个人简介：谢媛：女，博士，副教授，硕士生导师。
研究方向：药代动力学，代谢性疾病药理学。近年来一直从事代谢酶表达调控、代谢性疾病药理作用机制相关研究，具有丰富的药物代谢动力学研究经验。集中研究非酒精性脂肪肝病理机制、中药调控肥胖及脂肪肝状态下代谢酶改变及相关机制、中药调节脂质代谢紊乱的相关机理。主持项国家自然科学基金项目3项，江苏省自然科学基金项目1项，中国药科大学中央高校基本科研业务费专项资金项目2项。在FASEB J，Drug Metabolism and Disposition, Journal of Lipids Research等权威杂志发表多篇SCI论文。
联系方式：微信yytn555；电子邮箱：yuanxie58@yahoo.com
近五年代表论文
1）Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease.
Zhang B, Xu D, She L, Wang Z, Yang N, Sun R, Zhang Y, Yan C, Wei Q, Aa J, Liu B, Wang G, Xie Y.
FASEB J. 2018 Feb;32(2):757-767. doi: 10.1096/fj.R. Epub 2018 Jan 4. (IF:5.498)
2）Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance.
Wang L1,Zhang B2,Huang F2,Liu B2,Xie Y3. J Lipid Res.2016 Jul;57(7):1243-55. doi: 10.1194/jlr.M067397. Epub 2016 May 24. (IF:4.81)
3）Curcumin inhibits hepatic stellatecellactivation via suppression of succinate-associated HIF-1α induction.
She L, Xu D, Wang Z, Zhang Y, Wei Q, Aa J, Wang G, Liu B, Xie Y.
Mol Cell Endocrinol. 2018 Nov 15;476:129-138. doi: 10.1016/j.mce.2018.05.002. Epub 2018 May 7 (IF:3.754)
4）Curcumin restrains hepatic glucose production by blocking cAMP/PKA signaling and reducing acetyl CoA accumulation in high-fat diet (HFD)-fed mice.
Wang Z, Xu D, She L, Zhang Y, Wei Q, Aa J, Wang G, Liu B, Xie Y.
Mol Cell Endocrinol. 2018 Oct 15;474:127-136. doi: 10.1016/j.mce.2018.02.018. Epub 2018 Feb 27. (IF:3.754)
5）Reversing effects of lignans on CCl4-induced hepatic CYP450 down regulation by attenuating oxidative stress.
Xie Y, Hao H, Wang H, Guo C, Kang A, Wang G.
J Ethnopharmacol. 2014 Aug 8;155(1):213-21. doi: 10.1016/j.jep.2014.05.016. Epub 2014 Jun 5. (IF:3.115)
6）Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice.
Yan C, Zhang Y, Zhang X, Aa J, Wang G, Xie Y.
Biomed Pharmacother. 2018 Sep;105:274-281. doi: 10.1016/j.biopha.2018.05.135. Epub 2018 May 31. (IF:3.457)