张经纬，药物科学研究院，博士，副研究员，博士生导师。2006年毕业于中国药科大学基础药学理科基地班，获得学士学位。毕业时免试推荐至中国药科大学药物代谢动力学重点实验室直接攻读博士学位，师从王广基院士。博士毕业论文获2012年度江苏省优秀博士论文。博士毕业后留校工作，主要从事细胞药代动力学、分子药理学、中药/创新药物的药代动力学等研究工作，侧重于细胞药代动力学研究体系的建立及应用，药物代谢酶/转运体表达调控机制研究等。近几年来主持国家自然科学基金面上项目1项、国家自然科学基金青年基金1项、江苏省自然科学基金优秀青年基金1项、江苏省自然科学基金青年基金1项、教育部中央高校基本科研业务费专项资助（培育项目）1项，先后参加国家新药创制重大专项、国家自然科学基金重点项目、面上项目5项，同时负责多个横向课题研究。先后以第一作者/通讯作者发表SCI论文16篇（IF>5论文5篇）。获2017年江苏省科技进步一等奖（排名第三），江苏省“六大人才高峰”高层次人才（B类），江苏省青年科技人才托举工程。

主要研究方向
1、药物代谢酶/转运体表达调控机制研究
2、创新药物的药物代谢动力学研究

代表性成果（第一作者及通讯作者论文）
(1) Wang W (#), Cai Q (#), Zhou F, Liu J, Jin X, Ni P, Lu M(*), Wang G(*), Zhang J(*). Impaired pentose phosphate pathway in the development of 3D MCF-7 cells mediated intracellular redox disturbance and multi-cellular resistance without drug induction. Redox Biol. 2018，15: 253~265. [IF 7.126]
(2) Jin, Xiaoliang(#), Zhou, Fang(#), Liu, Yan, Cheng, Chen, Yao, Lan, Jia, Yuanwei, Wang, Guangji(*), Zhang, Jingwei(*), Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice. J Pharm Biomed Anal, 2018, 158:1~7 [IF 2.831]
(3) Liu, Jiali (#)，Yan, Fangrong (#)，Chen, Hongzhu，Wang, Wenjie，Liu, Wenyue，Hao, Kun，Wang, Guangji(*)，Zhou, Fang(*)， Zhang, Jingwei(*), A novel individual-cell-based mathematical model based on multicellular tumour spheroids for evaluating doxorubicin-related delivery in avascular regions，British Journal of Pharmacology，2017，174(17)：2862~2879 [IF 5.491]
(4) Chen, Qianying (#)，Chen, Hongzhu (#)，Wang, Wenjie，Liu, Jiali，Liu, Wenyue，Ni, Ping，Sang, Guowei，Wang, Guangji (*)，Zhou, Fang(*) , Zhang, Jingwei(*), Glycyrrhetic acid, but not glycyrrhizic acid, strengthened entecavir activity by promoting its subcellular distribution in the liver via efflux inhibition，Eur J Pharm Sci，2017，106：313~327 [IF 3.756]
(5) Ouyang, Bingchen (#)，Zhou, Fang (#)，Zhen, Le，Peng, Ying，Sun, Jianguo，Chen, Qianying，Jin, Xiaoliang，Wang, Guangji (*), Zhang, Jingwei(*), Simultaneous determination of tenofovir alafenamide and its active metabolites tenofovir and tenofovir diphosphate in HBV-infected hepatocyte with a sensitive LC-MS/MS method.，J Pharm Biomed Anal，2017，146：147~153 [IF 3.255]
(6) Liu, Yazhong(#)，Zhou, Fang(#)，Sang, Hua，Ye, Hui，Chen, Qianying，Yao, Lan，Ni, Ping，Wang, Guangji (*)，Zhang, Jingwei (*), LC-MS/MS method for the simultaneous determination of Lys-MCC-DM1, MCC-DM1 and DM1 as potential intracellular catabolites of the antibody-drug conjugate trastuzumab emtansine (T-DM1)，J Pharm Biomed Anal，2017，137：170~177 [IF 3.255]
(7) Yao, Lan(#)，Zhou, Fang(#)，Cai, Mingmin，Peng, Ying，Sun, Jianguo，Chen, Qianying，Jin, Xiaoliang，Wang, Guangji(*), Zhang, Jingwei(*), Development and validation of a sensitive LC-MS/MS method without derivatization/ion-pairing agents for etimicin quantification in rat plasma, internal ear and kidney.，J Pharm Biomed Anal，2017，146：96~102 [IF 3.255]
