宋振波
东北师范大学生命科学学院
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职　　称：副教授
研究方向：肿瘤发生机制
办公电话：**
办公地点：药物基因和蛋白筛选国家工程实验室
电子邮件：songzb484@nenu.edu.cn



个人简历
现为东北师范大学药物基因和蛋白筛选国家工程实验室副教授，硕士生导师，一直从事肿瘤发生机制和抗肿瘤药物筛选的研究。在国际著名期刊 Oncogene，Cell Death Dis，cell signal等发表SCI论文18篇,主持了2个C类科研项目以及1个D类项目和1个E类项目，并获得科研奖励2项。主要承担生物技术专业技术实践课和蛋白质与酶工程课程。工作经历2018年8月～2019年9月美国明尼苏达大学 访问学者2017年6月～至今 东北师范大学副教授2015年6月～2017年5月东北师范大学 讲师2013年5月～2015年5月东北师范大学化学学院博士后研究学习经历2006年9月～2011年7月东北师范大学遗传与细胞研究所 硕博连读2002年9月～2006年7月河南师范大学生命科学学院理学学士主要科研方向1.肿瘤发病机制研究 2.肿瘤代谢研究2.抗肿瘤中药新药筛选 3.中药抗肿瘤机制研究 硕士研究生招生专业硕士招生专业：细胞生物学（国家工程实验室）联系方式：电话：** QQ:微信：szb** 科研成果SCI 论文1. Ai HH, Liu B, Yang MT, Zuo QQ, Song ZB*, Bao YL*, Sun LG, Zhou L, Li YX. Expression and effects of TSP50 in mouse embryo and cardiac myocyte development. Biochem Biophys Res Commun. 2018 Jul 12;502(2):283-288.2.Song ZB, Wu P, Ni JS, Liu T, Fan C, Bao YL, Wu Y, Sun LG, Yu CL, Huang YX, Li YX (2017) Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling. Oncogene. doi:10.1038/onc.2017.1983.Song ZB, Ni JS, Bao YL*, et al. （2015.）Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression [J]. Cell Death Dis,6e17034.Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao*, and Yuxin Li**. Maspin Inhibits Macrophage Phagocytosis and Enhances Inflammatory Cytokine Production via Activation of NF-κB Signaling. Molecular Immunology. 2017, 82:94-1035. Ai HH, Zhou ZL, Sun LG*, Yang MT, Li W, Yu CL, Song ZB, Huang YX, Wu Y, Liu L, Yang XG, Zhao YQ, Bao YL*, Li YX. 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol negatively regulates activation of STAT3 and ERK pathways and exhibits anti-cancer effects in HepG2 cells. Apoptosis. 2017 Nov;22(11):1404-1418. 6.Song ZB, Liu B, Bao YL*, et al. 2014.The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation [J]. cellular signalling, 26(10):2266-22757.Zhenbo Song, Yongli Bao*, Yu Zhang, Xuguang Mi, Ping Wu, Yin Wu, ChunLei Yu, Ying Sun, LiHua Zheng, YanXin Huang, Biao Liu and YuXin Li*.Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the NF-kappa beta (NF-κB) signaling pathway. Biochem J. 2011 Jun 1;436(2):457-67.8.Yaqin Hou, Yao Yao, Yongli Bao*, Zhenbo Song*, Cheng Yang, Xiuli Gao, Wenjing Zhang, Luguo Sun, Chunlei Yu, Yanxin Huang, Guannan Wang, Yuxin Li. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HepG2 cells. Oxid Med Cell Longev. 2016:**.9.Yan Li, Yannan Wu, Xinlei Yao, Fang Hao, Chunlei Yu, Yongli Bao, Yin Wu, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Luguo Sun*, Yuxin Li*. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4). pii: E794. doi: 10.3390/ijms.Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao*, Yuxin Li*. Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling. Mol Immunol. 