Fei SUN
孫飛
PhD in Chemistry
The University of Chicago, 2012

Associate Professor
Department of Chemical and Biological Engineering

PG Programs Coordinator (Chemical and Biological Engineering)

Program Director of Bioengineering Graduate Program



(852) 3469 2442
kefsun@ust.hk
Room CYT2004
Personal Web

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Google Scholar
dRT7hHMAAAAJ

ORCID
0000-0002-3065-7471

Scopus ID
56727199000




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Bioengineering
Biopolymers
Biomaterials
Advanced materials



Publications

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All Years 46 2022 0 2021 6 2020 8 2019 2 2018 8 2017 4 2016 18

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2021 6

Cu₃Pd_xN nanocrystals for efficient CO₂ electrochemical reduction to methane
Electrochimica Acta, v. 371, March 2021, article number 137793
Li, Tiehuai; Wang, Jing; Zhu, Shangqian; Delmo, Ernest Pahuyo; Sun, Fei; Zhang, Lili; Gu, Meng; Shao, Minhua Article
Harnessing Proteins For Engineered Living Materials
Current Opinion in Solid State and Materials Science, v. 25, (1), February 2021, article number 100896
Xu, Lianjie; Wang, Xinyu; Sun, Fei; Cao, Yi; Zhong, Chao; Zhang, Wen Bin Article
Reaction: Engineer Biology for Uranium
Chem, v. 7, (2), February 2021, p. 274-275
Sun, Fei; He, Chuan Article
Time-dependent response of bio-polymer networks regulated by catch and slip bond-like kinetics of cross-linkers
Journal of the Mechanics and Physics of Solids, v. 147, February 2021, article number 104267
Wei, X.; Fang, C.; Gong, B.; Shao, X.; Sun, Fei; Qian, J.; Lin, Y. Article
Self-Assembly and Genetically Engineered Hydrogels
Tunable Hydrogels: Smart Materials for Biomedical Applications / Edited by Antonina Lavrentieva, Iliyana Pepelanova, Dror Seliktar. Switzerland : Springer Nature, 2021, p. 169-196, Book Series: Advances in Biochemical Engineering/Biotechnology, v. 178
Yang, Zhongguang; Sun, Fei Book chapter
The Spy that links: Creation of nonlinear protein architectures and materials using SpyTag/SpyCatcher chemistry
Methods in Enzymology / Edited by Maarten Merkx. Cambridge, Massachusetts : Academic Press, 2021, p. 283-301, Volume 647: Linkers in Biomacromolecules, Chapter 11
Wang, Ri; Sun, Fei Book chapter

2020 8

Calcium-responsive hydrogels enabled by inducible protein-protein interactions
Polymer Chemistry, v. 11, (31), 21 August 2020, p. 4973-4977
Luo, Jiren; Sun, Fei Article
Dynamically Tunable, Macroscopic Molecular Networks Enabled by Cellular Synthesis of 4-Arm Star-like Proteins
Matter, v. 2, (1), January 2020, p. 233-249
Yang, Zhongguang; Yang, Yang; Wang, Mo; Wang, Tingting; Fok, Hong Kiu Francis; Jiang, Bojing; Xiao, Wendi; Kou, Songzi; Guo, Yusong; Yan, Yan; Deng, Xin; Zhang, Wen-Bin; Sun, Fei Article
Editorial: Synthesis of Novel Hydrogels With Unique Mechanical Properties
Frontiers in Chemistry, v. 8, October 2020, article number 595392
Li, Ying; Blank, Kerstin G.; Sun, Fei; Cao, Yi Article
Genetically Encoded Click Chemistry?
Chinese Journal of Chemistry, May 2020
Sun, Fei; Zhang, Wenbin Article
Give Life to a Glue
Matter, v. 3, (6), December 2020, p. 1820-1822
Wang, Ri; Jiang, Bojing; Sun, Fei Article
Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly
Science Advances, v. 6, (41), 7 October 2020, article number eabc4824
Jiang, Bojing; Liu, Xiaotian; Yang, Chao; Yang, Zhongguang; Luo, Jiren; Kou, Songzi; Liu, Kai; Sun, Fei Article
Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly
Molecular Systems Design & Engineering, v. 5, (1), January 2020, p. 117-124
Cao, Yujie; Wei, Xi; Lin, Yuan; Sun, Fei Article
Photoresponsive hydrogels
Photochemistry / Editors: Angelo Albini, Stefano Protti. United Kingdom : Royal Society of Chemistry, 2020, p. 379-403, v. 47
Wang, Ri; Sun, Fei Book chapter

2019 2

Cobalt-Cross-Linked, Redox-Responsive Spy Network Protein Hydrogels
ACS Macro Letters, v. 8, (7), June 2019, p. 773-778
Kou, Songzi; Yang, Xin; Yang, Zhongguang; Liu, Xiaotian; Wegner, Seraphine V.; Sun, Fei Article
Enzymatic Assembly of Adhesive Molecular Networks With Sequence-dependent Mechanical Properties Inspired by Mussel Foot Proteins
Polymer Chemistry, v. 10, (7), Febuary 2019, p. 823-826
Park, Byung Min; Luo, Jiran; Sun, Fei Article

