张之昊，男，博士，2017年以特聘副研究员引进，硕士研究生导师。2010年毕业于中国药科大学药物化学系，同年加入澳门科技大学林瑞超教授课题组进行中药化学和代谢组学研究，并于2013年获颁博士学位。之后于密西西比大学，师从著名有天然产物化学家Ikhlas A. Khan教授开展博士后工作，后于2015年加入美国橡树林国家实验，师从著名生物学家Tim Tschaplinski教授开展博士后工作，进行代谢组学及生物能源转化研究。迄今已在国际知名学术期刊发表近19篇学术论文，其中以第一作者或通讯作者发表论文15篇，专利一篇。
研究方向
慢性肾脏病机制及生物标志物的代谢组学研究
与肾脏病相关天然产物活性物质基础研究
主持的科研项目
国家自然科学基金青年科学基金项目，**，主持；
中国药科大学高层次人才引进科研基金。
国家新药科技重大专项课题, 2017ZX**，治疗K-ras突变结直肠癌的天然环肽类创新药物TNH-1551-01注射剂新品种研发，在研，参与，2017/1-2020/12。
代表性论文：
Huachao Chen, Fei Li, Yongrong Yao, Zhe Wang, Zhihao Zhang*, Ninghua Tan*. Redox Dual-Responsive and O2?Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumor. Theranostics2019, 9 (1), 90-103. IF = 8.537
Hao Liang, Yun-Xing Ji, Rui-Han Wang, Zhi-Hao Zhang*, and Bo Zhang*. Visible-Light-Initiated Manganese-Catalyzed E-Selective Hydrosilylation and Hydrogermylation of Alkynes. Organic Letters2019, 21 (8): 2750-2754. IF = 6.492
Zhihao Zhang, Jun-Qiu He, Ying-Yong, Zhao, Huachao Chen, et al. Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ. Acta Pharmacol Sin, 2019, doi:10.1038/s41401-019-0319-4. IF = 4.010
Zhi-Hao Zhang, Hua Chen, Nosratola D. Vaziri, Jia-Rong Mao, LiZhang, Xu Bai, Ying-Yong Zhao^*. Metabolomic signatures of chronic kidneydisease of diverse etiologies in the rats and humans. Journal of Proteome Research2016, 15: 3802-3812. IF = 4.268
Zhi-Hao Zhang, Zulfiqar Ali, Shabana I. Khan, Ikhlas A. Khan^*. Cytotoxic monacolins from red yeast rice, a Chinese medicine and food. Food Chemistry2016, 202: 262-268. IF = 4.529
Zhi-Hao Zhang^#, Xiaoyan Wang^#*, Jingcheng Wang, Zhiying Jia, YuminLiu, Xie Xie, Chongchong Wang, Wei Jia^*. Metabonomics approach to assessingthe metabolism variation and endoexogenous metabolic interaction ofginsenosides in cold stress rats. Journal of Proteome Research2016, 15: 1842-1852. IF = 4.268
Zhi-Hao Zhang, Nosratola D. Vaziri, Feng Wei, Xian-Long Cheng, Xu Bai, Ying-Yong Zhao^*. An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinalein chronic renal failure.Scientific reports2016, 6: 22151. IF = 5.228
Xiaohan Yang, Rongbin Hu, Hengfu Yin, Jerry Jenkins, Shengqiang Shu, Haibao Tang, Degao Liu, Deborah A Weighill, Won Cheol Yim, Jungmin Ha, Karolina Heyduk, David M Goodstein, Hao-Bo Guo, Robert C Moseley, Elisabeth Fitzek, Sara Jawdy, Zhihao Zhang, Meng Xie, James Hartwell, Jane Grimwood, Paul E Abraham, Ritesh Mewalal, Juan D Beltrán, Susanna F Boxall, Louisa V Dever, Kaitlin J Palla, Rebecca Albion, Travis Garcia, Jesse A Mayer, Sung Don Lim, Ching Man Wai, Paul Peluso, Robert Van Buren, Henrique Cestari De Paoli, Anne M Borland, Hong Guo, Jin-Gui Chen, Wellington Muchero, Yanbin Yin, Daniel A Jacobson, Timothy J Tschaplinski, Robert L Hettich, Ray Ming, Klaus Winter, James H Leebens-Mack, J Andrew C Smith, John C Cushman, Jeremy Schmutz, Gerald A Tuskan. The Kalancho? genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism. Nature Communications, 2017, 8, 1899. IF = 11.878
Jessy Labbé, Wellington Muchero, Olaf Czarnecki, Juan Wang, Xiaoping Wang,Anthony C. Bryan1, Kaijie Zheng, Yongil Yang, Meng Xie?, Jin Zhang?, Dongfang Wang?,Peter Meidl1, Hemeng Wang, Jennifer L. Morrell-Falvey, Kevin R. Cope?, Lucas G. S. Maia,Jean-Michel Ané, Ritesh Mewalal1, Sara S. Jawdy1, Lee E. Gunter1, Wendy Schackwitz,Joel Martin?, Fran?ois Le Tacon, Ting Li, Zhihao Zhang, Priya Ranjan, Erika Lindquist,Xiaohan Yang?, Daniel A. Jacobson?, Timothy J. Tschaplinski?, Kerrie Barry,Jeremy Schmutz?, Jin-Gui Chen?* and Gerald A. Tuskan. Mediation of plant–mycorrhizal interaction by a lectin receptor-like kinase. Nature Plants, 2019, 5, 676–680. IF = 13.297
Hua Chen, Gang Cao, Dan-Qian Chen, Ming Wang, Nosratola D. Vaziri, Zhi-Hao Zhang, Jia-Rong Mao, Xu Bai, Ying-Yong Zhao^*. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression. Redox Biology2016, 10: 168-178.IF = 7.126

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主要学术、科研成果（350字以内）
本人主要从事慢性肾脏病机制及生物标志物的代谢组学研究以及与肾脏病相关天然产物活性物质基础研究。在国际知名期刊共发表论文17篇，中以第一作者或通讯作者发表Sci论文13篇，引用共计300次。申请专利一篇。
本人对中药大黄抗肾脏纤维化活性进行了系统研究，结果表明大黄乙酸乙酯提取物是大黄治疗慢性肾脏病的活性部位。针对大黄乙酸乙酯提取部位，采用活性导向分离，进一步分离得到活性成分芦荟大黄素和大黄酸。采用药效学、分子生物学及代谢组学的方法，首次揭示大黄活性成分通过调控TGF-β/Smad信号通路以及纠正异常的内源性小分子代谢物发挥抗肾间质纤维化作用，初步阐明大黄活性成分抗肾间质纤维化的作用机制，为寻找和开发新的治疗慢性肾脏病的药物奠定基础。