2017;82:94-103.11.Wenjing Zhang, Zhenbo Song, Yongli Bao *, Wenling Li, Xiaoguang Yang, Qi Wang, Chunlei Yu, Luguo Sun, Yanxin Huang, Yuxin Li *. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016; 105:66-79.12.Danfeng Wang, Yuqing Zhao, Yimeng Wang, Yan Rong, Hongshuang Qin, Yongli Bao*, Zhenbo Song, Chunlei Yu, Luguo Sun, Yuxin Li*. 25-methoxyl- dammarane-3, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation partially through down-regulation of testes-specific protease 50 expression. Tumor Biology, 2016, 37(9):11805-11813.13.Hongshuang Qin, Peipei Yu, Ying Sun, Danfeng Wang, Xiaofen Deng, Yongli Bao*, Jun Song*, Luguo Sun, Zhenbo Song, Yuxin Li. Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress. MOL MED REP. 2016,13(5): 5118-5124.14.Xiuli Gao, Hua Lin, Wei Zhao, Yaqin Hou, Yongli Bao*, Zhenbo Song, Luguo Sun, Shengyi Tian, Biao Liu*, Yuxin Li. JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells. Apoptosis. 2016,21(3):340-50. 15.Xuguang Mi, Zhenbo Song, Luguo Sun, Yongli Bao *, Chunlei Yu, Yin Wu, Yuxin Li. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation. Int J Biochem Cell Biol. 2016 ,73: 63–71.16.Cheng Yang, Dongmei Zhang, Zhenbo Song, Yaqin Hou, Yongli Bao*, Luguo Sun*, Chunlei Yu, Yuxin Li. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS ONE. 2015, 10(12):e**.17.Hongyan Wang, Yanxin Huang*, Lihua Zheng, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, Zhenbo Song, Ying Sun, Guannan Wang, Zhiqiang Ma*, Yuxin Li*. Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model．Computational Intellegence and Neruoscience, 2015, 2015:387409-1-1618.Xuguang Mi, Zhenbo Song, Ping Wu, Yuwei Zhang, Luguo Sun, Yongli Bao*,Yu Zhang, Lihua Zheng, Ying Sun, Chunlei Yu, Yin Wu*, Guannan Wang, Yuxin Li. Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression. Toxicology Letters, 2014, 224:349-35519.Yunfeng Qi, Yanxin Huang*, Hongyan Wang, Yu Zhang, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, zhenbo song, Lihua Zheng, Ying Sun, Guannan Wang, Yuxin Li*. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling. BMC Bioinformatics. 2013,14(1):41.20.Cong Fan, Yanxin Huang*, Yongli Bao*, Luguo Sun, Yin Wu, Chunei Yu, Yu Zhang, Zhenbo Song, Lihua Zheng, Ying Sun, Gjuannan Wang, Yuxin Li*. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database. Int J Mol Sci. 2012 Dec 14;13(12):17185-209.21.Yuyin Li, Yongli Bao*, Zhenbo Song, Luguo Sun, Ping Wu, Yu Zhang, Cong Fan, Yanxin Huang, Yin Wu, Chunlei Yu, Ying Sun, Lihua Zheng, Guannan Wang, and Yuxin Li*. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation. PLoS ONE. 2012, 7(5): e35030. Epub 2012 May 4. doi:10.1371/journal.pone.**.科研项目1.miRNA在TSP50诱导的乳腺癌发生中的作用及机制研究国家自然科学基金青年项目2.miR-4709-3p在TSP50相关的乳腺癌转移中的调节作用和机制研究吉林省科技厅青年科研基金3.TSP50蛋白酶活性中心催化三联体在其促肿瘤发生中的作用及机制研究 吉林省科技厅青年科研基金.4.TSP50活性中心的催化三联体在细胞增殖和侵袭中的作用及机制研究校内青年基金项目