2018 8

A Versatile and Robust Approach to Stimuli-Responsive Protein Multilayers with Biologically Enabled Unique Functions
Biomacromolecules, v. 19, (3), March 2018, p. 1065-1073
Zhang, X.-J.; Wang, X.-W.; Da, X.-D.; Shi, Y.; Liu, C.; Sun, Fei; Yang, S.; Zhang, W.-B. Article
An Intrinsically Disordered Peptide-Peptide Stapler for Highly Efficient Protein Ligation Both in Vivo and in Vitro
Journal of the American Chemical Society, v. 140, (50), December 2018, p. 17474-17483
Wu, Xia-Ling; Liu, Yajie; Liu, Dong; Sun, Fei; Zhang, Wen-Bin Article
B₁₂-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms
ACS Macro Letters, v. 7, (5), April 2018, p. 514-518
Wei, jingjing; Wu, wenhao; Wang, Ri; Yang, Zhongguang; Sun, Fei; Zhang, wenbin Article
Genetically Programming Stress-Relaxation Behavior in Entirely Protein-Based Molecular Networks
ACS Macro Letters, v. 7, (12), December 2018, p. 1468-1474
Yang, Zhongguang; Kou, Songzi; Wei, Xi; Zhang, Fengjie; Li, Fei; Wang, Xiao-Wei; Lin, Yuan; Wan, Chao; Zhang, Wen-Bin; Sun, Fei Article
Modular Functionalization of Crystalline Graphene by Recombinant Proteins: A Nanoplatform for Probing Biomolecules
Nanoscale, v. 10, (47), December 2018, p. 22572-22582
Tyagi, Abhishek; Liu, Xiaotian; Abidi, Irfan Haider; Gao, Zhaoli; Park, Byung Min; Zeng, Xiangze; Ou, Xuewu; Cagang, Aldrine Abenoja; Zhuang, Minghao; Hossain, Md Delowar; Zhang, Kai; Weng, Lutao; Sun, Fei; Luo, Zhengtang Article
Reversible hydrogels with tunable mechanical properties for optically controlling cell migration
Nano Research, v. 11, (10), Ocotber 2018, p. 5556-5565
Wu, xin; Huang, wenmao; Wu, wenhao; Xue, bin; Xiang, dongfang; Li, Ying; Qin, Meng; Sun, Fei; Wang, wei; Zhang, wenbin; Cao, yi Article
Synthesis of Entirely Protein-Based Hydrogels by Enzymatic Oxidation Enabling Water-Resistant Bioadhesion and Stem Cell Encapsulation
ACS Applied Bio Materials, v. 1, (5), November 2018, p. 1735-1740
Luo, Jiren; Liu, Xiaotian; Yang, Zhongguang; Sun, Fei Article
Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth
ACS Applied Nano Materials, v. 1, (4), March 2018, p. 1579-1585
Liu, Xiaotian; Yang, Xin; Yang, Zhongguang; Luo, jiren; Tian, xiaozhen; Liu, Kai; Kou, Songzi; Sun, Fei Article

2017 4

B₁₂-Dependent Photoresponsive Protein Hydrogels for Controlled Stem Cell/Protein Release
Proceedings of the National Academy of Sciences of the United States of America, v. 114, (23), June 2017, p. 5912-5917
Wang, Ri; Yang, Zhongguang; Luo, Jiren; Hsing, I-Ming; Sun, Fei Article
Entirely Recombinant Protein-based Hydrogels for Selective Heavy Metal Sequestration
POLYMER CHEMISTRY, v.8, (39), October 2017, p. 6158-6164
Kou, Songzi; Yang, Zhongguang; Luo, Jiren; Sun, Fei Article
Protein Hydrogel Microbeads for Selective Uranium Mining from Seawater
ACS Applied Materials and Interfaces, v. 9, (3), January 2017, p. 2035-2039
Kou, Songzi; Yang, Zhongguang; Sun, Fei Article
Unleashing Chemical Power From Protein Sequence Space Toward Genetically Encoded “click” Chemistry
Chinese Chemical Letters, v. v. 28, ((11)), 2017, p. 2078-2084
Sun, Fei; Zhang, Wen-Bin Article

2016 1

Microfluidics and Microbial Engineering
Lab on a Chip - Miniaturisation for Chemistry and Biology, v. 16, (3), February 2016, p. 432-446
Kou, Songzi; Cheng, Danhui; Sun, Fei; Hsing, I-Ming Article

2015 1

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo
Chemistry & Biology, v. 22, (8), August 2015, p. 1108-1121
Bedbrook, Claire; Kato, Mihoko; Kumar, Sripriya Ravindra; Lakshmanan, Anupama; Nath, Ravi D.; Sun, Fei; Sternberg, Paul W.; Arnold, Frances H.; Gradinaru, Viviana Article

2014 2

Steady-State Hydrogen Peroxide Induces Glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa
Journal of Bacteriology, v. 196, (14), 2014, p. 2499-2513
Deng, Xin; Liang, Haihua; Ulanovskaya, Olesya A.; Ji, Quanjiang; Zhou, Tianhong; Sun, Fei; Lu, Zhike; Hutchison, Alan L.; Lan, Lefu; Wu, Min; Cravatt, Benjamin F.; He, Chuan Article
Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry
Proceedings of the National Academy of Sciences of the United States of America, v. 111, (31), August 2014, p. 11269-11274
Sun, Fei; Zhang, Wen-Bin; Mahdavi, Alborz; Arnold, Frances H.; Tirrell, David A. Article

