi.12526.
Xin Li, Keke Guo, Tao Li, Shaoxin Ma, Shanshan An, Shanshan Wang, Jiao Di, Siyu He, Jihua Fu*. 5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats. Obesity Research & Clinical Practice. 2016, http://dx.doi.org/10.1016/j.orcp.2016.03.015.
Shudong Wang, Tao Li, Wei Qu, Xin Li, Shaoxin Ma, Zheng Wang, Wenya Liu, Shanshan Hou, and Jihua Fu*. The Effects of Xiangqing Anodyne Spray on Treating Acute Soft-Tissue Injury Mainly Depend on Suppressing Activations of AKT and p38 Pathways. Evidence-Based Complementary and Alternative Medicine. 2016, http://dx.doi.org/10.1155/2016/**.
Ying Han, Min Lin, Xiaobin Wang, Keke Guo, Shanshan Wang, Mengfei Sun, Jiao Wang, Xiaoyu Han, Ting Fu, Yang Hu, Jihua Fu*. Basis of aggravated hepatic lipid metabolism by chronic stress in high-fat diet-fed rat. Endocrine. 2015, 48:483–492.
Siyuan Gao, Xue Han, Jihua Fu*, Xiaoling Yuan, Xing Sun, Qiang Li. Influence of chronic stress on the compositions of hepatic cholesterol and triglyceride in male Wistar rats fed a high fat diet. Hepatology Research, 2012; 42: 686–695
WEI Wei, XIE Sheng-rong, FU Ji-hua*, LIU Wen, QI Jian-ping, PING Qi-neng*. Anti-inflammatory Effects of Components in Shuxiong Tablet and Its Possible Formulary Rationality. Chinese Herbal Medicines, 2010, 2(4): 297-304.
J.-h. Fu, H.-s. Sun, Y. Wang, W.-q. Zheng, Z.-y. Shi, Q.-j. Wang. The Effects of a Fat- and Sugar-Enriched Diet and Chronic Stress on Nonalcoholic Fatty Liver Disease in Male Wistar Rats. Dig Dis Sci. 2010, 55: 2227-2236.
J.-H. Fu, S.-R. Xie, S.-J. Kong, Y. Wang, W. Wei, Y. Shan, Y.-M. Luo. The combination of a high-fat diet and chronic stress aggravates insulin resistance in Wistar male rats. Exp Clin Endocrinol Diabetes. 2009,117(7):354-60.
Wei Wei, Ji-Hua Fu*, Chang-Hai Su ,Ying Shan, Yuan Wang, Shu-Jia Kong, Ji-Hui Zhao, Wan-Liang Lu, Shu-Ming Wang, Li Wang, A continued study on the bisoprolol and isosorbide dinitrate transdermal patches: cardiovascular protection in spontaneously hypertensive rats, Journal of Chinese Pharmaceutical Sciences, 2008, 17: 241-248.
Ji-Hui Zhao, Ji-Hua Fu*, Shu-Ming Wang et al. A novel transdermal patch incorporating isosorbide dinitrate with bisoprolol: In vitro and in vivo characterization, Int. J. Pharmaceut 2007; 337: 88-101.
新药研发
完成了“注射用天麻素、香荠降压颗粒、长华降压颗粒、桑丹安神片、天葵降压片、抑抗灵抗不孕药效学、地奥降压胶囊、活血止痛胶囊、玄七通痹胶囊、元天止痛胶囊、复方硝酸异山梨醇酯比索洛尔透皮贴剂”等新药的药效学和(或)毒理学研究。
联系方式
联系地址：南京童家巷24号,中国药科大学生理教研室,邮编210009
联系电话: (0)
E-mail: fjhfy_cpu@163.com