长期从事本科生和研究生的教学工作。1999年4月赴法国巴黎第五大学进行体内手性药物分离分析等研究。承担国家、省部级、国际合作及企业合作科研项目三十多项，在Carbon、J. Mater. Chem.、J Chromatogr.A 、Analyst、Int. J Pharm、Journal of Pharmaceutical and Biomedical Analysis 、J Chromatogr.B、J Chromatogr. Sci.、J Biochem. Biophys. Methods、Toxicology letters、Talanta、Journal of Nanoscience and Nanotechnology、International Journal of Biomedical Science 、J Nanoparticle Research、J Separation Science、Journal of Luminescence、Spectrochimica Acta Part A、J Food, Agri & Environ、Chromatographia、Luminescence、Spectroscopy、化学学报、化学进展、光谱学与光谱分析、分析化学、高分子学报、中国环境科学、药学学报、中国药科大学学报等国内外学术刊物上发表论文100余篇，其中SCI收载论文60余篇，EI收载论文6篇。编写《现代色谱分析》等教科书和教学参考书8本。申请专利13项。
研究方向为药物现代仪器分析、药物质量研究与评价和药物分析新材料与新技术。主要从事微量组分、主客体相互作用的分析方法研究、手性药物分离分析和分子模拟研究。特别关注体内药物和生物药物的分离分析及药物质量标准研究和制订。
主要学术兼职：国家食品药品监督管理局保健食品评审专家，国家863计划评审专家，教育部学位与研究生教育评审专家，国家科技奖励评审专家，江苏省食品药品监督管理局评审专家，农业部兽药评审专家，《Int.J.Biomed.Sci.》杂志编委，《JFood,Agri.Environ.》杂志助理编委。
主要学术成绩：镧系离子探针在肿瘤早期诊断及抗肿瘤筛选中的应用与国内外临床医药学专家和病理专家合作，开展了荧光光谱与临床医学的交叉研究。率先提出了以Tb-CPI为探针，用于肿瘤快速诊断和抗肿瘤药物筛选的新方法。发表相关研究文章10篇。
拟除虫菊酯及其异构体环境行为基础研究围绕拟除虫菊酯在环境的滞留、迁移、转化和归趋研究中的不足，开展了拟除虫菊酯及其异构体的环境行为研究。为了解菊酯类农药在环境中滞留、迁移、转化等行为,正确评价其药效和环境安全性提供科学依据。发表相关研究文章5篇。
手性药物分离分析采用手性固定相，反相高效液相色谱法直接拆分苯并二氮杂草类药物对映体，可用于苯并二氮杂草类药物对映体的分离测定和体内研究。同时，通过热力学参数的计算，对分离机理进行了研究。在J.Chromatogr.B等英文杂志发表SCI文章8篇。
分子印迹水相分离技术及其在药学中的应用基于溶剂热法制备了粒径、形貌、饱和磁化率均可灵活调节的磁性碳纳米管，实现了材料的可控性制备，并对复合机理进行了探讨；在磁性碳纳米管表面进行乙烯化和环糊精化修饰，合成了两种新型的功能单体MCNTs@C=C和MCNTs@β-CD，在分子印迹反应中同时作为基质材料和功能单体，从而提高印迹容量和印迹反应效率；结合纳米技术和表面分子印迹技术，在磁性碳纳米管表面制备分子印迹材料，应用于复杂样品的前处理，实现了基质材料和分离模式的技术创新；将磁性碳纳米管表面分子印迹材料应用于毛细管电色谱领域，同时作为柱塞和固定相，克服填充型毛细管电色谱柱柱塞制备困难、手性拆分效能低的瓶颈；探讨了磁性碳纳米管的合成机理、磁场辅助毛细管电色谱的构建原理、分子印迹孔穴与环糊精的空腔协同识别机制，为相关工作的研究提供了理论基础。
以GTFX为模板分子，制备了一种新型的M-MIP(两亲性M-MIP)，并用新的检测方法考察其两亲性，结果表明得到的纳米材料在水及生物体液中均具有较好的适应性；利用溶胶-凝胶法，在c-MMWCNTs的表面制备了Cu(II)印迹聚合物，研究了Cu(II)在材料表面的吸附行为。并将该聚合物应用于中药材中残留重金属离子的检测；采用计算机模拟技术选择合适的功能单体，合成了一种对表柔比星(EPI)具有选择性的新型的水相识别M-MIP，并应用于模板药物的吸附及体外的控释过程。发表文章10余篇。
近期发表的文章代表作：
1. Hua He et al，Mixed hemimicelle solid-phase extraction based on magnetic carbon nanotubes and ionic liquids for the determination of flavonoids，Carbon，2014, 72:274-286
2 Hua He, et al, Anticancer loading and controlled release of novel water-compatible magnetic nanomaterials as drug delivery agents, coupled to a computational modeling approach，J. Mater. Chem. B, 2013, 1, 4099–4109
3. Hua He et al，Mixed hemimicelles solid-phase extraction based on ionic liquid- coated Fe3O4/SiO2 nanoparticles for the determination of flavonoids in bio-matrix samples coupled with high performance liquid chromatography，Journal of Chromatography A, 2014，1324：78–85
4. Hua He, et al, Development of novel molecularly imprinted magnetic solid-phase extraction materials based on magnetic carbon nanotubes and their application for the determination of gatifloxacin in serum samples coupled with high performance liquid chromatography. Journal of Chromatography A2013, 1274, 44-53.
5. Hua He et al，Development of novel amphiphilic magnetic molecularly imprintedpolymers compatible with biological fluids for solid phase extractionand physicochemical behavior study，Journal of Chromatography A2013：1317：110-120