2013 3

Controlling Macromolecular Topology with Genetically Encoded SpyTag-SpyCatcher Chemistry
Journal of the American Chemical Society, v. 135, (37), September 2013, p. 13988-13997
Zhang, Wen-Bin; Sun, Fei; Tirrell, David A.; Arnold, Frances H. Article
Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (13), March 2013, p. 5010-5015
Ji, Quanjiang; Zhang, Liang; Jones, Marcus B.; Sun, Fei; Deng, Xin; Liang, Haihua; Cho, Hoonsik; Brugarolas, Pedro; Gao, Yihe N.; Peterson, Scott N.; Lan, Lefu; Bae, Taeok; He, Chuan Article
Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria
Cell Host and Microbe, v. 13, (3), March 2013, p. 358-370
Deng, Xin; Weerapana, Eranthie; Ulanovskaya, Olesya; Sun, Fei; Liang, Haihua; Ji, Quanjiang; Ye, Yan; Fu, Ye; Zhou, Lu; Li, Jiaxin; Zhang, Haiyan; Wang, Chu; Alvarez, Sophie; Hicks, Leslie M.; Lan, Lefu; Wu, Min; Cravatt, Benjamin F.; He, Chuan Article

2012 6

AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus
J Am Chem Soc., v.134, (1), 11 Jan 2012, p. 305-314
Sun, Fei; Ji, Quanjiang; Jones, Marcus B.; Deng, Xin; Liang, Haihua; Frank, Bryan; Telser, Joshua; Peterson, Scott N.; Bae, Taeok; He, Chuan Article
Expression of Multidrug Resistance Efflux Pump Gene norA Is Iron Responsive in Staphylococcus aureus
J. Bacteriol, v.194, (7), 2012, April, p. 1753-1762
Deng, Xin; Sun, Fei; Ji, Quanjiang; Liang, Haihua; Missiakas, Dominique; Lan, Lefu; He, Chuan Article
Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance
Proc Natl Acad Sci U S A., v.109, (38), 18 September 2012, p. 15461-15466
Sun, F.; Ding, Y.; Ji, Q.; Liang, Z.; Deng, X.; Wong, CC; Yi, C.; Zhang, L.; Xie, S.; Alvarez, S.; Hicks, LM; Luo, C.; Jiang, H.; Lan, L.; He, C. Article
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA
Proc Natl Acad Sci U S A, v.109, (23), 14 June 2012, p. 9095-9100
Sun, Fei; Liang, Haihua; Kong, Xiangqian; Xie, Sherrie; Cho, Hoonsik; Deng, Xin; Ji, Quanjiang; Zhang, Haiyan; Alvarez, Sophie; Hicks, Leslie M.; Bae, Taeok; Luo, Cheng; Jiang, Hualiang; He, Chuan Article
Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response
Journal of Biological Chemistry, v. 287, (25), June 2012, p. 21102-21109
Ji, Quanjiang; Zhang, Liang; Sun, Fei; Deng, Xeng; Liang, Haihua; Bae, Taeok; He, Chuan Article
The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus
Molecular Microbiology, v.86, (2), 2012, Oct, p. 331–348
Jeong, Do-Won; Cho, Hoonsik; Jones, Marcus B.; Shatzkes, Kenneth; Sun, Fei; Ji, Quanjiang; Liu, Qian; Peterson, Scott N.; He, Chuan; Bae, Taeok Article

2011 2

Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus
Chemistry & Biology, v.18, (8), 26 August 2011, p.1032–1041
Sun, Fei; Zhou, Lu; Zhao, Bing-Chuan; Deng, Xin; Cho, Hoonsik; Yi, Chengqi; Jian, Xing; Song, Chun-Xiao; Luan, Chi-Hao; Bae, Taeok; Liemail, Zigang; Heemail, Chuan Article
The tightly regulated copper window in yeast
Chem. Commun, v.47, 2011, p. 2571-2573
Wegner, Seraphine V.; Sun, Fei; Hernandeza, Nick; He, Chuan Article

2010 3

Aureusimines in Staphylococcus aureus are not involved in virulence
PLoS One, v.5, (12), 29 Dec 2010, article number e15703
Sun, Fei; Cho, Hoonsik; Jeong, Do-Won; Li, Chunling; He, Chuan; Bae, Taeok Article
CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis
J. Bacteriol, v.192, (15), 2010, Aug, p. 3883-3892
Li, Chunling; Sun, Fei; Cho, Hoonsik; Yelavarthi, Vamshi; Sohn, Changmo; He, Chuan; Schneewind, Olaf; Bae, Taeok Article
In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS
J Bacteriol, v.192, (8), 2010, Apr, p. 2111-2127
Sun, Fei; Li, Chunling; Jeong, Dowon; Sohn, Changmo; He, Chuan; Bae, Taeok Article


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Article 4

Cu₃Pd_xN nanocrystals for efficient CO₂ electrochemical reduction to methane
Electrochimica Acta, v. 371, March 2021, article number 137793
Li, Tiehuai; Wang, Jing; Zhu, Shangqian; Delmo, Ernest Pahuyo; Sun, Fei; Zhang, Lili; Gu, Meng; Shao, Minhua
Harnessing Proteins For Engineered Living Materials
Current Opinion in Solid State and Materials Science, v. 25, (1), February 2021, article number 100896
Xu, Lianjie; Wang, Xinyu; Sun, Fei; Cao, Yi; Zhong, Chao; Zhang, Wen Bin
Reaction: Engineer Biology for Uranium
Chem, v. 7, (2), February 2021, p. 274-275
Sun, Fei; He, Chuan
Time-dependent response of bio-polymer networks regulated by catch and slip bond-like kinetics of cross-linkers
Journal of the Mechanics and Physics of Solids, v. 147, February 2021, article number 104267
Wei, X.; Fang, C.; Gong, B.; Shao, X.; Sun, Fei; Qian, J.; Lin, Y.

