殷志琦，女，博士，教授，博士研究生导师
1997.7毕业于中国药科大学中药制剂专业，获理学学士学位；1997.9考入中国药科大学攻读博士学位；2002.6获中国药科大学药物化学专业博士学位。
2002.8-2017.10中药学院天然药物化学教研室，2017.11-至今中药学院中药制药系。并于2003.3-2004.3在香港科技大学生物系访问****工作1年，2012.3-2012.6月于上海外国语大学进修，2013.4-2014.4美国伊利诺伊大学芝加哥校区公派留学1年。
入选江苏省高校“青蓝工程”中青年学术带头人、江苏省第五期“333工程”第三层次培养对象、高校“青蓝工程”优秀青年骨干教师培养对象、第九批“六大人才高峰”高层次人才、第三届江苏省中医药十佳青年之星。
兼职
药学会成员、Chinese Chemical Letters青年编委
国家自然科学基金医学部同行评议专家
南京市、山东省、吉林省、江西省、广东省科技评审专家
Journal of Natural Products、Food Hydrocolloids、Food and Function、Phytomedicine、Fitoterapia、Chinese Chemical Letters、中国天然药物等杂志审稿人
招生方向
1007Z9 天然药物化学、1008Z1中药化学
1056 中药学（专业硕士）
研究方向
1. 治疗代谢综合症(如高血脂、糖尿病、肥胖、非酒精性脂肪肝等)的中药和天然药物中活性成分、药效和作用机制研究与开发。
2. 肠道领域药物和保健食品研发，如便秘、溃疡性结肠炎等。
研究成果
主持自然科学基金项目、江苏省自然科学基金、中央高校基本科研业务费专项重点项目、天然药物活性组分与药效国家重点实验室培育项目等。作为主要完成人参加“重大新药创制”科技重大专项“十一五”计划及多项省部级项目。主持多项企业委托项目。
近年在本课题相关领域共申请公开发明专利11项，发表研究论文100余篇，其中在Analytical Chemistry, Phytochemistry, Mol. Pharmaceutics, Phytomedicine，Oncotarget, Scientific Reports等等SCI期刊发表文章30余篇。
部分代表性论文
Triterpenic acids-enriched fraction from Cyclocarya paliurusattenuates insulin resistance and hepatic steatosis via PI3K/Akt/GSK3β pathway. Phytomedicine, 2019, 66, 153130
Rhein-based necrosis-avid MRI contrast agents for early evaluation of tumor response to microwave ablation therapy. Magn Reson Med.2019, 82:2212-2224
Cyclocarya paliurustriterpenic acids fraction attenuates kidney injury via AMPK-mTOR-regulated autophagy pathway in diabetic rats. Phytomedicine, 2019, 64: 153060.
First Evaluation of Radioiodinated Flavonoids as Necrosis-Avid Agents and Application in Early Assessme of Tumor Necrosis. Mol. Pharmaceutics, 2018, 15(1): 207-215
Triterpenic acids-enriched fraction from Cyclocarya paliurusattenuates non-alcoholic fatty liver disease via improving oxidative stress and mitochondrial dysfunction.Biomedicine & Pharmacotherapy, 2018, 104: 229-239.
¹³¹I-Evans blue: evaluation of necrosis targeting property and preliminary assessment of the mechanism in animal models. Acta Pharmaceutica Sinica B, 2018,8(3):390-400
Triterpenoids from Cyclocarya paliurusand their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells. Phytochemistry, 2017, 142,76-84
New triterpene saponins from the aerial parts of Androsace umbellate. RSC Advances, 2017, 7, 25765-25772
Novel 18F?Labeled 1?Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging. ACS Medicinal Chemistry Letters, 2017, 8: 191-195
Radiolabeled Rhein as Small-Molecule Necrosis Avid Agents for Imaging of Necrotic Myocardium. Analytical Chemistry, 2017, 89(2): 1260-1266
Effects of Glycosylation on Biodistribution and Imaging Quality of Necrotic Myocardium of Iodine-131 Labeled Sennidins.Mol Imaging Biol, 2016, 18(6): 877-886
The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. Phytomedicine, 2016, 23: 1475-1483
Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. Scientific Reports, 2016, 6:21341.
Synthesis and Evaluation of ¹³¹I?Skyrin as a Necrosis Avid Agent for Potential Targeted Radionuclide Therapy of Solid Tumors. Mol. Pharmaceutics, 2016, 13(1): 180-189
Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses. Mol. Pharmaceutics, 2016, 13(1): 232-240
联系方式
Tel: (O), **(L), **
E-mail: chyzq2005@126.comor cpu-yzq@cpu.edu.cn
通讯地址：
江苏省南京市鼓楼区童家巷24号中国药科大学中药制药系(210009)
江苏省南京市江宁区龙眠大道639号中国药科大学中药制药系(211198)