王琛，中国药科大学理学院教授，博导，国家优秀青年科学基金获得者，江苏省“青蓝工程”优秀青年骨干教师&中青年学术带头人，中国分析测试协会青年学术委员会委员，药物分析技术分会青年委员会委员；主要从事微纳流控生命分析新方法研究，已在Angew. Chem. Int. Ed., Nano lett., ACS Nano, Adv. Funct. Mater., Lab Chip, Anal. Chem.等期刊发表研究论文50 余篇；参编英文图书《Nanobiosensors: From Design to Applications》(Wiley)；是化学领域Sci. Bull., Anal. Chem., ACS catal., Theranostics, ACS Appl. Mater. Interfaces等期刊的邀请审稿人。
联系方式：E-mail:aben0310@163.com; wangchen@cpu.edu.cn
南京市江宁区龙眠大道639号，中国药科大学理学院实验楼C楼212
教育及工作经历：
2007.09-2011.09，南京大学化学化工学院，分析化学博士
2012.10-2016.10，南京大学物理学院，物理学博士后
2016.03-2017.03，美国麻省理工学院（MIT）材料与科学学院，访问****
2004.7-至今，中国药科大学理学院，化学系教师
主要研究方向：
1）纳米通道生物分析：发展纳米通道端面分析新方法，实现生物样品中小分子\离子、蛋白质、核酸、细胞等系列生物分子识别研究。
2）纳米酶的制作与应用：设计并制作高活性纳米酶，研究其生物催化新机制，并将其应用于肿瘤治疗和抗菌研究中。
3）等离激元增强光电分析：发展等离激元增强电化学及光学检测新方法，实现单分子、单细胞、单颗粒等系列高灵敏分析检测。
科研代表作：
2020
Zhou, Y.; Liao, X.; Han, J.; Chen, T. Wang, C.*, Ionic current rectification in asymmetric nanofluidic devices.Chinese Chemical Letters 2020, DOI: 10.1016/j.cclet.2020.05.033.
Liu, F. F.; Wang, C.*; Xia, X. H.*, Bio-inspired nanochannels: fabrication, modification and bioanalytical applications. Scientia Sinica Chimica 2020, 50, 867-881.
Hu, W. C.; Younis, M. R.; Zhou, Y.; Wang, C.*; Xia, X. H., In-situ fabrication of ultrasmall gold nanoparticles/2D MOFs hybrid as nanozyme for antibacterial therapy. Small2020, **.(Back Cover)
Wang, C.*; Zhao, X. P.; Liu, F. F.; Chen, Y. M.; Xia, X. H.*; Li, J.*, Dendrimer- Au nanoparticle network covered alumina membrane for ion rectification and enhanced bioanalysis. Nano Letters 2020, 20, 1846-1854.
Liu, F. F.; Zhao, X. P.; Liao, X. W.; Liu, W. Y.*; Chen, Y. M.; Wang, C.*, Ultrasensitive and label-free detection of cell surface glycan using nanochannel-ionchannel hybrid coupled with electrochemical detector. Analytical Chemistry2020, 92, 5509-5516.
Wang, C.*; Liu, F. F.; Tan, Z.; Chen, Y. M.; Hu, W. C.; Xia, X. H.*, Fabrication of bio-inspired 2D MOFs/PAA hybrid membrane for asymmetric ion transport. Advanced Functional Materials2020, 30, **.
Liu, F. F.; Guo, Y. C.; Wang, W.*; Chen, Y. M.; Wang, C.*, In-situ synthesis of MOFs/PAA hybrid with ultrahigh ionic current rectification. Nanoscale2020, 12, 11899-11907.(Back Cover)
Liu, F. F.; Zhao, X. P.; Kang, B.; Xia, X. H.; Wang, C.*, Non-linear mass transport in confined nanofluidic devices for label-free bioanalysis/sensors. TrAC Trends in Analytical Chemistry2020, 123: 115760.
2019
Wang, S. S.; Jiao, L.; Qian, Y. Y.; Hu, W. C.; Xu, G. Y.; Wang, C.*; Jiang, H. L.*, Boosting electrocatalytic hydrogen evolution over metal-organic frameworks by plasmon-induced hot-electron injection. Angewandte Chemie International Edition2019, 58(31): 10713-10717.
