张勇
姓名： 张勇

职称： 副教授
最高学位： 博士
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工作地点： 生命科学楼413室
研究方向： 生物高分子材料新型药物传递系统疫苗佐剂
教育经历： 2008—2009年University of East Anglia，药学院，联合培养博士
2003—2009年沈阳药科大学，药学院，药物制剂 理学博士
1998—2003年沈阳药科大学，药学院，药学（日语）理学学士

工作经历： 2017.09—现在 吉林大学，生命科学学院，副教授
2012.11—2017.09吉林大学，生命科学学院，讲师
2010.08—2012.08吉林大学，生命科学学院，博士后

荣誉称号： “岛津-华尔达杯”第五届吉林省大学生生命科学创新实验大赛，指导教师二等奖
研究成果： 课题组研究工作着重于疫苗制剂开发，质量控制和效果评估，旨在建立一个安全高效的佐剂/抗原递送平台，提高疫苗保护效力。现已成功研发各种疫苗佐剂（例如，角鲨烯纳米乳液，脂质体，环境敏感凝胶，QS21，MPL和PolyI：C），其中部分已扩大到中试规模。目前正在研究上述佐剂与候选抗原在不同接种途径联合免疫后的保护效果和相关机制。同时，课题组热衷于研究提高蛋白质/肽的酶稳定性及其在体外和离体膜屏障模型中递送效率的策略。这些策略包括：肽的结构修饰，聚合物纳米粒子/微粒以，生物材料的功能化修饰和自主装系统。 Selected Publications：
1. Shi W, Kou YM, Xiao JH, Zhang LJ, Gao F, Kong W, Su WH, Jiang CL*, Zhang Y*. Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants. Vaccine. 2018, In press.
2. Li F, Chen Y, Liu SB, Qi J, Wang WY, Wang CH, Zhong RY, Chen ZJ, Li XM, Guan YZ, Kong W, Zhang Y*. Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate. Int. J. Nanomedicine. 2017,12: 8197—8209.
3. Feng J, Chen Y, Li F, Cui LL, Shi NQ, Kong W, Zhang Y*. Synthesis, Characterization and In Vitro Evaluation of a Novel Glycol Chitosan-EDTA Conjugate to Inhibit Aminopeptidase-Mediated Degradation of Thymopoietin Oligopeptides. Molecules. 2017, 22(8): 1253.
4. Zhang Y*, Cui LL, Li F, Shi NQ, Li CL, Yu XH, Chen Y*, Kong W. Design, fabrication and biomedical applications of zein-based nano/micro-carrier systems. Int J Pharm. 2016,513(1-2):191-210.
5. Zhang Y*, Feng J, Cui LL, Zhang YB, Li WZ, Li CL, Shi NQ, Chen Y*, Kong W. Investigation into efficiency of a novel glycol chitosan-bestatin conjugate to protect thymopoietin oligopeptides from enzymatic degradation. J Pharm. Sci.(Ronald T. Borchardt Dedicated Issue) 2016,105(2): 828-837.
6. Sun YN, Wang MS, Sun BX, Li F, Liu SB, Zhang Y*, Zhou Y, Chen Y*, Kong W.An investigation into the gastrointestinal stability of exenatide in the presence of pure enzymes, everted intestinal rings and intestinal homogenates. Biol Pharm Bull. 2016,39(1):42-48.
7. Zhang Y*, Cui LL, Chen Y, Zhang H, Zhong J, Sun YN, Shi NQ, Li CL, Kong W*. Zein-based nanofibres for drug delivery: Classes and current applications. Curr Pharm Des. 2015,21(22)：3199-3207.
8. Zhang Y*, Cui LL, Che XX, Zhang H, Shi NQ, Li CL, Chen Y*, Kong W. Zein-based films and their usage for controlled delivery: Origin, classes and current landscape. J Control Release. 2015,206:206-217.
9. Shi NQ*, Qi XR*, Xiang B, Zhang Y. A survey on “Trojan Horse” peptides: Opportunities, issues and controlled entry to "Troy". J Control Release. 2014,194:53-70.
10. Wang MS, Zhang Y, Sun BX, Sun YN, Gong X, Wu YG, Zhang XZ, Kong W*, Chen Y*. Permeability of Exendin-4-Loaded Chitosan Nanoparticles across MDCK Cell Monolayers and Rat Small Intestine. Biol Pharm Bull. 2014,37(5):740-747.
11. Wang MS, Zhang Y, Feng J, Gu TJ, Dong QG, Yang X, Sun YN, Wu YG, Chen Y*, Kong W*. Preparation, characterization, and in vitro and in vivo investigation of chitosan-coated poly (d,l-lactide-co-glycolide) nanoparticles for intestinal delivery of exendin-4. Int. J. Nanomedicine. 2013,8:1141-54.
12. Dong QG, Zhang Y, Wang MS, Feng J, Zhang HH, Wu YG, Gu TJ, Yu XH, Jiang CL, Chen Y*, Li W, Kong W*. Improvement of enzymatic stability and intestinal permeability of deuterohemin-peptide conjugates by specific multi-site N-methylation. Amino Acids. 2012,43(6):2431-41.
13. Wang MS, Sun BX, Feng J, Zhang HH, Liu B, Li C, Chen Y*, Zhang Y*, Kong W. Investigation of transport mechanism of exendin-4 across MDCK cell monolayers. Biol. Pharm. Bull. 2012,35(5):745-52.
14. Zhang Y*, Deng YJ, Wang XL, Xu JH, Li ZQ*. Conformational and bioactivity analysis of insulin: freeze-drying TBA/water co-solvent system in the presence of surfactant and sugar. Int. J. Pharm. 2009,371(1-2):71-81.
15. Zhang Y, Deng YJ*, Lu M, Duncan Q.M. Craig, Li ZQ*. A spectroscopic investigation into interaction between bile salts and insulin in alkaline aqueous solution. J. Colloid Interface Sci. 2009,337(2):322-331.
16. Hao AJ, Deng YJ*, Li TF, Suo XB, Cao YH, Hao YL, Zhang Y. Degradation kinetics of fluorouracil-acetic-acid-dextran conjugate in aqueous solution. Drug Dev. Ind. Pharm. 2006,32(6):757-63.
17. Hao YL, Deng YJ*, Chen Y, Wang KZ, Hao AJ, Zhang Y.In-vitro cytotoxicity, in-vivo biodistribution and antitumor effect of PEGylated liposomal topotecan. J. Pharm. Pharmacol. 2005,57: 1279-1287.

专利
1. 张勇，陈妍，孔维。苯丁抑制素乙二醇壳聚糖及其制备方法（专利号5.x）