基本信息
职称：教授、博士生导师
学科专业：药物化学
讲授课程：药物合成反应
研究方向：药物合成新技术研究
 
联系方式
电话号码：
Email： jbxiang@jlu.edu.cn
网址：http://juccc.jlu.edu.cn
通讯地址：长春市富锦路1266号，吉林大学药学院612室
邮编：130021
 
个人简介
项金宝博士，男，1983年8月出生于浙江省永康市。2004年7月本科毕业于吉林大学化学学院，同年9月保送进入吉林大学化学学院攻读有机化学博士学位，师从柏旭教授。2008年12月博士毕业后入职药学院任讲师，2011年9月晋升为副教授，2016年9月通过教授职务评选（因缺出国经历延至2019年8月聘任），2016年12月遴选为博士研究生导师。2017年当选为吉林省药学会药物化学专业委员会委员。2018年入选吉林大学优秀青年教师培养计划重点培养阶段。2019年7月被聘任为吉林大学组合化学与创新药物研究中心主任。2017年11月至2019年8月期间在美国斯克利普斯研究所（Scripps Research）做访问学者，合作导师为美国国家科学院院士Phil S. Baran教授。
项金宝教授长期从事药物合成新技术开发与创新药物研究方面的科研工作。作为负责人主持国家自然科学基金项目1项，吉林省科技发展计划项目2项，吉林省教育厅项目1项，企业横向课题2项。2017年获吉林省科技进步奖二等奖1项（排名第二）。近五年研究成果以第一或通讯作者在Nature，Org. Lett.和ACS Comb. Sci.等国际著名期刊发表SCI 收录论文14篇，获授权发明专利2项。自2011年起担任国家自然科学基金评审专家，ACS Comb. Sci.、Bioorg. Med. Chem. Lett.、J. Org. Chem.等国际杂志审稿人。
研究兴趣：药物合成新工艺研究；潜在生物活性骨架的合成方法学研究；天然产物结构修饰与改造。
发表的学术论文：
1. Xiang, J.; Shang, M.; Kawamata, Y.; Lundberg, H.; Reisberg, S. H.; Chen, M.; Mykhailiuk, P.; Beutner, G.; Collins, M. R.; Davies, A.; Del Bel, M.; Gallego, G. M.; Spangler, J. E.; Starr, J.; Yang, S.; Blackmond, D. G.; Baran, P. S.* “Hindered Dialkyl Ether Synthesis with Electrogenerated Carbocations” Nature 2019, 573, 398–402.
2. Xie, W.; Gong, B.; Ning, S.; Liu, N.; Zhang, Z.; Che, X.; Zheng, L.; Xiang, J.* “Diethyl Phosphite Promoted Electrochemical Oxidation of Tetrahydroisoquinolines to 3,4-Dihydroisoquinolin-1(2H)-ones” Synlett 2019, DOI: 10.1055/s-
3. Bai, Y.; Liu, N.; Wang, S.-T.; Wang, S.-Y.; Ning, S.; Shi, L.; Cui L.*; Zhang, Z.; Xiang, J.* “Nickel-Catalyzed Electrochemical Phosphorylation of Aryl Bromides” Org. Lett. 2019, 21, 6835–6838.
4. Xie, W.; Liu, N.; Gong, B.; Ning, S.; Che, X.; Cui, L.*; Xiang, J.* “Electrochemical Cross‐Dehydrogenative Coupling of N‐Aryl‐tetrahydroisoquinolines with Phosphites and Indole” Eur. J. Org. Chem. 2019, 2498–2501.
5. Xie, W.; Ning, S.; Liu, N.; Bai, Y.; Wang, S.-T.; Wang, S.-Y.; Shi, L.; Che, X.; Xiang, J.* “Electrochemical Regioselective Bromination of Electron-Rich Aromatic Rings Using ⁿBu₄NBr” Synlett 2019, 30, 1313–1316.
6. Wang, T.; Ma, H.; Zhang, S.; Li, Z.; Zhang, M.; Li, F.; Sun, F.; Xiang, J.; Ke, M.; Wang, Q.* “Single-electron Oxidation/alterable C3- and C10-Arylation of 9-MeO-phenanthrene” Org. Lett. 2018, 20, 3591–3595.
