戴岳，博士，教授，博士生导师，中药药理学科带头人。
1985年在中国药科大学药学专业（药理专门化）获得学士学位，1988年在同校中药药理学专业获得硕士学位后留校任教，1998年在日本近畿大学药学部获得药学博士学位。曾在近畿大学和香港中文大学合作研究三年。2003年晋升教授，2005年晋升博士生导师。现任中药药理教研室主任，中国药理学会抗炎免疫药理专业委员会委员，江苏省药理学会中药药理专业委员会副主任委员，江苏省“333高层次人才培养工程”首批中青年科学技术带头人，“青蓝工程”中青年学术带头人，国家留学基金委评审专家，教育部留学回国人员科研启动基金评审专家，国家、江苏省新药评审专家，国家自然科学基金同行评议专家。中国药科大学学报编委，Brit J Pharmacol、Int Immunopharmacol和JEthnopharmacol等国际刊物通讯评议人。
从事中药抗炎免疫药理学研究，主要研究方向包括：1）外周Th17/Treg失衡在免疫性炎症中的关键调控作用，中药治疗类风湿关节炎和溃疡性结肠炎的活性成分及其作用机制；2）中药“双向调节作用”的物质基础和分子机制；3）中药活性成分的结构优化及新药发现。
主持过国家自然科学基金、“重大新药创制”科技重大专项、国家新药基金、高校博士点基金等国家级和省部级课题18项，企业合作项目20余项，发表研究论文200余篇（SCI收录104篇），获授权发明专利8项，转让抗关节炎和降血糖五类中药新药各1个（本人排名第二），作为副主编或编委编写《新编临床中药学》、《中药药理研究方法学》和《中国药材学》等专著5部。已培养博士和硕士研究生40余名，其中1名获得江苏省优秀硕士学位论文。
近期代表性研究论文：
1) Bei Tong, Xusheng Yuan, Yannong Dou, Xin Wu, Yuhui Wang, Yufeng Xia*, Yue Dai*. Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activating aryl hydrocarbon receptor. Laboratory Investigation. In press.
2) Wang Y, Xu X, Zhao P, Tong B, Wei Z*, Dai Y*. Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression. Oncotarget. 2016,7(17):23684-99
3) Bei Tong, Xusheng Yuan, Yannong Dou, Xin Wu, Guixin Chou,, Zhengtao Wang, Yufeng Xia*, Yue Dai*. Norisoboldine, an isoquinoline alkaloid, acts as an aryl hydrocarbon receptor ligand to induce intestinal Treg cells and thereby attenuate arthritis. The International Journal of Biochemistry & Cell Biology. 2016, 75: 63–73
4) Xia Y, Xia YF, Lv Q, Meng-Fan Y, Qiao SM, Yang Y, Wei ZF*, Dai Y*. Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting generation of hepatocyte growth factor via PPAR-γ in colon. British Journal of Pharmacology 2016, 173:1219-1235
5) Xusheng Yuan, Bei Tong, Yannong Dou, Xin Wu, Zhifeng Wei*, Yue Dai*. Tetrandrine ameliorates collagen-induced arthritis in mice by restoring the balance between Th17 and Treg cells via the aryl hydrocarbon receptor. Biochemical Pharmacology 2016, 101:87-99
6) Wu X, Dou Y, Yang Y, Bian D, Luo J, Tong B, Xia Y*, Dai Y*. Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway. Biochemical Pharmacology 2015, 15;96(4):323-36
7) Wei ZF, Lv Q, Xia Y, Yue MF, Shi C, Xia YF, Chou GX, Wang ZT, Dai Y*. Norisoboldine, an anti-arthritis alkaloid isolated from Radix Linderae, attenuates osteoclast differentiation and inflammatory bone erosion in an aryl hydrocarbon receptor-dependent manner. Int J Biol Sci. 2015, 17;11(9):1113-26
8) Yang Y, Wu X, Wei Z, Dou Y, Zhao D, Wang T, Bian D, Tong B, Xia Y, Xia Y*, Dai Y*. Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca2+/CaMKII signaling pathways in the small intestine. Pharmacological Research 2015, 95/96: 71-81
9) Bei Tong, Yannong Dou, TingWang, Juntao Yu, XinWu, Qian Lu, Guixin Chou, Zhengtao Wang, Lingyi Kong, Yue Dai*, Yufeng Xia*. Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues. Toxicology and Applied Pharmacology 2015, 282(1): 90–99
10)Bei Tong, Juntao Yu, Ting Wang,Yannong Dou, Xin Wu, Lingyi Kong, Yue Dai*, Yufeng Xia**. Sinomenine suppresses collagen-induced arthritis by reciprocal modulation of regulatory T cells and Th17 cells in gut-associated lymphoid tissues. Molecular Immunology 2015, 65: 94-103
11)Ting Wang, Zhifeng Wei, Yannong Dou, Yan Yang, Dandan Leng, Lingyi Kong, Yue Dai*, Yufeng Xia*. Intestinal interleukin-10 mobilization contributes to the anti-arthritis effect of orally administered madecassoside: a unique action mode of saponin compounds with poor bioavailability. Biochemical Pharmacology 2015, 94: 30-38
12)XH Gao, R Gao, YZ Tian, P McGonigle, JE Barrett, Y Dai* and H Hu*. A store-operated calcium channel inhibitor attenuates collagen-induced arthritis. British Journal of Pharmacology. 2015, 172(12):2991-3002
联系方式：中国药科大学中药药理教研室
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