所属二级学科：生物化学与分子生物学           
所 在 科 室：  感染与免疫研究中心 


    罗招庆，博士，博士生导师。2001年获美国伊利诺依大学厄巴那－香槟分校博士学位。2001-2004年在美国塔夫茨大学医学院做博士后研究。
    研究方向为病原生物学，以细菌致病机理和寄主免疫反应为重点，通过鉴定和阐明细菌毒力蛋白作用的生化和细胞生物学机制，以期获得干预感染的新策略。同时，由于长期与寄主免疫体系的共演化，毒力蛋白往往以独特方式干扰重要寄主的信号传导通路，对其功能的阐明能揭示正常生理条件下无法检测的信号传递机制。例如，我们最近揭示了一种全新的泛素化修饰机制，该泛素化过程不需要经典泛素修饰必需的E1和E2酶的参与，而是以NAD为能量源，通过ADP核糖基化激活泛素。该发现受到国际学术界广泛关注，被Science Signaling 杂志评为2016年细胞信号转导领域的十大突破之一，开创了一个全新的泛素化研究领域，对揭示泛素化修饰在细胞信号转导、疾病发生等方面的功能具有重要意义。近年来在Nature（3篇）、Nature Microbiology（1篇）、PNAS（6篇）、PLoS Pathogens (6篇)、Cell Research（2篇）等期刊发表论文30余篇，并受邀为Nature Reviews Microbiology、Journal of Cell Biology 和Cell Microbiology等撰写相关综述。现为PLoS Pathogens的副主编（Associate Editor） 及PLoS One 的学术编委（Academic Editor）。                                                                                                                  
 
代表性论文： 
Gan N, Zhen X, Liu Y, Xu X, He C, Qiu J, Liu Y, Fujimoto GM, Nakayasu ES, Zhou B, Zhao L, Puvar K, Das C, Ouyang S*, Luo ZQ*. Regulation of phosphoribosyl ubiquitination by a calmodulin-dependent glutamylase. Nature. 2019 Aug;572(7769):387-391. doi: 10.1038/s41586-019-1439-1. Epub 2019 Jul 22.
Gan N, Nakayasu ES, Hollenbeck PJ, Luo ZQ*. Legionella pneumophila inhibits immune signalling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N. Nat Microbiol. 2019 Jan;4(1):134-143. doi: 10.1038/s41564-018-0282-8. Epub 2018 Nov 12.
Qiu J and Luo ZQ*. Legionella and Coxiella effectors: Strength in diversity and activity. Nature Reviews Microbiology, 2017;15(10):591-605. PMID: **
Qiu J, Yu K, Fei X, Liu Y, Nakayasu ES, Piehowski PD, Shaw JB, Puvar K, Das C, Liu X, Luo ZQ*. A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination. Cell Res. 2017 ;27(7):865-881. PMID: **
Liu Y, Zhu W, Tan Y, Nakayasu ES, Staiger CJ, Luo ZQ*. A Legionella effector disrupts host cytoskeletal structure by cleaving actin. PLoS Pathog, 2017;13(1):e**. PMID: **
Qiu J, Sheedlo MJ, Yu K, Tan Y, Nakayasu ES, Das C, Liu X, Luo ZQ*. 2016. Ubiquitination independent of E1 and E2 enzymes by bacterial effectors. Nature. 533:120-124. PMID: ** (Highlighted and commented by Nature，Current Biology, Molecular Cell, Cell Host & Microbe, Science Signaling and Nature Review Microbiology).
Sheedlo MJ?, Qiu J?, Tan Y?, Paul LN, Luo ZQ*, Das C*. 2015. Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination. Proc. Natl. Acad. Sci. USA. 112(49):15090-5. ?, equal contribution authors. PMID: **
Zhu W.?, Tao L.?, Quick M.L,. Joyce J.A., Qu J.M., Luo Z.-Q*. 2015. Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection. PLoS Pathogens. 11(3):e**. doi: 10.1371/journal.ppat.**. eCollection 2015 Mar. ?,equal contribution authors. PMID: **
Hsu F?., Luo X?., Qiu J?., Teng Y.B., Jin J., Smolka M.B., Luo Z.-Q*., Mao Y*. 2014. The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. Proc. Natl. Acad. Sci. USA. 111(29):10538-43. doi: 10.1073/pnas.. Epub 2014 Jul 8. ?,equal contribution authors. PMID: **
Tan Y. Arnold A. J. and Luo ZQ*. 2011. Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination. Proc. Natl. Acad. Sci. USA. 108:21212-7 PMID: **
Tan Y. and Luo ZQ* 2011. Legionella pneumophila SidD is a deAMPylase that modifies Rab1. Nature. 475:506-509. PMID: **.
Fontana M. F., Banga S., Barry K. C., Shen X., Tan, Y., Luo ZQ*. and Vance E.V*.  2011. Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.  PLoS Pathogens. 7: e**. PMID: ** 
Xu L?., Shen X?., Bryan A., Banga S., Swanson M. and Luo ZQ*. 2010. Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector PLoS Pathogens 19;6(3):e**. ?, equal contribution authors, PMID: **
Liu Y., Gao P. Banga S. and Luo ZQ*.  2008. An in vivo gene deletion system for determining temporal requirement of bacterial virulence factors. Proc. Natl. Acad. Sci USA. 105:9385-90. (cited by Faculty 1000). PMID: **
Banga, S., Gao, P., Shen X., Fiscus V., Zong W-X., Chen L. and Luo ZQ*. 2007. Legionellapneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc. Natl. Acad. Sci. USA. 104: 5121-5126. PMID: **