Zhao, X. P.; Zhou, Y.; Zhang, Q. W.; Yang, D. R.; Wang, C.*; Xia, X. H.*, Nanochannel-ionchannel hybrid device for ultrasensitive monitoring of biomolecular recognition events. Analytical Chemistry2019, 91: 1185-1193.
Wang, S. S.; Zhao, X. P.; Liu, F. F.; Younis, M. R.; Xia, X. H.*; Wang, C.*, Direct plasmon-enhanced electrochemistry for enabling ultrasensitive and label-free detection of circulating tumor cells in blood. Analytical Chemistry2019, 91(7): 4413-4420.
Zhao, X. P.; Liu, F. F.; Hu, W. C.; Younis, M. R.; Wang, C.*; Xia, X. H.*, Biomimetic nanochannel-ionchannel hybrid for ultrasensitive and label-free detection of microRNA in cells. Analytical Chemistry2019, 91(5): 3582-3589.
Yue, W. Q.; Tan, Z.; Li, X. P.; Liu, F. F.; Wang, C.*, Micro/nanofluidic technologies for efficient isolation and detection of circulating tumor cells. TrAC Trends in Analytical Chemistry2019, 117:101-115.
Wang, S. S.; Hu, W. C.; Liu, F. F.; Xu, Q. Y.; Wang, C.*, Insights into direct plasmon-activated eletrocatalysis on gold nanostar via efficient photothermal effect and reduced activation energy. Electrochimica Acta2019, 301: 359-365.
Wang, C.; Wang, Y.; Zhou, Y.; Wu, Z. Q.; Xia, X. H.*, High-performance bioanalysis based on ion concentration polarization of micro-/nanofluidic devices. Analytical and Bioanalytical Chemistry2019, 411(18): 4007-4016.
Hu, W. C.; Shi, Y.; Zhou, Y.; Wang, C.; Younis, M. R.; Pang, J.; Wang, C.*; Xia, X. H.*, Plasmonic hot charge carriers activated Ni centres of metal-organic frameworks for the oxygen evolution reaction. Journal of Materials Chemistry A2019, 7(17): 10601-10609.
Liao, X. W.; Wang, S. S.; Xu, G. Y.; Wang, C.*, Enhanced electrocatalysis via boosted separation of hot charge carriers of plasmonic gold nanoparticles deposited on reduced graphene oxide. ChemElectroChem2019, 6(5): 1419-1426.
Younis, M. R.; Wang, C.; An, R.; Wang, S.; Younis, M. A.; Li, Z. Q.; Wang, Y.; Ihsan, A.; Ye, D.; Xia, X. H.*,Low power single laser activated synergistic cancer phototherapy using photosensitizer functionalized dual plasmonic photothermal nanoagents. ACS Nano2019, 13(2): 2544-2557.
2018
Zhao, X. P.; Wang, S. S.; Younis, M. R.; Xia, X. H.*; Wang, C.*, Asymmetric nanochannel-ionchannel hybrid for ultrasensitive and label-free detection of copper ions in blood. Analytical Chemistry2018, 90(1): 896-902.
Zhai, T. T.; Ye, D.; Shi, Y.; Zhang, Q. W.; Qin, X.; Wang, C.*; Xia, X. H.*, Plasmon coupling effect-enhanced imaging of metal ions in living cells using DNAzyme assembled core-satellite structures. ACS Applied Materials & Interfaces2018, 10 (40): 33966-33975.
Zhao, X. P.; Wang, S. S.; Younis, M. R.; Xia, X. H.*; Wang, C.*, Thermo and pH dual-actuating smart porous anodic aluminum for controllable drug release. Advanced Materials Interfaces2018, 5(13): **.
Wang, C.; Zhao, X. P.; Xu, Q. Y.; Nie, X. G.; Younis, M. R.; Liu, W. Y.; Xia, X. H.*, Importance of hot spots in gold nanostructures on direct plasmon-enhanced electrochemistry. ACS Applied Nano Materials2018, 1(10): 5805-5811.
Wang, C.; Shi, Y.; Yang, D. R.; Xia, X. H.*, Combining plasmonics and electrochemistry at the nanoscale. Current Opinion in Electrochemistry 2018, 7: 95-102.
Wang, C.; Cao, J.; Zhou, Y.; Xia, X. H.*, On-chip microfluidic generation of monodisperse bubbles for liquid interfacial tension measurement. Talanta2018, 176: 646-651.