6.Huan He, Deli Xiao, Jia He,Hui Li Hua He, Hao Dai and Jun Peng，Preparation of core–shell magnetic ion-imprinted polymer by sol-gel process for selective extraction of Cu(II) from herbal medicines，Analyst，2014，139：2459–2466
7. Hua He et al，Preparation of molecularly imprinted polymers on the surface of magnetic carbon nanotubes with pseudo template for rapid simultaneous extraction of four fluoroquinolones in egg samples. Analyst2013, 138, 3287-3296
8. Hua He et al，A sensitive LC–MS/MS method for simultaneous determination of amygdalin and paeoniflorin in human plasma and its application，Journal of Pharmaceutical and Biomedical Analysis,2014, 92:160–164
9.Hua He et al，Adsorption behavior of epirubicin hydrochloride on carboxylated carbon nanotubes ，International Journal of Pharmaceutics, 2011, 405（1-2）：153-161
10. Hua He et al，Single-step preparation of fluorescent carbon nanoparticles, and their application as a fluorometric probe for quercetin, Microchim Acta, 2014, 181: 1309-1316
11. Hua He et al，Magnetic carbon nanotubes: synthesis by a simple solvothermal process and application in magnetic targeted drug delivery system，J Nanopart Res ，2012，14:984-996
12. Hua He et al，Loading behavior of gatifloxacin in urine and lake water on a novel magnetic molecularly imprinted polymer used as extraction sorbent with spectrophotometric analysis. Journal of Separation Science, 2013, 36 (5), 898-906.
13. Hua He et al，Carbon Nanotubes: Applications in Pharmacy and Medicine，Biomed Res Int.2013;2013:578290. doi: 10.1155/2013/578290. Epub 2013 Sep 30.
14.Hua He et al，Label-free silver nanoparticles for the naked eye detection of entecavir，Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 126 :178–183
15.Hua He et al. Interaction of carboxylated single-walled carbon nanotubes with bovine serum albumin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 105: 45-51.
16. Hua He et al.. Simultaneous extraction of anthracyclines from urine using water-compatible magnetic nanoparticles with dummy template coupled with high performance liquid chromatography. Analytical methods,2014, 6:4421-4429
17. Hua He et al，Interaction of amidated single-walled carbon nanotubes with protein by multiple spectroscopic methods，Journal of Luminescence,2014, 145:125–131
18.Hua He et al，Microwave-assisted one-step green synthesis of amino- functionalized fluorescent carbon nitride dots from chitosan. Luminescence, 2013, 28, 612-615.
19.Hua He et al，Microwave assisted one-step green synthesis of carbon nitride dots from ionic liquids and their application as novel fluorescence probe for quercetin determination. Journal of Luminescence2013, 140, 120-125.
20．Hua He, et al, Molecularly Imprinted Stationary Phase Prepared by Reverse Micro-emulsion Polymerization for Selective Recognition of Gatifloxacin in Aqueous Media，J. Chromatogr Sci，2012，50（6）：499-509
21. Hua He et al，Chiral Separation of Ketoprofen on a Chirobiotic T Column and Its Chiral Recognition Mechanisms，Chromatographia，2012，75:1355–1363