Book chapter 2

Self-Assembly and Genetically Engineered Hydrogels
Tunable Hydrogels: Smart Materials for Biomedical Applications / Edited by Antonina Lavrentieva, Iliyana Pepelanova, Dror Seliktar. Switzerland : Springer Nature, 2021, p. 169-196, Book Series: Advances in Biochemical Engineering/Biotechnology, v. 178
Yang, Zhongguang; Sun, Fei
The Spy that links: Creation of nonlinear protein architectures and materials using SpyTag/SpyCatcher chemistry
Methods in Enzymology / Edited by Maarten Merkx. Cambridge, Massachusetts : Academic Press, 2021, p. 283-301, Volume 647: Linkers in Biomacromolecules, Chapter 11
Wang, Ri; Sun, Fei


Expand All Collapse All


Article 7

Calcium-responsive hydrogels enabled by inducible protein-protein interactions
Polymer Chemistry, v. 11, (31), 21 August 2020, p. 4973-4977
Luo, Jiren; Sun, Fei
Dynamically Tunable, Macroscopic Molecular Networks Enabled by Cellular Synthesis of 4-Arm Star-like Proteins
Matter, v. 2, (1), January 2020, p. 233-249
Yang, Zhongguang; Yang, Yang; Wang, Mo; Wang, Tingting; Fok, Hong Kiu Francis; Jiang, Bojing; Xiao, Wendi; Kou, Songzi; Guo, Yusong; Yan, Yan; Deng, Xin; Zhang, Wen-Bin; Sun, Fei
Editorial: Synthesis of Novel Hydrogels With Unique Mechanical Properties
Frontiers in Chemistry, v. 8, October 2020, article number 595392
Li, Ying; Blank, Kerstin G.; Sun, Fei; Cao, Yi
Genetically Encoded Click Chemistry?
Chinese Journal of Chemistry, May 2020
Sun, Fei; Zhang, Wenbin
Give Life to a Glue
Matter, v. 3, (6), December 2020, p. 1820-1822
Wang, Ri; Jiang, Bojing; Sun, Fei
Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly
Science Advances, v. 6, (41), 7 October 2020, article number eabc4824
Jiang, Bojing; Liu, Xiaotian; Yang, Chao; Yang, Zhongguang; Luo, Jiren; Kou, Songzi; Liu, Kai; Sun, Fei
Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly
Molecular Systems Design & Engineering, v. 5, (1), January 2020, p. 117-124
Cao, Yujie; Wei, Xi; Lin, Yuan; Sun, Fei

Book chapter 1

Photoresponsive hydrogels
Photochemistry / Editors: Angelo Albini, Stefano Protti. United Kingdom : Royal Society of Chemistry, 2020, p. 379-403, v. 47
Wang, Ri; Sun, Fei


Expand All Collapse All


Article 2

Cobalt-Cross-Linked, Redox-Responsive Spy Network Protein Hydrogels
ACS Macro Letters, v. 8, (7), June 2019, p. 773-778
Kou, Songzi; Yang, Xin; Yang, Zhongguang; Liu, Xiaotian; Wegner, Seraphine V.; Sun, Fei
Enzymatic Assembly of Adhesive Molecular Networks With Sequence-dependent Mechanical Properties Inspired by Mussel Foot Proteins
Polymer Chemistry, v. 10, (7), Febuary 2019, p. 823-826
Park, Byung Min; Luo, Jiran; Sun, Fei


