汪哲，男，1990年7月生，博士，中药学院副教授，硕士生导师。
教育工作经历
2007/09-2011/07 中国药科大学，中药学，理学学士学位
2011/09-2016/07 中国科学院昆明植物研究所，植物化学与西部植物资源持续利用国家重点实验室，药物化学，理学博士学位。期间先后在中国科学院上海生物化学与细胞生物学研究所细胞生物学国家重点实验室和四川大学生物治疗国家重点实验室从事近2年的合作研究
2016/10-至今 中国药科大学，中药学院，期间在香港中文大学中医中药研究所从事近2月的合作研究
研究方向
中药化学及肿瘤药理学，主要集中于含环肽植物及其内生真菌中活性环肽的发现、生物合成及作用机制研究。主持国家自然科学基金面上项目和青年项目、江苏省自然科学基金青年项目和中央高校基本科研业务费项目，参与国家科技重大新药专项和校双一流高峰项目。近年来，发表文章约20篇，包括Organic Letters、Journal of Natural Products、Phytochemistry、Tetrahedron Letters、Journal of Pharmaceutical and Biomedical Analysis、Cell Reports、Cell Death and Disease、Biochimica et Biophysica Acta-Molecular Cell research、Journal of Ethonopharmacology等，参与授权专利5项。
联系方式：wangzhe@cpu.edu.cn，**
近年来发表的论文
1. Li Feng^?, Jing Han^?, Jia Wang, An-Xin Zhang, Yuan-Yuan Miao, Ning-Hua Tan*, Zhe Wang*. Pestalopyrones A-D, four uncommon tricyclic pyrone derivatives from the endophytic fungus Pestalotiopsis sp. S3.Phytochemistry, 2020, 179, 112505.
2. Jing Wang^?, Jia Wang^?, Ling Li, Li Feng, Yu-Rong Wang, Zhe Wang*, Ning-Hua Tan*. RA-XII, a bicyclic hexapeptidic glucoside, exerts antitumor activity independent of apoptosis and suppresses protective autophagy in colorectal cancer cells. Journal of Ethonopharmacology, 2020, 266, 113428.
3. Yan-Yun Hu^?, Xue-Jia Zhang^?, Zhi-Hao Zhang, Zhe Wang*, Ning-Hua Tan*. Qualitative and quantitative analysis of quinones in multi-originRubiaspecies by ultra performance liquid chromatography tandem mass spectrometry combined with chemometrics. Journal of Pharmaceutical and Biomedical Analysis, 2020, 189, 113471.
4. Li Feng^?, Jia Wang^?, Shui Liu, Xue-Jia Zhang, Qi-Rui Bi, Yan-Yun Hu, Zhe Wang*, Ning-Hua Tan*. Colletopeptides A-D, anti-inflammatory cyclic tridepsipeptides from the plant endophytic fungus Collectotrichum sp. S8.Journal of Natural Products, 2019,82, 1434?1441.
5. Jia Wang^?, Ling Li^?, Jing Wang, Li-Hua Song, Ning-Hua Tan*, Zhe Wang*. Natural naphthohydroquinone dimer rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic cell death and inhibiting the NF-κB and Akt/mTOR/P70S6K pathway in human cancer cells. Cells, 2019, 8, 1593.
6. Zhe Wang^?, Si-Meng Zhao^?, Li-Hua Song^?, Yu-Zhi Pu, Qiang Wang, Guang-Zhi Zeng, Xing Liu, Ming Bai, Shao Li, Fa-Bao Gao, Li-Juan Chen*, Chen Wang*, Ning-Hua Tan*. Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1. Cell Death & Disease, 2018, 9, 715.
7.Zhe Wang^?, Si-Meng Zhao^?, Yan-Yun Hu^?, Li Feng, Li-Mei Zhao, Ying-Tong Di, Ning-Hua Tan*. Rubipodanones A-D, cytotoxic naphthohydroquinone dimers from the roots and rhizomes of Rubia podantha.Phytochemistry,2018, 145. 153-160.
8. Guang-Zhi Zeng^?, Zhe Wang^?, Li-Mei Zhao, Jun-Ting Fan, Ning-Hua Tan*. NF-κB and JNK mediated apoptosis and G0/G1 arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis. Journal of Ethnopharmacology, 2018, 230, 220-227.
9. Sen-Lin Li^?, Ze Hong^?, Zhe Wang^?, Fei Li^?, Jia-Hao Mei, Lu-Lu Huang, Xi-Wen Lou, Si-Meng Zhao, Li-Hua Song, Wei Chen, Qiang Wang, Heng, Liu, Yan-Ni Cai, Huan-Sha Yu, Hui-Min Xu, Guang-Zhi Zeng, Quan-Yi Wang, Juan-Juan Zhu, Xing Liu*, Ning-Hua Tan*, Chen Wang*. The cyclopeptide astin C specifically inhibits the innate immune CDN sensor STING. Cell Reports, 2018, 25, 3405-3421.
10.Si-Meng Zhao^?, Zhe Wang^?, Xiao-Qiang Chen, Mao-Bo Huang, Ning-Hua Tan*. (±)-Rubioncolin D, a pair of enantiomeric naphthohydroquinone dimers fromRubia oncotricha. Tetrahedron Letters, 2017, 58, 3041-3043.
11. Hoi-Wing Leung^?, Zhe Wang^?, Grace Gar-Lee Yue, Si-Meng Zhao, Julia Kin-Ming Lee, Kwok-Pui Fung, Ping-Chung Leung, Clara Bik-San Lau*, Ning-Hua Tan*. Cyclopeptide RA-V inhibits cell adhesion and invasion in both estrogen receptor positive and negative breast cancer cells via PI3K/AKT and NF-κB signaling pathways. Biochimica et Biophysica Acta-Molecular Cell Research, 2015, 1853, 1827-1840.
12. Si-Meng Zhao^?, Zhe Wang^?, Guang-Zhi Zeng*, Wei-Wu Song, Xiao-Qiang Chen, Xiao-Nian Li, Ning-Hua Tan*. New cytotoxic naphthohydroquinone dimers fromRubia alata. Organic Letters, 2014, 16, 5576-5579.