2017
Wang, C.; Nie, X. G.; Shi, Y.; Zhou, Y.; Xu, J. J.; Xia, X. H.*; Chen, H. Y., Direct plasmon-accelerated electrochemical reaction on gold nanoparticles. ACS Nano2017, 11(6): 5897-5905.
Wang, C.; Shi, Y.; Dan, Y. Y.; Nie, X. G.; Li, J.; Xia, X. H.*, Enhanced peroxidase-like performance of gold nanoparticles by hot electrons. Chemistry - A European Journal2017, 23(28): 6717-6723.(Hot Paper and Cover Paper)
Cao, J.; Zhao, X. P.; Younis, M. R.; Li, Z. Q.; Xia, X. H.*; Wang, C.*, Ultrasensitive capture, detection, and release of circulating tumor cells using a nanochannel-ion channel hybrid coupled with electrochemical detection technique. Analytical Chemistry2017, 89(20): 10957-10964.
Zhao, X. P.; Cao, J.; Nie, X. G.; Wang, S. S.; Wang, C.*; Xia, X. H., Label-free monitoring of the thrombin-aptamer recognition reaction using an array of nanochannels coupled with electrochemical detection. Electrochemistry Communications2017, 81: 5-9.
2016-2010
Wang, C.; Liu, H. L.; Li, Y. Q.; Cao, J.; Zheng, B.; Xia, X. H.*; Feng, F.*, A novel device of array nanochannels integrated electrochemical detector for detection of amyloid β aggregation and inhibitor screening. Electrochemistry Communications 2016, 66: 25-28.
Wang, C.; Shi, Y.; Wang, J.; Pang, J.; Xia, X. H.*, Ultrasensitive protein concentration detection on a micro/nanofluidic enrichment chip using fluorescence quenching. ACS Applied Materials Interfaces2015, 7(12): 6835-6841.
Wang, C.; Zhou, Y.; Zhang, K. X.; Nie, X. G.; Xia, X. H.*, Fast and sensitive detection of protein concentration in mild environments. Talanta2015, 135: 102-107.
Wang, C.; Ouyang, J.; Wang, Y. Y.; Ye, D. K.; Xia, X. H.*, Sensitive assay of protease activity on a micro/nanofluidics preconcentrator fused with the fluorescence resonance energy transfer detection technique. Analytical chemistry2014, 86(6): 3216-3221.
Wang, C.; Ye, D. K.; Wang, Y. Y.; Lu, T.*; Xia, X. H.*, Insights into the free state enzyme reaction kinetics in nanoconfinement. Lab on a Chip2013, 13 (8): 1546-1553.
Wang, C.; Xu, J. J.; Chen, H. Y.; Xia, X. H.*, Mass transport in nanofluidic devices. Science China Chemistry2012, 55(4): 453-468.
Wang, C.; Ouyang, J.; Ye, D. K.; Xu, J. J.; Chen, H. Y.; Xia, X. H.*, Rapid protein concentration, efficient fluorescence labeling and purification on a micro/nanofluidics chip. Lab on a Chip2012, 12(15): 2664-2671. (Hot Paper)
Wang, C.; Sheng, Z. H.; Ouyang, J.; Xu, J. J.; Chen, H. Y.; Xia, X. H.*, Nanoconfinement effects: glucose oxidase reaction kinetics in nanofluidics. Chemphyschem2012, 13 (3): 762-768.
Wang, C.; Ouyang, J.; Gao, H. L.; Chen, H. W.; Xu, J. J.; Xia, X. H.*; Chen, H. Y., UV-ablation nanochannels in micro/nanofluidics devices for biochemical analysis. Talanta2011, 85(1): 298-303.
Wang, C.; Li, S. J.; Wu, Z. Q.; Xu, J. J.; Chen, H. Y.; Xia, X. H.*, Study on the kinetics of homogeneous enzyme reactions in a micro/nanofluidics device. Lab on a Chip2010, 10(5): 639-646.
招生计划：
每年招收2-3名化学/药物分析硕士生和1-2名博士生。
具有推免资格的同学、有意报考本课题组硕博研究生的同学，请直接将简历发送至wangchen@cpu.edu.cn。热烈欢迎对科研有着浓厚的兴趣、勤奋踏实、有良好的团队协作精神的有志青年学生加入本研究小组。欢迎访问王琛课题组网站了解最新进展，课题组网站：https://www.x-mol.com/groups/wang_chen。