22.Hua He, et. al, The interaction between ketoprofen and bovine serum albumin by molecular simulation and spectroscopic methods. Spectroscopy, 2011,26:337-348.
23.Hua He, et al, Adsorption Behavior of Pazu?oxacin Mesilate on Amino-Functionalized Carbon Nanotubes, Journal of Nanoscience and Nanotechnology, 2012, 12:1-9
24.Hua He, et al, Adsorption behavior and adsorption mechanism of Cu(II) ions on amino-functionalized magnetic nanoparticles，Trans. Nonferrous Met. Soc. China2013，23：2657?2665
25. 何华等，羧基化多壁碳纳米管/Fe3 O4磁性复合材料对水中铜( II) 的吸附性能，新型炭材料（英文版）New Carbon Materials，2014, 29（4）:15-25

26. 何华等，三种酸氧化法对多壁碳纳米管的功能化及其含氧官能团含量的比较研究，分析化学，2011，39（5）:718-722
27. 何华等，离子液体双水相技术萃取头孢呋辛酯及其机理探究，分析化学，2012，40（8）：1252-1256

28.何华等，光谱法与分子模拟技术研究杨梅素与牛血清白蛋白的相互作用，化学学报，2012，70（2）:143-150

29．何华等，荧光光谱法研究共存碳纳米管对牛血清白蛋白与加替沙星相互作用的影响，光谱学与光谱分析，2011，31（1）:149-153
30.何华等，米托蒽醌与B-DNA相互作用的分子模拟，化学学报，2010，68（6）:551-556
31.何华等，PAMAM树状大分子对酮基布洛芬溶解度的影响，高分子学报，2010,7：876-883
32.何华等，不同代PAMAM树状大分子与牛血清白蛋白的相互作用研究，化学学报，2010，68（17）:1741-1748
33.何华等，聚酰胺-胺树状大分子靶向给药系统的研究进展,药学学报,2011,46(5):493?501
34.何华等，纳米结构分子印迹聚合物及其在药物分析中的应用进展，分析化学，2012，40（8）：1461-1468

