冯云鹏
东北师范大学生命科学学院
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职　　称：副教授
研究方向：Epigenetic regulation & Genome instability
办公电话：
办公地点：综合实验楼 314
电子邮件：fengyp839@nenu.edu.cn



个人简历
丹麦哥本哈根大学 (University of Copenhagen) 博士，丹麦生物技术与创新研究中心 (Biotech Research & Innovation Centre, BRIC) 博士后。2016年1月，入选东北师范大学引进人才计划回国工作。多年来致力于研究表观遗传调控在细胞代谢及基因组稳定性维护中的作用，鉴定了多个调控 DNA 复制和损伤的染色质调节因子。发现染色质结合因子 BRPF3、组蛋白供应以及泛素连接酶 TRAIP 在 DNA 复制和损伤应答过程中发挥至关重要的作用。此外，揭示了转录因子 ZBP-89 和 YY1通过控制组蛋白去乙酰化酶 HDACs 在关键基因启动子处的招募和结合，调节了目的基因的转录和表达，并最终影响细胞的衰老或凋亡。在 EMBO J、The Journal of Cell Biology、PNAS 等著名学术期刊共计发表 SCI 论文 18 篇，引用次数达 464 次。欢迎有志于研究表观遗传调控与基因组稳定性的同学加入我们的团队！2016 - 至今副教授，东北师范大学。2013 - 2015 博士后，哥本哈根大学，丹麦。 2009 - 2014 博士，哥本哈根大学，丹麦。 2008 - 2009 研究助理，哥本哈根大学，丹麦。2005 - 2008 硕士，遗传与细胞研究所，东北师范大学，中国。2001 - 2005 学士，生命科学学院，东北师范大学，中国。获奖情况:2013, 国家优秀留学博士奖学金，中国。2011, 最佳海报奖（第一名），国际会议 Frontiers in Cell Biology - 39th Annual Meeting,赫尔辛格，丹麦。教学信息：-细胞与遗传实验技术与方法-现代生命科学研究方法-细胞重要生命活动的调控机制-分子生物学实验-现代生物实验技术-细胞分子生物学（留学生）科研信息：-发表文章1.Chen L, Jiao Y, Guan X, Li X, Feng Y, Jiao M. (2018) Investigation of cell cycle-associated structural reorganization in nucleolar FC/DFCs from mouse MFC cells by electron microscopy. Microscopy 2.Hao F, Tian M, Feng Y, Quan C, Chen Y, Chen S, Wei M. (2018) Abrogation of Lupus Nephritis in Somatic Hypermutation-Deficient MRL/lpr Mice. J Immunol. 3.Jin X, Bu Q, Zou Y, Feng Y, Wei M. (2018) Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. Glycoconj J.4.Wang Y, Liu J, Jin X, Zhang D, Li D, Hao F, Feng Y, Gu S, Meng F, Tian M, Zheng Y, Xin L, Zhang X, Han X, Aravind L, Wei M. (2017) O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect. PNAS5.Guan X, Jiao Y, Chen L, Li X, Shang G, Wang F, Feng Y, Jiao M. (2017) Disruption and restoration of nucleolar FC and DFC during S phase in HeLa cells. Cell Biol Int.6.Feng Y*, Vlassis A*, Lalonde ME*, Lees M, Zhao X, Alabert C, Johansen JV, Sandelin A, C?té J, Groth A. (2016) BRPF3-HBO1 complex regulates replication origin firing and histone H3K14 acetylation. EMBO J 7.Hoffmann S, Smedegaard S, Nakamura K, R?schle M, Oka Y, Feng Y, Mann M, Groth A, Bekker-Jensen S, Mailand N. (2016) TRAIP is a PCNA-associated ubiquitin ligase that protects genome stability after replication