基本信息：
 
 


 
副教授、博士生导师
学科专业：生物药学
讲授课程：蛋白质组学、发酵工程
研究方向：单细胞水平分子诊断技术的研发与应用、抗肿瘤药物的研发
通讯地址：吉林省长春市富锦路1266号吉林大学药学院
邮编：130021
E-mail：liang@jlu.edu.cn
个人简介：
梁重阳，1981年出生，博士，副教授，博士生导师 ，于2009年至今在吉林大学药学院任教，主要从事单细胞水平分子诊断技术的研制以及蛋白质药物开发研究。在单细胞水平分子诊断技术方面，专注于表面增强拉曼技术在细胞生物学方面的应用，并致力于将单细胞水平表面增强拉曼光谱技术用于医学诊疗，已有多项研究成果发表于ACS Applied Materials & Interfaces，Nanoscale等学术期刊；在蛋白质药物开发方面，完成了一项原研药物美国FDA的申报工作，获得国内、国际授权专利20多项，以下为近期的研究成果。
学术论文：
[1]Jing Yue，Shuping Xu1*， Chongyang Liang* et al.Investigating Dynamic Molecular Events in Melanoma Cell Nucleus During Photodynamic Therapy by SERS Front. Chem.2019;DOI: 10.3389/fchem.2018.00665 (online publish)
 
[2]Jing Jin，Chongyang Liang*，Shuping Xu*In situ exploration of characteristics of macropinocytosis and size range of internalized substances in cells by 3D-structured illumination microscopy International Journal of Nanomedicine.2018;(13):5321–5333
 
[3]Rong Deng，Shuping Xu*，Chongyang Liang* et al.Glucose-bridged silver nanoparticle assemblies for highly sensitive molecular recognition of sialic acid on cancer cells via surface-enhanced raman scattering spectroscopy Talanta.2018;(179): 200–206
 
[4]JingZhang，Chongyang Liang*，Dianshuai Huanget al.In situ, accurate, surface-enhanced Raman scattering detection of cancer cell nucleus with synchronous location by an alkyne-labeled biomolecular probe Anal Bioanal Chem. 2018 ;(410):585–594
 
[5]Chongyang Liang*，Shuping Xu*， Shuqin Zhanget al. Organelle-Targeting Gold Nanorods for Macromolecular Pro?ling of Subcellular Organelles and Enhanced Cancer Cell Killing ACS Appl. Mater. Interfaces 2018, (10): 7910?7918
 
[6]Lijia Liang，Shuping Xu*，Chongyang Liang* et al. Organelle-targeting surface-enhanced Raman scattering (SERS) nanosensors for subcellular pH sensing Nanoscale.2018;(10):1622–1630  
 
[7]Rong Deng，Shuping Xu*，Chongyang Liang* et al. Tracing the Therapeutic Process of Targeted Aptamer/Drug Conjugate on Cancer Cells by Surface-Enhanced Raman Scattering Spectroscopy Anal. Chem. 2017;89:2844?2851
 
[8]Lijia Liang，Shuping Xu*^,，Chongyang Liang* et al. Tracing sialoglycans on cell membrane via surface-enhanced Raman scattering spectroscopy with a phenylboronic acid-based nanosensor in molecular recognition Biosensors and Bioelectronics .2017；(94):148–154
 
[9]Shilin Zhang，Chenyang Zhi，Chongyang Liang*et al. Umifenovir effectively inhibits IL-10 dependent persistent Coxsackie B4 virus infection Antiviral Research；2017；(141):165-173
 
[10]Chongyang Liang*，Weikang Li et al. A strategy of desgining the ligand of antibody affinity chromatography based on molecular dynamics simulation  Journal of Chromatography A，1463(2016): 81-89
 
[11]Lijia Liang，Shuping Xu*，Chongyang Liang* et al.In Situ Surface-Enhanced Raman Scattering Spectroscopy Exploring Molecular Changes of Drug-Treated Cancer Cell Nucleus Anal. Chem. 2015; 87:2504?2510
 
[12]Lijia Liang，Shuping Xu*，Chongyang Liang* et al. In Situ Surface-Enhanced Raman Scattering Spectroscopy Exploring Molecular Changes of Drug-Treated Cancer Cell Nucleus Anal. Chem. 2015; 87:2504?2510
专利：
（1）Fusion protein of ganoderma lucidum immunoregulatory protein and human serum albumin, and production method therefor and uses thereof （Xitian Zhang，Chongyang Liang，Fei Sun）(2.0)
（2）Use of recombinant lingzhi mushroom immunomodulatary protein in preparation of drugs for treating focal cerebral ischemia  （Xitian Zhang，Chongyang Liang，Fei Sun）
(EP**.8)
（3）重组灵芝免疫调节蛋白（rlz-8）在制备治疗黑色素瘤药物中的应用（孙非，梁重阳，张喜田）(ZL  2013 1 **.8)
（4）Applications of recombined ganoderma lucidum immunoregulation protein in preparing drugs for treating tissue fibrosis     （Xitian Zhang，Chongyang Liang，Fei Sun）
(US ** B2)
（5）重组灵芝免疫调节蛋白（rlz-8）在制备治疗骨质疏松药物中的应用（孙非，梁重阳，张喜田）(ZL  2014 1 **.X)
（6）重组灵芝免疫调节蛋白在制备治疗雌性激素脱发药物中的应用（孙非，梁重阳，张喜田）(ZL  2014 1 **.5)