Expand All Collapse All


Article 8

A Versatile and Robust Approach to Stimuli-Responsive Protein Multilayers with Biologically Enabled Unique Functions
Biomacromolecules, v. 19, (3), March 2018, p. 1065-1073
Zhang, X.-J.; Wang, X.-W.; Da, X.-D.; Shi, Y.; Liu, C.; Sun, Fei; Yang, S.; Zhang, W.-B.
An Intrinsically Disordered Peptide-Peptide Stapler for Highly Efficient Protein Ligation Both in Vivo and in Vitro
Journal of the American Chemical Society, v. 140, (50), December 2018, p. 17474-17483
Wu, Xia-Ling; Liu, Yajie; Liu, Dong; Sun, Fei; Zhang, Wen-Bin
B₁₂-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms
ACS Macro Letters, v. 7, (5), April 2018, p. 514-518
Wei, jingjing; Wu, wenhao; Wang, Ri; Yang, Zhongguang; Sun, Fei; Zhang, wenbin
Genetically Programming Stress-Relaxation Behavior in Entirely Protein-Based Molecular Networks
ACS Macro Letters, v. 7, (12), December 2018, p. 1468-1474
Yang, Zhongguang; Kou, Songzi; Wei, Xi; Zhang, Fengjie; Li, Fei; Wang, Xiao-Wei; Lin, Yuan; Wan, Chao; Zhang, Wen-Bin; Sun, Fei
Modular Functionalization of Crystalline Graphene by Recombinant Proteins: A Nanoplatform for Probing Biomolecules
Nanoscale, v. 10, (47), December 2018, p. 22572-22582
Tyagi, Abhishek; Liu, Xiaotian; Abidi, Irfan Haider; Gao, Zhaoli; Park, Byung Min; Zeng, Xiangze; Ou, Xuewu; Cagang, Aldrine Abenoja; Zhuang, Minghao; Hossain, Md Delowar; Zhang, Kai; Weng, Lutao; Sun, Fei; Luo, Zhengtang
Reversible hydrogels with tunable mechanical properties for optically controlling cell migration
Nano Research, v. 11, (10), Ocotber 2018, p. 5556-5565
Wu, xin; Huang, wenmao; Wu, wenhao; Xue, bin; Xiang, dongfang; Li, Ying; Qin, Meng; Sun, Fei; Wang, wei; Zhang, wenbin; Cao, yi
Synthesis of Entirely Protein-Based Hydrogels by Enzymatic Oxidation Enabling Water-Resistant Bioadhesion and Stem Cell Encapsulation
ACS Applied Bio Materials, v. 1, (5), November 2018, p. 1735-1740
Luo, Jiren; Liu, Xiaotian; Yang, Zhongguang; Sun, Fei
Versatile Engineered Protein Hydrogels Enabling Decoupled Mechanical and Biochemical Tuning for Cell Adhesion and Neurite Growth
ACS Applied Nano Materials, v. 1, (4), March 2018, p. 1579-1585
Liu, Xiaotian; Yang, Xin; Yang, Zhongguang; Luo, jiren; Tian, xiaozhen; Liu, Kai; Kou, Songzi; Sun, Fei


Expand All Collapse All


Article 4

B₁₂-Dependent Photoresponsive Protein Hydrogels for Controlled Stem Cell/Protein Release
Proceedings of the National Academy of Sciences of the United States of America, v. 114, (23), June 2017, p. 5912-5917
Wang, Ri; Yang, Zhongguang; Luo, Jiren; Hsing, I-Ming; Sun, Fei
Entirely Recombinant Protein-based Hydrogels for Selective Heavy Metal Sequestration
POLYMER CHEMISTRY, v.8, (39), October 2017, p. 6158-6164
Kou, Songzi; Yang, Zhongguang; Luo, Jiren; Sun, Fei
Protein Hydrogel Microbeads for Selective Uranium Mining from Seawater
ACS Applied Materials and Interfaces, v. 9, (3), January 2017, p. 2035-2039
Kou, Songzi; Yang, Zhongguang; Sun, Fei
Unleashing Chemical Power From Protein Sequence Space Toward Genetically Encoded “click” Chemistry
Chinese Chemical Letters, v. v. 28, ((11)), 2017, p. 2078-2084
Sun, Fei; Zhang, Wen-Bin


Expand All Collapse All


Article 1

Microfluidics and Microbial Engineering
Lab on a Chip - Miniaturisation for Chemistry and Biology, v. 16, (3), February 2016, p. 432-446
Kou, Songzi; Cheng, Danhui; Sun, Fei; Hsing, I-Ming


Expand All Collapse All


Article 1

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo
Chemistry & Biology, v. 22, (8), August 2015, p. 1108-1121
Bedbrook, Claire; Kato, Mihoko; Kumar, Sripriya Ravindra; Lakshmanan, Anupama; Nath, Ravi D.; Sun, Fei; Sternberg, Paul W.; Arnold, Frances H.; Gradinaru, Viviana


Expand All Collapse All


Article 2

Steady-State Hydrogen Peroxide Induces Glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa
Journal of Bacteriology, v. 196, (14), 2014, p. 2499-2513
Deng, Xin; Liang, Haihua; Ulanovskaya, Olesya A.; Ji, Quanjiang; Zhou, Tianhong; Sun, Fei; Lu, Zhike; Hutchison, Alan L.; Lan, Lefu; Wu, Min; Cravatt, Benjamin F.; He, Chuan
Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry
Proceedings of the National Academy of Sciences of the United States of America, v. 111, (31), August 2014, p. 11269-11274
Sun, Fei; Zhang, Wen-Bin; Mahdavi, Alborz; Arnold, Frances H.; Tirrell, David A.


Expand All Collapse All


Article 3

Controlling Macromolecular Topology with Genetically Encoded SpyTag-SpyCatcher Chemistry
Journal of the American Chemical Society, v. 135, (37), September 2013, p. 13988-13997
Zhang, Wen-Bin; Sun, Fei; Tirrell, David A.; Arnold, Frances H.
Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (13), March 2013, p. 5010-5015
Ji, Quanjiang; Zhang, Liang; Jones, Marcus B.; Sun, Fei; Deng, Xin; Liang, Haihua; Cho, Hoonsik; Brugarolas, Pedro; Gao, Yihe N.; Peterson, Scott N.; Lan, Lefu; Bae, Taeok; He, Chuan
Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria
Cell Host and Microbe, v. 13, (3), March 2013, p. 358-370
Deng, Xin; Weerapana, Eranthie; Ulanovskaya, Olesya; Sun, Fei; Liang, Haihua; Ji, Quanjiang; Ye, Yan; Fu, Ye; Zhou, Lu; Li, Jiaxin; Zhang, Haiyan; Wang, Chu; Alvarez, Sophie; Hicks, Leslie M.; Lan, Lefu; Wu, Min; Cravatt, Benjamin F.; He, Chuan