stress. J Cell Biol8.Mejlvang J*, Feng Y*, Alabert C, Neelsen K. J, Jasencakova Z, Zhao X, Lees M, Sandelin A, Pasero P, Lopes M, Groth A. (2014) New Histone Supply Regulates Replication Fork Speed and PCNA Unloading. (* Equal contribution). J Cell Biol9.Feng Y*, Wang X*, Xu L, Pan H, Zhu S, Liang Q, Huang B, Lu J. (2009) The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence. (* Equal contribution). FEBS J10.Wang X*, Feng Y*, Xu L, Chen Y, Zhang Y, Su D, Ren G, Lu J, Huang B. (2008) YY1 restrained cell senescence through repressing the transcription of p16. (* Equal contribution). BBA-MOL CELL RES11.Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A. (2012) Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. EMBO J12.Wang X, Feng Y, Zhao J, Pan H, Huang B, Lu J. (2010) The Expression of p16 is Regulated by The Reversible Histone Acetylation. Progress in Biochemistry and Biophysics 13.Su D, Zhu S, Han X, Feng Y, Huang H, Ren G, Pan L, Zhang Y, Lu J, Huang B. (2009) BMP4-Smad signal pathway mediates Adriamycin-induced premature senescence in lung cancer cells. J Biol Chem 14.Ren G, Zhang G, Dong Z, Liu Z, Li L, Feng Y, Su D, Zhang Y, Huang B, Lu J. (2009) Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. Int J Biochem Cell Biol 15.Zhang Y, Huang S, Dong W, Li L, Feng Y, Pan L, Han Z, Wang X, Ren G, Su D, Huang B, Lu J. (2009) SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer Lett 16.Wang X*, Pan L*, Feng Y, Wang Y, Han Q, Han L, Han S, Guo J, Huang B, Lu J. (2008) p300 plays a role in p16 (INK4a) expression and cell cycle arrest. Oncogene 17.Wang X, Feng Y, Pan L, Wang Y, Xu X, Lu J, Huang B. (2007) The proximal GC-rich region of p16 (INK4a) gene promoter plays a role in its transcriptional regulation. Mol Cell Biochem -科研项目：1.国家自然科学基金青年项目，**，组蛋白的O-GlcNAc糖基化修饰在DNA复制中的作用及机制研究，2017-01 - 2019-12，主持。2.青年探索培育基金，**KJ022，糖代谢调控因子在DNA复制中的作用及分子机制研究，2016-04 - 2017-11，主持。3.国家自然科学基金重大研究计划，**，间充质干细胞成骨分化中VDR及其靶基因参与遗传学调控机制的研究，2011-01 - 2013-12，已结题，参加。4.国家自然科学基金委员会面上项目，**，前列腺癌细胞中HOXB13基因沉默的表观遗传调控机制研究，2010-01 - 2012-12，已结题，参加。5.国家自然科学基金委员会面上项目，**，过表达BMP4促进肿瘤细胞过早性衰老及机制研究，2008-01 - 2010-12，已结题，参加。 6.东北师范大学校内自然科学青年基金，**，一个新的人肿瘤抑制因子RASSF2基因表达调控的表观遗传研究，2006-01 - 2007-12，已结题，参加。

