徐正一

东北师范大学生命科学学院


职　　称：教授
研究方向：
办公电话：**
办公地点：综合实验楼516
电子邮件：xuzy100@nenu.edu.cn



个人简历

徐正一教授长期以来从事植物脱落酸（ABA）信号代谢途径的分子机制与植物抗旱机制的年研究。徐正一教授于2012年获得韩国浦项工科大学(POSTECH)植物分子生物学博士学位(指导教授：韩国科学院院士兼植物顶级期刊Plant Cell编辑, Inhwan Hwang)；此后相继在Inhwan Hwang教授的实验室（韩国浦项工科大学）和美国科学院院士兼台湾科学院院士Jen Sheen教授的实验室（美国哈佛医学院遗传学系/Harvard Medical School）从事博士后研究工作。在博士及博士后期间，申请人的主攻方向是解析非生物胁迫下基因转录调控、抗逆激素脱落酸代谢途径的分子机制、以及植物细胞内吞过程中受体 AP-2 complex的作用机制以及它在植物发育过程中的意义，主要发现为(1) 揭示了储存在液泡里的脱落酸葡萄糖酯(ABA-GE)能被AtBG2水解并释放具有活性的ABA。(2) 发现与干旱胁迫响应中的重要转录因子bZIP结合的全新的NAC转录因子，并解析其在干旱胁迫响应中，调控相关基因转录的分子机制。(3)揭示了植物细胞内吞过程中起关键性作用的受体蛋白复合体 (Adaptor Protein Complex-2)调控花器官发育的分子机制。在美国哈佛大学医学院，徐正一教授开发了全新的“单细胞核RNA测序技术”（single-nucleus RNA Sequencing），并利用此项技术在单细胞水平解析植物根部干细胞生态位(root stem cell niche)的能量信号转导系统(energy signaling network)。教育经历2003-2007，中国，山东大学，生物技术专业，学士学位 (B.S.)2007-2012，韩国，浦项工科大学，分子生物学专业，博士学位 (Ph.D.)研究经历2012-2013，韩国，浦项工科大学(Pohang University of Science and Technology)，博士后2013-2015，美国，哈佛大学医学院/麻省总医院(Harvard Medical School/Massachusetts General Hospital)，博士后2015年6月-至今，东北师范大学生命科学学院，教授发表文章(近5年代表作)1. Zheng-Yi Xu, Kwang Hee Lee, Ting Dong, Jae Cheol Jeong, Jing Bo Jin, YuriKanno, Dae Heon Kim, Soo Youn Kim, Mitsunori Seo, Ray A. Bressan, Dae-Jin Yun, and Inhwan Hwang*. A Vacuolar β-Glucosidase Homolog That Possesses Glucose-Conjugated Abscisic Acid Hydrolyzing Activity Plays an Important Role in Osmotic Stress Responses in Arabidopsis, The Plant Cell, 2012, 24: 2184–2199. SCI期刊论文 (第一作者)2. Zheng-Yi Xu, Soo Youn Kim, Do Young Hyeon, Dae Heon Kim, Ting Dong,Youngmin Park, Jing Bo Jin, Se-Hwan Joo, Seong-Ki Kim, Jong Chan Hong,Daehee Hwang, and Inhwan Hwang*. The Arabidopsis NAC Transcription Factor ANAC096 Cooperates with bZIP-Type Transcription Factors in Dehydration and Osmotic Stress Responses, The Plant Cell, 2013,25: 4708–4724.SCI期刊论文(第一作者)3. Soo Youn Kim#, Zheng-Yi Xu#, Kyungyoung Song, Dae Heon Kim, Hyangju Kang, Ilka Reichardt, Eun Ju Sohn, Jirí Frim, Gerd Juergens, and Inhwan Hwang*. Adaptor Protein Complex 2–Mediated Endocytosis Is Crucial for Male Reproductive Organ Development in Arabidopsis, The Plant Cell, 2013, 25: 2970–2985. SCI期刊论文 (共同第一作者)4. Zheng-Yi Xu, Dae Heon Kim, Inhwan Hwang*. ABA homeostasis and signalinginvolving multiple subcellular compartments and multiple receptors, Plant Cell Reports, 2013 ,Issue 6, pp 807-813. Review, SCI期刊论文 (第一作者)5. Ting Dong, Zheng-Yi Xu, Youngmin Park, Dae Heon Kim, Yongjik Lee, andInhwan Hwang*. Abscisic Acid Uridine Diphosphate Glucosyltransferases Play a Crucial Role in Abscisic Acid Homeostasis in Arabidopsis, Plant Physiology, 2014, 165, pp. 277–289. SCI期刊论文6. Dae Heon Kim, Jae-Eun Lee, Zheng-Yi Xu, Kyoung Rok Geem, Yun Kwon, Joon Won Park, Inhwan Hwang*. Cytosolic targeting factor AKR2A captures chloroplast outer membrane-localized client proteins at the ribosome during translation, NATURE COMMUNICATIONS,2015, DOI: 10.1038/ncomms7843. SCI期刊论文7. Dae Heon Kim, Mi-Jeong Park,Gwang Hyeon Gwon, Antonina Silkov, Zheng-Yi Xu, Eun Chan Yang, Seohyeon Song, Kyungyoung Song, Younghyun Kim, Hwan Su Yoon, Barry Honig, Wonhwa Cho, Yunje Cho,and Inhwan Hwang, An Ankyrin Repeat Domain of AKR2 Drives Chloroplast Targeting through CoincidentBinding of Two Chloroplast Lipids, Developmental Cell, 2014, 30:598–609. SCI期刊论文8. Dae Heon Kim, Zheng-Yi Xu, Inhwan Hwang. AtHSP17.8 overexpression in transgenic lettuce gives rise to dehydration and salt stress resistance phenotypes through modulation of ABA-mediated signaling, Plant Cell Rep, 2013, 32:1953–1963. SCI期刊论文9. Simone Di Rubbo, Niloufer G. Irani, Soo Youn Kim, Zheng-Yi Xu, Astrid Gadeyne, Wim Dejonghe, Isabelle Vanhoutte, Geert Persiau, Dominique Eeckhout, Sibu Simon, Kyungyoung Song, Jürgen Kleine-Vehn, Jirí Friml, Geert De Jaeger, Dani?l Van Damme, Inhwan Hwang, Eugenia Russinova*. The Clathrin Adaptor Complex AP-2 Mediates Endocytosis of BRASSINOSTEROID INSENSITIVE1 in Arabidopsis, The Plant Cell,2013, 25: 2986–2997. SCI期刊论文10. Dae Heon Kim, Zheng-Yi Xu,Yun JeongNa, Yun-JooYoo, JunhoLee, Eun-JuSohn, and Inhwan Hwang*. Small Heat Shock Protein Hspl7.8 Functions as an AKR2A Cofactor in the Targeting of Chloroplast Outer Membrane Proteins in Arabidopsis, PlantPhysiology, 2011, 157,pp.132-146. SCI期刊论文11. Dae Heon Kim, Zheng-Yi Xu and Inhwan Hwang*. Generation of Transgenic Arabidopsis Plants Expressing mCherry-fused Organelle Marker Proteins, J. Plant Biol,2013, 56:399-406. SCI期刊论文著作“Springer 电子书Abscisic acid: Metabolism, Transport and Signaling”中，撰写了题目为“ABA Conjugates and Their Physiological Roles in Plant Cells”的一个章节(Zheng-Yi Xu, Yun-Joo Yoo and Inhwan Hwang)
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科研信息 （数据来源：科学技术处、社会科学处）