7. Zhu, T.; Xiang, J.* “Trifluoroacetic Acid-mediated Nucleophilic Substitution/Smiles Rearrangement Cascade Reaction: An Alternative Approach to Constructing Pyrrole-fused Dihydropteridines” Chem. Heterocycl. Compd. 2016, 52, 831–835.
8. Xiang, J.; Zhu, T.; Dang, Q.; Bai, X.* “Electronic Effects on the cis/trans Selectivity in Formation of Isoxazolidine-fused Eight-Membered Ring via an Intramolecular Nitrone-Alkene Cycloaddition” Chem. Heterocycl. Compd. 2016, 52, 601–608.
9. Xiang, J.; Zhang, Z.; Fu, R.; Ternansky, R. J.; Gladstone, P. L.; Allan, A. L.; Donate, F.; Parry, G.; Juarez, J.; Mazar, A. P.; Bai, X.* “The Discovery of Kinase Inhibitors by a Combination of Diversity-Oriented Synthesis and Selective Screening” Med. Chem. Commun. 2016, 7, 1946-1951.
10. Cui, L.; Wu, M.; Xiang, J.* “Iron and Nitrogen Co-functionalized Porous 3D Graphene Frameworks as an Efficient Oxygen Reduction Catalyst” RSC Adv. 2016, 6, 74886–74894.
11. Xie, H.; Gong, B.; Zhong, X.; Cui, H.; Xiang, J.* “Intramolecular Cycloaddition of Azomethine Ylides Activated by Aromatic Rings: Scope and Limitations” Chem. Heterocycl. Compd. 2016, 52, 484–492.
12. Guo, S.; Zhong, X.; Gong, B.; Cui, H.; Xiang, J.* “Synthesis of Pyrido[2,3-b][1,4]benzoxazepines via a Friedel?Crafts Cyclization” Chem. Heterocycl. Compd. 2016, 52, 326–330.
13. Xiang, J.; Zhang, Z.; Mu, Y.; Xu, X.; Guo, S.; Liu, Y.; Russo, D. P.; Zhu, H.; Yan, B.*; Bai, X.* “Discovery of Novel Tricyclic Thiazepine Derivatives as Anti-Drug-Resistant Cancer Agents by Combining Diversity-Oriented Synthesis and Converging Screening Approach” ACS Comb. Sci. 2016, 18, 230–235.
14. Mu, Y.; Liu, Y.; Xiang, J.; Zhang, Q.; Zhai, S.; Russo, D. P.; Zhu, H.; Bai, X.; Yan, B.* “From Fighting Depression to Conquering Tumors: A Novel Tricyclic Thiazepine Compound as a Tubulin Polymerization Inhibitor” Cell Death Dis. 2016, 7, e2143.
15. Xiang, J.; Leung, C.; Zhang, Z.; Hu, C.; Geng, C.; Liu, L.; Yi, L.; Li, Z.*; Berenson, J.; Bai, X.* “Synthesis and Evaluation of 2-Alkylthio-4-(N-substituted sulfonamide)pyrimidine Hydroxamic Acids as Anti-myeloma Agents” Chem. Biol. Drug Des. 2016, 87, 472–477.
16. Xiang, J.; Xie, H.; Li, Z.; Dang, Q.; Bai, X.* “Stereoselective Synthesis of 3?Carboxy-4,5-dihydropyrroles via an Intramolecular Iminium Ion Cyclization Reaction” Org. Lett. 2015, 17, 3818?3821.
17. Zhu, T.; Xiang, J.; Dang, Q.; Bai, X.* “Synthesis of Isoxazolidine-fused Eight-Membered Heterocycles via an Intramolecular Nitrone-Alkene Cycloaddition” Synlett. 2015, 26, 238–242.
18. Yang, K.; Xiang, J.*; Bao, G.; Dang, Q.*; Bai, X. “Synthesis of Highly Substituted 4H-Pyrido[1,2-a]pyrimidines via a One-Pot Three-Component Condensation Reaction” ACS Comb. Sci. 2013, 15, 519–524.
19. Xiang, J.; Li, H.; Yang, K.; Yi, L.; Xu, Y.*; Dang, Q.; Bai, X.* “Synthesis of Novel 4H-Pyrimido[1,6-a]pyrimidines via a One-Pot Three-component Condensation” Mol. Diversity 2012, 16, 173–181.