社会兼职




获奖情况 （数据来源：科学技术处、社会科学处）




教学信息 （数据来源：教务处）




科研信息


发表文章1.Chen L, Jiao Y, Guan X, Li X, Feng Y, Jiao M. (2018) Investigation of cell cycle-associated structural reorganization in nucleolar FC/DFCs from mouse MFC cells by electron microscopy. Microscopy 2.Hao F, Tian M, Feng Y, Quan C, Chen Y, Chen S, Wei M. (2018) Abrogation of Lupus Nephritis in Somatic Hypermutation-Deficient MRL/lpr Mice. J Immunol. 3.Jin X, Bu Q, Zou Y, Feng Y, Wei M. (2018) Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. Glycoconj J.4.Wang Y, Liu J, Jin X, Zhang D, Li D, Hao F, Feng Y, Gu S, Meng F, Tian M, Zheng Y, Xin L, Zhang X, Han X, Aravind L, Wei M. (2017) O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect. PNAS5.Guan X, Jiao Y, Chen L, Li X, Shang G, Wang F, Feng Y, Jiao M. (2017) Disruption and restoration of nucleolar FC and DFC during S phase in HeLa cells. Cell Biol Int.6.Feng Y*, Vlassis A*, Lalonde ME*, Lees M, Zhao X, Alabert C, Johansen JV, Sandelin A, C?té J, Groth A. (2016) BRPF3-HBO1 complex regulates replication origin firing and histone H3K14 acetylation. EMBO J 7.Hoffmann S, Smedegaard S, Nakamura K, R?schle M, Oka Y, Feng Y, Mann M, Groth A, Bekker-Jensen S, Mailand N. (2016) TRAIP is a PCNA-associated ubiquitin ligase that protects genome stability after replication stress. J Cell Biol8.Mejlvang J*, Feng Y*, Alabert C, Neelsen K. J, Jasencakova Z, Zhao X, Lees M, Sandelin A, Pasero P, Lopes M, Groth A. (2014) New Histone Supply Regulates Replication Fork Speed and PCNA Unloading. (* Equal contribution). J Cell Biol9.Feng Y*, Wang X*, Xu L, Pan H, Zhu S, Liang Q, Huang B, Lu J. (2009) The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence. (* Equal contribution). FEBS J10.Wang X*, Feng Y*, Xu L, Chen Y, Zhang Y, Su D, Ren G, Lu J, Huang B. (2008) YY1 restrained cell senescence through repressing the transcription of p16. (* Equal contribution). BBA-MOL CELL RES11.Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A. (2012) Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. EMBO J12.Wang X, Feng Y, Zhao J, Pan H, Huang B, Lu J. (2010) The Expression of p16 is Regulated by The Reversible Histone Acetylation. Progress in Biochemistry and Biophysics 13.Su D, Zhu S, Han X, Feng Y, Huang H, Ren G, Pan L, Zhang Y, Lu J, Huang B. (2009) BMP4-Smad signal pathway mediates Adriamycin-induced premature senescence in lung cancer cells. J Biol Chem 14.Ren G, Zhang G, Dong Z, Liu Z, Li L, Feng Y, Su D, Zhang Y, Huang B, Lu J. (2009) Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. Int J Biochem Cell Biol 15.Zhang Y, Huang S, Dong W, Li L, Feng Y, Pan L, Han Z, Wang X, Ren G, Su D, Huang B, Lu J. (2009) SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer Lett 16.Wang X*, Pan L*, Feng Y, Wang Y, Han Q, Han L, Han S, Guo J, Huang B, Lu J. (2008) p300 plays a role in p16 (INK4a) expression and cell cycle arrest. Oncogene 17.Wang X, Feng Y, Pan L, Wang Y, Xu X, Lu J, Huang B. (2007) The proximal GC-rich region of p16 (INK4a) gene promoter plays a role in its transcriptional regulation. Mol Cell Biochem 科研项目：1.国家自然科学基金青年项目，**，组蛋白的O-GlcNAc糖基化修饰在DNA复制中的作用及机制研究，2017-01 - 2019-12，主持。2.青年探索培育基金，**KJ022，糖代谢调控因子在DNA复制中的作用及分子机制研究，2016-04 - 2017-11，主持。3.国家自然科学基金重大研究计划，**，间充质干细胞成骨分化中VDR及其靶基因参与遗传学调控机制的研究，2011-01 - 2013-12，已结题，参加。4.国家自然科学基金委员会面上项目，**，前列腺癌细胞中HOXB13基因沉默的表观遗传调控机制研究，2010-01 - 2012-12，已结题，参加。5.国家自然科学基金委员会面上项目，**，过表达BMP4促进肿瘤细胞过早性衰老及机制研究，2008-01 - 2010-12，已结题，参加。 6.东北师范大学校内自然科学青年基金，**，一个新的人肿瘤抑制因子RASSF2基因表达调控的表观遗传研究，2006-01 - 2007-12，已结题，参加。


其它信息