Expand All Collapse All


Article 6

AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus
J Am Chem Soc., v.134, (1), 11 Jan 2012, p. 305-314
Sun, Fei; Ji, Quanjiang; Jones, Marcus B.; Deng, Xin; Liang, Haihua; Frank, Bryan; Telser, Joshua; Peterson, Scott N.; Bae, Taeok; He, Chuan
Expression of Multidrug Resistance Efflux Pump Gene norA Is Iron Responsive in Staphylococcus aureus
J. Bacteriol, v.194, (7), 2012, April, p. 1753-1762
Deng, Xin; Sun, Fei; Ji, Quanjiang; Liang, Haihua; Missiakas, Dominique; Lan, Lefu; He, Chuan
Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance
Proc Natl Acad Sci U S A., v.109, (38), 18 September 2012, p. 15461-15466
Sun, F.; Ding, Y.; Ji, Q.; Liang, Z.; Deng, X.; Wong, CC; Yi, C.; Zhang, L.; Xie, S.; Alvarez, S.; Hicks, LM; Luo, C.; Jiang, H.; Lan, L.; He, C.
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA
Proc Natl Acad Sci U S A, v.109, (23), 14 June 2012, p. 9095-9100
Sun, Fei; Liang, Haihua; Kong, Xiangqian; Xie, Sherrie; Cho, Hoonsik; Deng, Xin; Ji, Quanjiang; Zhang, Haiyan; Alvarez, Sophie; Hicks, Leslie M.; Bae, Taeok; Luo, Cheng; Jiang, Hualiang; He, Chuan
Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response
Journal of Biological Chemistry, v. 287, (25), June 2012, p. 21102-21109
Ji, Quanjiang; Zhang, Liang; Sun, Fei; Deng, Xeng; Liang, Haihua; Bae, Taeok; He, Chuan
The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus
Molecular Microbiology, v.86, (2), 2012, Oct, p. 331–348
Jeong, Do-Won; Cho, Hoonsik; Jones, Marcus B.; Shatzkes, Kenneth; Sun, Fei; Ji, Quanjiang; Liu, Qian; Peterson, Scott N.; He, Chuan; Bae, Taeok


Expand All Collapse All


Article 2

Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus
Chemistry & Biology, v.18, (8), 26 August 2011, p.1032–1041
Sun, Fei; Zhou, Lu; Zhao, Bing-Chuan; Deng, Xin; Cho, Hoonsik; Yi, Chengqi; Jian, Xing; Song, Chun-Xiao; Luan, Chi-Hao; Bae, Taeok; Liemail, Zigang; Heemail, Chuan
The tightly regulated copper window in yeast
Chem. Commun, v.47, 2011, p. 2571-2573
Wegner, Seraphine V.; Sun, Fei; Hernandeza, Nick; He, Chuan


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Article 3

Aureusimines in Staphylococcus aureus are not involved in virulence
PLoS One, v.5, (12), 29 Dec 2010, article number e15703
Sun, Fei; Cho, Hoonsik; Jeong, Do-Won; Li, Chunling; He, Chuan; Bae, Taeok
CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis
J. Bacteriol, v.192, (15), 2010, Aug, p. 3883-3892
Li, Chunling; Sun, Fei; Cho, Hoonsik; Yelavarthi, Vamshi; Sohn, Changmo; He, Chuan; Schneewind, Olaf; Bae, Taeok
In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS
J Bacteriol, v.192, (8), 2010, Apr, p. 2111-2127
Sun, Fei; Li, Chunling; Jeong, Dowon; Sohn, Changmo; He, Chuan; Bae, Taeok


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2016 1

Microfluidics and Microbial Engineering
Lab on a Chip - Miniaturisation for Chemistry and Biology, v. 16, (3), February 2016, p. 432-446
Kou, Songzi; Cheng, Danhui; Sun, Fei; Hsing, I-Ming Article

2015 1

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo
Chemistry & Biology, v. 22, (8), August 2015, p. 1108-1121
Bedbrook, Claire; Kato, Mihoko; Kumar, Sripriya Ravindra; Lakshmanan, Anupama; Nath, Ravi D.; Sun, Fei; Sternberg, Paul W.; Arnold, Frances H.; Gradinaru, Viviana Article

2014 2

Steady-State Hydrogen Peroxide Induces Glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa
Journal of Bacteriology, v. 196, (14), 2014, p. 2499-2513
Deng, Xin; Liang, Haihua; Ulanovskaya, Olesya A.; Ji, Quanjiang; Zhou, Tianhong; Sun, Fei; Lu, Zhike; Hutchison, Alan L.; Lan, Lefu; Wu, Min; Cravatt, Benjamin F.; He, Chuan Article
Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry
Proceedings of the National Academy of Sciences of the United States of America, v. 111, (31), August 2014, p. 11269-11274
Sun, Fei; Zhang, Wen-Bin; Mahdavi, Alborz; Arnold, Frances H.; Tirrell, David A. Article

