姓名

张伟东

职称

教授

办公地点

药学院404

办公电话

******

邮箱

weidongzhang@jlu.edu.cn

教育背景

2013-2016, 加拿大纪念大学, 博士后研究员

2012-2013，新加坡国立大学, 博士后研究员

2006-2009，中国药科大学 中药学博士

工作经历

2017-目前，吉林大学, 药学院, 教授/博士生导师

2016-2017, 加拿大水文研究所, 高级研究员

2009-2012，第四军医大学，讲师

主讲课程

药物分析、生药学

研究领域

中药活性成分与产品开发

科研成果

代表文章（一作/通讯）

1.Zhang WD*, Ying Zhang, Ruya Wang, Pan Zhang, Yanyan Zhang, Edward Randell, Mengyuan Zhang, Qiong Jia. Development and application of surface molecularly imprinted polymers toward amino acids, peptides, and proteins. Anal Chim Acta. 2022 Nov 22;1234:340319.

2.Zhang WD, Sun S, Aitken D, Likhodii S,et al. Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis. Rheumatology (Oxford), 2016;55:1566-74.

3.Zhang WD, Sun G, Likhodii S, et al. Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients. Osteoarthritis and Cartilage. 2016;24:827-34.

4.Zhang WD, Sun G, Likhodii S, Aref-Eshghi E, et al. Metabolomic analysis of human synovial fluid and plasma reveals that phosphatidylcholine metabolism is associated with both osteoarthritis and diabetes. Metabolomics. 2016,12:4.

5.Zhang WD, Likhodii S, Aref-Eshghi E, et al. Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis. J Rheumatol. 2015;42:859-65.

6.Zhang WD, Randell EW, Sun G,et al. Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes. PLoS One. 2017; 12;12(9): e0184105.

7.Zhang WD, Likhodii S, Zhang Y, et al. Classification of osteoarthritis phenotypes by metabolomics analysis. BMJ Open. 2014; 4(11):e006286.

8.Zhang WD, Wang PY, Wang Y, et al. Simultaneous determination of aurantio-obtusin, chrysoobtusin, obtusin and 1-desmethylobtusin in rat plasma by UHPLC-MS/MS. Biomed Chromatogr.2014, 28:369-74

9.Zhang WD, Wang Y, Wang Q,etal. Quality evaluation of Semen Cassiae by using ultra high-performance liquid chromatography coupled with mass spectrometry. Journal of Separation Science. 2012; 35, 2054-2062.

10.Zhang WD, Wang Q, Wang Y, etal. Application of ultrahigh -performance LC coupled with MS for analysis of lignans and quality control of Fructus Schisandrae chinensis. JSS. 2012;35, 2203-09.

11.Zhang WD, Yang WJ, Wang XJ. Simultaneous determination of tectorigenin, irigenin and irisflorentinin rat plasma and urine by UHPLC-MS/MS: Application to pharmacokinetics. J ChromatogrB. 2011; 879, 3735-3741.

12.Zhang WD, Wang XJ, Zhou SY, et al. Determination of free and glucuronidated kaempferol in rat plasma by LC-MS/MS : Application to pharmacokinetic study. J ChromatogrB.2010; 878, 2137-214.

13.Zhang WD, Qi LW, Yang XL, et al. Identification of the major metabolites of tectorigenin in rat bile by liquid chromatography combined with TOF and ion trap tandem mass spectrometry. RCM.2008; 22, 2677-84.

14.Zhang WD, Yang XL, Xu L. Identification of the key metabolites of tectorigenin in rat urine by LC-MSn. Biomed Chromatogr. 2009; 23, 219-221.

15.Zhang WD, Qi LW, Yang XL. Determination of tectorigenin in rat plasma:Application to a pharmacokinetic study after oral administration of tectorigenin or its prodrug tectoridin. Chromatogr.2008；68，1021-1025.

16.Wenbin Liu, Zhang WD*, Tongzhou Li, Zhiwei Zhou, Mingdu Luo, Xi Chen, Yuping Cai, Zheng-Jiang Zhu. Four-dimensional untargeted profiling of N‑Acylethanolamine lipids in the mouse brain using Ion Mobility−Mass Spectrometry. Anal Chem. 2022 Sep 13;94(36):12472-12480.

17.Yanyan Zhang, Zhen Li, Li Li, Mingyuan Gao, Yixin Lang, Mengyuan Zhang, Sergei Likhodii, Ting Hu, Muxin Zhang, Zhang WD*. Magnetic solid-phase extraction method with modified magnetic ferroferric oxide nanoparticles in a deep eutectic solvent and high-performance liquid chromatography used for the analysis of pharmacologically active ingredients of Epimedium folium. J Chromatogr A . 2022 Aug 30;1679:463395.

18.Bing Qin, Xiaoyan Yu, Mingyuan Gao, Yanyan Zhang, Chunling Wang, Hongle Wan, Li Li, Muxin Zhang, Mengyuan Zhang, Zhang WD*. Magnetic molecularly-imprinted microspheres with a core-shell structure for the extraction of catalpol from both Rehmannia glutinosa Libosch and biological samples. J Chromatogr A . 2023 Aug 30:1705:464183.

19.Ruya Wang, Zhang WD*, Weiqiang Liang, Xiao Wang, Lili Li, Zhenhua Wang, Miaomiao Li, Jun Li, Chunxia Ma. ACS Appl Mater Interfaces. 2024 Apr 10;16(14):17377-17392.

国际会议学术报告

1.2016：学术报告，第12届国际代谢组学大会.爱尔兰都柏林，Title: Hyperglycemia-related advanced glycation end-products is associated with the altered phosphytidylcholine metabolism in osteoarthritis patients.

2.2015：学术报告（Travel award获奖500美元， 获奖率10/500），第11届国际代谢组学大会.美国旧金山。Title: Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients.

3.2015：学术报告，2015世界骨性关节病大会.美国西雅图，Title: Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis.

4.2014：墙报，2014美国风湿病学院年会.波士顿。Title: Classification of osteoarthritis phenotypes by metabolomics analysis.

科研项目

聚焦于吉林省道地药材的活性成分研究开发，主持国家级和国际合作项目4项，省级科研项目5项，其他各类科研项目10余项。开发新药，保健品及医疗机构制剂10余个，授权专利8个。