20. Xie, H.; Xiang, J.; Dang, Q.*; Bai, X.* “A Highly Stereo-controlled Intramolecular Cycloaddition Reaction of Azomethine Ylide Activated by a Pyrimidine Ring: Access to Novel Tricyclic Hexahydro-1H-pyrrolo[2',3':4,5]pyrido[2,3-d]pyrimidines” Synlett. 2012, 23, 585–588.
21. Xiang, J.; Geng, C.; Yi, L.; Dang, Q.; Bai, X.* “Synthesis of Highly Substituted 2,3-Dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 4,6-Dichloro-5-formylpyrimidine, Amines and Aldehydes” Mol. Diversity 2011, 15, 839–847.
22. Xiang, J.; Hu, X.; Dang, Q.*; Bai, X.* “Synthesis of Novel 6,7-Dihydro-5H-pyrimido [4,5-e][1,4]diazepin-8(9H)-ones” J. Heterocyclic Chem. 2011, 48, 1091–1094.
23. Xiang, J.; Zhu, T.; Dang, Q.*; Bai, X.* “Stereochemistry as a Tool in Deciphering the Processes of a Tandem Iminium Cyclization and Smiles Rearrangement” J. Org. Chem. 2010, 75, 8147–8154.
24. Xiang, J.; Wen, D.; Xie, H.; Dang, Q.; Bai, X.* “Synthesis of Novel 8,9-Dihydro-5H-pyrimido[4,5-e][1,4]diazepin-7(6H)-ones” J. Comb. Chem. 2010, 12, 503–509.
25. Yang, F.; Zheng, L.; Xiang, J.; Dang, Q.; Bai, X.* “Synthesis of Hexahydrobenzo[b]pyrimido[4,5-h][1,6]naphthyridines via an Intramolecular Hetero-Diels-Alder Reaction” J. Comb. Chem. 2010, 12, 476–481.
26. Xiang, J.; Zheng, L.; Zhu, T.; Dang, Q.*; Bai, X.* “Synthesis of Novel Tricyclic 4-Chloro-7,8,10,11-tetrahydro-5H-benzo[e]pyrimido[4,5-b][1,4]diazepin-9(6H)-ones” J. Heterocyclic Chem. 2010, 47, 990–993.
27. Xiang, J.; Xie, H.; Wen, D.; Dang, Q.*; Bai, X.* “Synthesis of Pyrido[2,3-e]pyrrolo[1,2-a]pyrazine Derivatives  by Tandem Iminium Cyclization and Smiles Rearrangement” J. Org. Chem. 2008, 73, 3281–3283.
28. Xiang, J.; Zheng, L.; Xie, H.; Hu, X.; Dang, Q.*; Bai, X.* “Pyrrolo-dihydropteridines via a Cascade Reaction Consisting of Iminium Cyclization and O-N Smiles Rearrangement” Tetrahedron 2008, 64, 9101–9107.
29. Xiang, J.; Zheng, L.; Chen, F.; Dang, Q.; Bai, X.* “A Cascade Reaction Consisting of Pictet-Spengler-Type Cyclization and Smiles Rearrangement: Application to the Synthesis of Novel Pyrrole-Fused Dihydropteridines” Org. Lett. 2007, 9, 765–767.
30. Zheng, L.; Xiang, J.; Dang, Q.; Guo, S.; Bai, X.* “Design and Synthesis of a Tetra-cyclic Pyrimidine-Fused Benzodiazepine Library” J. Comb. Chem. 2006, 8, 381–387.
31. Zheng, L.; Dang, Q.; Guo, S.; Xiang, J.; Bai, X.* “Synthesis of Novel 1,6-Disubstituted-5,6-dihydropyrrolo[1,2-f] pteridines” Chem. J. Chinese Univ. 2006, 27, 1869–1872.
32. Zheng, L.; Xiang, J.; Dang, Q.; Guo, S.; Bai, X.* “Novel Heterocyclic Scaffold Consisting of Indole-Fused Pteridines” J. Comb. Chem. 2005, 7, 813–815.
33. Zheng, L.; Xiang, J.; Bai, X.* “A One-pot Procedure for Ring Enlargement of α-Chloromethyl N-Containing Heterocycles” J. Heterocyclic Chem. 2005, 43, 321–324.
34. Zheng, L.; Wang, T.; Wei, Z.; Xiang, J.; Bai, X.* “A Novel Intramolecular Diels–Alder Cyclization Involving Indoloazepines” Tetrahedron Lett. 2005, 46, 3529–3532.