社会兼职


细胞生物学和免疫学会会员
免疫学会会员


获奖情况


吉林省自然科学学术成果奖吉林省自然科学学术成果奖评审委员会三等 2018.5吉林省科学技术奖B类吉林省科学技术奖励委员会 一等2016.11吉林省自然科学学术成果奖 其它吉林省自然科学学术成果奖评审委员会二等 2014.9


教学信息


1.生物技术专业实践课2.蛋白质与酶工程


科研信息


SCI 论文1.Song ZB, Wu P, Ni JS, Liu T, Fan C, Bao YL, Wu Y, Sun LG, Yu CL, Huang YX, Li YX (2017) Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling. Oncogene. doi:10.1038/onc.2017.1982.Song ZB, Ni JS, Bao YL*, et al. （2015.）Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression [J]. Cell Death Dis,6e17033.Song ZB, Liu B, Bao YL*, et al. 2014.The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation [J]. cellular signalling, 26(10):2266-22754.Zhenbo Song, Yongli Bao*, Yu Zhang, Xuguang Mi, Ping Wu, Yin Wu, ChunLei Yu, Ying Sun, LiHua Zheng, YanXin Huang, Biao Liu and YuXin Li*.Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the NF-kappa beta (NF-κB) signaling pathway. Biochem J. 2011 Jun 1;436(2):457-67.5.Yaqin Hou, Yao Yao, Yongli Bao*, Zhenbo Song*, Cheng Yang, Xiuli Gao, Wenjing Zhang, Luguo Sun, Chunlei Yu, Yanxin Huang, Guannan Wang, Yuxin Li. Juglanthraquinone C induces intracellular ROS increase and apoptosis by activating the Akt/FoxO signal pathway in HepG2 cells. Oxid Med Cell Longev. 2016:**.6.Yan Li, Yannan Wu, Xinlei Yao, Fang Hao, Chunlei Yu, Yongli Bao, Yin Wu, Zhenbo Song, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Luguo Sun*, Yuxin Li*. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4). pii: E794. doi: 10.3390/ijms.Yimeng Wang, Luguo Sun, Zhenbo Song, Danfeng Wang, Yongli Bao*, Yuxin Li*. Maspin inhibits macrophage phagocytosis and enhances inflammatory cytokine production via activation of NF-κB signaling. Mol Immunol. 2017;82:94-103.8.Wenjing Zhang, Zhenbo Song, Yongli Bao *, Wenling Li, Xiaoguang Yang, Qi Wang, Chunlei Yu, Luguo Sun, Yanxin Huang, Yuxin Li *. Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models. Biochem Pharmacol. 2016; 105:66-79.9.Danfeng Wang, Yuqing Zhao, Yimeng Wang, Yan Rong, Hongshuang Qin, Yongli Bao*, Zhenbo Song, Chunlei Yu, Luguo Sun, Yuxin Li*. 25-methoxyl- dammarane-3, 12β, 20-triol and artemisinin synergistically inhibit MDA-MB-231 cell proliferation partially through down-regulation of testes-specific protease 50 expression. Tumor Biology, 2016, 37(9):11805-11813.10.Hongshuang Qin, Peipei Yu, Ying Sun, Danfeng Wang, Xiaofen Deng, Yongli Bao*, Jun Song*, Luguo Sun, Zhenbo Song, Yuxin Li. Paclitaxel inhibits selenoprotein S expression and attenuates endoplasmic reticulum stress. MOL MED REP. 2016,13(5): 5118-5124.11.Xiuli Gao, Hua Lin, Wei Zhao, Yaqin Hou, Yongli Bao*, Zhenbo Song, Luguo Sun, Shengyi Tian, Biao Liu*, Yuxin Li. JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells. Apoptosis. 2016,21(3):340-50. 12.Xuguang Mi, Zhenbo Song, Luguo Sun, Yongli Bao *, Chunlei Yu, Yin Wu, Yuxin Li. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation. Int J Biochem Cell Biol. 2016 ,73: 63–71.13.Cheng Yang, Dongmei Zhang, Zhenbo Song, Yaqin Hou, Yongli Bao*, Luguo Sun*, Chunlei Yu, Yuxin Li. Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-α and IL-1β, and activation of the NF-κB signaling pathway. PLoS ONE. 2015, 10(12):e**.14.Hongyan Wang, Yanxin Huang*, Lihua Zheng, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, Zhenbo Song, Ying Sun, Guannan Wang, Zhiqiang Ma*, Yuxin Li*. Modelling Coupled Oscillations in the Notch, Wnt, and FGF Signaling Pathways during Somitogenesis: A Comprehensive Mathematical Model．Computational Intellegence and Neruoscience, 2015, 2015:387409-1-1615.Xuguang Mi, Zhenbo Song, Ping Wu, Yuwei Zhang, Luguo Sun, Yongli Bao*,Yu Zhang, Lihua Zheng, Ying Sun, Chunlei Yu, Yin Wu*, Guannan Wang, Yuxin Li. Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression. Toxicology Letters, 2014, 224:349-35516.Yunfeng Qi, Yanxin Huang*, Hongyan Wang, Yu Zhang, Yongli Bao, Luguo Sun, Yin Wu, Chunlei Yu, zhenbo song, Lihua Zheng, Ying Sun, Guannan Wang, Yuxin Li*. Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling. BMC Bioinformatics. 2013,14(1):41.17.Cong Fan, Yanxin Huang*, Yongli Bao*, Luguo Sun, Yin Wu, Chunei Yu, Yu Zhang, Zhenbo Song, Lihua Zheng, Ying Sun, Gjuannan Wang, Yuxin Li*. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors from the National Cancer Institute (NCI) Molecular Database. Int J Mol Sci. 2012 Dec 14;13(12):17185-209.18.Yuyin Li, Yongli Bao*, Zhenbo Song, Luguo Sun, Ping Wu, Yu Zhang, Cong Fan, Yanxin Huang, Yin Wu, Chunlei Yu, Ying Sun, Lihua Zheng, Guannan Wang, and Yuxin Li*. The Threonine Protease Activity of Testes-Specific Protease 50 (TSP50) Is Essential for Its Function in Cell Proliferation. PLoS ONE. 2012, 7(5): e35030. Epub 2012 May 4. doi:10.1371/journal.pone.**.科研项目1.miRNA在TSP50诱导的乳腺癌发生中的作用及机制研究国家自然科学基金青年项目2.miR-4709-3p在TSP50相关的乳腺癌转移中的调节作用和机制研究吉林省科技厅青年科研基金3.TSP50蛋白酶活性中心催化三联体在其促肿瘤发生中的作用及机制研究 吉林省科技厅青年科研基金.4.TSP50活性中心的催化三联体在细胞增殖和侵袭中的作用及机制研究校内青年基金项目


其它信息