王烨
姓名： 王烨

职称： 副教授
最高学位： 博士
电话：
Email：
工作地点： 生命科学楼565
研究方向： 1.以疾病相关蛋白酶为靶点进行药物高通量虚拟筛选研究2.通过计算机辅助药物设计方法，对小分子药物进行设计、发现、以及分子机制研究3.应用分子模拟方法对蛋白酶进行结构和生物学功能性研究
教育经历： 2009/09 - 2012/06，吉林大学，分子酶学实验室，博士
2006/09 - 2009/06，吉林大学，分子酶学实验室，硕士
2002/09 - 2006/06，吉林大学，药学院药学系，学士

工作经历： 2012/07 – 至今，吉林大学，生命科学学院，讲师
研究成果： 1 Li Ren, Dahai Yu, YanyanWang, Liqiao Shen, Jinrui Zhang, Ye Wang*, Xuexun Fang*, Inhibiting effects of common trivalent metal ions on transmembrane-type 2 matrix metalloproteinase, Int J Biol Macromol., 2018, 119, 683-691.
2 Li Ren#, Ye Wang#, Lei Zhu, Liqiao Shen, Jinrui Zhang, Jingjing Wang, Haolong Li, Qingchuan Zheng, Dahai Yu, Xuexun Fang, Optimization of a MT1-MMPtargeting Peptide and Its Application in Near-infrared Fluorescence Tumor Imaging, Sci Rep. 2018, 8(1), 10334.
3 Ye Wang, Chengkai Zhang, Song An, Xuexun Fang and Dahai Yu, Engineering substrate promiscuity in 2,4-dichlorophenol hydroxylase by in silico design, RSC Adv., 2018, 8, 21184-21190.
4 Ye Wang, Miao Yu, Xiaonan Wang, Xin Zhang, Xizhu Wang and Xuexun Fang, Jatrorrhizine hydrochloride potentiates the neuraminidase inhibitory effect of oseltamivir towards H7N9 influenza, RSC Adv., 2015, 5, 64937–64943.
5 Ye Wang, Di Wu, Dahai Yu, Zhiyong Wang, Li Tian, Yanyan Wang, Weiwei Han and Xuexun Fang, Computational study on new natural polycyclic compounds of H1N1 influenza virus neuraminidase, J Mol Model, 2012, 18, 3445–3453.
6 Yanyan Wang, Ye Wang, Song An, Jinrui Zhang, Yuqian Han, Jinge Xu, Fang Yu, Dahai Yu, Xuexun Fang, Potent and selective inhibition of matrix metalloproteinases by lanthanide trichloride, RSC Adv., 2018, 8, 14347-14354.
7 Yanyan Wang, Ye Wang, Yang Zhan, Jinrui Zhang, Weiguo Liang, Xuexun Fang, Dahai Yu, Yan Feng, DNA binding ability of histone-like protein HPhA is negatively affected by interaction with Pb2+, Biometals, 2015, 28, 207–217.
8 Miao Yu, Ye Wang, Li Tian, Yanyan Wang, Xizhu Wang, Weiguo Liang, Jiyu Yang, Dahai Yu,a Tonghui Ma*, Xuexun Fang*, Safflomin A inhibits neuraminidase activity and influenza virus replication, RSC Adv., 2015, 5, 94053-94066.
9 Yuexi Wang, Ye Wang, Weiwei Han*, Yan Feng*, Improving Sensitivity of Enzyme to Organophosphorous Compounds by Combining Experiment and Theory Methods, CHEM. RES. CHINESE UNIVERSITIES, 2012, 28(4), 707-711.
10 Liyuan Hu, Mengjun Cheng, Yufeng Zhang, Lei Zhang, Ruopeng Cai, Changjiang Sun, Xin Feng, Liancheng Lei, Jingmin Gu, Ye Wang*, Wenyu Han*, The key sites of interaction between LysGH15CHAP domain and its substrate, Chin J Vet Sci, 2017, 37(3), 485-490.