35.何华等，分子印迹水相分离技术及其在分析化学中的应用，化学进展，
2011，2（10）:2140-2150

36.Hua He et al，Simultaneous extraction of anthracyclines from urine using water-compatible magnetic nanoparticles with a dummy template coupled with high performance liquid chromatography，Anal. Methods, 2014, 6（12）：4421-4429
37. Hua He et al，Label-free silver nanoparticles for visual colorimetric detection of etimicin，Anal. Methods, 2014, 6, 7906-7911
38.Hua He et al，Synthesis and analytical applications of molecularly imprinted polymers on the surface of carbon nanotubes: a review，Microchim Acta, 2015, 182: 893–908
39. Hua He et al，Magnetic solid-phase extraction based on Fe3O4 nanoparticles retrieval of chitosan for the determination of flavonoids in biological samples coupled with high performance liquid chromatography，RSC Adv., 2014, 4, 64843–6485
40. Hua He et al，Applications of magnetic surface imprinted materials for solid phase extraction of levofloxacin in serum samples，J. Mol. Recognit. 2015; 28: 277–284
41. Hua He et al，Porous carbon quantum dots: one step green synthesis via L-cysteine and application in metal ions detection，RSC Adv., 2015, 5, 2039–2046
42. Hua He et al，Colorimetric determination of o-phenylenediamine in water samples based on the formation of silver nanoparticles as a colorimetric probe，Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy，2015, 140（5）：328–333
43. Hua He et al，Microwave-assisted synthesis of BSA-modified silver nanoparticles as a selective fluorescent probe for detection and cellular imaging of cadmium (II)，Microchim Acta，2015，182:1255–1261
44. Hua He et al，Adsorption behavior of a computer-aid designed magnetic molecularly imprinted polymer via response surface methodology，RSC Adv., 2015, 5, 61161–61169
45.Hua He et al，One-step spontaneous synthesis of fluorescent carbon nanoparticles with thermosensitivity from polyethylene glycol，New J. Chem., 2015, 39, 7033–7039
46.Hua He et al，Metal-organic framework based crystalline sponge method for structure analysis[J]. Trac Trends in Analytical Chemistry,2018, 102:290-310.（IF=7.034）

47.Hua He et al，A regenerable sorbent composed of a zeolite imidazolate framework (ZIF-8), Fe3O4 and graphene oxide for enrichment of atorvastatin and simvastatin prior to their determination by HPLC[J].Microchimica Acta,2018, 185 (2), 141-149. （IF=5.705）

48.Hua He et al，Calcium-doped fluorescent carbon nanoparticles: spontaneous thermal synthesis, pH-sensitive fluorescence off-on, and mechanism[J]. Sensors and Actuators B: Chemical，2018，266：594–602. （IF=5.667）

49.Hua He et al，One-pot sustainable synthesis of magnetic MIL-100(Fe) with novel Fe3O4 morphology and its application in heterogeneous degradation. Dalton Trans, 2018, 47 (10), 3417-3424. （IF=4.099）

50.Hua He et al，Colorimetric sensor for cimetidine in human urine based on D-xylose protected gold nanoparticles[J]. Analyst, 2018, 143:2369-2376. （IF=3.864）
51.Hua He et al，Mixed Hemimicelle Solid-Phase Extraction Based on Magnetic Halloysite Nanotubes and Ionic Liquids for the Determination and Extraction of Azo Dyes in Environmental Water Samples[J]. Journal of Chromatography A, 2018,1551,10-20. （IF=3.716）

52.Hua He et al，Meriem Fizir, Wei Liu, Mu-Chuan Niu, Asma Itatahine, Yamina Ait Mehdi, Hua He*.Pierre Dramou*. QbD Approach by Computer Aided Design and Response Surface Methodology for Molecularly Imprinted Polymer Based on Magnetic Halloysite Nanotubes for Extraction of Norfloxacin from Real Samples[J]. Talanta, 2018,184, 266-276. （IF=4.244）
53.Hua He et al，Pierre Dramou*. Preparation of Multifunctional PEG-graft-Halloysite Nanotubes for Controlled Drug Release, Tumor Cell Targeting, and Bio-imaging[J]. Colloids and Surfaces B: Biointerfaces, 2018, 170, 322–329. （IF=3.997）
54.Hua He et al，Hua He*. Halloysite nanotubes in analytical sciences and in drug delivery: A review [J]. Microchimica Acta, 2018, 185(8)：389-421. （IF=5.705）
55.Hua He et al，Folic acid-conjugated chitosan oligosaccharide-magnetic halloysite nanotubes as a delivery system for camptothecin[J]. Carbohydrate Polymers, 2018, 197, 117–127. （IF=5.158）

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