(8) Liu, Wen-Yue(#)，Zhang, Jing-Wei(#)(co-first)，Yao, Xue-Quan，Jiang, Chao，He, Ji-Chao，Ni, Pin，Liu, Jia-Li，Chen, Qian-Ying，Li, Qing-Ran，Zang, Xiao-Jie，Yao, Lan，Liu, Ya-Zhong，Wang, Mu-Lan，Shen, Pei-Qiang，Wang, Guang-Ji(*)，Zhou, Fang(*)，Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution.，Acta Pharmacologica Sinica，2017，38（2）：264~276 [IF 3.233]
(9) Lu, Meng(#)，Zhou, Fang(#)，Hao, Kun，Liu, Jiali，Chen, Qianying，Ni, Ping，Zhou, Honghao，Wang, Guangji(*)，Zhang, Jingwei(*)，Alternation of adriamycin penetration kinetics in MCF-7 cells from 2D to 3D culture based on P-gp expression through the Chk2/p53/NF-kappaB pathway.，Biochemical Pharmacology，2015，93（2）：210~220 [IF 5.091]
(10) Zhang, Jing-Wei(#)，Liu, Jiali(#)，Zhao, Yanlei，Wang, Guangji(*)，Zhou, Fang(*)，Plasma and cellular pharmacokinetic considerations for the development and optimization of antitumor block copolymer micelles.，Expert Opin Drug Deliv，2015，12（2）：263~281 [IF 4.840]
(11) Zhang, Jingwei(#)，Sun, Yuan，Wang, Yaoyao，Lu, Meng，He, Jichao，Liu, Jiali，Chen, Qianying，Zhang, Xiaoxuan，Zhou, Fang(*)，Wang, Guangji(*)，Sun, Xianqiang，Non-antibiotic agent ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo as a potential NorA inhibitor.，European Journal of Pharmacology，2014，740：277~284 [IF 2.532]
(12) Zhang, Jingwei(#)，Zhou, Fang(#)(*)，Wu, Xiaolan，Zhang, Xiaoxuan，Chen, Yuancheng，Zha, Beth S，Niu, Fang，Lu, Meng，Hao, Gang，Sun, Yuan，Sun, Jianguo，Peng, Ying，Wang, Guangji(*)，Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells.，British Journal of Pharmacology，2012，165（1）：120~134 [IF 5.067]
(13) Zhang, Jingwei(#)，Lu, Meng(#)，Zhou, Fang(#)，Sun, Haopeng，Hao, Gang，Wu, Xiaolan，Wang, Guangji(*)，Key role of nuclear factor-kappaB in the cellular pharmacokinetics of adriamycin in MCF-7/Adr cells: the potential mechanism for synergy with 20(S)-ginsenoside Rh2.，Drug Metabolism and Disposition，2012，40（10）：1900~1908 [IF 3.361]
(14) Zhang, Jingwei(#)，Zhou, Fang(#)(*)，Lu, Meng，Ji, Wei，Niu, Fang，Zha, Weibin，Wu, Xiaolan，Hao, Haiping，Wang, Guangji(*)，Pharmacokinetics-pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic-pharmacodynamic strategy.，Current Drug Metabolism，2012，13（5）：558~576 [IF 4.405]
(15) Zhou, Fang(#)，Zhang, Jingwei(#)(co-first)，Li, Peng，Niu, Fang，Wu, Xiaolan，Wang, Guangji(*)，Roberts, Michael S，Toward a new age of cellular pharmacokinetics in drug discovery.，Drug Metabolism Reviews，2011，43（3）：335~345 [IF 6.400]
(16) Zhang, Jingwei(#)，Zhou, Fang(#)，Wu, Xiaolan，Gu, Yi，Ai, Hua，Zheng, Yuanting，Li, Yannan，Zhang, Xiaoxuan，Hao, Gang，Sun, Jianguo，Peng, Ying，Wang, Guangji(*)，20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions.，Drug Metabolism and Disposition，2010，38（12）：2179~2187 [IF 3.716]

联系方式
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