2013 3

Controlling Macromolecular Topology with Genetically Encoded SpyTag-SpyCatcher Chemistry
Journal of the American Chemical Society, v. 135, (37), September 2013, p. 13988-13997
Zhang, Wen-Bin; Sun, Fei; Tirrell, David A.; Arnold, Frances H. Article
Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR
Proceedings of the National Academy of Sciences of the United States of America, v. 110, (13), March 2013, p. 5010-5015
Ji, Quanjiang; Zhang, Liang; Jones, Marcus B.; Sun, Fei; Deng, Xin; Liang, Haihua; Cho, Hoonsik; Brugarolas, Pedro; Gao, Yihe N.; Peterson, Scott N.; Lan, Lefu; Bae, Taeok; He, Chuan Article
Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria
Cell Host and Microbe, v. 13, (3), March 2013, p. 358-370
Deng, Xin; Weerapana, Eranthie; Ulanovskaya, Olesya; Sun, Fei; Liang, Haihua; Ji, Quanjiang; Ye, Yan; Fu, Ye; Zhou, Lu; Li, Jiaxin; Zhang, Haiyan; Wang, Chu; Alvarez, Sophie; Hicks, Leslie M.; Lan, Lefu; Wu, Min; Cravatt, Benjamin F.; He, Chuan Article

2012 6

AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus
J Am Chem Soc., v.134, (1), 11 Jan 2012, p. 305-314
Sun, Fei; Ji, Quanjiang; Jones, Marcus B.; Deng, Xin; Liang, Haihua; Frank, Bryan; Telser, Joshua; Peterson, Scott N.; Bae, Taeok; He, Chuan Article
Expression of Multidrug Resistance Efflux Pump Gene norA Is Iron Responsive in Staphylococcus aureus
J. Bacteriol, v.194, (7), 2012, April, p. 1753-1762
Deng, Xin; Sun, Fei; Ji, Quanjiang; Liang, Haihua; Missiakas, Dominique; Lan, Lefu; He, Chuan Article
Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance
Proc Natl Acad Sci U S A., v.109, (38), 18 September 2012, p. 15461-15466
Sun, F.; Ding, Y.; Ji, Q.; Liang, Z.; Deng, X.; Wong, CC; Yi, C.; Zhang, L.; Xie, S.; Alvarez, S.; Hicks, LM; Luo, C.; Jiang, H.; Lan, L.; He, C. Article
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA
Proc Natl Acad Sci U S A, v.109, (23), 14 June 2012, p. 9095-9100
Sun, Fei; Liang, Haihua; Kong, Xiangqian; Xie, Sherrie; Cho, Hoonsik; Deng, Xin; Ji, Quanjiang; Zhang, Haiyan; Alvarez, Sophie; Hicks, Leslie M.; Bae, Taeok; Luo, Cheng; Jiang, Hualiang; He, Chuan Article
Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response
Journal of Biological Chemistry, v. 287, (25), June 2012, p. 21102-21109
Ji, Quanjiang; Zhang, Liang; Sun, Fei; Deng, Xeng; Liang, Haihua; Bae, Taeok; He, Chuan Article
The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus
Molecular Microbiology, v.86, (2), 2012, Oct, p. 331–348
Jeong, Do-Won; Cho, Hoonsik; Jones, Marcus B.; Shatzkes, Kenneth; Sun, Fei; Ji, Quanjiang; Liu, Qian; Peterson, Scott N.; He, Chuan; Bae, Taeok Article

2011 2

Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus
Chemistry & Biology, v.18, (8), 26 August 2011, p.1032–1041
Sun, Fei; Zhou, Lu; Zhao, Bing-Chuan; Deng, Xin; Cho, Hoonsik; Yi, Chengqi; Jian, Xing; Song, Chun-Xiao; Luan, Chi-Hao; Bae, Taeok; Liemail, Zigang; Heemail, Chuan Article
The tightly regulated copper window in yeast
Chem. Commun, v.47, 2011, p. 2571-2573
Wegner, Seraphine V.; Sun, Fei; Hernandeza, Nick; He, Chuan Article

2010 3

Aureusimines in Staphylococcus aureus are not involved in virulence
PLoS One, v.5, (12), 29 Dec 2010, article number e15703
Sun, Fei; Cho, Hoonsik; Jeong, Do-Won; Li, Chunling; He, Chuan; Bae, Taeok Article
CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis
J. Bacteriol, v.192, (15), 2010, Aug, p. 3883-3892
Li, Chunling; Sun, Fei; Cho, Hoonsik; Yelavarthi, Vamshi; Sohn, Changmo; He, Chuan; Schneewind, Olaf; Bae, Taeok Article
In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS
J Bacteriol, v.192, (8), 2010, Apr, p. 2111-2127
Sun, Fei; Li, Chunling; Jeong, Dowon; Sohn, Changmo; He, Chuan; Bae, Taeok Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 4 2020-21 Summer 1 2020-21 Spring 4 2020-21 Winter 0 2020-21 Fall 3

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BIEN6800U Bioengineering Seminar
CBME6000E Protein Engineering
CENG1600 Biotechnology and Its Business Opportunities
CENG5610 Protein Engineering


UROP1100D Undergraduate Research Opportunities Series 1


BIEN6800T Bioengineering Seminar
CENG4640 Biomolecular Engineering
CENG4920 Chemical Engineering Capstone Design
ENGG4902 Integrated Final Year Project - Second Major


BIEN6800S Bioengineering Seminar
CBME6000E Protein Engineering
CENG1600 Biotechnology and Its Business Opportunities


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy ALVINA, Maria Joscelind
Chemical and Biomolecular Engineering( 2021 - )

DONG, Haorong (co-supervision)
Bioscience and Biomedical Engineering( 2021 - )

FANG, Shiyu
Chemical and Biomolecular Engineering( 2021 - )

FOK, Hong Kiu Francis
Chemical and Biomolecular Engineering( 2020 - )

WONG, Ka Chin
Bioengineering( 2020 - )

LI, Tiehuai (co-supervision)
Chemical and Biomolecular Engineering( 2019 - )

LI, Manjia
Chemical and Biomolecular Engineering( 2018 - )

YI, Qikun
Chemical and Biomolecular Engineering( 2018 - )

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Master of Philosophy CUI, Duo
Chemical and Biomolecular Engineering( 2021 - )

SUN, Chenbo
Chemical and Biomolecular Engineering( 2021 - )

HUANG, Xinyu
Chemical and Biomolecular Engineering( 2020 - )

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Graduated RPGs

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Doctor of Philosophy PARK, Byung Min
Bioengineering( Completed in 2021 )

LUO, Jiren
Chemical and Biomolecular Engineering( Completed in 2020 )

CAO, Yujie
Chemical and Biomolecular Engineering( Completed in 2019 )

LIU, Xiaotian
Bioengineering( Completed in 2019 )

YANG, Zhongguang
Chemical and Biomolecular Engineering( Completed in 2019 )

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Master of Philosophy JIANG, Bojing (co-supervision)
Bioengineering( Completed in 2021 )

TSANG, Tsz Chun Victor (co-supervision)
Bioengineering( Completed in 2021 )

FOK, Hong Kiu Francis
Chemical and Biomolecular Engineering( Completed in 2020 )

WONG, Ka Chin
Technology Leadership and Entrepreneurship( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

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All Projects 11 Leading Projects 7 Participating Projects 4

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Stem cell-niche interactions in tissue maintenance and engineering


幹細胞與微環境互作在組織維持和組織工程中的應用 Participating


RGC - Theme-based Research Scheme


Project Team (HKUST)
XIE Ting (Lead)
CHEUNG Tom
GUO Yusong
LEUNG Danny Chi Yeu
LIU Kai
MAK Ho Yi
SUN Fei
WEN Zilong
WU Angela Ruohao
WU Zhenguo
YAN Yan


2022 -




Development of Materials for Axon Regeneration Enabled by Protein Topology Engineering


基於蛋白質拓撲工程的材料研發及其在軸突再生中的應用 Leading


RGC - General Research Fund


Project Team (HKUST)
SUN Fei (Lead)


2022 -




Protein engineering and chemical biology


蛋白質工程與化學生物學 Leading


National Natural Science Foundation of China


Project Team (HKUST)
SUN Fei (Lead)


2022 -




Developing A Handheld Photoacoustic Imaging System And Water-Soluble Proteins For Deep-Tissue And Cancer-Targeting In Vivo Imaging


通過開發手持式光聲成像系統和水溶性蛋白質，達到深層組織和靶向癌癥的體內成像 Participating


Innovation and Technology Fund


Project Team (HKUST)
WONG Terence Tsz Wai (Lead)
SUN Fei


2021 -




Injectable hydrogels for nerve regeneration enabled by protein engineering


基于蛋白質工程的可注射水凝膠及其在神經修復中的應用 Leading


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
SUN Fei (Lead)
LIU Kai


2021 -




National Key Research and Development Project for Synthetic Biology (Engineered Living Materials) sub-topic 2: Development of logic circuits based on protein-protein or protein-functional molecule interactions


生物活體功能材料的構建及應用-課題二之子課題2：開發基于蛋白-蛋白或蛋白-功能分子相互作用的邏輯回路 Participating


Ministry of Science and Technology of the People's Republic of China


Project Team (HKUST)
SUN Fei


2020 -




Develop Near-Infrared Light-Responsive Protein Hydrogels via Directed Evolution for Guided 3D Axon Elongation


利用定向進化發展近紅外光響應的蛋白質水凝膠及其在軸突生長方面的應用 Leading


RGC - General Research Fund


Project Team (HKUST)
SUN Fei (Lead)


2019 -




Developing adhesive protein hydrogels by enzymatic oxidation for wound healing and tissue repair


酶催化的蛋白質水凝膠材料的開發及其在組織粘合中的應用 Leading


Guangdong Natural Science Foundation


Project Team (HKUST)
SUN Fei (Lead)


2019 -




Entirely genetically engineered protein hydrogels for stem cell regulation and delivery


全重組蛋白水凝膠的設計及對干細胞的調控與傳遞 Leading


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
SUN Fei (Lead)


2018 - 2020




Synthetic biology approaches toward adhesive protein materials for 3D cell culturing and CTC detection


基于合成生物學對黏性蛋白質材料的開發及其腫瘤檢測的應用 Leading


PKU-HKUST Shenzhen-Hong Kong Institution


Project Team (HKUST)
SUN Fei (Lead)


2018 - 2020




Reconstitution of Postsynaptic Densities of Excitatory Synapses


興奮性神經突觸後致密區的重組研究 Participating


RGC - Collaborative Research Fund


Project Team (HKUST)
LIU Kai
SUN Fei


2018 - 2020